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Chapter 3 : Viral Infections of the Central Nervous System

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Abstract:

Central nervous system (CNS) symptoms (headache, lethargy, impaired psychomotor performance) are frequent components of viral infections; however, viral infections of the CNS occur infrequently and most often result in relatively benign, self-limited disease. Nevertheless, these infections have tremendous importance because of their potential for causing neurologic damage and death. The CNS is exquisitely sensitive to metabolic derangements and tissue injury. Clinical recovery is slow and often incomplete (1, 2). Patient history, while frequently suggestive of a diagnosis, remains an unreliable method for determining the specific etiology of CNS disease (1, 3). Tumors, infections, and autoimmune processes in the CNS often produce similar signs and symptoms (3). Different diseases may share common pathogenic mechanisms and therefore result in a similar clinical presentation. Furthermore, understanding disease pathogenesis provides a rational basis for the development of therapeutics including antivirals and strategies for the prevention of viral CNS infections.

Citation: Cassady K, Whitley R. 2017. Viral Infections of the Central Nervous System, p 31-45. In Richman D, Whitley R, Hayden F (ed), Clinical Virology, Fourth Edition. ASM Press, Washington, DC. doi: 10.1128/9781555819439.ch3
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FIGURE 1

Body surfaces as sites of virus infection and shedding.

Citation: Cassady K, Whitley R. 2017. Viral Infections of the Central Nervous System, p 31-45. In Richman D, Whitley R, Hayden F (ed), Clinical Virology, Fourth Edition. ASM Press, Washington, DC. doi: 10.1128/9781555819439.ch3
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Image of FIGURE 2
FIGURE 2

Routes of viral invasion of the central nervous system. CSF, cerebrospinal fluid.

Citation: Cassady K, Whitley R. 2017. Viral Infections of the Central Nervous System, p 31-45. In Richman D, Whitley R, Hayden F (ed), Clinical Virology, Fourth Edition. ASM Press, Washington, DC. doi: 10.1128/9781555819439.ch3
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References

