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Chapter 4 : Margaret Dayhoff: Catalyst of a Quiet Revolution

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Abstract:

Most researchers are familiar with Margaret Dayhoff’s name from the point accepted mutation series of amino acid scoring matrices. However, this contribution was only a small part of her work, which laid the foundations of the field of bioinformatics. In fact, her work was transformative, acquiring its power from a synthesis of the comparative approach of organismal biology and its application to molecular data (sequences) from a wide array of organisms. Remarkably, she was developing this groundbreaking work at a time when women scientists were rare and underappreciated. As the field of bioinformatics continues to grow in relevance, so does the power of her story to inspire new crops of female scientists.

Citation: Henzy J. 2018. Margaret Dayhoff: Catalyst of a Quiet Revolution, p 29-36. In Whitaker R, Barton H (ed), Women in Microbiology. ASM Press, Washington, DC. doi: 10.1128/9781555819545.ch4
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Figure 4

(Left) Photo of Margaret Dayhoff (then Margaret Oakley) during her high school days. (Right) Photo of Margaret Dayhoff from 1982. Photos courtesy of Ruth Dayhoff and Vincent Brannigan.

Citation: Henzy J. 2018. Margaret Dayhoff: Catalyst of a Quiet Revolution, p 29-36. In Whitaker R, Barton H (ed), Women in Microbiology. ASM Press, Washington, DC. doi: 10.1128/9781555819545.ch4
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References

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1. Dayhoff MO,, Schwartz RM,, Orcutt BC . 1978. Atlas of Protein Sequence and Structure, vol 5, p 345 352. National Biomedical Research Foundation, Washington, DC.
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5. Brannigan V . 7 March 2013. Grandma got STEM: Margaret and Ruth Dayhoff. https://ggstem.wordpress.com/2013/03/07/margaret-ruth-dayhoff/. Accessed 25 August 2017.
6. Wikipedia contributors . 2017. Robert Ledley, on Wikipedia: The Free Encyclopedia. https://en.wikipedia.org/wiki/Robert_Ledley. Accessed 25 August 2017.
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9. Strasser BJ . 2010. Collecting, comparing, and computing sequences: the making of Margaret O. Dayhoff’s Atlas of Protein Sequence and Structure, 1954–1965. J Hist Biol 43 : 623 660.
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12. Wilson EO . 1994. Naturalist. Island Press, Washington, DC.

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