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Chapter 8 : Antimicrobial Resistance in spp.

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Abstract:

More than 60 species have been recognized so far. Some of these, such as , , , , and , produce hemolytic factors and, when cultivated on solid media containing blood, can be classified as beta-hemolytic. However, nonhemolytic variants can also be observed ( ). Isolates belonging to other species, such as subsp. , , , , , , , and , produce hydrogen peroxide that partially lyses the erythrocytes, with the subsequent oxidation of the heme group resulting in a greenish pigment in the medium that is often interpreted as alpha-hemolysis. This oxidation process is influenced by several cultivation conditions and is variably evident. For this reason, it is preferable to consider those latter-mentioned species as nonhemolytic. The truly nonhemolytic species, mainly encompassing (formerly ), were also named gamma-hemolytic. A classification of species proposed by Rebecca Lancefield in the 1930s was based on the antigenic reaction of the cell wall-associated carbohydrates and remains classically used ( ). On the basis of this approach, streptococci are distributed into groups ranging from A to W, depending on the antibodies recognizing the specific carbohydrates of a definite streptococcal species. Nevertheless, the whole picture is sometimes complicated by the fact that several antibodies can react with isolates belonging to the same species. For instance, depending on the isolates, subsp. may be classified as belonging to the C or G group, while it may also be classified, even though less commonly, as group A or L ( ); isolates from may belong to either the C or G group; isolates from are sporadically considered as group D; isolates from are indifferently classified as group A, C, G, F, or N; isolates from subsp. belong to either group F or N; sporadic isolates belonging to subsp. can be considered as group C; isolates from the species can be considered as group N; and finally, isolates belonging to are classified in either group P, U, or V.

Citation: Haenni M, Lupo A, Madec J. 2018. Antimicrobial Resistance in spp., p 159-184. In Schwarz S, Cavaco L, Shen J (ed), Antimicrobial Resistance in Bacteria from Livestock and Companion Animals. ASM Press, Washington, DC. doi: 10.1128/microbiolspec.ARBA-0008-2017
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Ten-year evolution of resistance in France in (A) and (B) .

Citation: Haenni M, Lupo A, Madec J. 2018. Antimicrobial Resistance in spp., p 159-184. In Schwarz S, Cavaco L, Shen J (ed), Antimicrobial Resistance in Bacteria from Livestock and Companion Animals. ASM Press, Washington, DC. doi: 10.1128/microbiolspec.ARBA-0008-2017
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References

/content/book/10.1128/9781555819804.chap8
1. Póntigo F,, Moraga M,, Flores SV . 2015. Molecular phylogeny and a taxonomic proposal for the genus Streptococcus. Genet Mol Res 14 : 10905 10918.[CrossRef][PubMed]
2. Lancefield RC,, Freimer EH . 1966. Type-specific polysaccharide antigens of group B streptococci. J Hyg (Lond) 64 : 191 203.[CrossRef][PubMed]
3. Tanaka D,, Isobe J,, Watahiki M,, Nagai Y,, Katsukawa C,, Kawahara R,, Endoh M,, Okuno R,, Kumagai N,, Matsumoto M,, Morikawa Y,, Ikebe T,, Watanabe H, Working Group for Group A Streptococci in Japan . 2008. Genetic features of clinical isolates of Streptococcus dysgalactiae subsp. equisimilis possessing Lancefield’s group A antigen. J Clin Microbiol 46 : 1526 1529.
4. Brouwer S,, Barnett TC,, Rivera-Hernandez T,, Rohde M,, Walker MJ . 2016. Streptococcus pyogenes adhesion and colonization. FEBS Lett 590 : 3739 3757.[CrossRef][PubMed]
5. Carapetis JR,, Steer AC,, Mulholland EK,, Weber M . 2005. The global burden of group A streptococcal diseases. Lancet Infect Dis 5 : 685 694.[CrossRef]
6. Copperman SM . 1982. Cherchez le chien: household pets as reservoirs of persistent or recurrent streptococcal sore throats in children. N Y State J Med 82 : 1685 1687.[PubMed]
7. Farley MM . 2001. Group B streptococcal disease in nonpregnant adults. Clin Infect Dis 33 : 556 561.[CrossRef][PubMed]
8. Olivares-Fuster O,, Klesius PH,, Evans J,, Arias CR . 2008. Molecular typing of Streptococcus agalactiae isolates from fish. J Fish Dis 31 : 277 283.[CrossRef][PubMed]
9. Fischer A,, Liljander A,, Kaspar H,, Muriuki C,, Fuxelius HH,, Bongcam-Rudloff E,, de Villiers EP,, Huber CA,, Frey J,, Daubenberger C,, Bishop R,, Younan M,, Jores J . 2013. Camel Streptococcus agalactiae populations are associated with specific disease complexes and acquired the tetracycline resistance gene tetM via a Tn 916-like element. Vet Res (Faisalabad) 44 : 86.[CrossRef][PubMed]
10. Yildirim AO,, Lämmler C,, Weiss R . 2002. Identification and characterization of Streptococcus agalactiae isolated from horses. Vet Microbiol 85 : 31 35.[CrossRef][PubMed]
11. McDonald TJ,, McDonald JS . 1976. Streptococci isolated from bovine intramammary infections. Am J Vet Res 37 : 377 381.[PubMed]
12. Brochet M,, Couvé E,, Zouine M,, Vallaeys T,, Rusniok C,, Lamy MC,, Buchrieser C,, Trieu-Cuot P,, Kunst F,, Poyart C,, Glaser P . 2006. Genomic diversity and evolution within the species Streptococcus agalactiae. Microbes Infect 8 : 1227 1243.[CrossRef][PubMed]
13. Rajendram P,, Mar Kyaw W,, Leo YS,, Ho H,, Chen WK,, Lin R,, Pratim P,, Badaruddin H,, Ang B,, Barkham T,, Chow A . 2016. Group B streptococcus sequence type 283 disease linked to consumption of raw fish, Singapore. Emerg Infect Dis 22 : 1974 1977.[CrossRef][PubMed]
14. Evans JJ,, Klesius PH,, Pasnik DJ,, Bohnsack JF . 2009. Human Streptococcus agalactiae isolate in Nile tilapia ( Oreochromis niloticus). Emerg Infect Dis 15 : 774 776.[CrossRef][PubMed]
15. Bradley A . 2002. Bovine mastitis: an evolving disease. Vet J 164 : 116 128.[CrossRef][PubMed]
16. Leigh JA . 1999. Streptococcus uberis: a permanent barrier to the control of bovine mastitis? Vet J 157 : 225 238.[CrossRef][PubMed]
17. Schleifer KH,, Kilpper-Bälz R . 1984. Transfer of Streptococcus faecalis and Streptococcus faecium to the genus Enterococcus nom. rev. as Enterococcus faecalis comb. nov. and Enterococcus faecium comb. nov. Int J Syst Evol Microbiol 34 : 31 34.
