Chapter 39 : Mumps Virus

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Mumps virus, a member of the paramyxovirus family, causes a distinctive and generally benign systemic infection that is clinically characterized by fever and parotitis. In older literature, mumps was often termed “epidemic parotitis.” Historically, mumps occurred commonly among school-aged children but dramatically declined following the introduction of routine vaccination. Significant mumps outbreaks continue to occur, however, among previously infected or vaccinated individuals for reasons that are not fully understood. These cases of reinfection or vaccine failure can sometimes be difficult to diagnose due to mild clinical presentations and can be difficult to confirm due to limitations of current laboratory testing.

Citation: Gnann J, Latner D. 2017. Mumps Virus, p 929-948. In Richman D, Whitley R, Hayden F (ed), Clinical Virology, Fourth Edition. ASM Press, Washington, DC. doi: 10.1128/9781555819439.ch39
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Image of FIGURE 1

Structure of the mumps virion. Molecular weights of viral proteins as measured by gel electrophoresis are shown in parentheses. Data from Galinski and Wechsler ( ).

Citation: Gnann J, Latner D. 2017. Mumps Virus, p 929-948. In Richman D, Whitley R, Hayden F (ed), Clinical Virology, Fourth Edition. ASM Press, Washington, DC. doi: 10.1128/9781555819439.ch39
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Image of FIGURE 2

Genome organization of mumps virus. Number of nucleotides in messenger mRNA: and Protein: Amino acid residues in corresponding protein. Data from Pringle ( ).

Citation: Gnann J, Latner D. 2017. Mumps Virus, p 929-948. In Richman D, Whitley R, Hayden F (ed), Clinical Virology, Fourth Edition. ASM Press, Washington, DC. doi: 10.1128/9781555819439.ch39
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Image of FIGURE 3

Replication strategy of mumps virus.

Citation: Gnann J, Latner D. 2017. Mumps Virus, p 929-948. In Richman D, Whitley R, Hayden F (ed), Clinical Virology, Fourth Edition. ASM Press, Washington, DC. doi: 10.1128/9781555819439.ch39
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Image of FIGURE 4

Cytopathic effect of mumps virus replication in tissue culture. Cell-to-cell fusion in Vero cells during the course of infection with mumps virus (10x magnification). (A) uninfected, and 48 hours post infection (m.o.i. = 0.01) with (B) Jeryl Lynn strain, and (C) wild-type virus (genotype G).

Citation: Gnann J, Latner D. 2017. Mumps Virus, p 929-948. In Richman D, Whitley R, Hayden F (ed), Clinical Virology, Fourth Edition. ASM Press, Washington, DC. doi: 10.1128/9781555819439.ch39
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Image of FIGURE 5

Child with mumps displaying diffuse lymphedema of the neck due to parotitis. (Image courtesy of CDC Public Health Image Library.)

Citation: Gnann J, Latner D. 2017. Mumps Virus, p 929-948. In Richman D, Whitley R, Hayden F (ed), Clinical Virology, Fourth Edition. ASM Press, Washington, DC. doi: 10.1128/9781555819439.ch39
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