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Chapter 38 : Measles

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Abstract:

Measles is a highly contagious disease caused by infection with measles virus (MeV), and it has caused millions of deaths since its spread within human populations thousands of years ago. Disease begins with fever, cough, coryza, and conjunctivitis followed by the appearance of a characteristic maculopapular rash. Genetically, MeV is most closely related to rinderpest virus, a pathogen of cattle that was recently eradicated. MeV was originally a zoonotic infection that adapted to humans 5,000 to 10,000 years ago when populations achieved sufficient size in Middle Eastern river valley civilizations to maintain a continuous chain of transmission among susceptible individuals. Subsequent introduction of MeV into naive populations resulted in high mortality. Millions died as a result of European exploration of the New World, largely due to the introduction of diseases such as smallpox and measles into native Amerindian populations (1).

Citation: Moss W, Griffin D. 2017. Measles, p 903-928. In Richman D, Whitley R, Hayden F (ed), Clinical Virology, Fourth Edition. ASM Press, Washington, DC. doi: 10.1128/9781555819439.ch38
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Image of FIGURE 1
FIGURE 1

Measles virus (MeV) in cell culture. An extracellular virion (large solid arrow) is coated with glycoprotein spikes (small open arrows) with the viral nucleocapsid (small solid arrows) positioned beneath the envelope. An infected cell has a region on the membrane (large open arrow) with viral glycoprotein spikes and subjacent viral nucleocapsids that is a site of MeV maturation and budding. Free paramyxovirus nucleocapsids (small solid arrows) from a disrupted virion are shown in the inset. (Courtesy of Cynthia Goldsmith, William Bellini, and Erskine Palmer of the Centers for Disease Control and Prevention, Atlanta, GA.) [Adapted from Oxman, 2nd edition of .]

Citation: Moss W, Griffin D. 2017. Measles, p 903-928. In Richman D, Whitley R, Hayden F (ed), Clinical Virology, Fourth Edition. ASM Press, Washington, DC. doi: 10.1128/9781555819439.ch38
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Image of FIGURE 2
FIGURE 2

MeV structure, genome, and replication cycle. (a) MeV is a spherical, nonsegmented, single-stranded, negative-sense RNA virus. Of the six structural proteins, the phosphoprotein (P), large protein (L), and nucleoprotein (N) form the nucleocapsid that encloses the viral RNA. The hemagglutinin protein (H), fusion protein (F), and matrix protein (M), together with lipids from the host cell membrane, form the viral envelope. (b) The MeV RNA genome is comprised of approximately 16,000 nucleotides encoding eight proteins, two of which (V and C) are nonstructural proteins alternatively translated from the P gene. (c) The H protein interacts with F to mediate attachment and fusion of the viral envelope with the host cell membrane through specific receptors (CD46 and CD150) enabling viral entry into the cell. Remaining MeV proteins are involved in viral replication. The P protein regulates transcription, replication, and assembly of nucleocapsids. The M protein is critical for viral assembly. (From reference with permission of the publisher.) Source: Moss WJ, Griffin DE. Global measles elimination. 2006;4:900–908.

Citation: Moss W, Griffin D. 2017. Measles, p 903-928. In Richman D, Whitley R, Hayden F (ed), Clinical Virology, Fourth Edition. ASM Press, Washington, DC. doi: 10.1128/9781555819439.ch38
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Image of FIGURE 3
FIGURE 3

Basic pathogenesis of MeV infection. Panels summarize features of the pathogenesis of MeV infection. (a) The spread of the virus from the initial site of infection in the respiratory tract to the skin. Sites of infection are overlaid with virus titer. (b) The appearance of clinical signs and symptoms in relation to viral replication and the immune responses. (c) The immune responses to measles virus. The clinical manifestations arise coincident with the onset of the immune response. (From reference with permission of the publisher.) Source: Moss WJ, Griffin DE. Global measles elimination. 2006;4:900–908.

Citation: Moss W, Griffin D. 2017. Measles, p 903-928. In Richman D, Whitley R, Hayden F (ed), Clinical Virology, Fourth Edition. ASM Press, Washington, DC. doi: 10.1128/9781555819439.ch38
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Image of FIGURE 4
FIGURE 4

Histopathology of Koplik's spots (A) and the skin rash (B) of measles. The epidermal changes in both are characterized by multinucleated giant cells (arrows), focal parakeratosis, dyskeratosis and spongiosis, intracellular edema, and a sparse lymphocytic infiltrate. (Courtesy of D. W. R. Suringa, Tampa, FL). [adapted from Oxman, 2nd edition of .]

Citation: Moss W, Griffin D. 2017. Measles, p 903-928. In Richman D, Whitley R, Hayden F (ed), Clinical Virology, Fourth Edition. ASM Press, Washington, DC. doi: 10.1128/9781555819439.ch38
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Image of FIGURE 5
FIGURE 5

Potential mechanisms of immune suppression following measles virus infection. (From reference with permission of the publisher.) Source: Moss WJ, Ota MO, Griffin DE. Measles: Immune suppression and immune responses. 2004;36:1380–1385.

Citation: Moss W, Griffin D. 2017. Measles, p 903-928. In Richman D, Whitley R, Hayden F (ed), Clinical Virology, Fourth Edition. ASM Press, Washington, DC. doi: 10.1128/9781555819439.ch38
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Image of FIGURE 6
FIGURE 6

Schematic diagram of the clinical course of a typical case of measles. (Adapted from Oxman, 2nd edition of .)

Citation: Moss W, Griffin D. 2017. Measles, p 903-928. In Richman D, Whitley R, Hayden F (ed), Clinical Virology, Fourth Edition. ASM Press, Washington, DC. doi: 10.1128/9781555819439.ch38
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Image of FIGURE 7
FIGURE 7

Measles rash. Note the characteristic blotchy appearance. (From reference with permission of the publisher.) Source: Moss WJ, Griffin DE. Global measles elimination. 2006;4:900–908.

Citation: Moss W, Griffin D. 2017. Measles, p 903-928. In Richman D, Whitley R, Hayden F (ed), Clinical Virology, Fourth Edition. ASM Press, Washington, DC. doi: 10.1128/9781555819439.ch38
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Image of FIGURE 8
FIGURE 8

Measles giant cell pneumonia. Two multinucleated epithelial giant cells are visible in alveolar spaces in the lung of an immunosuppressed child who died of giant cell pneumonia. Eosinophilic Cowdry type A inclusion bodies are visible in many nuclei (arrows). (From reference with permission of the publisher.) [Adapted from Oxman, 2nd edition of .]