18. Köhler W . 2007. The present state of species within the genera Streptococcus and Enterococcus. Int J Med Microbiol 297 : 133 150.[CrossRef][PubMed]
19. Ben-Chetrit E,, Wiener-Well Y,, Kashat L,, Yinnon AM,, Assous MV . 2016. Streptococcus bovis new taxonomy: does subspecies distinction matter? Eur J Clin Microbiol Infect Dis 36( 2) : 387.[PubMed]
20. Dumke J,, Hinse D,, Vollmer T,, Schulz J,, Knabbe C,, Dreier J . 2015. Potential transmission pathways of Streptococcus gallolyticus subsp. gallolyticus. PLoS One 10 : e0126507.[CrossRef][PubMed]
21. Gherardi G,, Palmieri C,, Marini E,, Pompilio A,, Crocetta V,, Di Bonaventura G,, Creti R,, Facinelli B . 2016. Identification, antimicrobial resistance and molecular characterization of the human emerging pathogen Streptococcus gallolyticus subsp. pasteurianus. Diagn Microbiol Infect Dis 86 : 329 335.[CrossRef][PubMed]
22. Sheng WH,, Chuang YC,, Teng LJ,, Hsueh PR . 2014. Bacteraemia due to Streptococcus gallolyticus subspecies pasteurianus is associated with digestive tract malignancies and resistance to macrolides and clindamycin. J Infect 69 : 145 153.[CrossRef][PubMed]
23. Sturt AS,, Yang L,, Sandhu K,, Pei Z,, Cassai N,, Blaser MJ . 2010. Streptococcus gallolyticus subspecies pasteurianus (biotype II/2), a newly reported cause of adult meningitis. J Clin Microbiol 48 : 2247 2249.[CrossRef][PubMed]
24. Barnett J,, Ainsworth H,, Boon JD,, Twomey DF . 2008. Streptococcus gallolyticus subsp. pasteurianus septicaemia in goslings. Vet J 176 : 251 253.[CrossRef][PubMed]
25. Li M,, Gu C,, Zhang W,, Li S,, Liu J,, Qin C,, Su J,, Cheng G,, Hu X . 2013. Isolation and characterization of Streptococcus gallolyticus subsp. pasteurianus causing meningitis in ducklings. Vet Microbiol 162 : 930 936.[CrossRef][PubMed]
26. Marmolin ES,, Hartmeyer GN,, Christensen JJ,, Nielsen XC,, Dargis R,, Skov MN,, Knudsen E,, Kemp M,, Justesen US . 2016. Bacteremia with the bovis group streptococci: species identification and association with infective endocarditis and with gastrointestinal disease. Diagn Microbiol Infect Dis 85 : 239 242.[CrossRef][PubMed]
27. Wessman GE . 1986. Biology of the group E streptococci: a review. Vet Microbiol 12 : 297 328.[CrossRef]
28. Facklam R,, Elliott J,, Pigott N,, Franklin AR . 1995. Identification of Streptococcus porcinus from human sources. J Clin Microbiol 33 : 385 388.[PubMed]
29. Duarte RS,, Barros RR,, Facklam RR,, Teixeira LM . 2005. Phenotypic and genotypic characteristics of Streptococcus porcinus isolated from human sources. J Clin Microbiol 43 : 4592 4601.[CrossRef][PubMed]
30. Jonsson P,, Olsson SO,, Olofson AS,, Fälth C,, Holmberg O,, Funke H . 1991. Bacteriological investigations of clinical mastitis in heifers in Sweden. J Dairy Res 58 : 179 185.[CrossRef][PubMed]
31. Cuccuru C,, Meloni M,, Sala E,, Scaccabarozzi L,, Locatelli C,, Moroni P,, Bronzo V . 2011. Effects of intramammary infections on somatic cell score and milk yield in Sarda sheep. N Z Vet J 59 : 128 131.[CrossRef][PubMed]
32. Timoney JF . 2004. The pathogenic equine streptococci. Vet Res 35 : 397 409.[CrossRef][PubMed]
33. Hashikawa S,, Iinuma Y,, Furushita M,, Ohkura T,, Nada T,, Torii K,, Hasegawa T,, Ohta M . 2004. Characterization of group C and G streptococcal strains that cause streptococcal toxic shock syndrome. J Clin Microbiol 42 : 186 192.[CrossRef][PubMed]
34. Pinho MD,, Matos SC,, Pomba C,, Lübke-Becker A,, Wieler LH,, Preziuso S,, Melo-Cristino J,, Ramirez M . 2013. Multilocus sequence analysis of Streptococcus canis confirms the zoonotic origin of human infections and reveals genetic exchange with Streptococcus dysgalactiae subsp. equisimilis. J Clin Microbiol 51 : 1099 1109.[CrossRef][PubMed]
35. Iglauer F,, Kunstýr I,, Mörstedt R,, Farouq H,, Wullenweber M,, Damsch S . 1991. Streptococcus canis arthritis in a cat breeding colony. J Exp Anim Sci 34 : 59 65.[PubMed]
36. Lacave G,, Coutard A,, Troché G,, Augusto S,, Pons S,, Zuber B,, Laurent V,, Amara M,, Couzon B,, Bédos JP,, Pangon B,, Grimaldi D . 2016. Endocarditis caused by Streptococcus canis: an emerging zoonosis? Infection 44 : 111 114.[CrossRef][PubMed]
37. Goyette-Desjardins G,, Auger JP,, Xu J,, Segura M,, Gottschalk M . 2014. Streptococcus suis, an important pig pathogen and emerging zoonotic agent: an update on the worldwide distribution based on serotyping and sequence typing. Emerg Microbes Infect 3 : e45.[CrossRef][PubMed]
38. Segura M,, Calzas C,, Grenier D,, Gottschalk M . 2016. Initial steps of the pathogenesis of the infection caused by Streptococcus suis: fighting against nonspecific defenses. FEBS Lett 590 : 3772 3799.[CrossRef][PubMed]
39. Taniyama D,, Sakurai M,, Sakai T,, Kikuchi T,, Takahashi T . 2016. Human case of bacteremia due to Streptococcus suis serotype 5 in Japan: the first report and literature review. IDCases 6 : 36 38.[CrossRef][PubMed]
40. Ward PN,, Holden MT,, Leigh JA,, Lennard N,, Bignell A,, Barron A,, Clark L,, Quail MA,, Woodward J,, Barrell BG,, Egan SA,, Field TR,, Maskell D,, Kehoe M,, Dowson CG,, Chanter N,, Whatmore AM,, Bentley SD,, Parkhill J . 2009. Evidence for niche adaptation in the genome of the bovine pathogen Streptococcus uberis. BMC Genomics 10 : 54 71.[CrossRef][PubMed]
41. Phuektes P,, Mansell PD,, Dyson RS,, Hooper ND,, Dick JS,, Browning GF . 2001. Molecular epidemiology of Streptococcus uberis isolates from dairy cows with mastitis. J Clin Microbiol 39 : 1460 1466.[CrossRef][PubMed]
42. Wilesmith JW,, Francis PG,, Wilson CD . 1986. Incidence of clinical mastitis in a cohort of British dairy herds. Vet Rec 118 : 199 204.[CrossRef][PubMed]
43. Compton CW,, Heuer C,, Parker K,, McDougall S . 2007. Epidemiology of mastitis in pasture-grazed peripartum dairy heifers and its effects on productivity. J Dairy Sci 90 : 4157 4170.[CrossRef][PubMed]