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1. Cassady KA, Whitley RJ,. 2002. Viral central nervous system infections, p. 2744. In Richmond DD, Whitley RJ, Hayden FG (ed), Clinical Virology. ASM Press, Washington, D.C.
2. Moorthi S, Schneider WN, Dombovy ML. 1999. Rehabilitation outcomes in encephalitis—a retrospective study 1990–1997. Brain Inj 13:139146.[PubMed]
3. Whitley RJ, Cobbs CG, Alford CA Jr, Soong SJ, Hirsch MS, Connor JD, Corey L, Hanley DF, Levin M, Powell DA NIAD Collaborative Antiviral Study Group. 1989. Diseases that mimic herpes simplex encephalitis. Diagnosis, presentation, and outcome. JAMA 262:234239.[PubMed]
4. Scheld WM, Whitley RJ, Marra CM (ed). 2004. Infections of the Central Nervous System, 6th ed. Lippincott Williams & Wilkins, Philadelphia.
5. Whitley RJ, MacDonald N, Asher DM Committee on Infectious Diseases. 2000. American Academy of Pediatrics. Technical report: transmissible spongiform encephalopathies: A review for pediatricians. Pediatrics 106:11601165.[PubMed]
6. Nicolosi A, Hauser WA, Beghi E, Kurland LT. 1986. Epidemiology of central nervous system infections in Olmsted County, Minnesota, 1950–1981. J Infect Dis 154:399408.[PubMed]
7. Lee BE, Davies HD. 2007. Aseptic meningitis. Curr Opin Infect Dis 20:272277.[PubMed]
8. Nigrovic LE, Chiang VW. 2000. Cost analysis of enteroviral polymerase chain reaction in infants with fever and cerebrospinal fluid pleocytosis. Arch Pediatr Adolesc Med 154:817821.[PubMed]
9. Ramers C, Billman G, Hartin M, Ho S, Sawyer MH. 2000. Impact of a diagnostic cerebrospinal fluid enterovirus polymerase chain reaction test on patient management. JAMA 283:26802685.[PubMed]
10. Nagai T, Okafuji T, Miyazaki C, Ito Y, Kamada M, Kumagai T, Yuri K, Sakiyama H, Miyata A, Ihara T, Ochiai H, Shimomura K, Suzuki E, Torigoe S, Igarashi M, Kase T, Okuno Y, Nakayama T. 2007. A comparative study of the incidence of aseptic meningitis in symptomatic natural mumps patients and monovalent mumps vaccine recipients in Japan. Vaccine 25:27422747.[PubMed]
11. Sawyer MH. 1999. Enterovirus infections: diagnosis and treatment. Pediatr Infect Dis J 18:10331039, quiz 1040.[PubMed]
12. Kupila L, Vuorinen T, Vainionpää R, Hukkanen V, Marttila RJ, Kotilainen P. 2006. Etiology of aseptic meningitis and encephalitis in an adult population. Neurology 66:7580.[PubMed]
13. Kupila L, Vuorinen T, Vainionpäā R, Marttila RJ, Kotilainen P. 2005. Diagnosis of enteroviral meningitis by use of polymerase chain reaction of cerebrospinal fluid, stool, and serum specimens. Clin Infect Dis 40:982987.[PubMed]
14. Meece JK, Henkel JS, Glaser L, Reed KD. 2003. Mosquito surveillance for West Nile virus in southeastern Wisconsin—2002. Clin Med Res 1:3742.[PubMed]
15. Kimura H, Futamura M, Kito H, Ando T, Goto M, Kuzushima K, Shibata M, Morishima T. 1991. Detection of viral DNA in neonatal herpes simplex virus infections: frequent and prolonged presence in serum and cerebrospinal fluid. J Infect Dis 164:289293.[PubMed]
16. Stanberry LR, Floyd-Reising SA, Connelly BL, Alter SJ, Gilchrist MJ, Rubio C, Myers MG. 1994. Herpes simplex viremia: report of eight pediatric cases and review of the literature. Clin Infect Dis 18:401407.[PubMed]
17. Edens HA, Parkos CA. 2000. Modulation of epithelial and endothelial paracellular permeability by leukocytes. Adv Drug Deliv Rev 41:315328. Review. 93 refs.[PubMed]
18. Nagy Z, Martinez K. 1991. Astrocytic induction of endothelial tight junctions. Ann N Y Acad Sci 633:395404.[PubMed]
19. Becher B, Prat A, Antel JP. 2000. Brain-immune connection: immuno-regulatory properties of CNS-resident cells. Glia 29:293304.
20. Ichiyama T, Maeba S, Suenaga N, Saito K, Matsubara T, Furukawa S. 2005. Analysis of cytokine levels in cerebrospinal fluid in mumps meningitis: comparison with echovirus type 30 meningitis. Cytokine 30:243247.[PubMed]
