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Chapter 24 : Mycobacterial Biofilms: Revisiting Tuberculosis Bacilli in Extracellular Necrotizing Lesions

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Abstract:

The ongoing emergence of multidrug-resistant (MDR) and extensively drug-resistant (XDR) strains of not only underscores the limitations of our current tuberculosis (TB) control strategies but is also escalating the TB epidemic to a new level. Realizing the imminent threats of MDR- and XDR-TB and the urgency for new TB control measures, the World Health Organization has maintained TB control as high priority and set an ambitious goal of eradicating the disease by 2030 ( ). What remains an urgent need is the development of a shorter-duration combination of antimicrobial drug treatments that is more effective at eradicating drug-susceptible and drug-resistant strains of . However, progress toward this goal is hampered by a lack of understanding of factors that contribute to the expression of drug tolerance by , which contributes significantly to the need to treat patients from 6 to 9 months with antimicrobial drug combinations that have toxic side effects. In this review, we discuss the current state of our understanding of the host and pathogen factors that contribute to drug tolerance. Moreover, we highlight potential strategies that can be used to improve the efficacy of existing drugs against drug-tolerant . These strategies are based on our current knowledge of how and where drug-tolerant bacilli persist and on features of the complex host response that likely limit the penetration of antibiotics. A better understanding of the factors that contribute to the expression of drug tolerance reveals the potential value of adjunctive therapies that can be used to potentiate the effectiveness of existing and future anti-TB drugs.

Citation: Basaraba R, Ojha A. 2017. Mycobacterial Biofilms: Revisiting Tuberculosis Bacilli in Extracellular Necrotizing Lesions, p 533-539. In Jacobs, Jr. W, McShane H, Mizrahi V, Orme I (ed), Tuberculosis and the Tubercle Bacillus, Second Edition. ASM Press, Washington, DC. doi: 10.1128/microbiolspec.TBTB2-0024-2016
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Figure 1

Visualization of growth in a microfluidic device by time-lapse microscopy. The numbers at the bottom of the snapshots denote the time in minutes at which the snaps were taken. Note the distinct foci of multicellular communities from growth of individual cells. (Data collected by Jacob Richards in the laboratory of Anil Ojha).

Citation: Basaraba R, Ojha A. 2017. Mycobacterial Biofilms: Revisiting Tuberculosis Bacilli in Extracellular Necrotizing Lesions, p 533-539. In Jacobs, Jr. W, McShane H, Mizrahi V, Orme I (ed), Tuberculosis and the Tubercle Bacillus, Second Edition. ASM Press, Washington, DC. doi: 10.1128/microbiolspec.TBTB2-0024-2016
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