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Chapter 20 : Emerging Fungal Infections in the Pacific Northwest: The Unrecognized Burden and Geographic Range of and

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Emerging Fungal Infections in the Pacific Northwest: The Unrecognized Burden and Geographic Range of and , Page 1 of 2

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Abstract:

Fungal infections present a real challenge to public health, as they are ubiquitous in the environment and are not passed from human to human or generally transmitted by a vector, making exposure impossible to completely prevent. New opportunistic fungal pathogens are emerging in highly immunosuppressed (transplant) patients. These patient groups are highly susceptible to infections, and it is not unexpected that we find newly emerging infections. However, there are fungi that are known to be specific to certain geographic regions (often referred to as endemic) which are themselves emerging in new geographic areas and are not associated with immunosuppressed patients. Two of these such fungi are in the Southwest United States and , with most cases being recognized in Southern California. When regional or endemic diseases are encountered outside of their traditional geographic boundaries, especially in nontravelers, diagnosis can be delayed, leading to significant morbidity and mortality. These two fungi have recently emerged in the Pacific Northwest (PNW) of the United States.

Citation: Lockhart S, McCotter O, Chiller T. 2016. Emerging Fungal Infections in the Pacific Northwest: The Unrecognized Burden and Geographic Range of and , p 375-384. In Scheld W, Hughes J, Whitley R (ed), Emerging infections 10. ASM Press, Washington, DC. doi: 10.1128/microbiolspec.EI10-0016-2016
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Figure 1

Areas where coccidioidomycosis is known and suspected to be endemic in the United States and Mexico ( ). The map depicts approximate areas where in known to live or suspected to live based on studies from the late 1940s and early 1950s and from documented outbreak locations.

Citation: Lockhart S, McCotter O, Chiller T. 2016. Emerging Fungal Infections in the Pacific Northwest: The Unrecognized Burden and Geographic Range of and , p 375-384. In Scheld W, Hughes J, Whitley R (ed), Emerging infections 10. ASM Press, Washington, DC. doi: 10.1128/microbiolspec.EI10-0016-2016
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References

/content/book/10.1128/9781555819453.chap20
1. Kwon-Chung KJ,, Varma A . 2006. Do major species concepts support one, two or more species within Cryptococcus neoformans? FEMS Yeast Res 6 : 574587.[PubMed] [CrossRef]
2. Ellis D,, Pfeiffer T . 1992. The ecology of Cryptococcus neoformans . Eur J Epidemiol 8 : 321325.[PubMed] [CrossRef]
3. Wilson DE,, Bennett JE,, Bailey JW . 1968. Serologic grouping of Cryptococcus neoformans . Proc Soc Exp Biol Med 127 : 820823.[PubMed] [CrossRef]
4. Bennett JE,, Kwon-Chung KJ,, Howard DH . 1977. Epidemiologic differences among serotypes of Cryptococcus neoformans . Am J Epidemiol 105 : 582586.[PubMed]