21. Wang SM, Lei HY, Su LY, Wu JM, Yu CK, Wang JR, Liu CC. 2007. Cerebrospinal fluid cytokines in enterovirus 71 brain stem encephalitis and echovirus meningitis infections of varying severity. Clin Microbiol Infect 13:677682.[PubMed]
22. Nagafuchi M, Nagafuchi Y, Sato R, Imaizumi T, Ayabe M, Shoji H, Ichiyama T. 2006. Adult meningism and viral meningitis, 1997–2004: clinical data and cerebrospinal fluid cytokines. Intern Med 45:12091212.[PubMed]
23. Li Y, Zhang G, Ma R, Du Y, Zhang L, Li F, Fang F, Lv H, Wang Q, Zhang Y, Kang X. 2015. The diagnostic value of cerebrospinal fluids procalcitonin and lactate for the differential diagnosis of post-neurosurgical bacterial meningitis and aseptic meningitis. Clin Biochem 48:5054.[PubMed]
24. Sakushima K, Hayashino Y, Kawaguchi T, Jackson JL, Fukuhara S. 2011. Diagnostic accuracy of cerebrospinal fluid lactate for differentiating bacterial meningitis from aseptic meningitis: a meta-analysis. J Infect 62:255262.[PubMed]
25. Fragoso-Loyo H, Richaud-Patin Y, Orozco-Narváez A, Dávila-Maldonado L, Atisha-Fregoso Y, Llorente L, Sánchez-Guerrero J. 2007. Interleukin-6 and chemokines in the neuropsychiatric manifestations of systemic lupus erythematosus. Arthritis Rheum 56:12421250.[PubMed]
26. Cunningham CK, Bonville CA, Ochs HD, Seyama K, John PA, Rotbart HA, Weiner LB. 1999. Enteroviral meningoencephalitis as a complication of X-linked hyper IgM syndrome. J Pediatr 134:584588.[PubMed]
27. Schmugge M, Lauener R, Bossart W, Seger RA, Güngör T. 1999. Chronic enteroviral meningo-encephalitis in X-linked agammaglobulinaemia: favourable response to anti-enteroviral treatment. Eur J Pediatr 158:10101011. letter.[PubMed]
28. Rorabaugh ML, Berlin LE, Heldrich F, Roberts K, Rosenberg LA, Doran T, Modlin JF. 1993. Aseptic meningitis in infants younger than 2 years of age: acute illness and neurologic complications. Pediatrics 92:206211.[PubMed]
29. Bergström T, Vahlne A, Alestig K, Jeansson S, Forsgren M, Lycke E. 1990. Primary and recurrent herpes simplex virus type 2-induced meningitis. J Infect Dis 162:322330.[PubMed]
30. Jensenius M, Myrvang B, Størvold G, Bucher A, Hellum KB, Bruu AL. 1998. Herpes simplex virus type 2 DNA detected in cerebrospinal fluid of 9 patients with Mollaret's meningitis. Acta Neurol Scand 98:209212.[PubMed]
31. Hosoya M, Honzumi K, Sato M, Katayose M, Kato K, Suzuki H. 1998. Application of PCR for various neurotropic viruses on the diagnosis of viral meningitis. J Clin Virol 11:117124.[PubMed]
32. Negrini B, Kelleher KJ, Wald ER. 2000. Cerebrospinal fluid findings in aseptic versus bacterial meningitis. Pediatrics 105:316319.[PubMed]
33. Varki AP, Puthuran P. 1979. Value of second lumbar puncture in confirming a diagnosis of aseptic meningitis. A prospective study. Arch Neurol 36:581582.[PubMed]
34. Nigrovic LE, Kuppermann N, Macias CG, Cannavino CR, Moro-Sutherland DM, Schremmer RD, Schwab SH, Agrawal D, Mansour KM, Bennett JE, Katsogridakis YL, Mohseni MM, Bulloch B, Steele DW, Kaplan RL, Herman MI, Bandyopadhyay S, Dayan P, Truong UT, Wang VJ, Bonsu BK, Chapman JL, Kanegaye JT, Malley R Pediatric Emergency Medicine Collaborative Research Committee of the American Academy of Pediatrics. 2007. Clinical prediction rule for identifying children with cerebrospinal fluid pleocytosis at very low risk of bacterial meningitis. JAMA 297:5260.[PubMed]
35. Jeffery KJ, Read SJ, Peto TE, Mayon-White RT, Bangham CR. 1997. Diagnosis of viral infections of the central nervous system: clinical interpretation of PCR results. Lancet 349:313317.[PubMed]