Citation: Moss W, Griffin D. 2017. Measles, p 903-928. In Richman D, Whitley R, Hayden F (ed), Clinical Virology, Fourth Edition. ASM Press, Washington, DC. doi: 10.1128/9781555819439.ch38
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Image of FIGURE 9
FIGURE 9

Measles virus vaccines. Most attenuated measles vaccines were developed from the Edmonston strain of measles virus. The Edmonston B vaccine was the first licensed measles vaccine but was associated with a high frequency of fever and rash. The further attenuated Schwarz and Edmonston-Zagreb vaccines are widely used throughout the world. The Moraten vaccine is the only measles vaccine used in the United States. [: Markowitz LE. Measles control in the 1990s: immunization before 9 months of age. Document WHO/EPI/GEN/90.3. Geneva: World Health Organization, 1990. : Cutts FT. Measles. Module 7. The Immunological Basis for Immunization Series. Document WHO/EPI/GEN/93.17. Geneva: World Health Organization, 1993.] (From reference with permission of the publisher.) Source: Moss WJ, Griffin DE. Global measles elimination. 2006;4:900–908.

Citation: Moss W, Griffin D. 2017. Measles, p 903-928. In Richman D, Whitley R, Hayden F (ed), Clinical Virology, Fourth Edition. ASM Press, Washington, DC. doi: 10.1128/9781555819439.ch38
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References