5. Chaturvedi S,, Dyavaiah M,, Larsen RA,, Chaturvedi V . 2005. Cryptococcus gattii in AIDS patients, southern California. Emerg Infect Dis 11 : 16861692.[PubMed] [CrossRef]
6. Denton JF,, Di Salvo AF . 1968. The prevalence of Cryptococcus neoformans in various natural habitats. Sabouraudia 6 : 213217.[PubMed] [CrossRef]
7. Fromtling RA,, Shadomy S,, Shadomy HJ,, Dismukes WE . 1982. Serotype B/C Cryptococcus neoformans isolated from patients in nonendemic areas. J Clin Microbiol 16 : 408410.[PubMed]
8. Bottone EJ,, Kirschner PA,, Salkin IF . 1986. Isolation of highly encapsulated Cryptococcus neoformans serotype B from a patient in New York City. J Clin Microbiol 23 : 186188.[PubMed]
9. Hoang LM,, Maguire JA,, Doyle P,, Fyfe M,, Roscoe DL . 2004. Cryptococcus neoformans infections at Vancouver Hospital and Health Sciences Centre (1997–2002): epidemiology, microbiology and histopathology. J Med Microbiol 53 : 935940.[PubMed] [CrossRef]
10. Duncan C,, Stephen C,, Lester S,, Bartlett KH . 2005. Sub-clinical infection and asymptomatic carriage of Cryptococcus gattii in dogs and cats during an outbreak of cryptococcosis. Med Mycol 43 : 511516.[PubMed] [CrossRef]
11. Duncan C,, Schwantje H,, Stephen C,, Campbell J,, Bartlett K . 2006. Cryptococcus gattii in wildlife of Vancouver Island, British Columbia, Canada. J Wildl Dis 42 : 175178.[PubMed] [CrossRef]
12. Kidd SE,, Bach PJ,, Hingston AO,, Mak S,, Chow Y,, MacDougall L,, Kronstad JW,, Bartlett KH . 2007. Cryptococcus gattii dispersal mechanisms, British Columbia, Canada. Emerg Infect Dis 13 : 5157.[PubMed] [CrossRef]
13. Kidd SE,, Chow Y,, Mak S,, Bach PJ,, Chen H,, Hingston AO,, Kronstad JW,, Bartlett KH . 2007. Characterization of environmental sources of the human and animal pathogen Cryptococcus gattii in British Columbia, Canada, and the Pacific Northwest of the United States. Appl Environ Microbiol 73 : 14331443.[PubMed] [CrossRef]
14. MacDougall L,, Kidd SE,, Galanis E,, Mak S,, Leslie MJ,, Cieslak PR,, Kronstad JW,, Morshed MG,, Bartlett KH . 2007. Spread of Cryptococcus gattii in British Columbia, Canada, and detection in the Pacific Northwest, USA. Emerg Infect Dis 13 : 4250.[PubMed] [CrossRef]
15. MacDougall L,, Fyfe M . 2006. Emergence of Cryptococcus gattii in a novel environment provides clues to its incubation period. J Clin Microbiol 44 : 18511852.[PubMed] [CrossRef]
16. Bartlett KH,, Kidd SE,, Kronstad JW . 2008. The emergence of Cryptococcus gattii in British Columbia and the Pacific Northwest. Curr Infect Dis Rep 10 : 5865.[PubMed] [CrossRef]
17. Fraser JA,, Giles SS,, Wenink EC,, Geunes-Boyer SG,, Wright JR,, Diezmann S,, Allen A,, Stajich JE,, Dietrich FS,, Perfect JR,, Heitman J . 2005. Same-sex mating and the origin of the Vancouver Island Cryptococcus gattii outbreak. Nature 437 : 13601364.[PubMed] [CrossRef]
18. Kidd SE,, Hagen F,, Tscharke RL,, Huynh M,, Bartlett KH,, Fyfe M,, Macdougall L,, Boekhout T,, Kwon-Chung KJ,, Meyer W . 2004. A rare genotype of Cryptococcus gattii caused the cryptococcosis outbreak on Vancouver Island (British Columbia, Canada). Proc Natl Acad Sci USA 101 : 1725817263.[PubMed] [CrossRef]
