Chapter 34 : Women Microbiologists at Rutgers in the Early Golden Age of Antibiotics

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Women Microbiologists at Rutgers in the Early Golden Age of Antibiotics, Page 1 of 2

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Streptomycin was discovered at Rutgers University by a graduate student named Albert Schatz, working in the laboratory of Selman Waksman. This golden age of antibiotic discovery unfolded against the backdrop of World War II and opened new doors for women in microbiology, who welcomed the opportunity to use their intellects, participate in the war effort, and experience the thrill of scientific discovery. Elizabeth Horning initiated the direct plate screening method used by Schatz, replacing a prior, slow enrichment protocol. Doris Jones provided one of the first streptomycin-producing strains and then performed the first animal trials, illustrating the nontoxic nature of streptomycin in chicks. Elizabeth Bugie (later Gregory) confirmed the antimicrobial activity of streptomycin and was coauthor on the first published paper about it. Her name was left off the patent because Waksman predicted she would “just get married.” Christine Reilly developed quick screening methods for the isolation of antibiotic-producing strains and demonstrated the first case of streptomycin resistance. Dorris Hutchison advanced our understanding of streptomycin’s effect on the tubercle bacillus. Vivian Schatz backed her husband, Albert, in his quixotic battle for appropriate recognition. Overall, women in the Waksman laboratory made substantial intellectual contributions, conducted independent research, provided technical and scholarly input to ongoing projects, and were intimately concerned at every level of the research. These women merit greater recognition for their key contributions in the development of the world’s antibiotics.

Citation: Eveleigh D, Bennett J. 2018. Women Microbiologists at Rutgers in the Early Golden Age of Antibiotics, p 317-329. In Whitaker R, Barton H (ed), Women in Microbiology. ASM Press, Washington, DC. doi: 10.1128/9781555819545.ch34
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Figure 1

The Rutgers Microbiology Department, New Jersey College of Agriculture and Experiment Station, 1946. Top Row (L to R): Donald B. Johnstone (gs), Aldrage B. Cooper (lab tech), Dr. Merritt C. Fernald (asst. res. specialist), Lloyd R. Frederick (gs). Second Row (L to R): John D. Schenone (res. assoc.), Christine R. Frazier (lab asst.), Dorothy G. Smith (gs), Doris I. Jones (gs), [not recorded?], Kenneth L. Temple (gs). Third Row (L to R): John Q. Adams (lab asst.), Vivian Gerber (gs), Viola A. Battista (secretary), Dorothy Nycz (secretary), Clara H. Wark (lab asst.), Claire B. Landers (gs). Fourth and Fifth Rows (L to R): Donald M. Reynolds (gs), Dr. Robert Starkey, Doris W. Wilson (gs), Dr. Selman Waksman, Dorothy J. Randolph (lab asst.), Dr. Walton B. Geiger (assoc. biochemist), H. Christine Reilly (gs). gs, graduate student. Courtesy of Special Collections and University Archives, Rutgers University Libraries.