/content/book/10.1128/9781555819439.ch38
1. McNeill WH . 1976. Plagues and Peoples. Penguin, London.
2. Panum P . 1938. Observations made during the epidemic of measles on the Faroe Islands in the year 1846. Med Classics 3 : 829 886.
3. Enders JF . 1964. Francis Home and his experimental approach to medicine. Bull Hist Med 38 : 101 112.[PubMed]
4. Enders JF, Peebles TC . 1954. Propagation in tissue cultures of cytopathogenic agents from patients with measles. Proc Soc Exp Biol Med 86 : 277 286.[PubMed]
5. Frank SA, Bush RM . 2007. Barriers to antigenic escape by pathogens: trade-off between reproductive rate and antigenic mutability. BMC Evol Biol 7 : 229.[PubMed]
6. Fulton BO, Sachs D, Beaty SM, Won ST, Lee B, Palese P, Heaton NS . 2015. Mutational analysis of measles virus suggests constraints on antigenic variation of the glycoproteins. Cell Reports 11 : 1331 1338.[PubMed]
7. Hashiguchi T, Kajikawa M, Maita N, Takeda M, Kuroki K, Sasaki K, Kohda D, Yanagi Y, Maenaka K . 2007. Crystal structure of measles virus hemagglutinin provides insight into effective vaccines. Proc Natl Acad Sci USA 104 : 19535 19540.[PubMed]
8. Rota PA, Rota JS, Redd SB, Papania MJ, Bellini WJ . 2004. Genetic analysis of measles viruses isolated in the United States between 1989 and 2001: absence of an endemic genotype since 1994. J Infect Dis 189( Suppl 1) : S160 S164.[PubMed]
9. Rota PA, Brown K, Mankertz A, Santibanez S, Shulga S, Muller CP, Hübschen JM, Siqueira M, Beirnes J, Ahmed H, Triki H, Al-Busaidy S, Dosseh A, Byabamazima C, Smit S, Akoua-Koffi C, Bwogi J, Bukenya H, Wairagkar N, Ramamurty N, Incomserb P, Pattamadilok S, Jee Y, Lim W, Xu W, Komase K, Takeda M, Tran T, Castillo-Solorzano C, Chenoweth P, Brown D, Mulders MN, Bellini WJ, Featherstone D . 2011. Global distribution of measles genotypes and measles molecular epidemiology. J Infect Dis 204( Suppl 1) : S514 S523.[PubMed]
10. Tamin A, Rota PA, Wang ZD, Heath JL, Anderson LJ, Bellini WJ . 1994. Antigenic analysis of current wild type and vaccine strains of measles virus. J Infect Dis 170 : 795 801.[PubMed]
11. Klingele M, Hartter HK, Adu F, Ammerlaan W, Ikusika W, Muller CP . 2000. Resistance of recent measles virus wild-type isolates to antibody-mediated neutralization by vaccinees with antibody. J Med Virol 62 : 91 98.[PubMed]
12. Xu W, Tamin A, Rota JS, Zhang L, Bellini WJ, Rota PA . 1998. New genetic group of measles virus isolated in the People's Republic of China. Virus Res 54 : 147 156.[PubMed]
13. Wild TF, Buckland R . 1995. Functional aspects of envelope-associated measles virus proteins. Curr Top Microbiol Immunol 191 : 51 64.[PubMed]
14. Karlin D, Longhi S, Canard B . 2002. Substitution of two residues in the measles virus nucleoprotein results in an impaired self-association. Virology 302 : 420 432.[PubMed]
15. Longhi S, Receveur-Bréchot V, Karlin D, Johansson K, Darbon H, Bhella D, Yeo R, Finet S, Canard B . 2003. The C-terminal domain of the measles virus nucleoprotein is intrinsically disordered and folds upon binding to the C-terminal moiety of the phosphoprotein. J Biol Chem 278 : 18638 18648.[PubMed]
16. Caignard G, Guerbois M, Labernardière JL, Jacob Y, Jones LM, Wild F, Tangy F, Vidalain PO ; Infectious Mapping Project I-MAP . 2007. Measles virus V protein blocks Jak1-mediated phosphorylation of STAT1 to escape IFN-alpha/beta signaling. Virology 368 : 351 362.[PubMed]
17. Nakatsu Y, Takeda M, Ohno S, Koga R, Yanagi Y . 2006. Translational inhibition and increased interferon induction in cells infected with C protein-deficient measles virus. J Virol 80 : 11861 11867.[PubMed]
18. Nakatsu Y, Takeda M, Ohno S, Shirogane Y, Iwasaki M, Yanagi Y . 2008. Measles virus circumvents the host interferon response by different actions of the C and V proteins. J Virol 82 : 8296 8306.[PubMed]
19. Hashiguchi T, Maenaka K, Yanagi Y . 2011. Measles virus hemagglutinin: structural insights into cell entry and measles vaccine. Front Microbiol 2 : 247.[PubMed]
20. Hashiguchi T, Ose T, Kubota M, Maita N, Kamishikiryo J, Maenaka K, Yanagi Y . 2011. Structure of the measles virus hemagglutinin bound to its cellular receptor SLAM. Nat Struct Mol Biol 18 : 135 141.[PubMed]
21. Santiago C, Celma ML, Stehle T, Casasnovas JM . 2010. Structure of the measles virus hemagglutinin bound to the CD46 receptor. Nat Struct Mol Biol 17 : 124 129.[PubMed]
22. Plemper RK, Brindley MA, Iorio RM . 2011. Structural and mechanistic studies of measles virus illuminate paramyxovirus entry. PLoS Pathog 7 : e1002058.[PubMed]
23. Iwasaki M, Takeda M, Shirogane Y, Nakatsu Y, Nakamura T, Yanagi Y . 2009. The matrix protein of measles virus regulates viral RNA synthesis and assembly by interacting with the nucleocapsid protein. J Virol 83 : 10374 10383.[PubMed]
24. Runkler N, Pohl C, Schneider-Schaulies S, Klenk HD, Maisner A . 2007. Measles virus nucleocapsid transport to the plasma membrane requires stable expression and surface accumulation of the viral matrix protein. Cell Microbiol 9 : 1203 1214.[PubMed]
25. Dörig RE, Marcil A, Chopra A, Richardson CD . 1993. The human CD46 molecule is a receptor for measles virus (Edmonston strain). Cell 75 : 295 305.[PubMed]
26. Naniche D, Varior-Krishnan G, Cervoni F, Wild TF, Rossi B, Rabourdin-Combe C, Gerlier D . 1993. Human membrane cofactor protein (CD46) acts as a cellular receptor for measles virus. J Virol 67 : 6025 6032.[PubMed]
27. Tatsuo H, Ono N, Tanaka K, Yanagi Y . 2000. SLAM (CDw150) is a cellular receptor for measles virus. Nature 406 : 893 897.[PubMed]
28. Mühlebach MD, Mateo M, Sinn PL, Prüfer S, Uhlig KM, Leonard VH, Navaratnarajah CK, Frenzke M, Wong XX, Sawatsky B, Ramachandran S, McCray PB Jr, Cichutek K, von Messling V, Lopez M, Cattaneo R . 2011. Adherens junction protein nectin-4 is the epithelial receptor for measles virus. Nature 480 : 530 533.[PubMed]
29. Noyce RS, Bondre DG, Ha MN, Lin LT, Sisson G, Tsao MS, Richardson CD . 2011. Tumor cell marker PVRL4 (nectin 4) is an epithelial cell receptor for measles virus. PLoS Pathog 7 : e1002240.[PubMed]
30. Kemper C, Chan AC, Green JM, Brett KA, Murphy KM, Atkinson JP . 2003. Activation of human CD4 + cells with CD3 and CD46 induces a T-regulatory cell 1 phenotype. Nature 421 : 388 392.[PubMed]
31. Yanagi Y, Ono N, Tatsuo H, Hashimoto K, Minagawa H . 2002. Measles virus receptor SLAM (CD150). Virology 299 : 155 161.[PubMed]