44. Hasson KW,, Wyld EM,, Fan Y,, Lingsweiller SW,, Weaver SJ,, Cheng J,, Varner PW . 2009. Streptococcosis in farmed Litopenaeus vannamei: a new emerging bacterial disease of penaeid shrimp. Dis Aquat Organ 86 : 93 106.[CrossRef][PubMed]
45. Parker KI,, Compton C,, Anniss FM,, Weir A,, Heuer C,, McDougall S . 2007. Subclinical and clinical mastitis in heifers following the use of a teat sealant precalving. J Dairy Sci 90 : 207 218.[CrossRef]
46. Dodd FH . 1983. Mastitis: progress on control. J Dairy Sci 66 : 1773 1780.[CrossRef]
47. Zehner MM,, Farnsworth RJ,, Appleman RD,, Larntz K,, Springer JA . 1986. Growth of environmental mastitis pathogens in various bedding materials. J Dairy Sci 69 : 1932 1941.[CrossRef]
48. Koh TH,, Sng LH,, Yuen SM,, Thomas CK,, Tan PL,, Tan SH,, Wong NS . 2009. Streptococcal cellulitis following preparation of fresh raw seafood. Zoonoses Public Health 56 : 206 208.[CrossRef][PubMed]
49. Weinstein MR,, Litt M,, Kertesz DA,, Wyper P,, Rose D,, Coulter M,, McGeer A,, Facklam R,, Ostach C,, Willey BM,, Borczyk A,, Low DE . 1997. Invasive infections due to a fish pathogen, Streptococcus iniae. S. iniae Study Group. N Engl J Med 337 : 589 594.[CrossRef][PubMed]
50. Nilson B,, Olaison L,, Rasmussen M . 2016. Clinical presentation of infective endocarditis caused by different groups of non-beta haemolytic streptococci. Eur J Clin Microbiol Infect Dis 35 : 215 218.[CrossRef][PubMed]
51. Simón-Soro A,, Mira A . 2015. Solving the etiology of dental caries. Trends Microbiol 23 : 76 82.[CrossRef][PubMed]
52. Yombi J,, Belkhir L,, Jonckheere S,, Wilmes D,, Cornu O,, Vandercam B,, Rodriguez-Villalobos H . 2012. Streptococcus gordonii septic arthritis: two cases and review of literature. BMC Infect Dis 12 : 215 220.[CrossRef][PubMed]
53. Burrell MH,, Mackintosh ME,, Taylor CE . 1986. Isolation of Streptococcus pneumoniae from the respiratory tract of horses. Equine Vet J 18 : 183 186.[CrossRef][PubMed]
54. Köndgen S,, Calvignac-Spencer S,, Grützmacher K,, Keil V,, Mätz-Rensing K,, Nowak K,, Metzger S,, Kiyang J,, Becker AL,, Deschner T,, Wittig RM,, Lankester F,, Leendertz FH . 2017. Evidence for human Streptococcus pneumoniae in wild and captive chimpanzees: a potential threat to wild populations. Sci Rep 7 : 14581.[CrossRef][PubMed]
55. Beighton D,, Hayday H . 1982. The streptococcal flora of the tongue of the monkey Macaca fascicularis. Arch Oral Biol 27 : 331 335.[CrossRef][PubMed]
56. Devriese LA,, Hommez J,, Pot B,, Haesebrouck F . 1994. Identification and composition of the streptococcal and enterococcal flora of tonsils, intestines and faeces of pigs. J Appl Bacteriol 77 : 31 36.[CrossRef][PubMed]
57. Devriese LA,, Pot B,, Vandamme P,, Kersters K,, Collins MD,, Alvarez N,, Haesebrouck F,, Hommez J . 1997. Streptococcus hyovaginalis sp. nov. and Streptococcus thoraltensis sp. nov., from the genital tract of sows. Int J Syst Bacteriol 47 : 1073 1077.[CrossRef][PubMed]
58. Freedman ML,, Coykendall AL,, O’Neill EM . 1982. Physiology of “mutans-like” Streptococcus ferus from wild rats. Infect Immun 35 : 476 482.[PubMed]
59. Zhu H,, Willcox MD,, Knox KW . 2000. A new species of oral Streptococcus isolated from Sprague-Dawley rats, Streptococcus orisratti sp. nov. Int J Syst Evol Microbiol 50 : 55 61.[CrossRef][PubMed]
60. Rinkinen ML,, Koort JM,, Ouwehand AC,, Westermarck E,, Björkroth KJ . 2004. Streptococcus alactolyticus is the dominating culturable lactic acid bacterium species in canine jejunum and feces of four fistulated dogs. FEMS Microbiol Lett 230 : 35 39.[CrossRef]
61. Toepfner N,, Shetty S,, Kunze M,, Orlowska-Volk M,, Krüger M,, Berner R,, Hentschel R . 2014. Fulminant neonatal sepsis due to Streptococcus alactolyticus: a case report and review. APMIS 122 : 654 656.[CrossRef][PubMed]
62. Beighton D,, Russell RR,, Hayday H . 1981. The isolation of characterization of Streptococcus mutans serotype h from dental plaque of monkeys ( Macaca fascicularis). J Gen Microbiol 124 : 271 279.
63. Yoo SY,, Kim KJ,, Lim SH,, Kim KW,, Hwang HK,, Min BM,, Choe SJ,, Kook JK . 2005. First isolation of Streptococcus downei from human dental plaques. FEMS Microbiol Lett 249 : 323 326.[CrossRef][PubMed]
64. Aryasinghe L,, Sabbar S,, Kazim Y,, Awan LM,, Khan HK . 2014. Streptococcus pluranimalium: a novel human pathogen? Int J Surg Case Rep 5 : 1242 1246.[CrossRef][PubMed]
65. Devriese LA,, Vandamme P,, Collins MD,, Alvarez N,, Pot B,, Hommez J,, Butaye P,, Haesebrouck F . 1999. Streptococcus pluranimalium sp. nov., from cattle and other animals. Int J Syst Bacteriol 49 : 1221 1226.[CrossRef][PubMed]
66. Facklam R . 2002. What happened to the streptococci: overview of taxonomic and nomenclature changes. Clin Microbiol Rev 15 : 613 630.[CrossRef][PubMed]
67. Silley P,, Simjee S,, Schwarz S . 2012. Surveillance and monitoring ofantimicrobial resistance and antibiotic consumption in humans and animals. Rev Sci Tech 31 : 105 120.[CrossRef][PubMed]
68. de Jong A,, Thomas V,, Klein U,, Marion H,, Moyaert H,, Simjee S,, Vallé M . 2013. Pan-European resistance monitoring programmes encompassing food-borne bacteria and target pathogens of food-producing and companion animals. Int J Antimicrob Agents 41 : 403 409.[CrossRef][PubMed]
69. Metcalf BJ,, Chochua S,, Gertz RE Jr,, Hawkins PA,, Ricaldi J,, Li Z,, Walker H,, Tran T,, Rivers J,, Mathis S,, Jackson D,, Glennen A,, Lynfield R,, McGee L,, Beall B, Active Bacterial Core surveillance team . 2017. Short-read whole genome sequencing for determination of antimicrobial resistance mechanisms and capsular serotypes of current invasive Streptococcus agalactiae recovered in the USA. Clin Microbiol Infect 23 : 574e577 574e514.