19. Byrnes EJ III,, Li W,, Ren P,, Lewit Y,, Voelz K,, Fraser JA,, Dietrich FS,, May RC,, Chaturvedi S,, Chaturvedi V,, Heitman J . 2011. A diverse population of Cryptococcus gattii molecular type VGIII in southern Californian HIV/AIDS patients. PLoS Pathog 7 : e1002205. [PubMed] [CrossRef]
20. Hagen F,, Khayhan K,, Theelen B,, Kolecka A,, Polacheck I,, Sionov E,, Falk R,, Parnmen S,, Lumbsch HT,, Boekhout T . 2015. Recognition of seven species in the Cryptococcus gattii/Cryptococcus neoformans species complex. Fungal Genet Biol 78 : 1648.[PubMed] [CrossRef]
21. Mak S,, Klinkenberg B,, Bartlett K,, Fyfe M . 2010. Ecological niche modeling of Cryptococcus gattii in British Columbia, Canada. Environ Health Perspect 118 : 653658.[PubMed] [CrossRef]
22. Upton A,, Fraser JA,, Kidd SE,, Bretz C,, Bartlett KH,, Heitman J,, Marr KA . 2007. First contemporary case of human infection with Cryptococcus gattii in Puget Sound: evidence for spread of the Vancouver Island outbreak. J Clin Microbiol 45 : 30863088.[PubMed] [CrossRef]
23. Iqbal N,, DeBess EE,, Wohrle R,, Sun B,, Nett RJ,, Ahlquist AM,, Chiller T,, Lockhart SR , Cryptococcus gattii Public Health Working Group . 2010. Correlation of genotype and in vitro susceptibilities of Cryptococcus gattii strains from the Pacific Northwest of the United States. J Clin Microbiol 48 : 539544.[PubMed] [CrossRef]
24. Lockhart SR,, Iqbal N,, Harris JR,, Grossman NT,, DeBess E,, Wohrle R,, Marsden-Haug N,, Vugia DJ . 2013. Cryptococcus gattii in the United States: genotypic diversity of human and veterinary isolates. PLoS One 8 : e74737. [PubMed] [CrossRef]
25. Byrnes EJ III,, Li W,, Lewit Y,, Ma H,, Voelz K,, Ren P,, Carter DA,, Chaturvedi V,, Bildfell RJ,, May RC,, Heitman J . 2010. Emergence and pathogenicity of highly virulent Cryptococcus gattii genotypes in the northwest United States. PLoS Pathog 6 : e1000850. [PubMed] [CrossRef]
26. Byrnes EJ III,, Bildfell RJ,, Frank SA,, Mitchell TG,, Marr KA,, Heitman J . 2009. Molecular evidence that the range of the Vancouver Island outbreak of Cryptococcus gattii infection has expanded into the Pacific Northwest in the United States. J Infect Dis 199 : 10811086.[PubMed] [CrossRef]
27. Engelthaler DM,, Hicks ND,, Gillece JD,, Roe CC,, Schupp JM,, Driebe EM,, Gilgado F,, Carriconde F,, Trilles L,, Firacative C,, Ngamskulrungroj P,, Castañeda E,, Lazera MS,, Melhem MS,, Pérez-Bercoff A,, Huttley G,, Sorrell TC,, Voelz K,, May RC,, Fisher MC,, Thompson GR III,, Lockhart SR,, Keim P,, Meyer W . 2014. Cryptococcus gattii in North American Pacific Northwest: whole-population genome analysis provides insights into species evolution and dispersal. mBio 5 : e01464-14. [PubMed] [CrossRef]
28. Ngamskulrungroj P,, Serena C,, Gilgado F,, Malik R,, Meyer W . 2011. Global VGIIa isolates are of comparable virulence to the major fatal Cryptococcus gattii Vancouver Island outbreak genotype. Clin Microbiol Infect 17 : 251258.[PubMed] [CrossRef]
29. Kidd SE,, Guo H,, Bartlett KH,, Xu J,, Kronstad JW . 2005. Comparative gene genealogies indicate that two clonal lineages of Cryptococcus gattii in British Columbia resemble strains from other geographical areas. Eukaryot Cell 4 : 16291638.[PubMed] [CrossRef]