36. Pang J, Modlin J, Yolken R. 1992. Use of modified nucleotides and uracil-DNA glycosylase (UNG) for the control of contamination in the PCR-based amplification of RNA. Mol Cell Probes 6:251256.[PubMed]
37. Tetzner R, Dietrich D, Distler J. 2007. Control of carry-over contamination for PCR-based DNA methylation quantification using bisulfite treated DNA. Nucleic Acids Res 35:e4.[PubMed]
38. Kuno G. 1998. Universal diagnostic RT-PCR protocol for arboviruses. J Virol Methods 72:2741.[PubMed]
39. Schuster FL, Glaser C, Honarmand S, Maguire JH, Visvesvara GS. 2004. Balamuthia amebic encephalitis risk, Hispanic Americans. Emerg Infect Dis 10:15101512.[PubMed]
40. Kiderlen AF, Laube U. 2004. Balamuthia mandrillaris, an opportunistic agent of granulomatous amebic encephalitis, infects the brain via the olfactory nerve pathway. Parasitol Res 94:4952.[PubMed]
41. Rodríguez SC, Olguín AM, Miralles CP, Viladrich PF. 2006. Characteristics of meningitis caused by Ibuprofen: report of 2 cases with recurrent episodes and review of the literature. Medicine (Baltimore) 85:214220.[PubMed]
42. Abzug MJ, Keyserling HL, Lee ML, Levin MJ, Rotbart HA. 1995. Neonatal enterovirus infection: virology, serology, and effects of intravenous immune globulin. Clin Infect Dis 20:12011206.[PubMed]
43. Valduss D, Murray DL, Karna P, Lapour K, Dyke J. 1993. Use of intravenous immunoglobulin in twin neonates with disseminated coxsackie B1 infection. Clin Pediatr (Phila) 32:561563.[PubMed]
44. Nowak-Wegrzyn A, Phipatanakul W, Winkelstein JA, Forman MS, Lederman HM. 2001. Successful treatment of enterovirus infection with the use of pleconaril in 2 infants with severe combined immunodeficiency. Clin Infect Dis 32:E13E14.[PubMed]
45. Bauer S, Gottesman G, Sirota L, Litmanovitz I, Ashkenazi S, Levi I. 2002. Severe Coxsackie virus B infection in preterm newborns treated with pleconaril. Eur J Pediatr 161:491493.[PubMed]
46. Rotbart HA, Webster AD Pleconaril Treatment Registry Group. 2001. Treatment of potentially life-threatening enterovirus infections with pleconaril. Clin Infect Dis 32:228235.[PubMed]
47. Desmond RA, Accortt NA, Talley L, Villano SA, Soong SJ, Whitley RJ. 2006. Enteroviral meningitis: natural history and outcome of pleconaril therapy. Antimicrob Agents Chemother 50:24092414.[PubMed]
48. Abzug MJ, Cloud G, Bradley J, Sánchez PJ, Romero J, Powell D, Lepow M, Mani C, Capparelli EV, Blount S, Lakeman F, Whitley RJ, Kimberlin DW National Institute of Allergy and Infectious Diseases Collaborative Antiviral Study Group. 2003. Double blind placebo-controlled trial of pleconaril in infants with enterovirus meningitis. Pediatr Infect Dis J 22:335341.[PubMed]
49. Whitley RJ, Gnann JW Jr. 1992. Acyclovir: a decade later. N Engl J Med 327:782789.[PubMed]
50. Conway JH, Weinberg A, Ashley RL, Amer J, Levin MJ. 1997. Viral meningitis in a preadolescent child caused by reactivation of latent herpes simplex (type 1). Pediatr Infect Dis J 16:627629.[PubMed]
51. De La Blanchardiere A, Rozenberg F, Caumes E, Picard O, Lionnet F, Livartowski J, Coste J, Sicard D, Lebon P, Salmon-Cèron D. 2000. Neurological complications of varicella-zoster virus infection in adults with human immunodeficiency virus infection. Scand J Infect Dis 32:263269.[PubMed]
52. Gilden DH, Kleinschmidt-DeMasters BK, LaGuardia JJ, Mahalingam R, Cohrs RJ. 2000. Neurologic complications of the reactivation of varicella-zoster virus. N Engl J Med 342:635645.
53. Koskiniemi M, Korppi M, Mustonen K, Rantala H, Muttilainen M, Herrgård E, Ukkonen P, Vaheri A. 1997. Epidemiology of encephalitis in children. A prospective multicentre study. Eur J Pediatr 156:541545.[PubMed]
54. Khetsuriani N, Holman RC, Lamonte-Fowlkes AC, Selik RM, Anderson LJ. 2007. Trends in encephalitis-associated deaths in the United States. Epidemiol Infect 135:583591.[PubMed]