70. Li Y,, Metcalf BJ,, Chochua S,, Li Z,, Gertz RE Jr,, Walker H,, Hawkins PA,, Tran T,, Whitney CG,, McGee L,, Beall BW . 2016. Penicillin-binding protein transpeptidase signatures for tracking and predicting beta-lactam resistance levels in Streptococcus pneumoniae. MBio 7 :pii e00756-16.[CrossRef][PubMed]
71. Mobegi FM,, Cremers AJ,, de Jonge MI,, Bentley SD,, van Hijum SA,, Zomer A . 2017. Deciphering the distance to antibiotic resistance for the pneumococcus using genome sequencing data. Sci Rep 7 : 42808.[CrossRef][PubMed]
72. MARAN . 2009. Monitoring of Antimicrobial Resistance and Antibiotic Usage in Animals in The Netherlands in 2008. CIDC-Lelystad, Lelystad, The Netherlands.
73. Leclercq R . 2002. Mechanisms of resistance to macrolides and lincosamides: nature of the resistance elements and their clinical implications. Clin Infect Dis 34 : 482 492.[CrossRef][PubMed]
74. Collignon P,, Powers JH,, Chiller TM,, Aidara-Kane A,, Aarestrup FM . 2009. World Health Organization ranking of antimicrobials according to their importance in human medicine: a critical step for developing risk management strategies for the use of antimicrobials in food production animals. Clin Infect Dis 49 : 132 141.[CrossRef][PubMed]
75. Edmondson PW . 1989. An economic justification of “blitz” therapy to eradicate Streptococcus agalactiae from a dairy herd. Vet Rec 125 : 591 593.[PubMed]
76. Pyörälä S,, Baptiste KE,, Catry B,, van Duijkeren E,, Greko C,, Moreno MA,, Pomba MC,, Rantala M,, Ružauskas M,, Sanders P,, Threlfall EJ,, Torren-Edo J,, Törneke K . 2014. Macrolides and lincosamides in cattle and pigs: use and development of antimicrobial resistance. Vet J 200 : 230 239.[CrossRef][PubMed]
77. De Mouy D,, Cavallo JD,, Leclercq R,, Fabre R, AFICORPI-BIO Network. Association de Formation Continue en Pathologie Infectieuse des Biologistes . 2001. Antibiotic susceptibility and mechanisms of erythromycin resistance in clinical isolates of Streptococcus agalactiae: French multicenter study. Antimicrob Agents Chemother 45 : 2400 2402.[CrossRef][PubMed]
78. Puopolo KM,, Klinzing DC,, Lin MP,, Yesucevitz DL,, Cieslewicz MJ . 2007. A composite transposon associated with erythromycin and clindamycin resistance in group B Streptococcus. J Med Microbiol 56 : 947 955.[CrossRef][PubMed]
79. Cai Y,, Kong F,, Gilbert GL . 2007. Three new macrolide efflux ( mef) gene variants in Streptococcus agalactiae. J Clin Microbiol 45 : 2754 2755.[CrossRef][PubMed]
80. Ambrose KD,, Nisbet R,, Stephens DS . 2005. Macrolide efflux in Streptococcus pneumoniae is mediated by a dual efflux pump ( mel and mef) and is erythromycin inducible. Antimicrob Agents Chemother 49 : 4203 4209.[CrossRef][PubMed]
81. Gay K,, Stephens DS . 2001. Structure and dissemination of a chromosomal insertion element encoding macrolide efflux in Streptococcus pneumoniae. J Infect Dis 184 : 56 65.[CrossRef][PubMed]
82. Mingoia M,, Vecchi M,, Cochetti I,, Tili E,, Vitali LA,, Manzin A,, Varaldo PE,, Montanari MP . 2007. Composite structure of Streptococcus pneumoniae containing the erythromycin efflux resistance gene mefI and the chloramphenicol resistance gene catQ. Antimicrob Agents Chemother 51 : 3983 3987.[CrossRef][PubMed]
83. Santagati M,, Iannelli F,, Cascone C,, Campanile F,, Oggioni MR,, Stefani S,, Pozzi G . 2003. The novel conjugative transposon tn1207.3 carries the macrolide efflux gene mef(A) in Streptococcus pyogenes. Microb Drug Resist 9 : 243 247.[CrossRef][PubMed]
84. Clancy J,, Dib-Hajj F,, Petitpas JW,, Yuan W . 1997. Cloning and characterization of a novel macrolide efflux gene, mreA, from Streptococcus agalactiae. Antimicrob Agents Chemother 41 : 2719 2723.[PubMed]
85. Bozdogan B,, Berrezouga L,, Kuo MS,, Yurek DA,, Farley KA,, Stockman BJ,, Leclercq R . 1999. A new resistance gene, linB, conferring resistance to lincosamides by nucleotidylation in Enterococcus faecium HM1025. Antimicrob Agents Chemother 43 : 925 929.[PubMed]
86. de Azavedo JC,, McGavin M,, Duncan C,, Low DE,, McGeer A . 2001. Prevalence and mechanisms of macrolide resistance in invasive and noninvasive group B streptococcus isolates from Ontario, Canada. Antimicrob Agents Chemother 45 : 3504 3508.[CrossRef]
87. Achard A,, Villers C,, Pichereau V,, Leclercq R . 2005. New lnu(C) gene conferring resistance to lincomycin by nucleotidylation in Streptococcus agalactiae UCN36. Antimicrob Agents Chemother 49 : 2716 2719.[CrossRef][PubMed]
88. Petinaki E,, Guérin-Faublée V,, Pichereau V,, Villers C,, Achard A,, Malbruny B,, Leclercq R . 2008. Lincomycin resistance gene lnu(D) in Streptococcus uberis. Antimicrob Agents Chemother 52 : 626 630.[CrossRef][PubMed]
89. Chesneau O,, Tsvetkova K,, Courvalin P . 2007. Resistance phenotypes conferred by macrolide phosphotransferases. FEMS Microbiol Lett 269 : 317 322.[CrossRef][PubMed]
90. Rato MG,, Bexiga R,, Florindo C,, Cavaco LM,, Vilela CL,, Santos-Sanches I . 2013. Antimicrobial resistance and molecular epidemiology of streptococci from bovine mastitis. Vet Microbiol 161 : 286 294.[CrossRef][PubMed]
91. Dogan B,, Schukken YH,, Santisteban C,, Boor KJ . 2005. Distribution of serotypes and antimicrobial resistance genes among Streptococcus agalactiae isolates from bovine and human hosts. J Clin Microbiol 43 : 5899 5906.[CrossRef][PubMed]
92. Gao J,, Yu FQ,, Luo LP,, He JZ,, Hou RG,, Zhang HQ,, Li SM,, Su JL,, Han B . 2012. Antibiotic resistance of Streptococcus agalactiae from cows with mastitis. Vet J 194 : 423 424.[CrossRef][PubMed]
93. Pinto TC,, Costa NS,, Vianna Souza AR,, Silva LG,, Corrêa AB,, Fernandes FG,, Oliveira IC,, Mattos MC,, Rosado AS,, Benchetrit LC . 2013. Distribution of serotypes and evaluation of antimicrobial susceptibility among human and bovine Streptococcus agalactiae strains isolated in Brazil between 1980 and 2006. Braz J Infect Dis 17 : 131 136.[CrossRef][PubMed]