32. Erlenhöfer C, Duprex WP, Rima BK, ter Meulen V, Schneider-Schaulies J . 2002. Analysis of receptor (CD46, CD150) usage by measles virus. J Gen Virol 83 : 1431 1436.[PubMed]
33. Hummel KB, Bellini WJ, Offermann MK . 1998. Strain-specific differences in LFA-1 induction on measles virus-infected monocytes and adhesion and viral transmission to endothelial cells. J Virol 72 : 8403 8407.[PubMed]
34. Hashimoto K, Ono N, Tatsuo H, Minagawa H, Takeda M, Takeuchi K, Yanagi Y . 2002. SLAM (CD150)-independent measles virus entry as revealed by recombinant virus expressing green fluorescent protein. J Virol 76 : 6743 6749.[PubMed]
35. Horikami SM, Moyer SA . 1995. Structure, transcription, and replication of measles virus. Curr Top Microbiol Immunol 191 : 35 50.[PubMed]
36. Liljeroos L, Huiskonen JT, Ora A, Susi P, Butcher SJ . 2011. Electron cryotomography of measles virus reveals how matrix protein coats the ribonucleocapsid within intact virions. Proc Natl Acad Sci USA 108 : 18085 18090.[PubMed]
37. Pohl C, Duprex WP, Krohne G, Rima BK, Schneider-Schaulies S . 2007. Measles virus M and F proteins associate with detergent-resistant membrane fractions and promote formation of virus-like particles. J Gen Virol 88 : 1243 1250.[PubMed]
38. Kobune F, Sakata H, Sugiura A . 1990. Marmoset lymphoblastoid cells as a sensitive host for isolation of measles virus. J Virol 64 : 700 705.[PubMed]
39. Ono N, Tatsuo H, Hidaka Y, Aoki T, Minagawa H, Yanagi Y . 2001. Measles viruses on throat swabs from measles patients use signaling lymphocytic activation molecule (CDw150) but not CD46 as a cellular receptor. J Virol 75 : 4399 4401.[PubMed]
40. World Health Organization . 2015. Progress towards regional measles elimination, worldwide, 2000–2014. Wkly Epidemiol Rec 90 : 623631.[PubMed]
41. Clemmons NS, Gastanaduy PA, Fiebelkorn AP, Redd SB, Wallace GS ; Centers for Disease Control and Prevention (CDC) . 2015. Measles—United States, January 4-April 2, 2015. MMWR Morb Mortal Wkly Rep 64 : 373 376.[PubMed]
42. Parker AA, Staggs W, Dayan GH, Ortega-Sánchez IR, Rota PA, Lowe L, Boardman P, Teclaw R, Graves C, LeBaron CW . 2006. Implications of a 2005 measles outbreak in Indiana for sustained elimination of measles in the United States. N Engl J Med 355 : 447 455.[PubMed]
43. Roush SW, Murphy TV ; Vaccine-Preventable Disease Table Working Group . 2007. Historical comparisons of morbidity and mortality for vaccine-preventable diseases in the United States. JAMA 298 : 2155 2163.[PubMed]
44. Feikin DR, Lezotte DC, Hamman RF, Salmon DA, Chen RT, Hoffman RE . 2000. Individual and community risks of measles and pertussis associated with personal exemptions to immunization. JAMA 284 : 3145 3150.[PubMed]
45. Christensen PE, Schmidt H, Bang HO, Andersen V, Jordal B, Jensen O . 1953. An epidemic of measles in southern Greenland, 1951; measles in virgin soil. II. The epidemic proper. Acta Med Scand 144 : 430 449.[PubMed]
46. Black FL . 1966. Measles endemicity in insular populations: critical community size and its evolutionary implication. J Theor Biol 11 : 207 211.[PubMed]
47. Fine PE, Clarkson JA . 1982. Measles in England and Wales—I: an analysis of factors underlying seasonal patterns. Int J Epidemiol 11 : 5 14.[PubMed]
48. de Quadros CA, Hersh BS, Nogueira AC, Carrasco PA, da Silveira CM . 1998. Measles eradication: experience in the Americas. Bull World Health Organ 76( Suppl 2) : 47 52.[PubMed]
49. Hutchins S, Markowitz L, Atkinson W, Swint E, Hadler S . 1996. Measles outbreaks in the United States, 1987 through 1990. Pediatr Infect Dis J 15 : 31 38.[PubMed]
50. Albrecht P, Ennis FA, Saltzman EJ, Krugman S . 1977. Persistence of maternal antibody in infants beyond 12 months: mechanism of measles vaccine failure. J Pediatr 91 : 715 718.[PubMed]
51. Premenko-Lanier M, Hodge G, Rota P, Tamin A, Bellini W, McChesney M . 2006. Maternal antibody inhibits both cellular and humoral immunity in response to measles vaccination at birth. Virology 350 : 429 432.[PubMed]
52. Cáceres VM, Strebel PM, Sutter RW . 2000. Factors determining prevalence of maternal antibody to measles virus throughout infancy: a review. Clin Infect Dis 31 : 110 119.[PubMed]
53. Scott S, Moss WJ, Cousens S, Beeler JA, Audet SA, Mugala N, Quinn TC, Griffin DE, Cutts FT . 2007. The influence of HIV-1 exposure and infection on levels of passively acquired antibodies to measles virus in Zambian infants. Clin Infect Dis 45 : 1417 1424.[PubMed]
54. Whittle HC, Aaby P, Samb B, Jensen H, Bennett J, Simondon F . 1999. Effect of subclinical infection on maintaining immunity against measles in vaccinated children in West Africa. Lancet 353 : 98 102.[PubMed]
55. Vardas E, Kreis S . 1999. Isolation of measles virus from a naturally-immune, asymptomatically re-infected individual. J Clin Virol 13 : 173 179.[PubMed]
56. Ehresmann KR, Hedberg CW, Grimm MB, Norton CA, MacDonald KL, Osterholm MT . 1995. An outbreak of measles at an international sporting event with airborne transmission in a domed stadium. J Infect Dis 171 : 679 683.[PubMed]
57. Scheifele DW, Forbes CE . 1972. Prolonged giant cell excretion in severe African measles. Pediatrics 50 : 867 873.[PubMed]
58. Dossetor J, Whittle HC, Greenwood BM . 1977. Persistent measles infection in malnourished children. BMJ 1 : 1633 1635.[PubMed]
59. Permar SR, Moss WJ, Ryon JJ, Monze M, Cutts F, Quinn TC, Griffin DE . 2001. Prolonged measles virus shedding in human immunodeficiency virus-infected children, detected by reverse transcriptase-polymerase chain reaction. J Infect Dis 183 : 532 538.[PubMed]
60. Riddell MA, Moss WJ, Hauer D, Monze M, Griffin DE . 2007. Slow clearance of measles virus RNA after acute infection. J Clin Virol 39 : 312 317.[PubMed]
61. Nakata Y, Nakayama T, Ide Y, Kizu R, Koinuma G, Bamba M . 2002. Measles virus genome detected up to four months in a case of congenital measles. Acta Paediatr 91 : 1263 1265.[PubMed]
62. Salama P, Assefa F, Talley L, Spiegel P, van Der Veen A, Gotway CA . 2001. Malnutrition, measles, mortality, and the humanitarian response during a famine in Ehiopia. JAMA 286 : 563 571.[PubMed]
63. Aaby P, Bukh J, Lisse IM, Smits AJ . 1984. Overcrowding and intensive exposure as determinants of measles mortality. Am J Epidemiol 120 : 49 63.[PubMed]
64. Semba RD, Bloem MW . 2004. Measles blindness. Surv Ophthalmol 49 : 243 255.[PubMed]