55. McNabb SJ, Jajosky RA, Hall-Baker PA, Adams DA, Sharp P, Anderson WJ, Javier AJ, Jones GJ, Nitschke DA, Worshams CA, Richard RA Jr Centers for Disease Control and Prevention (CDC). 2007. Summary of notifiable diseases—United States, 2005. MMWR Morb Mortal Wkly Rep 54:192.[PubMed]
56. Sejvar JJ. 2006. The evolving epidemiology of viral encephalitis. Curr Opin Neurol 19:350357.[PubMed]
57. Ayukawa R, Fujimoto H, Ayabe M, Shoji H, Matsui R, Iwata Y, Fukuda H, Ochi K, Noda K, Ono Y, Sakai K, Takehisa Y, Yasui K. 2004. An unexpected outbreak of Japanese encephalitis in the Chugoku district of Japan, 2002. Jpn J Infect Dis 57:6366.[PubMed]
58. Handy R, Lang S. Flavivirus encephalitis. N Engl J Med. 2004;3511803–1804.
59. Pape WJ, Fitzsimmons TD, Hoffman RE. 1999. Risk for rabies transmission from encounters with bats, Colorado, 1977–1996. Emerg Infect Dis 5:433437.[PubMed]
60. Anonymous, Centers for Disease Control and Prevention (CDC). 2000. Human rabies—California, Georgia, Minnesota, New York, and Wisconsin, 2000. MMWR Morb Mortal Wkly Rep 49:11111115.[PubMed]
61. Hampson K, Coudeville L, Lembo T, Sambo M, Kieffer A, Attlan M, Barrat J, Blanton JD, Briggs DJ, Cleaveland S, Costa P, Freuling CM, Hiby E, Knopf L, Leanes F, Meslin FX, Metlin A, Miranda ME, Müller T, Nel LH, Recuenco S, Rupprecht CE, Schumacher C, Taylor L, Vigilato MA, Zinsstag J, Dushoff J Global Alliance for Rabies Control Partners for Rabies Prevention. 2015. Estimating the global burden of endemic canine rabies. PLoS Negl Trop Dis 9:e0003709.[PubMed]
62. Stüve O, Zamvil SS. 1999. Pathogenesis, diagnosis, and treatment of acute disseminated encephalomyelitis. Curr Opin Neurol 12:395401. Review. 99 refs.[PubMed]
63. Armangue T, Leypoldt F, Málaga I, Raspall-Chaure M, Marti I, Nichter C, Pugh J, Vicente-Rasoamalala M, Lafuente-Hidalgo M, Macaya A, Ke M, Titulaer MJ, Höftberger R, Sheriff H, Glaser C, Dalmau J. 2014. Herpes simplex virus encephalitis is a trigger of brain autoimmunity. Ann Neurol 75:317323.[PubMed]
64. Gable MS, Sheriff H, Dalmau J, Tilley DH, Glaser CA. 2012. The frequency of autoimmune N-methyl-D-aspartate receptor encephalitis surpasses that of individual viral etiologies in young individuals enrolled in the California Encephalitis Project. Clin Infect Dis 54:899904.[PubMed]
65. Collee JG, Bradley R, Liberski PP. 2006. Variant CJD (vCJD) and bovine spongiform encephalopathy (BSE): 10 and 20 years on: part 2. Folia Neuropathol 44:102110.[PubMed]
66. Rotbart HA, Brennan PJ, Fife KH, Romero JR, Griffin JA, McKinlay MA, Hayden FG. 1998. Enterovirus meningitis in adults. Clin Infect Dis 27:896898.[PubMed]
67. Chou J, Kern ER, Whitley RJ, Roizman B. 1990. Mapping of herpes simplex virus-1 neurovirulence to gamma 134.5, a gene nonessential for growth in culture. Science 250:12621266.[PubMed]
68. Markovitz NS, Baunoch D, Roizman B. 1997. The range and distribution of murine central nervous system cells infected with the gamma(1)34.5- mutant of herpes simplex virus 1. J Virol 71:55605569.[PubMed]
69. Griffin DE. 1998. A review of alphavirus replication in neurons. Neurosci Biobehav Rev 22:721723.[PubMed]
70. Sutton JM, Dickinson J, Walker JT, Raven ND. 2006. Methods to minimize the risks of Creutzfeldt-Jakob disease transmission by surgical procedures: where to set the standard? Clin Infect Dis 43:757764.[PubMed]
71. Hilton DA. 2006. Pathogenesis and prevalence of variant Creutzfeldt-Jakob disease. J Pathol 208:134141.[PubMed]
72. Hewitt P. 2006. vCJD and blood transfusion in the United Kingdom. Transfus Clin Biol 13:312316.[PubMed]
73. Dobra SA, Bennett PG. 2006. vCJD and blood transfusion: risk assessment in the United Kingdom. Transfus Clin Biol 13:307311.[PubMed]
