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Chapter 30 : Human Parvoviruses

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Human Parvoviruses, Page 1 of 2

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Abstract:

Parvoviruses have been isolated from a wide range of animals, including mammals, birds, insects, crustaceans, and reptiles. These viruses tend to be species-specific and can cause a variety of serious diseases in their host species (1). The first parvoviruses isolated from humans were adeno-associated parvoviruses, which have not yet been linked with disease. Until recently the only parvovirus associated with human disease was human parvovirus B19 (B19V), which was fortuitously identified in 1975 during an evaluation of tests for hepatitis B virus antigens (2). B19V has been associated with erythema infectiosum, transient aplastic crisis, chronic anemia in patients with impaired immune systems, hydrops fetalis, and purportedly a number of other conditions (3). Seven additional parvoviruses have recently been detected in humans by molecular screening for new sequences, including human bocavirus (HBoV)1–4, tetraparvovirus (PARV4), bufavirus (BuV), and tusavirus (TuV) (4–9). HBoV1 causes acute respiratory illness (10) and, as with HBoV2 and 3, possibly also encephalitis (11). The other recently discovered human parvoviruses are yet to be associated with human disease.

Citation: Söderlund-Venermo M, Brown K, Erdman D. 2017. Human Parvoviruses, p 679-699. In Richman D, Whitley R, Hayden F (ed), Clinical Virology, Fourth Edition. ASM Press, Washington, DC. doi: 10.1128/9781555819439.ch30
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Image of FIGURE 1
FIGURE 1

Neighbor joining phylogenetic tree derived from ORF1 (nonstructural protein) amino acid sequences obtained from GenBank and used by ICTV to classify parvoviruses ( ). Subfamilies and shown as gray circles. For simplicity, only one representative member of the is shown and only genera of the with members known to infect humans are shown as yellow circles (, , and , genera are therefore excluded). Representative human parvoviruses (in red), putative human viruses (in blue), and prototype viruses when not human (in black) are shown within each genus. AA, amino acid; AaeDV1, densovirus 1; AAV1, AAV2, AAV5, adeno-associated viruses 1, 2, 5; B19V1–3, parvovirus B19 genotypes 1–3; BPV1, bovine parvovirus 1; BuV1–3, bufavirus genotypes 1–3; HBoV1–4, human bocavirueses 1–4; MVM, minute virus of mice; PARV4 1–3, tetraparvovirus genotypes 1–3; TuV1, tusavirus genotype 1.

Citation: Söderlund-Venermo M, Brown K, Erdman D. 2017. Human Parvoviruses, p 679-699. In Richman D, Whitley R, Hayden F (ed), Clinical Virology, Fourth Edition. ASM Press, Washington, DC. doi: 10.1128/9781555819439.ch30
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Image of FIGURE 2
FIGURE 2

Electron micrograph (X170,000) of B19V empty particles in a serum specimen from a patient with transient aplastic crisis. Courtesy of G. William Gary, CDC, Atlanta, GA.

Citation: Söderlund-Venermo M, Brown K, Erdman D. 2017. Human Parvoviruses, p 679-699. In Richman D, Whitley R, Hayden F (ed), Clinical Virology, Fourth Edition. ASM Press, Washington, DC. doi: 10.1128/9781555819439.ch30
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Image of FIGURE 3
FIGURE 3

Schematic of B19 mRNA produced in erythroid progenitor cells. The thin line represents introns and the heavy line represents the nontranslated portion of exons. The filled box represents translated portions of exons. The numbers below the line indicate the start or end of the respective exon. All mRNAs are initiated at the same promotor (P6). The NS protein (first mRNA) is in one reading frame; the 7.5 kDa, VP1, and VP2 proteins are in a second reading frame (-1 relative to the NS protein); and the 11.0 kDa protein is in the third reading frame. Based on data from references and .

Citation: Söderlund-Venermo M, Brown K, Erdman D. 2017. Human Parvoviruses, p 679-699. In Richman D, Whitley R, Hayden F (ed), Clinical Virology, Fourth Edition. ASM Press, Washington, DC. doi: 10.1128/9781555819439.ch30
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Image of FIGURE 4
FIGURE 4

Rates of B19V IgG antibody positivity by age. Adapted from reference .

Citation: Söderlund-Venermo M, Brown K, Erdman D. 2017. Human Parvoviruses, p 679-699. In Richman D, Whitley R, Hayden F (ed), Clinical Virology, Fourth Edition. ASM Press, Washington, DC. doi: 10.1128/9781555819439.ch30
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Image of FIGURE 5
FIGURE 5

(A) Hematoxylin and eosin stain of bone marrow from patient with B19V infection. Note prominent intranuclear inclusions (arrows). (B) Immunostaining of B19V antigens in bone marrow (immunoalkaline phosphatase stain, naphthol fast red substrate with light hematoxylin counterstain). Original magnification of both images, X630. Panels courtesy of Wun-Ju Shieh, CDC, Atlanta, GA.

Citation: Söderlund-Venermo M, Brown K, Erdman D. 2017. Human Parvoviruses, p 679-699. In Richman D, Whitley R, Hayden F (ed), Clinical Virology, Fourth Edition. ASM Press, Washington, DC. doi: 10.1128/9781555819439.ch30
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Image of FIGURE 6
FIGURE 6

Pathophysiology of parvovirus B19 infection. Inoculation of normal subjects and natural infection resulted in fifth disease (Panel A; study reported by Anderson et al. [ ]). A two-phase illness was produced under control conditions; most subjects noted only the typical rash, joint symptoms, or both, corresponding to the appearance of specific antiviral antibodies. Reticulocytopenia occurs during viremia, but hemoglobin levels do not decline below normal values. H denotes hemoglobin, and R reticulocytes. Transient aplastic crisis occurs in patients with underlying hemolysis or erythroid stress who are infected with parvovirus B19 (Panel B; study reported by Saarinen et al. [ ]). Cessation of erythropoiesis causes severe anemia, because of the higher demand for red cells. Chronic pure red-cell aplasia is due to persistent infection (Panel C; study reported by Kurtzman et al. [ ]). Anemia persists because of the failure of the humoral immune response to clear parvovirus B19. Reprinted from reference .

Citation: Söderlund-Venermo M, Brown K, Erdman D. 2017. Human Parvoviruses, p 679-699. In Richman D, Whitley R, Hayden F (ed), Clinical Virology, Fourth Edition. ASM Press, Washington, DC. doi: 10.1128/9781555819439.ch30
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Image of FIGURE 7
FIGURE 7

Erythema infectiosum (fifth disease) associated with parvovirus B19.

Citation: Söderlund-Venermo M, Brown K, Erdman D. 2017. Human Parvoviruses, p 679-699. In Richman D, Whitley R, Hayden F (ed), Clinical Virology, Fourth Edition. ASM Press, Washington, DC. doi: 10.1128/9781555819439.ch30
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