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Chapter 40 : Zoonotic Paramyxoviruses

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Zoonotic Paramyxoviruses, Page 1 of 2

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Abstract:

This chapter focuses on emergent paramyxoviruses that are associated with zoonotic disease. Hendra virus (HeV), Nipah virus (NiV), Menangle virus (MenPV), and Sosuga virus (SosPV) are known to have caused severe zoonotic infections, and Tioman virus (TioPV), Achimota virus (AchPV), and Mojiang virus (MojPV) are also suspected of causing them. These viruses, which have emerged or been detected over the last two decades, are potential threats to both livestock animals and humans (Table 1). In particular, HeV and NiV have caused fatal diseases in animals and humans, and outbreaks of NiV continue to occur almost annually. Molecular biological studies have made substantial contributions to the characterization of emergent zoonotic paramyxoviruses. Sequencing studies provide an accurate picture of the relative taxonomic position of these viruses and provide rapid diagnostic capabilities. In the case of outbreaks of NiV in Malaysia, Bangladesh, and India, molecular biological data quickly identified the etiologic agent present, and reverse transcriptase PCR (RT-PCR) and serologic assays were used to rapidly confirm NiV infections in humans and animals (1–4).

Citation: Anderson D, Wang L. 2017. Zoonotic Paramyxoviruses, p 949-966. In Richman D, Whitley R, Hayden F (ed), Clinical Virology, Fourth Edition. ASM Press, Washington, DC. doi: 10.1128/9781555819439.ch40
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Image of FIGURE 1
FIGURE 1

Phylogenetic analysis of the sequences of the open reading frame of the N protein gene from selected viruses in the subfamily . The genus name is on the right. Abbreviations of virus names and sequence accession numbers are as follows: Achimota virus 1 (AchPV1) JX051319; Achimota virus 2 (AchPV2) JX051320; Atlantic salmon paramyxovirus (AsaPV) EU156171; Avian paramyxovirus 6 (APMV6) AY029299; Bat paramyxovirus/Eid hel/GH-M74a/GHA/2009 (BPV-M74a) HQ660129; Beilong virus (BeiPV) DQ100461; Bovine parainfluenza virus 3 (bPIV3) AF178654; Canine distemper virus (CDV) AF014953; Cedar virus (CedPV) JQ001776; Fer-de-lance paramyxovirus (FdlPV) NC_005084; Hendra virus (HeV) AF017149; Human parainfluenza virus 2 (hPIV2) AF533010; Human parainfluenza virus 3 (hPIV3) Z11575; J virus (JPV) AY900001; Menangle virus (MenPV) AF326114; Measles virus (MeV) AB016162; Mojiang virus (MojPV) KF278639; Mossman virus (MosPV) AY286409; Mumps virus (MuV) AB000388; Newcastle disease virus (NDV) AF077761; Nipah virus, Bangladesh strain (NiV-BD) AY988601; Nipah virus, Malaysian strain (NiV-MY) AJ627196; Parainfluenza virus 5 (PIV5) AF052755; Rinderpest virus (RPV) Z30697; Salem virus (SalPV), AF237881; Sendai virus (SeV) M19661; Sosuga virus (SosPV) KF774436; Tioman virus (TioPV) AF298895; Tupaia paramyxovirus (TupPV) AF079780.

Citation: Anderson D, Wang L. 2017. Zoonotic Paramyxoviruses, p 949-966. In Richman D, Whitley R, Hayden F (ed), Clinical Virology, Fourth Edition. ASM Press, Washington, DC. doi: 10.1128/9781555819439.ch40
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Image of FIGURE 2
FIGURE 2

Schematic representation of the genomes of viruses in the subfamily . Genomes are single-stranded, negative-sense RNA shown in the 3’-to-5’ (left-to-right) orientation. Boxes indicate protein-coding regions, and solid lines indicate noncoding regions. The genome, coding regions, and untranslated regions are drawn to scale. The six conserved genes present in all paramyxovirus genomes are indicated as follows: light shaded = RNA polymerase and nucleocapsid genes (N, P and L); slanted = envelope membrane protein genes (F and attachment protein); white = matrix protein (M). The dark shaded boxes represent genes which are not commonly shared among members of the subfamily. The scale at the bottom represents genome size in nucleotides.

Citation: Anderson D, Wang L. 2017. Zoonotic Paramyxoviruses, p 949-966. In Richman D, Whitley R, Hayden F (ed), Clinical Virology, Fourth Edition. ASM Press, Washington, DC. doi: 10.1128/9781555819439.ch40
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Image of FIGURE 3
FIGURE 3

Schematic representation of the coding strategy found in the P protein gene of NiV. The predicted P protein mRNA is 2,704 nucleotides in length (nucleotides with asterisks indicate the location of the P protein gene sequence within the sequence with GenBank accession no. AF212302). The P protein is encoded by a faithful transcript of the viral genomic RNA from an opening reading frame beginning at nucleotide 106 of the mRNA. The RNA editing site is indicated by the vertical arrow. The addition of a nontemplated G nucleotide at the RNA editing site (nucleotide 1325) allows access to a different reading frame (–1 relative to P). The V protein contains the amino-terminal domain of the P protein (horizontal lines) joined to the cysteine-rich domain that is unique to the V protein (diagonal lines). The addition of two nontemplated G nucleotides at the RNA editing site produces the mRNA for the W protein in which the amino-terminal domain of P is joined to carboxyl-terminal domain unique for W (diagonal lines). The C protein (gray box) is expressed from an ORF that begins at nucleotide 128 (or 131) and overlaps P in the +1 frame.