65. Garenne M . 1994. Sex differences in measles mortality: a world review. Int J Epidemiol 23 : 632 642.[PubMed]
66. Perry RT, Halsey NA . 2004. The clinical significance of measles: a review. J Infect Dis 189( Suppl 1) : S4 S16.[PubMed]
67. Halsey NA . 1993. Increased mortality after high titer measles vaccines: too much of a good thing. Pediatr Infect Dis J 12 : 462 465.[PubMed]
68. Moss WJ, Monze M, Ryon JJ, Quinn TC, Griffin DE, Cutts F . 2002. Prospective study of measles in hospitalized, human immunodeficiency virus (HIV)-infected and HIV-uninfected children in Zambia. Clin Infect Dis 35 : 189 196.[PubMed]
69. Moss WJ, Scott S, Mugala N, Ndhlovu Z, Beeler JA, Audet SA, Ngala M, Mwangala S, Nkonga-Mwangilwa C, Ryon JJ, Monze M, Kasolo F, Quinn TC, Cousens S, Griffin DE, Cutts FT . 2007. Immunogenicity of standard-titer measles vaccine in HIV-1-infected and uninfected Zambian children: an observational study. J Infect Dis 196 : 347 355.[PubMed]
70. Moss WJ, Cutts F, Griffin DE . 1999. Implications of the human immunodeficiency virus epidemic for control and eradication of measles. Clin Infect Dis 29 : 106 112.[PubMed]
71. Helfand RF, Moss WJ, Harpaz R, Scott S, Cutts F . 2005. Evaluating the impact of the HIV pandemic on measles control and elimination. Bull World Health Organ 83 : 329 337.[PubMed]
72. Rainwater-Lovett K, Nkamba HC, Mubiana-Mbewe M, Bolton-Moore C, Moss WJ . 2013. Changes in measles serostatus among HIV-infected Zambian children initiating antiretroviral therapy before and after the 2010 measles outbreak and supplemental immunization activities. J Infect Dis 208 : 1747 1755.[PubMed]
73. World Health Organization . 2015. Meeting of the Strategic Advisory Group of Experts on immunization, October 2015—conclusions and recommendations. Wkly Epidemiol Rec 90 : 681699.[PubMed]
74. Lessler J, Reich NG, Brookmeyer R, Perl TM, Nelson KE, Cummings DA . 2009. Incubation periods of acute respiratory viral infections: a systematic review. Lancet Infect Dis 9 : 291 300.[PubMed]
75. Zilliox MJ, Parmigiani G, Griffin DE . 2006. Gene expression patterns in dendritic cells infected with measles virus compared with other pathogens. Proc Natl Acad Sci USA 103 : 3363 3368.[PubMed]
76. Esolen LM, Ward BJ, Moench TR, Griffin DE . 1993. Infection of monocytes during measles. J Infect Dis 168 : 47 52.[PubMed]
77. de Swart RL, Ludlow M, de Witte L, Yanagi Y, van Amerongen G, McQuaid S, Yüksel S, Geijtenbeek TB, Duprex WP, Osterhaus AD . 2007. Predominant infection of CD150+ lymphocytes and dendritic cells during measles virus infection of macaques. PLoS Pathog 3 : e178.[PubMed]
78. Leonard VH, Sinn PL, Hodge G, Miest T, Devaux P, Oezguen N, Braun W, McCray PB Jr, McChesney MB, Cattaneo R . 2008. Measles virus blind to its epithelial cell receptor remains virulent in rhesus monkeys but cannot cross the airway epithelium and is not shed. J Clin Invest 118 : 2448 2458.[PubMed]
79. Kimura A, Tosaka K, Nakao T . 1975. Measles rash. I. Light and electron microscopic study of skin eruptions. Arch Virol 47 : 295 307.[PubMed]
80. Griffin DE . 1995. Immune responses during measles virus infection. Curr Top Microbiol Immunol 191 : 117 134.[PubMed]
81. Griffin DE, Ward BJ, Jauregui E, Johnson RT, Vaisberg A . 1990. Natural killer cell activity during measles. Clin Exp Immunol 81 : 218 224.[PubMed]
82. Griffin DE, Ward BJ, Jauregui E, Johnson RT, Vaisberg A . 1990. Immune activation during measles: interferon-γ and neopterin in plasma and cerebrospinal fluid in complicated and uncomplicated disease. J Infect Dis 161 : 449 453.[PubMed]
83. Naniche D, Yeh A, Eto D, Manchester M, Friedman RM, Oldstone MBA . 2000. Evasion of host defenses by measles virus: wild-type measles virus infection interferes with induction of Alpha/Beta interferon production. J Virol 74 : 7478 7484.[PubMed]
84. Shivakoti R, Hauer D, Adams RJ, Lin WH, Duprex WP, de Swart RL, Griffin DE . 2015. Limited in vivo production of type I or type III interferon after infection of macaques with vaccine or wild-type strains of measles virus. J Interferon Cytokine Res 35 : 292 301.[PubMed]
85. tenOever BR, Servant MJ, Grandvaux N, Lin R, Hiscott J . 2002. Recognition of the measles virus nucleocapsid as a mechanism of IRF-3 activation. J Virol 76 : 3659 3669.[PubMed]
86. Fontana JM, Bankamp B, Bellini WJ, Rota PA . 2008. Regulation of interferon signaling by the C and V proteins from attenuated and wild-type strains of measles virus. Virology 374 : 71 81.[PubMed]
87. Bouche FB, Ertl OT, Muller CP . 2002. Neutralizing B cell response in measles. Viral Immunol 15 : 451 471.[PubMed]
88. Nair N, Moss WJ, Scott S, Mugala N, Ndhlovu ZM, Lilo K, Ryon JJ, Monze M, Quinn TC, Cousens S, Cutts F, Griffin DE . 2009. HIV-1 infection in Zambian children impairs the development and avidity maturation of measles virus-specific immunoglobulin G after vaccination and infection. J Infect Dis 200 : 1031 1038.[PubMed]
89. Brown DW, Ramsay ME, Richards AF, Miller E . 1994. Salivary diagnosis of measles: a study of notified cases in the United Kingdom, 1991–3. BMJ 308 : 1015 1017.[PubMed]
90. Griffin DE, Cooper SJ, Hirsch RL, Johnson RT, Lindo de Soriano I, Roedenbeck S, Vaisberg A . 1985. Changes in plasma IgE levels during complicated and uncomplicated measles virus infections. J Allergy Clin Immunol 76 : 206 213.[PubMed]
91. de Swart RL, Yüksel S, Osterhaus AD . 2005. Relative contributions of measles virus hemagglutinin- and fusion protein-specific serum antibodies to virus neutralization. J Virol 79 : 11547 11551.[PubMed]
92. Colf LA, Juo ZS, Garcia KC . 2007. Structure of the measles virus hemagglutinin. Nat Struct Mol Biol 14 : 1227 1228.[PubMed]
93. Ertl OT, Wenz DC, Bouche FB, Berbers GA, Muller CP . 2003. Immunodominant domains of the Measles virus hemagglutinin protein eliciting a neutralizing human B cell response. Arch Virol 148 : 2195 2206.[PubMed]
94. Polack FP, Lee SH, Permar S, Manyara E, Nousari HG, Jeng Y, Mustafa F, Valsamakis A, Adams RJ, Robinson HL, Griffin DE . 2000. Successful DNA immunization against measles: neutralizing antibody against either the hemagglutinin or fusion glycoprotein protects rhesus macaques without evidence of atypical measles. Nat Med 6 : 776 781.[PubMed]