30. Billmyre RB,, Croll D,, Li W,, Mieczkowski P,, Carter DA,, Cuomo CA,, Kronstad JW,, Heitman J . 2014. Highly recombinant VGII Cryptococcus gattii population develops clonal outbreak clusters through both sexual macroevolution and asexual microevolution. mBio 5 : e01494-14. [PubMed] [CrossRef]
31. Hagen F,, Ceresini PC,, Polacheck I,, Ma H,, van Nieuwerburgh F,, Gabaldón T,, Kagan S,, Pursall ER,, Hoogveld HL,, van Iersel LJ,, Klau GW,, Kelk SM,, Stougie L,, Bartlett KH,, Voelz K,, Pryszcz LP,, Castañeda E,, Lazera M,, Meyer W,, Deforce D,, Meis JF,, May RC,, Klaassen CH,, Boekhout T . 2013. Ancient dispersal of the human fungal pathogen Cryptococcus gattii from the Amazon rainforest. PLoS One 8 : e71148. [PubMed] [CrossRef]
32. Kunadharaju R,, Choe U,, Harris JR,, Lockhart SR,, Greene JN . 2013. Cryptococcus gattii, Florida, USA, 2011. Emerg Infect Dis 19 : 519521.[PubMed] [CrossRef]
33. Galanis E,, Hoang L,, Kibsey P,, Morshed M,, Phillips P . 2009. Clinical presentation, diagnosis and management of Cryptococcus gattii cases: lessons learned from British Columbia. Can J Infect Dis Med Microbiol 20 : 2328.[PubMed] [CrossRef]
34. Harris JR,, Lockhart SR,, Debess E,, Marsden-Haug N,, Goldoft M,, Wohrle R,, Lee S,, Smelser C,, Park B,, Chiller T . 2011. Cryptococcus gattii in the United States: clinical aspects of infection with an emerging pathogen. Clin Infect Dis 53 : 11881195.[PubMed] [CrossRef]
35. Harris JR,, Lockhart SR,, Sondermeyer G,, Vugia DJ,, Crist MB,, D’Angelo MT,, Sellers B,, Franco-Paredes C,, Makvandi M,, Smelser C,, Greene J,, Stanek D,, Signs K,, Nett RJ,, Chiller T,, Park BJ . 2013. Cryptococcus gattii infections in multiple states outside the US Pacific Northwest. Emerg Infect Dis 19 : 16201626.[PubMed] [CrossRef]
36. Galanis E,, Macdougall L,, Kidd S,, Morshed M , British Columbia Cryptococcus gattii Working Group . 2010. Epidemiology of Cryptococcus gattii, British Columbia, Canada, 1999–2007. Emerg Infect Dis 16 : 251257.[PubMed] [CrossRef]
37. Farrer RA,, Desjardins CA,, Sakthikumar S,, Gujja S,, Saif S,, Zeng Q,, Chen Y,, Voelz K,, Heitman J,, May RC,, Fisher MC,, Cuomo CA . 2015. Genome evolution and innovation across the four major lineages of Cryptococcus gattii . mBio 6 : e00868-15. [PubMed] [CrossRef]
38. Fisher FS,, Bultman MW,, Johnson SM,, Pappagianis D,, Zaborsky E . 2007. Coccidioides niches and habitat parameters in the southwestern United States: a matter of scale. Ann NY Acad Sci 1111 : 4772.[PubMed] [CrossRef]
39. Sun SH,, Sekhon SS,, Huppert M . 1979. Electron microscopic studies of saprobic and parasitic forms of Coccidioides immitis . Sabouraudia 17 : 265273.[PubMed] [CrossRef]
40. Galgiani JN . 1993. Coccidioidomycosis. West J Med 159 : 153171.[PubMed]
41. Einstein HE,, Johnson RH . 1993. Coccidioidomycosis: new aspects of epidemiology and therapy. Clin Infect Dis 16 : 349354.[PubMed] [CrossRef]
42. Smith CE,, Beard RR,, Rosenberger HG,, Whiting EG . 1946. Effect of season and dust control on coccidioidomycosis. JAMA 132 : 833838.[PubMed] [CrossRef]
43. Smith CE,, Whiting EG,, Baker EE,, Rosenberger HG,, Beard RR,, Saito MT . 1948. The use of coccidioidin. Am Rev Tuberc 57 : 330360.[PubMed]