Citation: Anderson D, Wang L. 2017. Zoonotic Paramyxoviruses, p 949-966. In Richman D, Whitley R, Hayden F (ed), Clinical Virology, Fourth Edition. ASM Press, Washington, DC. doi: 10.1128/9781555819439.ch40
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Image of FIGURE 4
FIGURE 4

Range of the genus Pteropus (shaded area). Locations where human infections of henipaviruses have occurred are designated by stars.

Citation: Anderson D, Wang L. 2017. Zoonotic Paramyxoviruses, p 949-966. In Richman D, Whitley R, Hayden F (ed), Clinical Virology, Fourth Edition. ASM Press, Washington, DC. doi: 10.1128/9781555819439.ch40
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References

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1. Chadha MS, Comer JA, Lowe L, Rota PA, Rollin PE, Bellini WJ, Ksiazek TG, Mishra A. 2006. Nipah virus-associated encephalitis outbreak, Siliguri, India. Emerg Infect Dis 12:235240.[PubMed]
2. Chua KB, Bellini WJ, Rota PA, Harcourt BH, Tamin A, Lam SK, Ksiazek TG, Rollin PE, Zaki SR, Shieh W, Goldsmith CS, Gubler DJ, Roehrig JT, Eaton B, Gould AR, Olson J, Field H, Daniels P, Ling AE, Peters CJ, Anderson LJ, Mahy BW. 2000. Nipah virus: a recently emergent deadly paramyxovirus. Science 288:14321435.[PubMed]
3. Harcourt BH, Tamin A, Halpin K, Ksiazek TG, Rollin PE, Bellini WJ, Rota PA. 2001. Molecular characterization of the polymerase gene and genomic termini of Nipah virus. Virology 287:192201.[PubMed]
4. Harcourt BH, Lowe L, Tamin A, Liu X, Bankamp B, Bowden N, Rollin PE, Comer JA, Ksiazek TG, Hossain MJ, Gurley ES, Breiman RF, Bellini WJ, Rota PA. 2005. Genetic characterization of Nipah virus, Bangladesh, 2004. Emerg Infect Dis 11:15941597.[PubMed]
5. Chant K, Chan R, Smith M, Dwyer DE, Kirkland P The NSW Expert Group. 1998. Probable human infection with a newly described virus in the family Paramyxoviridae. Emerg Infect Dis 4:273275.[PubMed]
6. Philbey AW, Kirkland PD, Ross AD, Davis RJ, Gleeson AB, Love RJ, Daniels PW, Gould AR, Hyatt AD. 1998. An apparently new virus (family Paramyxoviridae) infectious for pigs, humans, and fruit bats. Emerg Infect Dis 4:269271.[PubMed]
7. Philbey AW, Ross AD, Kirkland PD, Love RJ. 2007. Skeletal and neurological malformations in pigs congenitally infected with Menangle virus. Aust Vet J 85:134140.[PubMed]
8. Albariño CG, Foltzer M, Towner JS, Rowe LA, Campbell S, Jaramillo CM, Bird BH, Reeder DM, Vodzak ME, Rota P, Metcalfe MG, Spiropoulou CF, Knust B, Vincent JP, Frace MA, Nichol ST, Rollin PE, Ströher U. 2014. Novel paramyxovirus associated with severe acute febrile disease, South Sudan and Uganda, 2012. Emerg Infect Dis 20:211216.[PubMed]
9. Chua KB, Wang LF, Lam SK, Crameri G, Yu M, Wise T, Boyle D, Hyatt AD, Eaton BT. 2001. Tioman virus, a novel paramyxovirus isolated from fruit bats in Malaysia. Virology 283:215229.[PubMed]
10. Yaiw KC, Bingham J, Crameri G, Mungall B, Hyatt A, Yu M, Eaton B, Shamala D, Wang LF, Thong Wong K. 2008. Tioman virus, a paramyxovirus of bat origin, causes mild disease in pigs and has a predilection for lymphoid tissues. J Virol 82:565568.[PubMed]
11. Yaiw KC, Crameri G, Wang L, Chong HT, Chua KB, Tan CT, Goh KJ, Shamala D, Wong KT. 2007. Serological evidence of possible human infection with Tioman virus, a newly described paramyxovirus of bat origin. J Infect Dis 196:884886.[PubMed]
12. Halpin K, Hyatt AD, Plowright RK, Epstein JH, Daszak P, Field HE, Wang L, Daniels PW Henipavirus Ecology Research Group. 2007. Emerging viruses: coming in on a wrinkled wing and a prayer. Clin Infect Dis 44:711717.[PubMed]
13. Halpin K, Mungall BA. 2007. Recent progress in henipavirus research. Comp Immunol Microbiol Infect Dis 30:287307[CrossRef].[PubMed]
14. Eaton BT, Broder CC, Middleton D, Wang LF. 2006. Hendra and Nipah viruses: different and dangerous. Nat Rev Microbiol 4:2335.[PubMed]
15. Wang L-F, Mackenzie JS, Broder CC,. 2013. Henipaviruses, p 10701085. In Knipe DM, , et al (ed), Fields Virology. 1, 6th ed. Lippincott Williams & Wilkins, Philadelphia, PA.
