1887

Chapter 10 : Antimicrobial Resistance in

MyBook is a cheap paperback edition of the original book and will be sold at uniform, low price.

Preview this chapter:
Zoom in
Zoomout

Antimicrobial Resistance in , Page 1 of 2

| /docserver/preview/fulltext/10.1128/9781555819804/9781555819798_Chap10-1.gif /docserver/preview/fulltext/10.1128/9781555819804/9781555819798_Chap10-2.gif

Abstract:

, a Gram-positive facultative intracellular pathogen, is one of the most important causes of disease in foals between 3 weeks and 5 months of age. has also emerged as a common opportunistic pathogen in immunocompromised people, especially those infected with the human immunodeficiency virus ( ). Infection in both foals and people is most commonly characterized by life-threatening pyogranulomatous pneumonia, but extrapulmonary infections are also common ( ). In foals, extrapulmonary disorders might occur concurrent with or independent of pneumonia, and some foals have multiple extrapulmonary disorders concurrently ( ). Because ultrasonographic screening for early detection has become routine practice at many farms endemic for pneumonia caused by , the most frequently recognized form of infection on those farms is a subclinical form in which foals develop sonographic evidence of peripheral pulmonary consolidation or abscessation without manifesting clinical signs ( ).

Citation: Giguère S, Berghaus L, Willingham-Lane J. 2018. Antimicrobial Resistance in , p 229-236. In Schwarz S, Cavaco L, Shen J (ed), Antimicrobial Resistance in Bacteria from Livestock and Companion Animals. ASM Press, Washington, DC. doi: 10.1128/microbiolspec.ARBA-0004-2016
Highlighted Text: Show | Hide
Loading full text...

Full text loading...