94. Haenni M,, Saras E,, Bertin S,, Leblond P,, Madec JY,, Payot S . 2010. Diversity and mobility of integrative and conjugative elements in bovine isolates of Streptococcus agalactiae, S. dysgalactiae subsp. dysgalactiae, and S. uberis. Appl Environ Microbiol 76 : 7957 7965.[CrossRef]
95. Loch IM,, Glenn K,, Zadoks RN . 2005. Macrolide and lincosamide resistance genes of environmental streptococci from bovine milk. Vet Microbiol 111 : 133 138.[CrossRef][PubMed]
96. Haenni M,, Saras E,, Chaussière S,, Treilles M,, Madec JY . 2011. ermB-mediated erythromycin resistance in Streptococcus uberis from bovine mastitis. Vet J 189 : 356 358.[CrossRef][PubMed]
97. Schmitt-Van de Leemput E,, Zadoks RN . 2007. Genotypic and phenotypic detection of macrolide and lincosamide resistance in Streptococcus uberis. J Dairy Sci 90 : 5089 5096.[CrossRef][PubMed]
98. Achard A,, Guérin-Faublée V,, Pichereau V,, Villers C,, Leclercq R . 2008. Emergence of macrolide resistance gene mph(B) in Streptococcus uberis and cooperative effects with rdmC-like gene. Antimicrob Agents Chemother 52 : 2767 2770.[CrossRef][PubMed]
99. Hendriksen RS,, Mevius DJ,, Schroeter A,, Teale C,, Meunier D,, Butaye P,, Franco A,, Utinane A,, Amado A,, Moreno M,, Greko C,, Stärk K,, Berghold C,, Myllyniemi AL,, Wasyl D,, Sunde M,, Aarestrup FM . 2008. Prevalence of antimicrobial resistance among bacterial pathogens isolated from cattle in different European countries: 2002–2004. Acta Vet Scand 50 : 28 38.[CrossRef][PubMed]
100. Thomas V,, de Jong A,, Moyaert H,, Simjee S,, El Garch F,, Morrissey I,, Marion H,, Vallé M . 2015. Antimicrobial susceptibility monitoring of mastitis pathogens isolated from acute cases of clinical mastitis in dairy cows across Europe: VetPath results. Int J Antimicrob Agents 46 : 13 20.[CrossRef][PubMed]
101. Persson Y,, Nyman AK,, Grönlund-Andersson U . 2011. Etiology and antimicrobial susceptibility of udder pathogens from cases of subclinical mastitis in dairy cows in Sweden. Acta Vet Scand 53 : 36.[CrossRef][PubMed]
102. Aarestrup FM,, Rasmussen SR,, Artursson K,, Jensen NE . 1998. Trends in the resistance to antimicrobial agents of Streptococcus suis isolates from Denmark and Sweden. Vet Microbiol 63 : 71 80.[CrossRef][PubMed]
103. Wasteson Y,, Høie S,, Roberts MC . 1994. Characterization of antibiotic resistance in Streptococcus suis. Vet Microbiol 41 : 41 49.[CrossRef][PubMed]
104. Gurung M,, Tamang MD,, Moon DC,, Kim SR,, Jeong JH,, Jang GC,, Jung SC,, Park YH,, Lim SK . 2015. Molecular basis of resistance to selected antimicrobial agents in the emerging zoonotic pathogen Streptococcus suis. J Clin Microbiol 53 : 2332 2336.[CrossRef][PubMed]
105. Palmieri C,, Varaldo PE,, Facinelli B . 2011. Streptococcus suis, an emerging drug-resistant animal and human pathogen. Front Microbiol 2 : 235 241.[CrossRef][PubMed]
106. Zhao Q,, Wendlandt S,, Li H,, Li J,, Wu C,, Shen J,, Schwarz S,, Wang Y . 2014. Identification of the novel lincosamide resistance gene lnu(E) truncated by IS Enfa5- cfr-IS Enfa5 insertion in Streptococcus suis: de novo synthesis and confirmation of functional activity in Staphylococcus aureus. Antimicrob Agents Chemother 58 : 1785 1788.[CrossRef][PubMed]
107. Hendriksen RS,, Mevius DJ,, Schroeter A,, Teale C,, Jouy E,, Butaye P,, Franco A,, Utinane A,, Amado A,, Moreno M,, Greko C,, Stärk KD,, Berghold C,, Myllyniemi AL,, Hoszowski A,, Sunde M,, Aarestrup FM . 2008. Occurrence of antimicrobial resistance among bacterial pathogens and indicator bacteria in pigs in different European countries from year 2002–2004: the ARBAO-II study. Acta Vet Scand 50 : 19 29.[CrossRef][PubMed]
108. Lüthje P,, Schwarz S . 2007. Molecular basis of resistance to macrolides and lincosamides among staphylococci and streptococci from various animal sources collected in the resistance monitoring program BfT-GermVet. Int J Antimicrob Agents 29 : 528 535.[CrossRef][PubMed]
109. Silva LG,, Genteluci GL,, Corrêa de Mattos M,, Glatthardt T,, Sá Figueiredo AM,, Ferreira-Carvalho BT . 2015. Group C Streptococcus dysgalactiae subsp. equisimilis in south-east Brazil: genetic diversity, resistance profile and the first report of human and equine isolates belonging to the same multilocus sequence typing lineage. J Med Microbiol 64 : 551 558.[CrossRef][PubMed]
110. Pedersen K,, Pedersen K,, Jensen H,, Finster K,, Jensen VF,, Heuer OE . 2007. Occurrence of antimicrobial resistance in bacteria from diagnostic samples from dogs. J Antimicrob Chemother 60 : 775 781.[CrossRef][PubMed]
111. Chopra I,, Roberts M . 2001. Tetracycline antibiotics: mode of action, applications, molecular biology, and epidemiology of bacterial resistance. Microbiol Mol Biol Rev 65 : 232 260.[CrossRef][PubMed]
112. Speer BS,, Shoemaker NB,, Salyers AA . 1992. Bacterial resistance to tetracycline: mechanisms, transfer, and clinical significance. Clin Microbiol Rev 5 : 387 399.[CrossRef][PubMed]
113. Roberts MC . 1996. Tetracycline resistance determinants: mechanisms of action, regulation of expression, genetic mobility, and distribution. FEMS Microbiol Rev 19 : 1 24.[CrossRef]
114. Kazimierczak KA,, Rincon MT,, Patterson AJ,, Martin JC,, Young P,, Flint HJ,, Scott KP . 2008. A new tetracycline efflux gene, tet(40), is located in tandem with tet(O/32/O) in a human gut firmicute bacterium and in metagenomic library clones. Antimicrob Agents Chemother 52 : 4001 4009.[CrossRef][PubMed]
115. Moulin G,, Cavalié P,, Pellanne I,, Chevance A,, Laval A,, Millemann Y,, Colin P,, Chauvin C, Antimicrobial Resistance ad hoc Group of the French Food Safety Agency . 2008. A comparison of antimicrobial usage in human and veterinary medicine in France from 1999 to 2005. J Antimicrob Chemother 62 : 617 625.[CrossRef][PubMed]
116. Report UOH . 2015. Joint report on human and animal antibiotic use, sales and resistance, 2013. https://www.gov.uk/government/collections/antimicrobial-resistance-amr-information-and-resources.