16. Baker KS, Todd S, Marsh GA, Crameri G, Barr J, Kamins AO, Peel AJ, Yu M, Hayman DTS, Nadjm B, Mtove G, Amos B, Reyburn H, Nyarko E, Suu-Ire R, Murcia PR, Cunningham AA, Wood JLN, Wang LF. 2013. Novel, potentially zoonotic paramyxoviruses from the African straw-colored fruit bat Eidolon helvum. J Virol 87:13481358.[PubMed]
17. Wu Z, Yang L, Yang F, Ren X, Jiang J, Dong J, Sun L, Zhu Y, Zhou H, Jin Q. 2014. Novel Henipa-like virus, Mojiang Paramyxovirus, in rats, China, 2012. Emerg Infect Dis 20:10641066.[PubMed]
18. Murray K, Selleck P, Hooper P, Hyatt A, Gould A, Gleeson L, Westbury H, Hiley L, Selvey L, Rodwell B, Ketterer P. 1995. A morbillivirus that caused fatal disease in horses and humans. Science 268:9497.[PubMed]
19. Harcourt BH, Tamin A, Ksiazek TG, Rollin PE, Anderson LJ, Bellini WJ, Rota PA. 2000. Molecular characterization of Nipah virus, a newly emergent paramyxovirus. Virology 271:334349.[PubMed]
20. Lamb RA, Collins PL, Kolakofsky D, Melero JA, Nagai Y, Oldstone MBA, Pringle CR, Rima BK,. 2005. Paramyxoviridae, p 655668. In Fauquet CM, Mayo MA, Maniloff J, Desselberger U, Ball LA (ed), Virus Taxonomy: VIIIth Report of the International Committee on Taxonomy of Viruses, 8th ed. Elsevier Academic Press, London.
21. Bowden TR, Westenberg M, Wang LF, Eaton BT, Boyle DB. 2001. Molecular characterization of Menangle virus, a novel paramyxovirus which infects pigs, fruit bats, and humans. Virology 283:358373.[PubMed]
22. Franke J, Essbauer S, Ahne W, Blahak S. 2001. Identification and molecular characterization of 18 paramyxoviruses isolated from snakes. Virus Res 80:6774.[PubMed]
23. Osterhaus AD, Groen J, De Vries P, UytdeHaag FG, Klingeborn B, Zarnke R. 1988. Canine distemper virus in seals. Nature 335:403404.[PubMed]
24. Domingo M, Visa J, Pumarola M, Marco AJ, Ferrer L, Rabanal R, Kennedy S. 1992. Pathologic and immunocytochemical studies of morbillivirus infection in striped dolphins (Stenella coeruleoalba). Vet Pathol 29:110.[PubMed]
25. Roelke-Parker ME, Munson L, Packer C, Kock R, Cleaveland S, Carpenter M, O'Brien SJ, Pospischil A, Hofmann-Lehmann R, Lutz H, Mwamengele GL, Mgasa MN, Machange GA, Summers BA, Appel MJ. 1996. A canine distemper virus epidemic in Serengeti lions (Panthera leo). Nature 379:441445.[PubMed]
26. Jack PJ, Boyle DB, Eaton BT, Wang LF. 2005. The complete genome sequence of J virus reveals a unique genome structure in the family Paramyxoviridae. J Virol 79:1069010700.[PubMed]
27. Li Z, Yu M, Zhang H, Magoffin DE, Jack PJ, Hyatt A, Wang HY, Wang LF. 2006. Beilong virus, a novel paramyxovirus with the largest genome of non-segmented negative-stranded RNA viruses. Virology 346:219228.[PubMed]
28. Calain P, Roux L. 1993. The rule of six, a basic feature for efficient replication of Sendai virus defective interfering RNA. J Virol 67:48224830.[PubMed]
29. Halpin K, Bankamp B, Harcourt BH, Bellini WJ, Rota PA. 2004. Nipah virus conforms to the rule of six in a minigenome replication assay. J Gen Virol 85:701707.[PubMed]
30. Wang LF, Michalski WP, Yu M, Pritchard LI, Crameri G, Shiell B, Eaton BT. 1998. A novel P/V/C gene in a new member of the Paramyxoviridae family, which causes lethal infection in humans, horses, and other animals. J Virol 72:14821490.[PubMed]
31. Wang LF, Yu M, Hansson E, Pritchard LI, Shiell B, Michalski WP, Eaton BT. 2000. The exceptionally large genome of Hendra virus: support for creation of a new genus within the family Paramyxoviridae. J Virol 74:99729979.[PubMed]
32. Smith I, Broos A, de Jong C, Zeddeman A, Smith C, Smith G, Moore F, Barr J, Crameri G, Marsh G, Tachedjian M, Yu M, Kung YH, Wang LF, Field H. 2011. Identifying Hendra virus diversity in pteropid bats. PLoS One 6:e25275.[PubMed]
33. Marsh GA, Todd S, Foord A, Hansson E, Davies K, Wright L, Morrissy C, Halpin K, Middleton D, Field HE, Daniels P, Wang LF. 2010. Genome sequence conservation of Hendra virus isolates during spillover to horses, Australia. Emerg Infect Dis 16:17671769.[PubMed]
34. Lamb RA, Parks GD,. 2013. Paramyxoviridae, p 957995. In Knipe DM, , et al (ed), Fields Virology. 1, 6th ed. Lippincott Williams & Wilkins, Philadelphia, PA.