References

/content/book/10.1128/9781555819804.chap10
1. Arlotti M,, Zoboli G,, Moscatelli GL,, Magnani G,, Maserati R,, Borghi V,, Andreoni M,, Libanore M,, Bonazzi L,, Piscina A,, Ciammarughi R . 1996. Rhodococcus equi infection in HIV-positive subjects: a retrospective analysis of 24 cases. Scand J Infect Dis 28 : 463 467.[CrossRef][PubMed]
2. Donisi A,, Suardi MG,, Casari S,, Longo M,, Cadeo GP,, Carosi G . 1996. Rhodococcus equi infection in HIV-infected patients. AIDS 10 : 359 362.[CrossRef][PubMed]
3. Yamshchikov AV,, Schuetz A,, Lyon GM . 2010. Rhodococcus equi infection. Lancet Infect Dis 10 : 350 359.[CrossRef][PubMed]
4. Giguère S,, Cohen ND,, Chaffin MK,, Hines SA,, Hondalus MK,, Prescott JF,, Slovis NM . 2011. Rhodococcus equi: clinical manifestations, virulence, and immunity. J Vet Intern Med 25 : 1221 1230.[CrossRef][PubMed]
5. Reuss SM,, Chaffin MK,, Cohen ND . 2009. Extrapulmonary disorders associated with Rhodococcus equi infection in foals: 150 cases (1987–2007). J Am Vet Med Assoc 235 : 855 863.[CrossRef][PubMed]
6. Zink MC,, Yager JA,, Smart NL . 1986. Corynebacterium equi infections in horses, 1958–1984: a review of 131 cases. Can Vet J 27 : 213 217.[PubMed]
7. Slovis NM,, McCracken JL,, Mundy G . 2005. How to use thoracic ultrasound to screen foals for Rhodococcus equi at affected farms. Proc Am Assoc Equine Pract 51 : 274 278.
8. Venner M,, Kerth R,, Klug E . 2007. Evaluation of tulathromycin in the treatment of pulmonary abscesses in foals. Vet J 174 : 418 421.[CrossRef][PubMed]
9. Komijn RE,, Wisselink HJ,, Rijsman VM,, Stockhofe-Zurwieden N,, Bakker D,, van Zijderveld FG,, Eger T,, Wagenaar JA,, Putirulan FF,, Urlings BA . 2007. Granulomatous lesions in lymph nodes of slaughter pigs bacteriologically negative for Mycobacterium avium subsp. avium and positive for Rhodococcus equi. Vet Microbiol 120 : 352 357.[CrossRef][PubMed]
10. Madarame H,, Yaegashi R,, Fukunaga N,, Matsukuma M,, Mutoh K,, Morisawa N,, Sasaki Y,, Tsubaki S,, Hasegawa Y,, Takai S . 1998. Pathogenicity of Rhodococcus equi strains possessing virulence-associated 15- to 17-kDa and 20-kDa antigens: experimental and natural cases in pigs. J Comp Pathol 119 : 397 405.[CrossRef][PubMed]
11. Takai S,, Fukunaga N,, Ochiai S,, Sakai T,, Sasaki Y,, Tsubaki S . 1996. Isolation of virulent and intermediately virulent Rhodococcus equi from soil and sand on parks and yards in Japan. J Vet Med Sci 58 : 669 672.[CrossRef][PubMed]
12. Flynn O,, Quigley F,, Costello E,, O’Grady D,, Gogarty A,, Mc Guirk J,, Takai S . 2001. Virulence-associated protein characterisation of Rhodococcus equi isolated from bovine lymph nodes. Vet Microbiol 78 : 221 228.[CrossRef]
13. Hong CB,, Donahue JM . 1995. Rhodococcus equi-associated necrotizing lymphadenitis in a llama. J Comp Pathol 113 : 85 88.[CrossRef]
14. Kinne J,, Madarame H,, Takai S,, Jose S,, Wernery U . 2011. Disseminated Rhodococcus equi infection in dromedary camels ( Camelus dromedarius). Vet Microbiol 149 : 269 272.[CrossRef][PubMed]
15. Tkachuk-Saad O,, Lusis P,, Welsh RD,, Prescott JF . 1998. Rhodococcus equi infections in goats. Vet Rec 143 : 311 312.[CrossRef][PubMed]
16. Bryan LK,, Clark SD,, Diaz-Delgado J,, Lawhon SD,, Edwards JF . 2016. Rhodococcus equi infections in dogs. Vet Pathol.[PubMed]
17. Takai S,, Martens RJ,, Julian A,, Garcia Ribeiro M,, Rodrigues de Farias M,, Sasaki Y,, Inuzuka K,, Kakuda T,, Tsubaki S,, Prescott JF . 2003. Virulence of Rhodococcus equi isolated from cats and dogs. J Clin Microbiol 41 : 4468 4470.[CrossRef][PubMed]