44. Smith CE,, Beard RR . 1946. Varieties of coccidioidal infection in relation to the epidemiology and control of the diseases. Am J Public Health Nations Health 36 : 13941402.[PubMed] [CrossRef]
45. Smith CE,, Beard RR,, Saito MT . 1948. Pathogenesis of coccidioidomycosis with special reference to pulmonary cavitation. Ann Intern Med 29 : 623655.[PubMed] [CrossRef]
46. Valdivia L,, Nix D,, Wright M,, Lindberg E,, Fagan T,, Lieberman D,, Stoffer T,, Ampel NM,, Galgiani JN . 2006. Coccidioidomycosis as a common cause of community-acquired pneumonia. Emerg Infect Dis 12 : 958962.[PubMed] [CrossRef]
47. Kim MM,, Blair JE,, Carey EJ,, Wu Q,, Smilack JD . 2009. Coccidioidal pneumonia, Phoenix, Arizona, USA, 2000–2004. Emerg Infect Dis 15 : 397401.[PubMed] [CrossRef]
48. Thompson GR III . 2011. Pulmonary coccidioidomycosis. Semin Respir Crit Care Med 32 : 754763.[PubMed] [CrossRef]
49. Adam RD,, Elliott SP,, Taljanovic MS . 2009. The spectrum and presentation of disseminated coccidioidomycosis. Am J Med 122 : 770777.[PubMed] [CrossRef]
50. Borchers AT,, Gershwin ME . 2010. The immune response in coccidioidomycosis. Autoimmun Rev 10 : 94102.[PubMed] [CrossRef]
51. Edwards PQ,, Palmer CE . 1957. Prevalence of sensitivity to coccidioidin, with special reference to specific and nonspecific reactions to coccidioidin and to histoplasmin. Dis Chest 31 : 3560.[PubMed] [CrossRef]
52. Loofbourow JC,, Pappagianis D,, Cooper TY . 1969. Endemic coccidioidomycosis in Northern California. An outbreak in the Capay Valley of Yolo County. Calif Med 111 : 59.[PubMed]
53. Werner SB,, Pappagianis D,, Heindl I,, Mickel A . 1972. An epidemic of coccidioidomycosis among archeology students in northern California. N Engl J Med 286 : 507512.[PubMed] [CrossRef]
54. Petersen LR,, Marshall SL,, Barton-Dickson C,, Hajjeh RA,, Lindsley MD,, Warnock DW,, Panackal AA,, Shaffer JB,, Haddad MB,, Fisher FS,, Dennis DT,, Morgan J . 2004. Coccidioidomycosis among workers at an archeological site, northeastern Utah. Emerg Infect Dis 10 : 637642.[PubMed] [CrossRef]
55. Marsden-Haug N,, Hill H,, Litvintseva AP,, Engelthaler DM,, Driebe EM,, Roe CC,, Ralston C,, Hurst S,, Goldoft M,, Gade L,, Wohrle R,, Thompson GR,, Brandt ME,, Chiller T , Centers for Disease Control and Prevention . 2014. Coccidioides immitis identified in soil outside of its known range—Washington, 2013. MMWR Morb Mortal Wkly Rep 63 : 450. [PubMed]
56. Marsden-Haug N,, Goldoft M,, Ralston C,, Limaye AP,, Chua J,, Hill H,, Jecha L,, Thompson GR III,, Chiller T . 2013. Coccidioidomycosis acquired in Washington State. Clin Infect Dis 56 : 847850.[PubMed] [CrossRef]
57. Litvintseva AP,, Marsden-Haug N,, Hurst S,, Hill H,, Gade L,, Driebe EM,, Ralston C,, Roe C,, Barker BM,, Goldoft M,, Keim P,, Wohrle R,, Thompson GR III,, Engelthaler DM,, Brandt ME,, Chiller T . 2015. Valley fever: finding new places for an old disease: Coccidioides immitis found in Washington State soil associated with recent human infection. Clin Infect Dis 60 : e1e3.[PubMed] [CrossRef]
58. CDC . 2016. Sources of valley fever (coccidioidomycosis). CDC, Atlanta, GA. http://www.cdc.gov/fungal/diseases/coccidioidomycosis/causes.html. Accessed 6 March 2016.

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