35. Lamb RA, Jardetzky TS. 2007. Structural basis of viral invasion: lessons from paramyxovirus F. Curr Opin Struct Biol 17:427436.[PubMed]
36. Lau SK, Woo PC, Wong BH, Wong AY, Tsoi HW, Wang M, Lee P, Xu H, Poon RW, Guo R, Li KS, Chan KH, Zheng BJ, Yuen KY. 2010. Identification and complete genome analysis of three novel paramyxoviruses, Tuhoko virus 1, 2 and 3, in fruit bats from China. Virology 404:106116.[PubMed]
37. Chan YP, Koh CL, Lam SK, Wang LF. 2004. Mapping of domains responsible for nucleocapsid protein-phosphoprotein interaction of Henipaviruses. J Gen Virol 85:16751684.[PubMed]
38. Thomas SM, Lamb RA, Paterson RG. 1988. Two mRNAs that differ by two nontemplated nucleotides encode the amino coterminal proteins P and V of the paramyxovirus SV5. Cell 54:891902.[PubMed]
39. Vidal S, Kolakofsky D. 1989. Modified model for the switch from Sendai virus transcription to replication. J Virol 63:19511958.[PubMed]
40. Naniche D, Yeh A, Eto D, Manchester M, Friedman RM, Oldstone MB. 2000. Evasion of host defenses by measles virus: wild-type measles virus infection interferes with induction of Alpha/Beta interferon production. J Virol 74:74787484.[PubMed]
41. He B, Paterson RG, Stock N, Durbin JE, Durbin RK, Goodbourn S, Randall RE, Lamb RA. 2002. Recovery of paramyxovirus simian virus 5 with a V protein lacking the conserved cysteine-rich domain: the multifunctional V protein blocks both interferon-beta induction and interferon signaling. Virology 303:1532.[PubMed]
42. Komatsu T, Takeuchi K, Yokoo J, Gotoh B. 2002. Sendai virus C protein impairs both phosphorylation and dephosphorylation processes of Stat1. FEBS Lett 511:139144.[PubMed]
43. Poole E, He B, Lamb RA, Randall RE, Goodbourn S. 2002. The V proteins of simian virus 5 and other paramyxoviruses inhibit induction of interferon-beta. Virology 303:3346.[PubMed]
44. Horvath CM. 2004. Weapons of STAT destruction. Interferon evasion by paramyxovirus V protein. Eur J Biochem 271:46214628.[PubMed]
45. Rodriguez JJ, Horvath CM. 2004. Host evasion by emerging paramyxoviruses: hendra virus and Nipah virus v proteins inhibit interferon signaling. Viral Immunol 17:210219.[PubMed]
46. Conzelmann KK. 2005. Transcriptional activation of alpha/beta interferon genes: interference by nonsegmented negative-strand RNA viruses. J Virol 79:52415248.[PubMed]
47. Park MS, Shaw ML, Muñoz-Jordan J, Cros JF, Nakaya T, Bouvier N, Palese P, García-Sastre A, Basler CF. 2003. Newcastle disease virus (NDV)-based assay demonstrates interferon-antagonist activity for the NDV V protein and the Nipah virus V, W, and C proteins. J Virol 77:15011511.[PubMed]
48. Rodriguez JJ, Parisien JP, Horvath CM. 2002. Nipah virus V protein evades alpha and gamma interferons by preventing STAT1 and STAT2 activation and nuclear accumulation. J Virol 76:1147611483.[PubMed]
49. Rodriguez JJ, Wang LF, Horvath CM. 2003. Hendra virus V protein inhibits interferon signaling by preventing STAT1 and STAT2 nuclear accumulation. J Virol 77:1184211845.[PubMed]
50. Shaw ML, García-Sastre A, Palese P, Basler CF. 2004. Nipah virus V and W proteins have a common STAT1-binding domain yet inhibit STAT1 activation from the cytoplasmic and nuclear compartments, respectively. J Virol 78:56335641.[PubMed]
51. Shaw ML, Cardenas WB, Zamarin D, Palese P, Basler CF. 2005. Nuclear localization of the Nipah virus W protein allows for inhibition of both virus- and toll-like receptor 3-triggered signaling pathways. J Virol 79:60786088.[PubMed]
52. Hagmaier K, Stock N, Goodbourn S, Wang LF, Randall R. 2006. A single amino acid substitution in the V protein of Nipah virus alters its ability to block interferon signalling in cells from different species. J Gen Virol 87:36493653.[PubMed]
53. Poch O, Blumberg BM, Bougueleret L, Tordo N. 1990. Sequence comparison of five polymerases (L proteins) of unsegmented negative-strand RNA viruses: theoretical assignment of functional domains. J Gen Virol 71:11531162.[PubMed]
54. Tidona CA, Kurz HW, Gelderblom HR, Darai G. 1999. Isolation and molecular characterization of a novel cytopathogenic paramyxovirus from tree shrews. Virology 258:425434.[PubMed]
55. Magoffin DE, Mackenzie JS, Wang L-F. 2007. Genetic analysis of J-virus and Beilong virus using minireplicons. Virology 364:103111.[PubMed]