117. FDA . 2014. 2012 Summary report on antimicrobials sold or distributed for use in food-producing animals. FDA, Washington, DC. http://www.fda.gov/downloads/ForIndustry/UserFees/AnimalDrugUserFeeActADUFA/UCM416983.pdf.
118. van den Bogaard AE,, Bruinsma N,, Stobberingh EE . 2000. The effect of banning avoparcin on VRE carriage in The Netherlands. J Antimicrob Chemother 46 : 146 148.[CrossRef][PubMed]
119. Da Cunha V,, Davies MR,, Douarre PE,, Rosinski-Chupin I,, Margarit I,, Spinali S,, Perkins T,, Lechat P,, Dmytruk N,, Sauvage E,, Ma L,, Romi B,, Tichit M,, Lopez-Sanchez MJ,, Descorps-Declere S,, Souche E,, Buchrieser C,, Trieu-Cuot P,, Moszer I,, Clermont D,, Maione D,, Bouchier C,, McMillan DJ,, Parkhill J,, Telford JL,, Dougan G,, Walker MJ,, Holden MTG,, Poyart C,, Glaser P,, Glaser P, DEVANI Consortium . 2014. Streptococcus agalactiae clones infecting humans were selected and fixed through the extensive use of tetracycline. Nat Commun 5 : 4544.[CrossRef][PubMed]
120. Roberts MC . 2005. Update on acquired tetracycline resistance genes. FEMS Microbiol Lett 245 : 195 203.[CrossRef][PubMed]
121. Roberts MC,, Schwarz S . 2016. Tetracycline and phenicol resistance genes and mechanisms: importance for agriculture, the environment, and humans. J Environ Qual 45 : 576 592.[CrossRef][PubMed]
122. Khan SA,, Novick RP . 1983. Complete nucleotide sequence of pT181, a tetracycline-resistance plasmid from Staphylococcus aureus. Plasmid 10 : 251 259.[CrossRef]
123. Burdett V,, Inamine J,, Rajagopalan S . 1982. Heterogeneity of tetracycline resistance determinants in Streptococcus. J Bacteriol 149 : 995 1004.[PubMed]
124. Hartley DL,, Jones KR,, Tobian JA,, LeBlanc DJ,, Macrina FL . 1984. Disseminated tetracycline resistance in oral streptococci: implication of a conjugative transposon. Infect Immun 45 : 13 17.[PubMed]
125. Courvalin P,, Carlier C . 1987. Tn 1545: a conjugative shuttle transposon. Mol Gen Genet 206 : 259 264.[CrossRef][PubMed]
126. Clewell DB,, Flannagan SE,, Jaworski DD,, Clewell DB . 1995. Unconstrained bacterial promiscuity: the Tn 916-Tn 1545 family of conjugative transposons. Trends Microbiol 3 : 229 236.[CrossRef]
127. Rice LB . 1998. Tn 916 family conjugative transposons and dissemination of antimicrobial resistance determinants. Antimicrob Agents Chemother 42 : 1871 1877.[PubMed]
128. Sougakoff W,, Papadopoulou B,, Nordmann P,, Courvalin P . 1987. Nucleotide sequence and distribution of gene tetO encoding tetracycline resistance in Campylobacter coli. FEMS Microbiol Lett 44 : 153 159.[CrossRef]
129. Charpentier E,, Gerbaud G,, Courvalin P . 1993. Characterization of a new class of tetracycline-resistance gene tet(S) in Listeria monocytogenes BM4210. Gene 131 : 27 34.[CrossRef][PubMed]
130. Fletcher HM,, Macrina FL . 1991. Molecular survey of clindamycin and tetracycline resistance determinants in Bacteroides species. Antimicrob Agents Chemother 35 : 2415 2418.[CrossRef][PubMed]
131. Clermont D,, Chesneau O,, De Cespédès G,, Horaud T . 1997. New tetracycline resistance determinants coding for ribosomal protection in streptococci and nucleotide sequence of tet(T) isolated from Streptococcus pyogenes A498. Antimicrob Agents Chemother 41 : 112 116.[PubMed]
132. Barbosa TM,, Scott KP,, Flint HJ . 1999. Evidence for recent intergeneric transfer of a new tetracycline resistance gene, tet(W), isolated from Butyrivibrio fibrisolvens, and the occurrence of tet(O) in ruminal bacteria. Environ Microbiol 1 : 53 64.[CrossRef][PubMed]
133. Bengtsson B,, Unnerstad HE,, Ekman T,, Artursson K,, Nilsson-Ost M,, Waller KP . 2009. Antimicrobial susceptibility of udder pathogens from cases of acute clinical mastitis in dairy cows. Vet Microbiol 136 : 142 149.[CrossRef][PubMed]
134. Guérin-Faublée V,, Tardy F,, Bouveron C,, Carret G . 2002. Antimicrobial susceptibility of Streptococcus species isolated from clinical mastitis in dairy cows. Int J Antimicrob Agents 19 : 219 226.[CrossRef][PubMed]
135. Botrel MA,, Haenni M,, Morignat E,, Sulpice P,, Madec JY,, Calavas D . 2010. Distribution and antimicrobial resistance of clinical and subclinical mastitis pathogens in dairy cows in Rhône-Alpes, France. Foodborne Pathog Dis 7 : 479 487.[CrossRef]
136. Rossitto PV,, Ruiz L,, Kikuchi Y,, Glenn K,, Luiz K,, Watts JL,, Cullor JS . 2002. Antibiotic susceptibility patterns for environmental streptococci isolated from bovine mastitis in central California dairies. J Dairy Sci 85 : 132 138.[CrossRef]
137. Brown MB,, Roberts MC . 1991. Tetracycline resistance determinants in streptococcal species isolated from the bovine mammary gland. Vet Microbiol 29 : 173 180.[CrossRef]
138. Lollai SA,, Ziccheddu M,, Duprè I,, Piras D . 2016. Characterization of resistance to tetracyclines and aminoglycosides of sheep mastitis pathogens: study of the effect of gene content on resistance. J Appl Microbiol 121 : 941 951.[CrossRef][PubMed]
139. Wisselink HJ,, Veldman KT,, Van den Eede C,, Salmon SA,, Mevius DJ . 2006. Quantitative susceptibility of Streptococcus suis strains isolated from diseased pigs in seven European countries to antimicrobial agents licensed in veterinary medicine. Vet Microbiol 113 : 73 82.[CrossRef][PubMed]
140. Princivalli MS,, Palmieri C,, Magi G,, Vignaroli C,, Manzin A,, Camporese A,, Barocci S,, Magistrali C,, Facinelli B . 2009. Genetic diversity of Streptococcus suis clinical isolates from pigs and humans in Italy (2003–2007). Euro Surveill 14 : pii=19310. http://www.eurosurveillance.org/content/10.2807/ese.14.33.19310-en.[CrossRef][PubMed]
