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Chapter 2 : The View from Here: The Evolution of the Genetic Code

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The View from Here: The Evolution of the Genetic Code, Page 1 of 2

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Abstract:

Although the genetic code is well established, a very exciting unsolved problem is discovering how codons were related to amino acids in the evolution of protein synthesis. How did a tRNA and a tRNA synthetase first evolve, and what was their ancestral source? How were the genes for the first tRNA and tRNA synthetase duplicated, and how was their specificity varied? Can we offer any explanation for why there are two classes of tRNA synthetases? Can one predict which tRNAs evolved from one another? Similarly, can we predict which tRNA synthetases evolved from an existing tRNA synthetase?

Citation: Yanofsky C. 2016. The View from Here: The Evolution of the Genetic Code, p 6-7. In Schaechter M, In the Company of Microbes: 10 Years of Small Things Considered. ASM Press, Washington, DC. doi: 10.1128/9781555819606.ch2
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Citation: Yanofsky C. 2016. The View from Here: The Evolution of the Genetic Code, p 6-7. In Schaechter M, In the Company of Microbes: 10 Years of Small Things Considered. ASM Press, Washington, DC. doi: 10.1128/9781555819606.ch2
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Charles Yanofsky is Professor Emeritus of Biological Sciences at Stanford University and a 2003 recipient of the National Medal of Science.

Citation: Yanofsky C. 2016. The View from Here: The Evolution of the Genetic Code, p 6-7. In Schaechter M, In the Company of Microbes: 10 Years of Small Things Considered. ASM Press, Washington, DC. doi: 10.1128/9781555819606.ch2
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