56. Marsh GA, de Jong C, Barr JA, Tachedjian M, Smith C, Middleton D, Yu M, Todd S, Foord AJ, Haring V, Payne J, Robinson R, Broz I, Crameri G, Field HE, Wang LF. 2012. Cedar virus: a novel Henipavirus isolated from Australian bats. PLoS Pathog 8:e1002836.[PubMed]
57. Drexler JF, Corman VM, Müller MA, Maganga GD, Vallo P, Binger T, Gloza-Rausch F, Cottontail VM, Rasche A, Yordanov S, Seebens A, Knörnschild M, Oppong S, Adu Sarkodie Y, Pongombo C, Lukashev AN, Schmidt-Chanasit J, Stöcker A, Carneiro AJ, Erbar S, Maisner A, Fronhoffs F, Buettner R, Kalko EK, Kruppa T, Franke CR, Kallies R, Yandoko ER, Herrler G, Reusken C, Hassanin A, Krüger DH, Matthee S, Ulrich RG, Leroy EM, Drosten C. 2012. Bats host major mammalian paramyxoviruses. Nat Commun 3:796.[PubMed]
58. Bossart KN, Wang LF, Flora MN, Chua KB, Lam SK, Eaton BT, Broder CC. 2002. Membrane fusion tropism and heterotypic functional activities of the Nipah virus and Hendra virus envelope glycoproteins. J Virol 76:1118611198.[PubMed]
59. Tamin A, Harcourt BH, Ksiazek TG, Rollin PE, Bellini WJ, Rota PA. 2002. Functional properties of the fusion and attachment glycoproteins of Nipah virus. Virology 296:190200.[PubMed]
60. Chua KB, Wang LF, Lam SK, Eaton BT. 2002. Full length genome sequence of Tioman virus, a novel paramyxovirus in the genus Rubulavirus isolated from fruit bats in Malaysia. Arch Virol 147:13231348.[PubMed]
61. Langedijk JP, Daus FJ, van Oirschot JT. 1997. Sequence and structure alignment of Paramyxoviridae attachment proteins and discovery of enzymatic activity for a morbillivirus hemagglutinin. J Virol 71:61556167.[PubMed]
62. Moll M, Diederich S, Klenk HD, Czub M, Maisner A. 2004. Ubiquitous activation of the Nipah virus fusion protein does not require a basic amino acid at the cleavage site. J Virol 78:97059712.[PubMed]
63. Meulendyke KA, Wurth MA, McCann RO, Dutch RE. 2005. Endocytosis plays a critical role in proteolytic processing of the Hendra virus fusion protein. J Virol 79:1264312649.[PubMed]
64. Michalski WP, Crameri G, Wang L, Shiell BJ, Eaton B. 2000. The cleavage activation and sites of glycosylation in the fusion protein of Hendra virus. Virus Res 69:8393.[PubMed]
65. Vogt C, Eickmann M, Diederich S, Moll M, Maisner A. 2005. Endocytosis of the Nipah virus glycoproteins. J Virol 79:38653872.[PubMed]
66. Pager CT, Dutch RE. 2005. Cathepsin L is involved in proteolytic processing of the Hendra virus fusion protein. J Virol 79:1271412720.[PubMed]
67. Aguilar HC, Matreyek KA, Filone CM, Hashimi ST, Levroney EL, Negrete OA, Bertolotti-Ciarlet A, Choi DY, McHardy I, Fulcher JA, Su SV, Wolf MC, Kohatsu L, Baum LG, Lee B. 2006. N-glycans on Nipah virus fusion protein protect against neutralization but reduce membrane fusion and viral entry. J Virol 80:48784889.[PubMed]
68. Moll M, Kaufmann A, Maisner A. 2004. Influence of N-glycans on processing and biological activity of the nipah virus fusion protein. J Virol 78:72747278.[PubMed]
69. Crameri G, Wang LF, Morrissy C, White J, Eaton BT. 2002. A rapid immune plaque assay for the detection of Hendra and Nipah viruses and anti-virus antibodies. J Virol Methods 99:4151.[PubMed]
70. Guillaume V, Contamin H, Loth P, Grosjean I, Courbot MC, Deubel V, Buckland R, Wild TF. 2006. Antibody prophylaxis and therapy against Nipah virus infection in hamsters. J Virol 80:19721978.[PubMed]
71. Weingartl HM, Berhane Y, Caswell JL, Loosmore S, Audonnet JC, Roth JA, Czub M. 2006. Recombinant nipah virus vaccines protect pigs against challenge. J Virol 80:79297938.[PubMed]
72. Guillaume V, Contamin H, Loth P, Georges-Courbot MC, Lefeuvre A, Marianneau P, Chua KB, Lam SK, Buckland R, Deubel V, Wild TF. 2004. Nipah virus: vaccination and passive protection studies in a hamster model. J Virol 78:834840.[PubMed]
73. Plattet P, Plemper RK. 2013. Envelope protein dynamics in paramyxovirus entry. MBio 4:e00413-13.[PubMed]
74. Yu M, Hansson E, Langedijk JP, Eaton BT, Wang LF. 1998. The attachment protein of Hendra virus has high structural similarity but limited primary sequence homology compared with viruses in the genus Paramyxovirus. Virology 251:227233.[PubMed]
75. Bonaparte MI, Dimitrov AS, Bossart KN, Crameri G, Mungall BA, Bishop KA, Choudhry V, Dimitrov DS, Wang LF, Eaton BT, Broder CC. 2005. Ephrin-B2 ligand is a functional receptor for Hendra virus and Nipah virus. Proc Natl Acad Sci USA 102:1065210657.[PubMed]