95. Chen RT, Markowitz LE, Albrecht P, Stewart JA, Mofenson LM, Preblud SR, Orenstein WA . 1990. Measles antibody: reevaluation of protective titers. J Infect Dis 162 : 1036 1042.[PubMed]
96. Amanna IJ, Carlson NE, Slifka MK . 2007. Duration of humoral immunity to common viral and vaccine antigens. N Engl J Med 357 : 1903 1915.[PubMed]
97. Lin WH, Kouyos RD, Adams RJ, Grenfell BT, Griffin DE . 2012. Prolonged persistence of measles virus RNA is characteristic of primary infection dynamics. Proc Natl Acad Sci USA 109 : 14989 14994.[PubMed]
98. Forthal DN, Landucci G, Habis A, Zartarian M, Katz J, Tilles JG . 1994. Measles virus-specific functional antibody responses and viremia during acute measles. J Infect Dis 169 : 1377 1380.[PubMed]
99. Fujinami RS, Oldstone MB . 1979. Antiviral antibody reacting on the plasma membrane alters measles virus expression inside the cell. Nature 279 : 529 530.[PubMed]
100. Permar SR, Klumpp SA, Mansfield KG, Carville AA, Gorgone DA, Lifton MA, Schmitz JE, Reimann KA, Polack FP, Griffin DE, Letvin NL . 2004. Limited contribution of humoral immunity to the clearance of measles viremia in rhesus monkeys. J Infect Dis 190 : 998 1005.[PubMed]
101. Good RA, Zak SJ . 1956. Disturbances in gamma globulin synthesis as experiments of nature. Pediatrics 18 : 109 149.[PubMed]
102. Jaye A, Magnusen AF, Sadiq AD, Corrah T, Whittle HC . 1998. Ex vivo analysis of cytotoxic T lymphocytes to measles antigens during infection and after vaccination in Gambian children. J Clin Invest 102 : 1969 1977.[PubMed]
103. Griffin DE, Ward BJ, Jauregui E, Johnson RT, Vaisberg A . 1989. Immune activation in measles. N Engl J Med 320 : 1667 1672.[PubMed]
104. Griffin DE, Ward BJ, Juaregui E, Johnson RT, Vaisberg A . 1992. Immune activation during measles: β 2-microglobulin in plasma and cerebrospinal fluid in complicated and uncomplicated disease. J Infect Dis 166 : 1170 1173.[PubMed]
105. Jaye A, Magnusen AF, Whittle HC . 1998. Human leukocyte antigen class I- and class II-restricted cytotoxic T lymphocyte responses to measles antigens in immune adults. J Infect Dis 177 : 1282 1289.[PubMed]
106. Nanan R, Carstens C, Kreth HW . 1995. Demonstration of virus-specific CD8+ memory T cells in measles-seropositive individuals by in vitro peptide stimulation. Clin Exp Immunol 102 : 40 45.[PubMed]
107. Permar SR, Klumpp SA, Mansfield KG, Kim WK, Gorgone DA, Lifton MA, Williams KC, Schmitz JE, Reimann KA, Axthelm MK, Polack FP, Griffin DE, Letvin NL . 2003. Role of CD8(+) lymphocytes in control and clearance of measles virus infection of rhesus monkeys. J Virol 77 : 4396 4400.[PubMed]
108. Ota MO, Ndhlovu Z, Oh S, Piyasirisilp S, Berzofsky JA, Moss WJ, Griffin DE . 2007. Hemagglutinin protein is a primary target of the measles virus-specific HLA-A2-restricted CD8+ T cell response during measles and after vaccination. J Infect Dis 195 : 1799 1807.[PubMed]
109. Griffin DE, Ward BJ . 1993. Differential CD4 T cell activation in measles. J Infect Dis 168 : 275 281.[PubMed]
110. Moss WJ, Ryon JJ, Monze M, Griffin DE . 2002. Differential regulation of interleukin (IL)-4, IL-5, and IL-10 during measles in Zambian children. J Infect Dis 186 : 879 887.[PubMed]
111. Enders JF, McCarthy K, Mitus A, Cheatham WJ . 1959. Isolation of measles virus at autopsy in cases of giant-cell pneumonia without rash. N Engl J Med 261 : 875 881.[PubMed]
112. Markowitz LE, Chandler FW, Roldan EO, Saldana MJ, Roach KC, Hutchins SS, Preblud SR, Mitchell CD, Scott GB . 1988. Fatal measles pneumonia without rash in a child with AIDS. J Infect Dis 158 : 480 483.[PubMed]
113. Moss WJ, Ota MO, Griffin DE . 2004. Measles: immune suppression and immune responses. Int J Biochem Cell Biol 36 : 1380 1385.[PubMed]
114. Tamashiro VG, Perez HH, Griffin DE . 1987. Prospective study of the magnitude and duration of changes in tuberculin reactivity during uncomplicated and complicated measles. Pediatr Infect Dis J 6 : 451 454.[PubMed]
115. Griffin DE, Ward BJ, Esolen LM . 1994. Pathogenesis of measles virus infection: an hypothesis for altered immune responses. J Infect Dis 170( Suppl 1) : S24 S31.[PubMed]
116. Moss WJ, Griffin DE . 2012. Measles. Lancet 379 : 153 164.[PubMed]
117. Ryon JJ, Moss WJ, Monze M, Griffin DE . 2002. Functional and phenotypic changes in circulating lymphocytes from hospitalized Zambian children with measles. Clin Diagn Lab Immunol 9 : 994 1003.[PubMed]
118. Hirsch RL, Griffin DE, Johnson RT, Cooper SJ, Lindo de Soriano I, Roedenbeck S, Vaisberg A . 1984. Cellular immune responses during complicated and uncomplicated measles virus infections of man. Clin Immunol Immunopathol 31 : 1 12.[PubMed]
119. Karp CL, Wysocka M, Wahl LM, Ahearn JM, Cuomo PJ, Sherry B, Trinchieri G, Griffin DE . 1996. Mechanism of suppression of cell-mediated immunity by measles virus. Science 273 : 228 231.[PubMed]
120. Atabani SF, Byrnes AA, Jaye A, Kidd IM, Magnusen AF, Whittle H, Karp CL . 2001. Natural measles causes prolonged suppression of interleukin-12 production. J Infect Dis 184 : 1 9.[PubMed]
121. Krause PJ, Cherry JD, Deseda-Tous J, Champion JG, Strassburg M, Sullivan C, Spencer MJ, Bryson YJ, Welliver RC, Boyer KM . 1979. Epidemic measles in young adults. Clinical, epidemiologic, and serologic studies. Ann Intern Med 90 : 873 876.[PubMed]
122. Wong RD, Goetz MB, Mathisen G, Henry D . 1993. Clinical and laboratory features of measles in hospitalized adults. Am J Med 95 : 377 383.[PubMed]
123. Fulginiti VA, Eller JJ, Downie AW, Kempe CH . 1967. Altered reactivity to measles virus. Atypical measles in children previously immunized with inactivated measles virus vaccines. JAMA 202 : 1075 1080.[PubMed]
124. Polack FP, Auwaerter PG, Lee SH, Nousari HC, Valsamakis A, Leiferman KM, Diwan A, Adams RJ, Griffin DE . 1999. Production of atypical measles in rhesus macaques: evidence for disease mediated by immune complex formation and eosinophils in the presence of fusion-inhibiting antibody. Nat Med 5 : 629 634.[PubMed]
125. Polack FP, Hoffman SJ, Crujeiras G, Griffin DE . 2003. A role for nonprotective complement-fixing antibodies with low avidity for measles virus in atypical measles. Nat Med 9 : 1209 1213.[PubMed]
126. Atmar RL, Englund JA, Hammill H . 1992. Complications of measles during pregnancy. Clin Infect Dis 14 : 217 226.[PubMed]
127. Kaplan LJ, Daum RS, Smaron M, McCarthy CA . 1992. Severe measles in immunocompromised patients. JAMA 267 : 1237 1241.[PubMed]