18. Riesenberg A,, Kaspar H,, Feßler AT,, Werckenthin C,, Schwarz S . 2016. Susceptibility testing of Rhodococcus equi: an interlaboratory test. Vet Microbiol 194 : 30 35.[CrossRef][PubMed]
19. Riesenberg A,, Feßler AT,, Frömke C,, Kadlec K,, Klarmann D,, Kreienbrock L,, Werckenthin C,, Schwarz S . 2013. Harmonization of antimicrobial susceptibility testing by broth microdilution for Rhodococcus equi of animal origin. J Antimicrob Chemother 68 : 2173 2175.[CrossRef][PubMed]
20. Berghaus LJ,, Giguère S,, Guldbech K,, Warner E,, Ugorji U,, Berghaus RD . 2015. Comparison of Etest, disk diffusion, and broth macrodilution for in vitro susceptibility testing of Rhodococcus equi. J Clin Microbiol 53 : 314 318.[CrossRef][PubMed]
21. Giguère S,, Lee EA,, Guldbech KM,, Berghaus LJ . 2012. In vitro synergy, pharmacodynamics, and postantibiotic effect of 11 antimicrobial agents against Rhodococcus equi. Vet Microbiol 160 : 207 213.[CrossRef][PubMed]
22. Nordmann P,, Ronco E . 1992. In-vitro antimicrobial susceptibility of Rhodococcus equi. J Antimicrob Chemother 29 : 383 393.[CrossRef][PubMed]
23. Prescott JF,, Nicholson VM . 1984. The effects of combinations of selected antibiotics on the growth of Corynebacterium equi. J Vet Pharmacol Ther 7 : 61 64.[CrossRef][PubMed]
24. Blondeau JM . 2009. New concepts in antimicrobial susceptibility testing: the mutant prevention concentration and mutant selection window approach. Vet Dermatol 20 : 383 396.[CrossRef][PubMed]
25. Berghaus LJ,, Giguère S,, Guldbech K . 2013. Mutant prevention concentration and mutant selection window for 10 antimicrobial agents against Rhodococcus equi. Vet Microbiol 166 : 670 675.[CrossRef][PubMed]
26. Giguère S,, Hondalus MK,, Yager JA,, Darrah P,, Mosser DM,, Prescott JF . 1999. Role of the 85-kilobase plasmid and plasmid-encoded virulence-associated protein A in intracellular survival and virulence of Rhodococcus equi. Infect Immun 67 : 3548 3557.[PubMed]
27. Berghaus LJ,, Giguère S,, Sturgill TL,, Bade D,, Malinski TJ,, Huang R . 2012. Plasma pharmacokinetics, pulmonary distribution, and in vitro activity of gamithromycin in foals. J Vet Pharmacol Ther 35 : 59 66.[CrossRef][PubMed]
28. Giguère S,, Jacks S,, Roberts GD,, Hernandez J,, Long MT,, Ellis C . 2004. Retrospective comparison of azithromycin, clarithromycin, and erythromycin for the treatment of foals with Rhodococcus equi pneumonia. J Vet Intern Med 18 : 568 573.[CrossRef][PubMed]
29. Giguère S,, Cohen ND,, Chaffin MK,, Slovis NM,, Hondalus MK,, Hines SA,, Prescott JF . 2011. Diagnosis, treatment, control, and prevention of infections caused by Rhodococcus equi in foals. J Vet Intern Med 25 : 1209 1220.[CrossRef][PubMed]
30. Hillidge CJ . 1987. Use of erythromycin-rifampin combination in treatment of Rhodococcus equi pneumonia. Vet Microbiol 14 : 337 342.[CrossRef][PubMed]
31. Kenney DG,, Robbins SC,, Prescott JF,, Kaushik A,, Baird JD . 1994. Development of reactive arthritis and resistance to erythromycin and rifampin in a foal during treatment for Rhodococcus equi pneumonia. Equine Vet J 26 : 246 248.[CrossRef][PubMed]
32. Fines M,, Pronost S,, Maillard K,, Taouji S,, Leclercq R . 2001. Characterization of mutations in the rpoB gene associated with rifampin resistance in Rhodococcus equi isolated from foals. J Clin Microbiol 39 : 2784 2787.[CrossRef][PubMed]
33. Takai S,, Takeda K,, Nakano Y,, Karasawa T,, Furugoori J,, Sasaki Y,, Tsubaki S,, Higuchi T,, Anzai T,, Wada R,, Kamada M . 1997. Emergence of rifampin-resistant Rhodococcus equi in an infected foal. J Clin Microbiol 35 : 1904 1908.[PubMed]