76. Negrete OA, Levroney EL, Aguilar HC, Bertolotti-Ciarlet A, Nazarian R, Tajyar S, Lee B. 2005. EphrinB2 is the entry receptor for Nipah virus, an emergent deadly paramyxovirus. Nature 436:401405.[PubMed]
77. Liu Q, Bradel-Tretheway B, Monreal AI, Saludes JP, Lu X, Nicola AV, Aguilar HC. 2015. Nipah virus attachment glycoprotein stalk C-terminal region links receptor binding to fusion triggering. J Virol 89:18381850.[PubMed]
78. Negrete OA, Wolf MC, Aguilar HC, Enterlein S, Wang W, Mühlberger E, Su SV, Bertolotti-Ciarlet A, Flick R, Lee B. 2006. Two key residues in ephrinB3 are critical for its use as an alternative receptor for Nipah virus. PLoS Pathog 2:e7.[PubMed]
79. Negrete OA, Chu D, Aguilar HC, Lee B. 2007. Single amino acid changes in the Nipah and Hendra virus attachment glycoproteins distinguish ephrinB2 from ephrinB3 usage. J Virol 81:1080410814.[PubMed]
80. Sawatsky B, Grolla A, Kuzenko N, Weingartl H, Czub M. 2007. Inhibition of henipavirus infection by Nipah virus attachment glycoprotein occurs without cell-surface downregulation of ephrin-B2 or ephrin-B3. J Gen Virol 88:582591.[PubMed]
81. Chua KB, Lam SK, Tan CT, Hooi PS, Goh KJ, Chew NK, Tan KS, Kamarulzaman A, Wong KT. 2000. High mortality in Nipah encephalitis is associated with presence of virus in cerebrospinal fluid. Ann Neurol 48:802805.[PubMed]
82. Aljofan M, Saubern S, Meyer AG, Marsh G, Meers J, Mungall BA. 2009. Characteristics of Nipah virus and Hendra virus replication in different cell lines and their suitability for antiviral screening. Virus Res 142:9299.[PubMed]
83. Kurth A, Kohl C, Brinkmann A, Ebinger A, Harper JA, Wang LF, Mühldorfer K, Wibbelt G. 2012. Novel paramyxoviruses in free-ranging European bats. PLoS One 7:e38688.[PubMed]
84. Wilkinson DA, Temmam S, Lebarbenchon C, Lagadec E, Chotte J, Guillebaud J, Ramasindrazana B, Héraud JM, de Lamballerie X, Goodman SM, Dellagi K, Pascalis H. 2012. Identification of novel paramyxoviruses in insectivorous bats of the Southwest Indian Ocean. Virus Res 170:159163.[PubMed]
85. Crameri G, Todd S, Grimley S, McEachern JA, Marsh GA, Smith C, Tachedjian M, De Jong C, Virtue ER, Yu M, Bulach D, Liu JP, Michalski WP, Middleton D, Field HE, Wang LF. 2009. Establishment, immortalisation and characterisation of pteropid bat cell lines. PLoS One 4:e8266.[PubMed]
86. Barr JA, Smith C, Marsh GA, Field H, Wang LF. 2012. Evidence of bat origin for Menangle virus, a zoonotic paramyxovirus first isolated from diseased pigs. J Gen Virol 93:25902594.[PubMed]
87. de Wit E, Munster VJ. 2015. Animal models of disease shed light on Nipah virus pathogenesis and transmission. J Pathol 235:196205.[PubMed]
88. Mungall BA, Middleton D, Crameri G, Bingham J, Halpin K, Russell G, Green D, McEachern J, Pritchard LI, Eaton BT, Wang LF, Bossart KN, Broder CC. 2006. Feline model of acute nipah virus infection and protection with a soluble glycoprotein-based subunit vaccine. J Virol 80:1229312302.[PubMed]
89. Middleton DJ, Westbury HA, Morrissy CJ, van der Heide BM, Russell GM, Braun MA, Hyatt AD. 2002. Experimental Nipah virus infection in pigs and cats. J Comp Pathol 126:124136.[PubMed]
90. Weingartl H, Czub S, Copps J, Berhane Y, Middleton D, Marszal P, Gren J, Smith G, Ganske S, Manning L, Czub M. 2005. Invasion of the central nervous system in a porcine host by nipah virus. J Virol 79:75287534.[PubMed]
91. Middleton DJ, Morrissy CJ, van der Heide BM, Russell GM, Braun MA, Westbury HA, Halpin K, Daniels PW. 2007. Experimental Nipah virus infection in pteropid bats (Pteropus poliocephalus). J Comp Pathol 136:266272.[PubMed]
92. Murray K, Rogers R, Selvey L, Selleck P, Hyatt A, Gould A, Gleeson L, Hooper P, Westbury H. 1995. A novel morbillivirus pneumonia of horses and its transmission to humans. Emerg Infect Dis 1:3133.[PubMed]
93. O'Sullivan JD, Allworth AM, Paterson DL, Snow TM, Boots R, Gleeson LJ, Gould AR, Hyatt AD, Bradfield J. 1997. Fatal encephalitis due to novel paramyxovirus transmitted from horses. Lancet 349:9395.[PubMed]
94. Hooper PT, Gould AR, Russell GM, Kattenbelt JA, Mitchell G. 1996. The retrospective diagnosis of a second outbreak of equine morbillivirus infection. Aust Vet J 74:244245.[PubMed]
95. Williamson MM, Hooper PT, Selleck PW, Gleeson LJ, Daniels PW, Westbury HA, Murray PK. 1998. Transmission studies of Hendra virus (equine morbillivirus) in fruit bats, horses and cats. Aust Vet J 76:813818.[PubMed]