128. Moss WJ, Fisher C, Scott S, Monze M, Ryon JJ, Quinn TC, Griffin DE, Cutts FT . 2008. HIV type 1 infection is a risk factor for mortality in hospitalized Zambian children with measles. Clin Infect Dis 46 : 523 527.[PubMed]
129. Mustafa MM, Weitman SD, Winick NJ, Bellini WJ, Timmons CF, Siegel JD . 1993. Subacute measles encephalitis in the young immunocompromised host: report of two cases diagnosed by polymerase chain reaction and treated with ribavirin and review of the literature. Clin Infect Dis 16 : 654 660.[PubMed]
130. Bitnun A, Shannon P, Durward A, Rota PA, Bellini WJ, Graham C, Wang E, Ford-Jones EL, Cox P, Becker L, Fearon M, Petric M, Tellier R . 1999. Measles inclusion-body encephalitis caused by the vaccine strain of measles virus. Clin Infect Dis 29 : 855 861.[PubMed]
131. Duke T, Mgone CS . 2003. Measles: not just another viral exanthem. Lancet 361 : 763 773.[PubMed]
132. Esolen LM, Takahashi K, Johnson RT, Vaisberg A, Moench TR, Wesselingh SL, Griffin DE . 1995. Brain endothelial cell infection in children with acute fatal measles. J Clin Invest 96 : 2478 2481.[PubMed]
133. Johnson RT, Griffin DE, Hirsch RL, Wolinsky JS, Roedenbeck S, Lindo de Soriano I, Vaisberg A . 1984. Measles encephalomyelitis—clinical and immunologic studies. N Engl J Med 310 : 137 141.[PubMed]
134. Gendelman HE, Wolinsky JS, Johnson RT, Pressman NJ, Pezeshkpour GH, Boisset GF . 1984. Measles encephalomyelitis: lack of evidence of viral invasion of the central nervous system and quantitative study of the nature of demyelination. Ann Neurol 15 : 353 360.[PubMed]
135. Bellini WJ, Rota JS, Lowe LE, Katz RS, Dyken PR, Zaki SR, Shieh WJ, Rota PA . 2005. Subacute sclerosing panencephalitis: more cases of this fatal disease are prevented by measles immunization than was previously recognized. J Infect Dis 192 : 1686 1693.[PubMed]
136. Halsey NA, Modlin JF, Jabbour JT, Dubey L, Eddins DL, Ludwig DD . 1980. Risk factors in subacute sclerosing panencephalitis: a case-control study. Am J Epidemiol 111 : 415 424.[PubMed]
137. Jabbour JT, Garcia JH, Lemmi H, Ragland J, Duenas DA, Sever JL . 1969. Subacute sclerosing panencephalitis. A multidisciplinary study of eight cases. JAMA 207 : 2248 2254.[PubMed]
138. Sidhu MS, Crowley J, Lowenthal A, Karcher D, Menonna J, Cook S, Udem S, Dowling P . 1994. Defective measles virus in human subacute sclerosing panencephalitis brain. Virology 202 : 631 641.[PubMed]
139. Cattaneo R, Schmid A, Spielhofer P, Kaelin K, Baczko K, Ter Meulen V, Pardowitz J, Flanagan S, Rima BK, Udem SA, Billeter MA . 1989. Mutated and hypermutated genes of persistent measles viruses which caused lethal human brain diseases. Virology 173 : 415 425.[PubMed]
140. Hirano A, Wang AH, Gombart AF, Wong TC . 1992. The matrix proteins of neurovirulent subacute sclerosing panencephalitis virus and its acute measles virus progenitor are functionally different. Proc Natl Acad Sci USA 89 : 8745 8749.[PubMed]
141. Kühne M, Brown DW, Jin L . 2006. Genetic variability of measles virus in acute and persistent infections. Infect Genet Evol 6 : 269 276.[PubMed]
142. Metz H, Gregoriou M, Sandifer P . 1964. Subacute sclerosing pan-encephalitis. A review of 17 cases with special reference to clincial diagnostic criteria. Arch Dis Child 39 : 554 557.[PubMed]
143. Greenberg BL, Sack RB, Salazar-Lindo E, Budge E, Gutierrez M, Campos M, Visberg A, Leon-Barna R, Vi A, Maurutia D, Gomez M, Lindo I, Jaurequi E . 1991. Measles-associated diarrhea in hospitalized children in Lima, Peru: pathogenic agents and impact on growth. J Infect Dis 163 : 495 502.[PubMed]
144. Finkel HE . 1964. Measles myocarditis. Am Heart J 67 : 679 683.[PubMed]
145. Bellini WJ, Helfand RF . 2003. The challenges and strategies for laboratory diagnosis of measles in an international setting. J Infect Dis 187( Suppl 1) : S283 S290.[PubMed]
146. Cohen BJ, Audet S, Andrews N, Beeler J ; WHO working group on measles plaque reduction neutralization test . 2007. Plaque reduction neutralization test for measles antibodies: description of a standardised laboratory method for use in immunogenicity studies of aerosol vaccination. Vaccine 26 : 59 66.[PubMed]
147. El Mubarak HS, Ibrahim SA, Vos HW, Mukhtar MM, Mustafa OA, Wild TF, Osterhaus AD, de Swart RL . 2004. Measles virus protein-specific IgM, IgA, and IgG subclass responses during the acute and convalescent phase of infection. J Med Virol 72 : 290 298.[PubMed]
148. Maldonado YA, Lawrence EC, DeHovitz R, Hartzell H, Albrecht P . 1995. Early loss of passive measles antibody in infants of mothers with vaccine-induced immunity. Pediatrics 96 : 447 450.[PubMed]
149. Endo A, Izumi H, Miyashita M, Taniguchi K, Okubo O, Harada K . 2001. Current efficacy of postexposure prophylaxis against measles with immunoglobulin. J Pediatr 138 : 926 928.[PubMed]
150. Enders JF, Katz SL, Holloway A . 1962. Development of attenuated measles-virus vaccines. A summary of recent investigation. Am J Dis Child 103 : 335 340.[PubMed]
151. Rota JS, Wang ZD, Rota PA, Bellini WJ . 1994. Comparison of sequences of the H, F, and N coding genes of measles virus vaccine strains. Virus Res 31 : 317 330.[PubMed]
152. Cutts FT, Clements CJ, Bennett JV . 1997. Alternative routes of measles immunization: a review. Biologicals 25 : 323 338.[PubMed]
153. Ovsyannikova IG, Dhiman N, Jacobson RM, Vierkant RA, Poland GA . 2003. Frequency of measles virus-specific CD4+ and CD8+ T cells in subjects seronegative or highly seropositive for measles vaccine. Clin Diagn Lab Immunol 10 : 411 416.[PubMed]
154. Wong-Chew RM, Islas-Romero R, García-García ML, Beeler JA, Audet S, Santos-Preciado JI, Gans H, Lew-Yasukawa L, Maldonado YA, Arvin AM, Valdespino-Gómez JL . 2006. Immunogenicity of aerosol measles vaccine given as the primary measles immunization to nine-month-old Mexican children. Vaccine 24 : 683 690.[PubMed]
155. Edens C, Collins ML, Goodson JL, Rota PA, Prausnitz MR . 2015. A microneedle patch containing measles vaccine is immunogenic in non-human primates. Vaccine 33 : 4712 4718.[PubMed]
156. Cutts FT, Grabowsky M, Markowitz LE . 1995. The effect of dose and strain of live attenuated measles vaccines on serological responses in young infants. Biologicals 23 : 95 106.[PubMed]
157. World Health Organization . 2004. Measles vaccines. Wkly Epidemiol Rec 79 : 130142.[PubMed]