141. Kataoka Y,, Yoshida T,, Sawada T . 2000. A 10-year survey of antimicrobial susceptibility of Streptococcus suis isolates from swine in Japan. J Vet Med Sci 62 : 1053 1057.[CrossRef][PubMed]
142. Zhang C,, Ning Y,, Zhang Z,, Song L,, Qiu H,, Gao H . 2008. In vitro antimicrobial susceptibility of Streptococcus suis strains isolated from clinically healthy sows in China. Vet Microbiol 131 : 386 392.[CrossRef][PubMed]
143. Vela AI,, Moreno MA,, Cebolla JA,, González S,, Latre MV,, Domínguez L,, Fernández-Garayzábal JF . 2005. Antimicrobial susceptibility of clinical strains of Streptococcus suis isolated from pigs in Spain. Vet Microbiol 105 : 143 147.[CrossRef][PubMed]
144. Soares TC,, Paes AC,, Megid J,, Ribolla PE,, Paduan KS,, Gottschalk M . 2014. Antimicrobial susceptibility of Streptococcus suis isolated from clinically healthy swine in Brazil. Can J Vet Res 78 : 145 149.[PubMed]
145. Manzin A,, Palmieri C,, Serra C,, Saddi B,, Princivalli MS,, Loi G,, Angioni G,, Tiddia F,, Varaldo PE,, Facinelli B . 2008. Streptococcus suis meningitis without history of animal contact, Italy. Emerg Infect Dis 14 : 1946 1948.[CrossRef][PubMed]
146. Chen L,, Song Y,, Wei Z,, He H,, Zhang A,, Jin M . 2013. Antimicrobial susceptibility, tetracycline and erythromycin resistance genes, and multilocus sequence typing of Streptococcus suis isolates from diseased pigs in China. J Vet Med Sci 75 : 583 587.[CrossRef][PubMed]
147. Chander Y,, Oliveira SR,, Goyal SM . 2011. Identification of the tet(B) resistance gene in Streptococcus suis. Vet J 189 : 359 360.[CrossRef][PubMed]
148. Haenni M,, Hourquet C,, Saras E,, Madec JY . 2015. Genetic determinants of antimicrobial resistance in Streptococcus canis in France. J Glob Antimicrob Resist 3 : 142 143.[CrossRef][PubMed]
149. Tsuyuki Y,, Kurita G,, Murata Y,, Goto M,, Takahashi T . 2017. Identification of group G streptococci isolates from companion animals in Japan and their antimicrobial resistance. Jpn J Infect Dis 70 : 394 398.[CrossRef][PubMed]
150. Moyaert H,, De Graef EM,, Haesebrouck F,, Decostere A . 2006. Acquired antimicrobial resistance in the intestinal microbiota of diverse cat populations. Res Vet Sci 81 : 1 7.[CrossRef][PubMed]
151. Pérez-Trallero E,, Fernández-Mazarrasa C,, García-Rey C,, Bouza E,, Aguilar L,, García-de-Lomas J,, Baquero F, Spanish Surveillance Group for Respiratory Pathogens . 2001. Antimicrobial susceptibilities of 1,684 Streptococcus pneumoniae and 2,039 Streptococcus pyogenes isolates and their ecological relationships: results of a 1-year (1998–1999) multicenter surveillance study in Spain. Antimicrob Agents Chemother 45 : 3334 3340.[CrossRef][PubMed]
152. Filipe SR,, Tomasz A . 2000. Inhibition of the expression of penicillin resistance in Streptococcus pneumoniae by inactivation of cell wall muropeptide branching genes. Proc Natl Acad Sci USA 97 : 4891 4896.[CrossRef][PubMed]
153. Guenzi E,, Gasc AM,, Sicard MA,, Hakenbeck R . 1994. A two-component signal-transducing system is involved in competence and penicillin susceptibility in laboratory mutants of Streptococcus pneumoniae. Mol Microbiol 12 : 505 515.[CrossRef][PubMed]
154. Crisóstomo MI,, Vollmer W,, Kharat AS,, Inhülsen S,, Gehre F,, Buckenmaier S,, Tomasz A . 2006. Attenuation of penicillin resistance in a peptidoglycan O-acetyl transferase mutant of Streptococcus pneumoniae. Mol Microbiol 61 : 1497 1509.[CrossRef][PubMed]
155. Dias R,, Félix D,, Caniça M,, Trombe MC . 2009. The highly conserved serine threonine kinase StkP of Streptococcus pneumoniae contributes to penicillin susceptibility independently from genes encoding penicillin-binding proteins. BMC Microbiol 9 : 121.[CrossRef][PubMed]
156. Soualhine H,, Brochu V,, Ménard F,, Papadopoulou B,, Weiss K,, Bergeron MG,, Légaré D,, Drummelsmith J,, Ouellette M . 2005. A proteomic analysis of penicillin resistance in Streptococcus pneumoniae reveals a novel role for PstS, a subunit of the phosphate ABC transporter. Mol Microbiol 58 : 1430 1440.[CrossRef][PubMed]
157. Fani F,, Leprohon P,, Légaré D,, Ouellette M . 2011. Whole genome sequencing of penicillin-resistant Streptococcus pneumoniae reveals mutations in penicillin-binding proteins and in a putative iron permease. Genome Biol 12 : R115.[CrossRef][PubMed]
158. Goldstein FW . 1999. Penicillin-resistant Streptococcus pneumoniae: selection by both beta-lactam and non-beta-lactam antibiotics. J Antimicrob Chemother 44 : 141 144.[CrossRef][PubMed]
159. Anonymous . 2008. Recent trends in antimicrobial resistance among Streptococcus pneumoniae and Staphylococcus aureus isolates: the French experience. Euro Surveill 13 : pii=19035. http://eurosurveillance.org/content/10.2807/ese.13.46.19035-en.
160. Dagan R,, Klugman KP . 2008. Impact of conjugate pneumococcal vaccines on antibiotic resistance. Lancet Infect Dis 8 : 785 795.[CrossRef]
161. Kimura K,, Suzuki S,, Wachino J,, Kurokawa H,, Yamane K,, Shibata N,, Nagano N,, Kato H,, Shibayama K,, Arakawa Y . 2008. First molecular characterization of group B streptococci with reduced penicillin susceptibility. Antimicrob Agents Chemother 52 : 2890 2897.[CrossRef][PubMed]
162. Nagano N,, Nagano Y,, Kimura K,, Tamai K,, Yanagisawa H,, Arakawa Y . 2008. Genetic heterogeneity in pbp genes among clinically isolated group B streptococci with reduced penicillin susceptibility. Antimicrob Agents Chemother 52 : 4258 4267.[CrossRef][PubMed]
163. Kimura K,, Nagano N,, Arakawa Y . 2015. Classification of group B streptococci with reduced β-lactam susceptibility (GBS-RBS) based on the amino acid substitutions in PBPs. J Antimicrob Chemother 70 : 1601 1603.
