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Chapter 36 : Rotaviruses

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Rotaviruses, Page 1 of 2

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Abstract:

Acute infectious diarrhea is one of the two most frequent diseases of young children. Until the early 1970s, numerous unsuccessful attempts were made to grow viral agents responsible for acute infectious diarrhea of children. The etiologic agent of epizootic diarrhea of infant mice (EDIM) was identified by electron microscopy in 1963 (1). Nonetheless, it was only with the discovery of the virus responsible for calf scours (with this same approach) in 1969 by Mebus et al (2) and of the human Norwalk virus by Kapikian et al (3) in 1972 that the methodology for identification of the viruses responsible for severe diarrhea in children was established. Using electron microscopy, Bishop et al (4) identified the first human rotavirus in an intestinal biopsy from a child with diarrhea. At roughly the same time, other groups used immune electron microscopy to identify the enteric caliciviruses and astroviruses, viruses that were also difficult to grow , as additional causes of acute infectious diarrhea in children and adults. Shortly after the discovery of human rotaviruses, it was realized that the EDIM virus and the calf scours virus were morphologically and antigenically related, and all these strains were grouped in the genus rotavirus. In rapid order, rotaviruses were shown to be among the most important pathogens of acute diarrhea in the young of many animals, including humans.

Citation: Franco M, Angel J, Greenberg H. 2017. Rotaviruses, p 853-872. In Richman D, Whitley R, Hayden F (ed), Clinical Virology, Fourth Edition. ASM Press, Washington, DC. doi: 10.1128/9781555819439.ch36
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Image of FIGURE 1
FIGURE 1

Map of the world showing rotavirus mortality in 2008, reproduced with permission from ( ).

Citation: Franco M, Angel J, Greenberg H. 2017. Rotaviruses, p 853-872. In Richman D, Whitley R, Hayden F (ed), Clinical Virology, Fourth Edition. ASM Press, Washington, DC. doi: 10.1128/9781555819439.ch36
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Image of FIGURE 2
FIGURE 2

Computer image reconstruction of a rotavirus triple-layered particle based on cryoelectronmicroscopy. VP4, the spike protein, and VP7 compose the outer viral layer, in the cutaway, the middle layer is composed of VP6 and inside this layer, the core (that contains VP1 and VP3 and the viral RNA not seen) formed by VP2 can be seen. [Image courtesy of Mark Yeager and reproduced with permission from ( )].

Citation: Franco M, Angel J, Greenberg H. 2017. Rotaviruses, p 853-872. In Richman D, Whitley R, Hayden F (ed), Clinical Virology, Fourth Edition. ASM Press, Washington, DC. doi: 10.1128/9781555819439.ch36
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Image of FIGURE 3
FIGURE 3

Schematic representation of the rotavirus replication cycle in intestinal polarized epithelial cells. The initial cell attachment step involves binding to cellular glycans and subsequent interactions with multiple receptors/coreceptors mediated by VP8* and VP5*, respectively ( ). As a second step in entry, RVA have been proposed to interact with integrins α2β1, αVβ3, and αXβ2 and with the heat shock cognate protein hsc70 ( ). Although not completely established, most studies suggest that rotaviruses enter cells by endocytosis ( ) and then lose VP7 and VP4 ( ). In the cytoplasm, double-layered particles gain transcriptase activity and begin to synthesize viral mRNAs. Viral proteins accumulate in the cytoplasm in an electron-dense region called the viroplasm, where the viral genome is replicated and the assembly of progeny double-layered particles takes place ( ). An initial stage in viral assembly that is incompletely understood involves the assortment of single-stranded positive RNA strands corresponding to each one of the 11 gene segments ( ). A viral intermediate particle that consists of VP1, VP2, VP3, and probably all the nonstructural proteins, except NSP4, is then formed ( ). This complex acquires VP6 and during this process the nonstructural proteins are lost. Subsequently, the double-layered particles via VP6 interact with NSP4 that has been synthesized by ER ribosomes ( ). This interaction leads to budding of the double-layered particles (DLP) into the ER lumen. In this organelle the particles acquire a transient lipid membrane. Subsequently the viral particles acquire VP7 and VP4 and lose the transient enveloping membrane. The exit of the mature triple-layered viral particles from the ER and the cell has been incompletely elucidated and may involve a raft-dependent pathway before cell lysis occurs ( ) or may be a postlysis event. The mechanism of cell death induced by rotavirus (before or after viral exit) is incompletely understood but is dependent on cell apoptosis and in mice ( ).

Citation: Franco M, Angel J, Greenberg H. 2017. Rotaviruses, p 853-872. In Richman D, Whitley R, Hayden F (ed), Clinical Virology, Fourth Edition. ASM Press, Washington, DC. doi: 10.1128/9781555819439.ch36
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Image of FIGURE 4
FIGURE 4

Cross-section of the small bowel villi from a rotavirus-infected mouse immunostained for rotavirus antigen. Note the restriction of growth of rotavirus to the mature villus tip cells of the small bowel.

Citation: Franco M, Angel J, Greenberg H. 2017. Rotaviruses, p 853-872. In Richman D, Whitley R, Hayden F (ed), Clinical Virology, Fourth Edition. ASM Press, Washington, DC. doi: 10.1128/9781555819439.ch36
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