96. Williamson MM, Hooper PT, Selleck PW, Westbury HA, Slocombe RF. 2000. Experimental hendra virus infectionin pregnant guinea-pigs and fruit Bats (Pteropus poliocephalus). J Comp Pathol 122:201207.[PubMed]
97. Middleton D, Pallister J, Klein R, Feng YR, Haining J, Arkinstall R, Frazer L, Huang JA, Edwards N, Wareing M, Elhay M, Hashmi Z, Bingham J, Yamada M, Johnson D, White J, Foord A, Heine HG, Marsh GA, Broder CC, Wang LF. 2014. Hendra virus vaccine, a one health approach to protecting horse, human, and environmental health. Emerg Infect Dis 20:372379.[PubMed]
98. Selvey LA, Wells RM, McCormack JG, Ansford AJ, Murray K, Rogers RJ, Lavercombe PS, Selleck P, Sheridan JW. 1995. Infection of humans and horses by a newly described morbillivirus. Med J Aust 162:642645.[PubMed]
99. McCormack JG, Allworth AM, Selvey LA, Selleck PW. 1999. Transmissibility from horses to humans of a novel paramyxovirus, equine morbillivirus (EMV). J Infect 38:2223.[PubMed]
100. Rogers RJ, Douglas IC, Baldock FC, Glanville RJ, Seppanen KT, Gleeson LJ, Selleck PN, Dunn KJ. 1996. Investigation of a second focus of equine morbillivirus infection in coastal Queensland. Aust Vet J 74:243244.[PubMed]
101. Ward MP, Black PF, Childs AJ, Baldock FC, Webster WR, Rodwell BJ, Brouwer SL. 1996. Negative findings from serological studies of equine morbillivirus in the Queensland horse population. Aust Vet J 74:241243.[PubMed]
102. Halpin K, Young PL, Field H, Mackenzie JS. 1999. Newly discovered viruses of flying foxes. Vet Microbiol 68:8387.[PubMed]
103. Halpin K, Young PL, Field HE, Mackenzie JS. 2000. Isolation of Hendra virus from pteropid bats: a natural reservoir of Hendra virus. J Gen Virol 81:19271932.[PubMed]
104. Yob JM, Field H, Rashdi AM, Morrissy C, van der Heide B, Rota P, bin Adzhar A, White J, Daniels P, Jamaluddin A, Ksiazek T. 2001. Nipah virus infection in bats (order Chiroptera) in peninsular Malaysia. Emerg Infect Dis 7:439441.[PubMed]
105. Young PL, Halpin K, Selleck PW, Field H, Gravel JL, Kelly MA, Mackenzie JS. 1996. Serologic evidence for the presence in Pteropus bats of a paramyxovirus related to equine morbillivirus. Emerg Infect Dis 2:239240.[PubMed]
106. Field HE, Barratt PC, Hughes RJ, Shield J, Sullivan ND. 2000. A fatal case of Hendra virus infection in a horse in north Queensland: clinical and epidemiological features. Aust Vet J 78:279280.[PubMed]
107. Croser EL, Marsh GA. 2013. The changing face of the henipaviruses. Vet Microbiol 167:151158.[PubMed]
108. Centers for Disease Control and Prevention (CDC). 1999. Outbreak of Hendra-like virus—Malaysia and Singapore, 1998–1999. MMWR Morb Mortal Wkly Rep 48:265269.[PubMed]
109. Centers for Disease Control and Prevention (CDC). 1999. Update: outbreak of Nipah virus—Malaysia and Singapore, 1999. MMWR Morb Mortal Wkly Rep 48:335337.[PubMed]
110. Chew MH, Arguin PM, Shay DK, Goh KT, Rollin PE, Shieh WJ, Zaki SR, Rota PA, Ling AE, Ksiazek TG, Chew SK, Anderson LJ. 2000. Risk factors for Nipah virus infection among abattoir workers in Singapore. J Infect Dis 181:17601763.[PubMed]
111. Paton NI, Leo YS, Zaki SR, Auchus AP, Lee KE, Ling AE, Chew SK, Ang B, Rollin PE, Umapathi T, Sng I, Lee CC, Lim E, Ksiazek TG. 1999. Outbreak of Nipah-virus infection among abattoir workers in Singapore. Lancet 354:12531256[CrossRef].[PubMed]
112. Hsu VP, Hossain MJ, Parashar UD, Ali MM, Ksiazek TG, Kuzmin I, Niezgoda M, Rupprecht C, Bresee J, Breiman RF. 2004. Nipah virus encephalitis reemergence, Bangladesh. Emerg Infect Dis 10:20822087 1.[PubMed]
113. Clayton BA, Wang LF, Marsh GA. 2013. Henipaviruses: an updated review focusing on the pteropid reservoir and features of transmission. Zoonoses Public Health 60:6983.[PubMed]
114. Tan K-S, Tan C-T, Goh K-J. 1999. Epidemiological aspects of Nipah virus infection. Neurol. J. Southeast Asia 4:7781.
115. Luby SP, Gurley ES, Hossain MJ. 2009. Transmission of human infection with Nipah virus. Clin Infect Dis 49:17431748.[PubMed]
116. Chua KB. 2003. Nipah virus outbreak in Malaysia. J Clin Virol 26:265275.[PubMed]
117. Chong HT, Hossain MJ, Tan CT. 2008. Differences in epidemiologic and clinical features of Nipah virus encephalitis between the Malaysian and Bangladesh outbreaks. Neurol Asia 13:2326.