Citation: Eveleigh D, Bennett J. 2018. Women Microbiologists at Rutgers in the Early Golden Age of Antibiotics, p 317-329. In Whitaker R, Barton H (ed), Women in Microbiology. ASM Press, Washington, DC. doi: 10.1128/9781555819545.ch34
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1. Ryan F. 1992. The Forgotten Plague. How the Battle against Tuberculosis Was Won—and Lost. Little, Brown and Co, Boston, MA.
2. Meyers MA. 2012. Prize Fight. The Race and the Rivalry to be the First in Science. Palgrave Macmillan Ltd, London, UK.
3. Pringle P. 2012. Experiment Eleven. Dark Secrets behind the Discovery of a Wonder Drug. Walker and Co, New York, NY.
4. Rosen W. 2017. Miracle Cure. The Creation of Antibiotics and the Birth of Modern Medicine. Viking Press, New York, NY.
5. Lechevalier HA,. 1980. The search for antibiotics at Rutgers University, p 120. In Parascandola J (ed), The History of Antibiotics. American Institute of the History of Pharmacy, Madison, WI.
6. Schatz A. 1965. Antibiotics and dentistry. Part 1. Some personal reflections on the discovery of streptomycin. Pak Dent Rev 15:125134.
7. Schatz A. 1993. The true story of the discovery of streptomycin. Actinomycetes 4:2739.
8. Woodruff HB. 2014. Selman A. Waksman, winner of the 1952 Nobel Prize for Physiology or Medicine. Appl Environ Microbiol 80:28.
9. Horning ES. 1942. The distribution and properties of antagonistic fungi and actinomycetes in nature. Ph.D. thesis. Rutgers, The State University of New Jersey, New Brunswick, NJ.
10. Waksman SA,, Horning ES. 1943. The distribution of antagonistic fungi in nature and their antibiotic action. Mycologia 35:4765.
11. Waksman SA,, Horning ES,, Spencer EL. 1943. Two antagonistic fungi, Aspergillus fumigatus and Aspergillus clavatus, and their antibiotic substances. J Bacteriol 45:233248.
12. Waksman SA,, Horning ES,, Spencer EL. 1942. The production of two antibacterial substances, fumigacin and clavicin. Science 96:202203.
13. Waksman SA,, Horning ES,, Welsch M,, Woodruff HB. 1942. Distribution of antagonistic actinomycetes in nature. Soil Sci 54:281296.
14. Bugie EJ. 1944. Production of antibiotic substances by Aspergillus flavus and Chaetomium cochliodes. M.Sc. thesis. Rutgers, The State University of New Jersey, New Brunswick, NJ.
15. Waksman SA,, Bugie E. 1943. Strain specificity and production of antibiotic substances. II. Aspergillus flavus-oryzae group. Proc Natl Acad Sci U S A 29:282288.
16. Waksman SA,, Bugie E. 1944. Chaetomin, a new antibiotic substance produced by Chaetomium cochliodes: I. Formation and properties. J Bacteriol 48:527530.
17. Waksman SA,, Bugie E. 1943. Action of antibiotic substances upon Ceratostomella ulmi. Proc Soc Exp Biol Med 54:7982.
18. Waksman SA,, Bugie E,, Reilly HC. 1944. Bacteriostatic and bactericidal properties of antibiotic substances, with special reference to plant pathogenic bacteria. Bull Torrey Bot Club 71:197121.
19. Waksman SA,, Geiger WB,, Bugie E. 1947. Micromonosporin, an antibiotic substance from a little known group of microorganisms. J Bacteriol 53:355357.
20. Solotorovsky M,, Bugie EJ,, Frost BM. 1948. The effect of penicillin on the growth of Mycobacterium tuberculosis in Dubos’ medium. J Bacteriol 55:555559.
21. Solotorovsky M,, Gregory FJ,, Ironson EJ,, Bugie EJ,, O’Neill RC,, Pfister K III. 1952. Pyrazinoic acid amide—an agent active against experimental murine tuberculosis. Proc Soc Exp Biol Med 79:563565.
22. Schatz A,, Bugie E,, Waksman SA. 1944. Streptomycin, a substance exhibiting antibiotic activity against gram positive and gram negative bacteria. Proc Soc Exp Biol Med 55:6669.
23. Waksman SA,, Schatz A. 21 September 1948. Streptomycin and process of preparation. US patent 2449866.
24. Snowbeck C. 14 April 2001. Obituary: Elizabeth Gregory: did McCandless woman get fair shake for role in discovery of streptomycin? Pittsburgh Post-Gazette, Pittsburgh, PA.
25. Jones D. 1945. The effect of micro-organisms and antibiotic substances upon viruses. M.Sc. thesis. Rutgers, The State University of New Jersey, New Brunswick, NJ.
26. Jones D,, Metzger HJ,, Schatz A,, Waksman SA. 1944. Control of gram-negative bacteria in experimental animals. Science 100:103105.
27. Jones D,, Beaudette FR,, Geiger WB,, Waksman SA. 1945. A search for virus-inactivating substances among microorganisms. Science 101:665668.
28. Jones D. 1945. The effect of antibiotic substances on bacteriophages. J Bacteriol 50:341346.
29. Jones D,, Schatz AL. 1946. Methods of study of antiphage agents produced by microorganisms. J Bacteriol 52:327335.
30. Schatz AI,, Jones D. 1947. The production of antiphage agents by actinomycetes. Bull Torrey Bot Club 74:919.
31. Jones D. 1953. The isolation and study of variants on Staphylococcus phage P1 and its host Staphylococcus aureus. Ph.D. thesis. University of California, Berkeley, Berkeley, CA.
32. Jones D. 1977. A personal glimpse at the discovery of streptomycin. Unpublished talk presented at the Douglass College Alumnae Annual Reunion. Cited in the Douglass Associate Alumnae bulletin, Spring, p 6.
33. Shelton T. 17 July 2017. Greater Philadelphia honors Vivian Schatz. Women’s International League for Peace and Freedom, Philadelphia, PA. http://wilpfus.org/news/updates/greater-philadelphia-honors-vivian-schatz. Accessed 6 February 2018.
34. Reilly HC. 1946. Antibacterial properties of streptothricin and streptomycin. Ph.D. thesis. Rutgers, The State University of New Jersey, New Brunswick, NJ.
35. Waksman SA,, Schatz A,, Reilly HC. 1946. Metabolism and chemical nature of Streptomyces griseus. J Bacteriol 51:753759.
36. Waksman SA,, Reilly HC,, Schatz A. 1945. Strain specificity and production of antibiotic substances. V. Strain resistance of bacteria to antibiotic substances, especially to streptomycin. Proc Natl Acad Sci U S A 31:157164.
37. Reilly HC,, Harris DA,, Waksman SA. 1947. An actinophage for Streptomyces griseus. J Bacteriol 54:451466.
38. Hutchison D. 1949. Production and tuberculostatic properties of streptothricin-like antibiotics. Ph.D. thesis. Rutgers, The State University of New Jersey, New Brunswick, NJ.
39. Hutchison D,, Swart EA,, Waksman SA. 1949. Production, isolation and antimicrobial, notably antituberculosis, properties of streptothricin VI. Arch Biochem 22:1630.
40. Swart EA,, Hutchison D,, Waksman SA. 1949. Neomycin, recovery and purification. Arch Biochem 24:92103.
41. Waksman SA,, Hutchison D,, Katz E. 1949. Neomycin activity upon Mycobacterium tuberculosis and other mycobacteria. Am Rev Tuberc 60:7889.

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