34. Giguère S,, Lee E,, Williams E,, Cohen ND,, Chaffin MK,, Halbert N,, Martens RJ,, Franklin RP,, Clark CC,, Slovis NM . 2010. Determination of the prevalence of antimicrobial resistance to macrolide antimicrobials or rifampin in Rhodococcus equi isolates and treatment outcome in foals infected with antimicrobial-resistant isolates of R equi. J Am Vet Med Assoc 237 : 74 81.[CrossRef][PubMed]
35. Burton AJ,, Giguère S,, Sturgill TL,, Berghaus LJ,, Slovis NM,, Whitman JL,, Levering C,, Kuskie KR,, Cohen ND . 2013. Macrolide- and rifampin-resistant Rhodococcus equi on a horse breeding farm, Kentucky, USA. Emerg Infect Dis 19 : 282 285.[CrossRef][PubMed]
36. Liu H,, Wang Y,, Yan J,, Wang C,, He H,, Forbes BA . 2014. Appearance of multidrug-resistant virulent Rhodococcus equi clinical isolates obtained in China. J Clin Microbiol 52 : 703.[CrossRef][PubMed]
37. McNeil MM,, Brown JM . 1992. Distribution and antimicrobial susceptibility of Rhodococcus equi from clinical specimens. Eur J Epidemiol 8 : 437 443.[CrossRef][PubMed]
38. Roberts MC . 2004. Resistance to macrolide, lincosamide, streptogramin, ketolide, and oxazolidinone antibiotics. Mol Biotechnol 28 : 47 62.[CrossRef][PubMed]
39. Roberts MC . 2008. Update on macrolide-lincosamide-streptogramin, ketolide, and oxazolidinone resistance genes. FEMS Microbiol Lett 282 : 147 159.[CrossRef][PubMed]
40. Franceschi F,, Kanyo Z,, Sherer EC,, Sutcliffe J . 2004. Macrolide resistance from the ribosome perspective. Curr Drug Targets Infect Disord 4 : 177 191.[CrossRef][PubMed]
41. Anastasi E,, Giguère S,, Berghaus LJ,, Hondalus MK,, Willingham-Lane JM,, MacArthur I,, Cohen ND,, Roberts MC,, Vazquez-Boland JA . 2015. Novel transferable erm(46) determinant responsible for emerging macrolide resistance in Rhodococcus equi. J Antimicrob Chemother 70 : 3184 3190.[PubMed]
42. Asoh N,, Watanabe H,, Fines-Guyon M,, Watanabe K,, Oishi K,, Kositsakulchai W,, Sanchai T,, Kunsuikmengrai K,, Kahintapong S,, Khantawa B,, Tharavichitkul P,, Sirisanthana T,, Nagatake T . 2003. Emergence of rifampin-resistant Rhodococcus equi with several types of mutations in the rpoB gene among AIDS patients in northern Thailand. J Clin Microbiol 41 : 2337 2340.[CrossRef][PubMed]
43. Riesenberg A,, Feßler AT,, Erol E,, Prenger-Berninghoff E,, Stamm I,, Böse R,, Heusinger A,, Klarmann D,, Werckenthin C,, Schwarz S . 2014. MICs of 32 antimicrobial agents for Rhodococcus equi isolates of animal origin. J Antimicrob Chemother 69 : 1045 1049.[CrossRef][PubMed]
44. Quan S,, Venter H,, Dabbs ER . 1997. Ribosylative inactivation of rifampin by Mycobacterium smegmatis is a principal contributor to its low susceptibility to this antibiotic. Antimicrob Agents Chemother 41 : 2456 2460.[PubMed]
45. Spanogiannopoulos P,, Waglechner N,, Koteva K,, Wright GD . 2014. A rifamycin inactivating phosphotransferase family shared by environmental and pathogenic bacteria. Proc Natl Acad Sci USA 111 : 7102 7107.[CrossRef][PubMed]
46. Hoshino Y,, Fujii S,, Shinonaga H,, Arai K,, Saito F,, Fukai T,, Satoh H,, Miyazaki Y,, Ishikawa J . 2010. Monooxygenation of rifampicin catalyzed by the rox gene product of Nocardia farcinica: structure elucidation, gene identification and role in drug resistance. J Antibiot (Tokyo) 63 : 23 28.[CrossRef][PubMed]