74. Suja MS, Mahadevan A, Sundaram C, Mani J, Sagar BC, Hemachudha T, Wacharapluesadee S, Madhusudana SN, Shankar SK. 2004. Rabies encephalitis following fox bite—histological and immunohistochemical evaluation of lesions caused by virus. Clin Neuropathol 23:271276.[PubMed]
75. Sejvar JJ. 2007. The long-term outcomes of human West Nile virus infection. Clin Infect Dis 44:16171624.[PubMed]
76. Ho DD, Hirsch MS. 1985. Acute viral encephalitis. Med Clin North Am 69:415429.[PubMed]
77. Steiner I, Budka H, Chaudhuri A, Koskiniemi M, Sainio K, Salonen O, Kennedy PG. 2005. Viral encephalitis: a review of diagnostic methods and guidelines for management. Eur J Neurol 12:331343.[PubMed]
78. Debiasi RL, Tyler KL. 2004. Molecular methods for diagnosis of viral encephalitis. Clin Microbiol Rev 17:903925.[PubMed]
79. Fonseca-Aten M, Messina AF, Jafri HS, Sánchez PJ. 2005. Herpes simplex virus encephalitis during suppressive therapy with acyclovir in a premature infant. Pediatrics 115:804809.[PubMed]
80. Deresiewicz RL, Thaler SJ, Hsu L, Zamani AA. 1997. Clinical and neuroradiographic manifestations of eastern equine encephalitis. N Engl J Med 336:18671874.[PubMed]
81. Maschke M, Kastrup O, Forsting M, Diener HC. 2004. Update on neuroimaging in infectious central nervous system disease. Curr Opin Neurol 17:475480.[PubMed]
82. Kennedy PG. 2005. Viral encephalitis. J Neurol 252:268272.[PubMed]
83. Domingues RB, Lakeman FD, Mayo MS, Whitley RJ. 1998. Application of competitive PCR to cerebrospinal fluid samples from patients with herpes simplex encephalitis. J Clin Microbiol 36:22292234.[PubMed]
84. Santhosh SR, Parida MM, Dash PK, Pateriya A, Pattnaik B, Pradhan HK, Tripathi NK, Ambuj S, Gupta N, Saxena P, Lakshmana Rao PV. 2007. Development and evaluation of SYBR Green I-based one-step real-time RT-PCR assay for detection and quantitation of Japanese encephalitis virus. J Virol Methods 143:7380.[PubMed]
85. Krasnianski A, Meissner B, Heinemann U, Zerr I. Clinical findings and diagnostic tests in Creutzfeldt-Jakob disease and variant Creutzfeldt-Jakob disease. Folia Neuropathol. 2004;42 Suppl B:2438.
86. Tschampa HJ, Kallenberg K, Urbach H, Meissner B, Nicolay C, Kretzschmar HA, Knauth M, Zerr I. 2005. MRI in the diagnosis of sporadic Creutzfeldt-Jakob disease: a study on inter-observer agreement. Brain 128:20262033.[PubMed]
87. Parida M, Dash PK, Tripathi NK, Ambuj Sannarangaiah S, Saxena P, Agarwal S, Sahni AK, Singh SP, Rathi AK, Bhargava R, Abhyankar A, Verma SK, Rao PV, Sekhar K. 2006. Japanese encephalitis outbreak, India, 2005. Emerg Infect Dis 12:14271430.[PubMed]
88. Solomon T. 2006. Control of Japanese encephalitis—within our grasp? N Engl J Med 355:869871.[PubMed]
89. Palmisano CT, Taylor V, Caillouet K, Byrd B, Wesson DM. 2005. Impact of West Nile virus outbreak upon St. Tammany Parish Mosquito Abatement District. J Am Mosq Control Assoc 21:3338.[PubMed]
90. Moran GJ, Talan DA, Mower W, Newdow M, Ong S, Nakase JY, Pinner RW, Childs JE Emergency ID Net Study Group. 2000. Appropriateness of rabies postexposure prophylaxis treatment for animal exposures. JAMA 284:10011007.[PubMed]
91. Centers for Disease Control and Prevention (CDC). 2004. Bovine spongiform encephalopathy in a dairy cow—Washington state, 2003. MMWR Morb Mortal Wkly Rep 52:12801285.[PubMed]
92. Echevarría JM, Casas I, Martínez-Martín P. 1997. Infections of the nervous system caused by varicella-zoster virus: a review. Intervirology 40:7284. Review. 131 refs.[PubMed]
93. Maschke M, Kastrup O, Esser S, Ross B, Hengge U, Hufnagel A. 2000. Incidence and prevalence of neurological disorders associated with HIV since the introduction of highly active antiretroviral therapy (HAART). J Neurol Neurosurg Psychiatry 69:376380.[PubMed]