118. Mohd Nor MN, Gan CH, Ong BL. 2000. Nipah virus infection of pigs in peninsular Malaysia. Rev Sci Tech 19:160165.[PubMed]
119. Parashar UD, Sunn LM, Ong F, Mounts AW, Arif MT, Ksiazek TG, Kamaluddin MA, Mustafa AN, Kaur H, Ding LM, Othman G, Radzi HM, Kitsutani PT, Stockton PC, Arokiasamy J, Gary HE Jr, Anderson LJ. 2000. Case-control study of risk factors for human infection with a new zoonotic paramyxovirus, Nipah virus, during a 1998–1999 outbreak of severe encephalitis in Malaysia. J Infect Dis 181:17551759.[PubMed]
120. Hooper PT, Williamson MM. 2000. Hendra and Nipah virus infections. Vet Clin North Am Equine Pract 16:597603, xi. xi.[PubMed]
121. Rahman MA, Hossain MJ, Sultana S, Homaira N, Khan SU, Rahman M, Gurley ES, Rollin PE, Lo MK, Comer JA, Lowe L, Rota PA, Ksiazek TG, Kenah E, Sharker Y, Luby SP. 2012. Date palm sap linked to Nipah virus outbreak in Bangladesh, 2008. Vector Borne Zoonotic Dis 12:6572.[PubMed]
122. Goh KJ, Tan CT, Chew NK, Tan PS, Kamarulzaman A, Sarji SA, Wong KT, Abdullah BJ, Chua KB, Lam SK. 2000. Clinical features of Nipah virus encephalitis among pig farmers in Malaysia. N Engl J Med 342:12291235.[PubMed]
123. Chua KB, Lam SK, Goh KJ, Hooi PS, Ksiazek TG, Kamarulzaman A, Olson J, Tan CT. 2001. The presence of Nipah virus in respiratory secretions and urine of patients during an outbreak of Nipah virus encephalitis in Malaysia. J Infect 42:4043.[PubMed]
124. Mounts AW, Kaur H, Parashar UD, Ksiazek TG, Cannon D, Arokiasamy JT, Anderson LJ, Lye MS Nipah Virus Nosocomial Study Group. 2001. A cohort study of health care workers to assess nosocomial transmissibility of Nipah virus, Malaysia, 1999. J Infect Dis 183:810813.[PubMed]
125. Blum LS, Khan R, Nahar N, Breiman RF. 2009. In-depth assessment of an outbreak of Nipah encephalitis with person-to-person transmission in Bangladesh: implications for prevention and control strategies. Am J Trop Med Hyg 80:96102.[PubMed]
126. Gurley ES, Montgomery JM, Hossain MJ, Bell M, Azad AK, Islam MR, Molla MA, Carroll DS, Ksiazek TG, Rota PA, Lowe L, Comer JA, Rollin P, Czub M, Grolla A, Feldmann H, Luby SP, Woodward JL, Breiman RF. 2007. Person-to-person transmission of Nipah virus in a Bangladeshi community. Emerg Infect Dis 13:10311037.[PubMed]
127. Homaira N, Rahman M, Hossain MJ, Epstein JH, Sultana R, Khan MS, Podder G, Nahar K, Ahmed B, Gurley ES, Daszak P, Lipkin WI, Rollin PE, Comer JA, Ksiazek TG, Luby SP. 2010. Nipah virus outbreak with person-to-person transmission in a district of Bangladesh, 2007. Epidemiol Infect 138:16301636.[PubMed]
128. Luby SP, Hossain MJ, Gurley ES, Ahmed BN, Banu S, Khan SU, Homaira N, Rota PA, Rollin PE, Comer JA, Kenah E, Ksiazek TG, Rahman M. 2009. Recurrent zoonotic transmission of Nipah virus into humans, Bangladesh, 2001–2007. Emerg Infect Dis 15:12291235.[PubMed]
129. Iehlé C, Razafitrimo G, Razainirina J, Andriaholinirina N, Goodman SM, Faure C, Georges-Courbot MC, Rousset D, Reynes JM. 2007. Henipavirus and Tioman virus antibodies in pteropodid bats, Madagascar. Emerg Infect Dis 13:159161.[PubMed]
130. Epstein JH, Prakash V, Smith CS, Daszak P, McLaughlin AB, Meehan G, Field HE, Cunningham AA. 2008. Henipavirus infection in fruit bats (Pteropus giganteus), India. Emerg Infect Dis 14:13091311 2.[PubMed]
131. Reynes JM, Counor D, Ong S, Faure C, Seng V, Molia S, Walston J, Georges-Courbot MC, Deubel V, Sarthou JL. 2005. Nipah virus in Lyle's flying foxes, Cambodia. Emerg Infect Dis 11:10421047.
132. Wacharapluesadee S, Lumlertdacha B, Boongird K, Wanghongsa S, Chanhome L, Rollin P, Stockton P, Rupprecht CE, Ksiazek TG, Hemachudha T. 2005. Bat Nipah virus, Thailand. Emerg Infect Dis 11:19491951.[PubMed]
133. Wacharapluesadee S, Hemachudha T. 2007. Duplex nested RT-PCR for detection of Nipah virus RNA from urine specimens of bats. J Virol Methods 141:97101.[PubMed]
134. Wacharapluesadee S, Boongird K, Wanghongsa S, Ratanasetyuth N, Supavonwong P, Saengsen D, Gongal GN, Hemachudha T. 2010. A longitudinal study of the prevalence of Nipah virus in Pteropus lylei bats in Thailand: evidence for seasonal preference in disease transmission. Vector Borne Zoonotic Dis 10:183190.[PubMed]
135. Breed AC, Meers J, Sendow I, Bossart KN, Barr JA, Smith I, Wacharapluesadee S, Wang L, Field HE. 2013. The distribution of henipaviruses in Southeast Asia and Australasia: is Wallace's line a barrier to Nipah virus? PLoS One 8:e61316.[PubMed]
136. Kirkland PD, Love RJ, Philbey AW, Ross AD, Davis RJ, Hart KG. 2001. Epidemiology and control of Menangle virus in pigs. Aust Vet J 79:199206.[PubMed]
137. Amman BR, Albariño CG, Bird BH, Nyakarahuka L, Sealy TK, Balinandi S, Schuh AJ, Campbell SM, Ströher U, Jones ME, Vodzack ME, Reeder DM, Kaboyo W, Nichol ST, Towner JS. 2015. A recently discovered pathogenic paramyxovirus, sosuga virus, is present in Rousettus aegyptiacus fruit bats at multiple locations in Uganda. J Wildl Dis 51:774779.[PubMed]
138. Drexler JF, Corman VM, Gloza-Rausch F, Seebens A, Annan A, Ipsen A, Kruppa T, Müller MA, Kalko EK, Adu-Sarkodie Y, Oppong S, Drosten C. 2009. Henipavirus RNA in African bats. PLoS One 4:e6367.[PubMed]