47. Andersen SJ,, Quan S,, Gowan B,, Dabbs ER . 1997. Monooxygenase-like sequence of a Rhodococcus equi gene conferring increased resistance to rifampin by inactivating this antibiotic. Antimicrob Agents Chemother 41 : 218 221.[PubMed]
48. Vivrette S,, Bostian A,, Bermingham E,, Papich MG . 2001. Quinolone induced arthropathy in neonatal foals. Proc. Am. Assoc. Equine Pract 47 : 376 377.
49. Jacks SS,, Giguère S,, Nguyen A . 2003. In vitro susceptibilities of Rhodococcus equi and other common equine pathogens to azithromycin, clarithromycin, and 20 other antimicrobials. Antimicrob Agents Chemother 47 : 1742 1745.[CrossRef][PubMed]
50. Giguère S, . 2006. Antimicrobial drug use in horses, p 449 462. In Giguère S,, Prescott JF,, Baggot JD,, Walker RD,, Dowling PM (ed), Antimicrobial Therapy in Veterinary Medicine, 4th ed. Blackwell Publishing, Ames IA.
51. Gundelly P,, Suzuki Y,, Ribes JA,, Thornton A . 2016. Differences in Rhodococcus equi infections based on immune status and antibiotic susceptibility of clinical isolates in a case series of 12 patients and cases in the literature. BioMed Res Int 2016 : 2737295.[CrossRef][PubMed]
52. Niwa H,, Hobo S,, Anzai T . 2006. A nucleotide mutation associated with fluoroquinolone resistance observed in gyrA of in vitro obtained Rhodococcus equi mutants. Vet Microbiol 115 : 264 268.[CrossRef][PubMed]
53. Niwa H,, Lasker BA . 2010. Mutant selection window and characterization of allelic diversity for ciprofloxacin-resistant mutants of Rhodococcus equi. Antimicrob Agents Chemother 54 : 3520 3523.[CrossRef][PubMed]
54. Gudeta DD,, Moodley A,, Bortolaia V,, Guardabassi L . 2014. vanO, a new glycopeptide resistance operon in environmental Rhodococcus equi isolates. Antimicrob Agents Chemother 58 : 1768 1770.[CrossRef][PubMed]
55. Letek M,, González P,, Macarthur I,, Rodríguez H,, Freeman TC,, Valero-Rello A,, Blanco M,, Buckley T,, Cherevach I,, Fahey R,, Hapeshi A,, Holdstock J,, Leadon D,, Navas J,, Ocampo A,, Quail MA,, Sanders M,, Scortti MM,, Prescott JF,, Fogarty U,, Meijer WG,, Parkhill J,, Bentley SD,, Vázquez-Boland JA . 2010. The genome of a pathogenic Rhodococcus: cooptive virulence underpinned by key gene acquisitions. PLoS Genet 6 : e1001145.[CrossRef][PubMed]
56. Nordmann P,, Nicolas MH,, Gutmann L . 1993. Penicillin-binding proteins of Rhodococcus equi: potential role in resistance to imipenem. Antimicrob Agents Chemother 37 : 1406 1409.[CrossRef][PubMed]
57. Carlson KL,, Kuskie KR,, Chaffin KM,, Libal MC,, Giguère S,, Lawhon SD,, Cohen ND . 2010. Antimicrobial activity of tulathromycin and 14 other antimicrobials against virulent Rhodococcus equi in vitro. Vet Ther 11 : E1 E9.[PubMed]

Tables

Generic image for table
Table 1

MIC data for isolates susceptible to macrolides and rifampin

Citation: Giguère S, Berghaus L, Willingham-Lane J. 2018. Antimicrobial Resistance in , p 229-236. In Schwarz S, Cavaco L, Shen J (ed), Antimicrobial Resistance in Bacteria from Livestock and Companion Animals. ASM Press, Washington, DC. doi: 10.1128/microbiolspec.ARBA-0004-2016
Generic image for table
Table 2

Mutations in the gene associated with rifampin resistance in

Citation: Giguère S, Berghaus L, Willingham-Lane J. 2018. Antimicrobial Resistance in , p 229-236. In Schwarz S, Cavaco L, Shen J (ed), Antimicrobial Resistance in Bacteria from Livestock and Companion Animals. ASM Press, Washington, DC. doi: 10.1128/microbiolspec.ARBA-0004-2016

This is a required field
Please enter a valid email address
Please check the format of the address you have entered.
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error