158. Dhiman N, Ovsyannikova IG, Cunningham JM, Vierkant RA, Kennedy RB, Pankratz VS, Poland GA, Jacobson RM . 2007. Associations between measles vaccine immunity and single-nucleotide polymorphisms in cytokine and cytokine receptor genes. J Infect Dis 195 : 21 29.[PubMed]
159. Ovsyannikova IG, Pankratz VS, Vierkant RA, Jacobson RM, Poland GA . 2006. Human leukocyte antigen haplotypes in the genetic control of immune response to measles-mumps-rubella vaccine. J Infect Dis 193 : 655 663.[PubMed]
160. Scott S, Cutts FT, Nyandu B . 1999. Mild illness at or after measles vaccination does not reduce seroresponse in young children. Vaccine 17 : 837 843.[PubMed]
161. Aaby P, Jensen H, Samb B, Cisse B, Sodemann M, Jakobsen M, Poulsen A, Rodrigues A, Lisse IM, Simondon F, Whittle H . 2003. Differences in female-male mortality after high-titre measles vaccine and association with subsequent vaccination with diphtheria-tetanus-pertussis and inactivated poliovirus: reanalysis of West African studies. Lancet 361 : 2183 2188.[PubMed]
162. Anders JF, Jacobson RM, Poland GA, Jacobsen SJ, Wollan PC . 1996. Secondary failure rates of measles vaccines: a metaanalysis of published studies. Pediatr Infect Dis J 15 : 62 66.[PubMed]
163. Ozanne G, d'Halewyn MA . 1992. Secondary immune response in a vaccinated population during a large measles epidemic. J Clin Microbiol 30 : 1778 1782.[PubMed]
164. De Serres G, Markowski F, Toth E, Landry M, Auger D, Mercier M, Bélanger P, Turmel B, Arruda H, Boulianne N, Ward BJ, Skowronski DM . 2013. Largest measles epidemic in North America in a decade—Quebec, Canada, 2011: contribution of susceptibility, serendipity, and superspreading events. J Infect Dis 207 : 990 998.[PubMed]
165. Beeler J, Varricchio F, Wise R . 1996. Thrombocytopenia after immunization with measles vaccines: review of the vaccine adverse events reporting system (1990 to 1994). Pediatr Infect Dis J 15 : 88 90.[PubMed]
166. Angel JB, Walpita P, Lerch RA, Sidhu MS, Masurekar M, DeLellis RA, Noble JT, Snydman DR, Udem SA . 1998. Vaccine-associated measles pneumonitis in an adult with AIDS. Ann Intern Med 129 : 104 106.[PubMed]
167. Okada H, Sato TA, Katayama A, Higuchi K, Shichijo K, Tsuchiya T, Takayama N, Takeuchi Y, Abe T, Okabe N, Tashiro M . 2001. Comparative analysis of host responses related to immunosuppression between measles patients and vaccine recipients with live attenuated measles vaccines. Arch Virol 146 : 859 874.[PubMed]
168. Wakefield AJ, Murch SH, Anthony A, Linnell J, Casson DM, Malik M, Berelowitz M, Dhillon AP, Thomson MA, Harvey P, Valentine A, Davies SE, Walker-Smith JA . 1998. Ileal-lymphoid-nodular hyperplasia, non-specific colitis, and pervasive developmental disorder in children. Lancet 351 : 637 641.[PubMed]
169. Offit PA, Coffin SE . 2003. Communicating science to the public: MMR vaccine and autism. Vaccine 22 : 1 6.[PubMed]
170. DeStefano F, Thompson WW . 2004. MMR vaccine and autism: an update of the scientific evidence. Expert Rev Vaccines 3 : 19 22.[PubMed]
171. Griffin DE, Pan CH, Moss WJ . 2008. Measles vaccines. Front Biosci 13 : 1352 1370.[PubMed]
172. Lin WH, Vilalta A, Adams RJ, Rolland A, Sullivan SM, Griffin DE . 2013. Vaxfectin adjuvant improves antibody responses of juvenile rhesus macaques to a DNA vaccine encoding the measles virus hemagglutinin and fusion proteins. J Virol 87 : 6560 6568.[PubMed]
173. Pan CH, Valsamakis A, Colella T, Nair N, Adams RJ, Polack FP, Greer CE, Perri S, Polo JM, Griffin DE . 2005. Modulation of disease, T cell responses, and measles virus clearance in monkeys vaccinated with H-encoding alphavirus replicon particles. Proc Natl Acad Sci USA 102 : 11581 11588.[PubMed]
174. Higginson D, Theodoratou E, Nair H, Huda T, Zgaga L, Jadhav SS, Omer SB, Rudan I, Campbell H . 2011. An evaluation of respiratory administration of measles vaccine for prevention of acute lower respiratory infections in children. BMC Public Health 11( Suppl 3) : S31.[PubMed]
175. Sabin AB . 1983. Immunization against measles by aerosol. Rev Infect Dis 5 : 514 523.[PubMed]
176. Sabin AB, Fernández de Castro J, Flores Arechiga A, Sever JL, Madden DL, Shekarchi I . 1982. Clinical trials of inhaled aerosol of human diploid and chick embryo measles vaccine. Lancet 2 : 604.[PubMed]
177. Sabin AB, Flores Arechiga A, Fernández de Castro J, Sever JL, Madden DL, Shekarchi I, Albrecht P . 1983. Successful immunization of children with and without maternal antibody by aerosolized measles vaccine. I. Different results with undiluted human diploid cell and chick embryo fibroblast vaccines. JAMA 249 : 2651 2662.[PubMed]
178. Sabin AB, Flores Arechiga A, Fernández de Castro J, Albrecht P, Sever JL, Shekarchi I . 1984. Successful immunization of infants with and without maternal antibody by aerosolized measles vaccine. II. Vaccine comparisons and evidence for multiple antibody response. JAMA 251 : 2363 2371.[PubMed]
179. Lin WH, Griffin DE, Rota PA, Papania M, Cape SP, Bennett D, Quinn B, Sievers RE, Shermer C, Powell K, Adams RJ, Godin S, Winston S . 2011. Successful respiratory immunization with dry powder live-attenuated measles virus vaccine in rhesus macaques. Proc Natl Acad Sci USA 108 : 2987 2992.[PubMed]
180. Low N, Bavdekar A, Jeyaseelan L, Hirve S, Ramanathan K, Andrews NJ, Shaikh N, Jadi RS, Rajagopal A, Brown KE, Brown D, Fink JB, John O, Scott P, Riveros-Balta AX, Greco M, Dhere R, Kulkarni PS, Henao Restrepo AM . 2015. A randomized, controlled trial of an aerosolized vaccine against measles. N Engl J Med 372 : 1519 1529.[PubMed]
181. Garrison LP Jr, Bauch CT, Bresnahan BW, Hazlet TK, Kadiyala S, Veenstra DL . 2011. Using cost-effectiveness analysis to support research and development portfolio prioritization for product innovations in measles vaccination. J Infect Dis 204( Suppl 1) : S124 S132.[PubMed]
182. Wolfson LJ, Strebel PM, Gacic-Dobo M, Hoekstra EJ, McFarland JW, Hersh BS Measles Initiative . 2007. Has the 2005 measles mortality reduction goal been achieved? A natural history modelling study. Lancet 369 : 191 200.[PubMed]
183. Pan American Health Organization . 1999. Measles Eradication. Field Guide. Pan American Health Organization, Washington, DC.
184. Sencer DJ, Dull HB, Langmuir AD . 1967. Epidemiologic basis for eradication of measles in 1967. Public Health Rep 82 : 253