Tables

Generic image for table
TABLE 1

DNA viruses: type of disease, epidemiologic data, and pathogenesis of viral infections of the CNS

Citation: Cassady K, Whitley R. 2017. Viral Infections of the Central Nervous System, p 31-45. In Richman D, Whitley R, Hayden F (ed), Clinical Virology, Fourth Edition. ASM Press, Washington, DC. doi: 10.1128/9781555819439.ch3
Generic image for table
TABLE 2a

RNA viruses: type of disease, epidemiologic data, and pathogenesis of viral infections of the CNS

Citation: Cassady K, Whitley R. 2017. Viral Infections of the Central Nervous System, p 31-45. In Richman D, Whitley R, Hayden F (ed), Clinical Virology, Fourth Edition. ASM Press, Washington, DC. doi: 10.1128/9781555819439.ch3
Generic image for table
TABLE 2b

RNA viruses: type of disease, epidemiologic data, and pathogenesis of viral infections of the CNS

Citation: Cassady K, Whitley R. 2017. Viral Infections of the Central Nervous System, p 31-45. In Richman D, Whitley R, Hayden F (ed), Clinical Virology, Fourth Edition. ASM Press, Washington, DC. doi: 10.1128/9781555819439.ch3
Generic image for table
TABLE 3

Differential diagnosis for encephalitis and meningitis

Citation: Cassady K, Whitley R. 2017. Viral Infections of the Central Nervous System, p 31-45. In Richman D, Whitley R, Hayden F (ed), Clinical Virology, Fourth Edition. ASM Press, Washington, DC. doi: 10.1128/9781555819439.ch3

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