164. Cain D,, Malouin F,, Dargis M,, Harel J,, Gottschalk M . 1995. Alterations in penicillin-binding proteins in strains of Streptococcus suis possessing moderate and high levels of resistance to penicillin. FEMS Microbiol Lett 130 : 121 127.[CrossRef][PubMed]
165. Haenni M,, Galofaro L,, Ythier M,, Giddey M,, Majcherczyk P,, Moreillon P,, Madec JY . 2010. Penicillin-binding protein gene alterations in Streptococcus uberis isolates presenting decreased susceptibility to penicillin. Antimicrob Agents Chemother 54 : 1140 1145.[CrossRef][PubMed]
166. Haenni M,, Saras E,, Madec JY . 2010. Demonstration of a shift towards penicillin resistance in the Streptococcus uberis population. J Med Microbiol 59 : 993 995.[CrossRef][PubMed]
167. Rüegsegger F,, Ruf J,, Tschuor A,, Sigrist Y,, Rosskopf M,, Hässig M . 2014. Antimicrobial susceptibility of mastitis pathogens of dairy cows in Switzerland. Schweiz Arch Tierheilkd 156 : 483 488.[CrossRef][PubMed]
168. Kalmus P,, Aasmäe B,, Kärssin A,, Orro T,, Kask K . 2011. Udder pathogens and their resistance to antimicrobial agents in dairy cows in Estonia. Acta Vet Scand 53 : 4.[CrossRef][PubMed]
169. Bal EB,, Bayar S,, Bal MA . 2010. Antimicrobial susceptibilities of coagulase-negative staphylococci (CNS) and streptococci from bovine subclinical mastitis cases. J Microbiol 48 : 267 274.[CrossRef][PubMed]
170. Zhang C,, Zhang Z,, Song L,, Fan X,, Wen F,, Xu S,, Ning Y . 2015. Antimicrobial resistance profile and genotypic characteristics of Streptococcus suis capsular type 2 isolated from clinical carrier sows and diseased pigs in China. BioMed Res Int 2015 : 284303.[PubMed]
171. van Hout J,, Heuvelink A,, Gonggrijp M . 2016. Monitoring of antimicrobial susceptibility of Streptococcus suis in the Netherlands, 2013–2015. Vet Microbiol 194 : 5 10.[CrossRef][PubMed]
172. Moreno LZ,, da Costa BL,, Matajira CE,, Gomes VT,, Mesquita RE,, Silva AP,, Moreno AM . 2016. Molecular and antimicrobial susceptibility profiling of Streptococcus dysgalactiae isolated from swine. Diagn Microbiol Infect Dis 86 : 178 180.[CrossRef][PubMed]
173. Drlica K,, Zhao X . 1997. DNA gyrase, topoisomerase IV, and the 4-quinolones. Microbiol Mol Biol Rev 61 : 377 392.[PubMed]
174. Escudero JA,, San Millan A,, Gutierrez B,, Hidalgo L,, La Ragione RM,, AbuOun M,, Galimand M,, Ferrándiz MJ,, Domínguez L,, de la Campa AG,, Gonzalez-Zorn B . 2011. Fluoroquinolone efflux in Streptococcus suis is mediated by SatAB and not by SmrA. Antimicrob Agents Chemother 55 : 5850 5860.[CrossRef][PubMed]
175. Meunier D,, Acar JF,, Martel JL,, Kroemer S,, Vallé M . 2004. Seven years survey of susceptibility to marbofloxacin of bovine pathogenic strains from eight European countries. Int J Antimicrob Agents 24 : 268 278.[CrossRef][PubMed]
176. Kroemer S,, Galland D,, Guérin-Faublée V,, Giboin H,, Woehrlé-Fontaine F . 2012. Survey of marbofloxacin susceptibility of bacteria isolated from cattle with respiratory disease and mastitis in Europe. Vet Rec 170 : 53.[CrossRef][PubMed]
177. El Garch F,, de Jong A,, Simjee S,, Moyaert H,, Klein U,, Ludwig C,, Marion H,, Haag-Diergarten S,, Richard-Mazet A,, Thomas V,, Siegwart E . 2016. Monitoring of antimicrobial susceptibility of respiratory tract pathogens isolated from diseased cattle and pigs across Europe, 2009–2012: VetPath results. Vet Microbiol 194 : 11 22.[CrossRef][PubMed]
178. Morrissey I,, Moyaert H,, de Jong A,, El Garch F,, Klein U,, Ludwig C,, Thiry J,, Youala M . 2016. Antimicrobial susceptibility monitoring of bacterial pathogens isolated from respiratory tract infections in dogs and cats across Europe: ComPath results. Vet Microbiol 191 : 44 51.[CrossRef][PubMed]
179. Ludwig C,, de Jong A,, Moyaert H,, El Garch F,, Janes R,, Klein U,, Morrissey I,, Thiry J,, Youala M . 2016. Antimicrobial susceptibility monitoring of dermatological bacterial pathogens isolated from diseased dogs and cats across Europe (ComPath results). J Appl Microbiol 121 : 1254 1267.[CrossRef][PubMed]
180. Burrus V,, Pavlovic G,, Decaris B,, Guédon G . 2002. Conjugative transposons: the tip of the iceberg. Mol Microbiol 46 : 601 610.[CrossRef][PubMed]
181. Wozniak RA,, Waldor MK . 2010. Integrative and conjugative elements: mosaic mobile genetic elements enabling dynamic lateral gene flow. Nat Rev Microbiol 8 : 552 563.[CrossRef][PubMed]
182. Santoro F,, Vianna ME,, Roberts AP . 2014. Variation on a theme; an overview of the Tn 916/Tn 1545 family of mobile genetic elements in the oral and nasopharyngeal streptococci. Front Microbiol 5 : 535 545.[CrossRef][PubMed]
183. Roberts AP,, Mullany P . 2011. Tn 916-like genetic elements: a diverse group of modular mobile elements conferring antibiotic resistance. FEMS Microbiol Rev 35 : 856 871.[CrossRef][PubMed]
184. Ambroset C,, Coluzzi C,, Guédon G,, Devignes MD,, Loux V,, Lacroix T,, Payot S,, Leblond-Bourget N . 2016. New insights into the classification and integration specificity of Streptococcus integrative conjugative elements through extensive genome exploration. Front Microbiol 6 : 1483 1504.[CrossRef][PubMed]
185. Huang J,, Ma J,, Shang K,, Hu X,, Liang Y,, Li D,, Wu Z,, Dai L,, Chen L,, Wang L . 2016. Evolution and diversity of the antimicrobial resistance associated mobilome in Streptococcus suis: a probable mobile genetic elements reservoir for other streptococci. Front Cell Infect Microbiol 6 : 118.[CrossRef][PubMed]
186. Brenciani A,, Tiberi E,, Morici E,, Oryasin E,, Giovanetti E,, Varaldo PE . 2012. ICE Sp1116, the genetic element responsible for erm(B)-mediated, inducible resistance to erythromycin in Streptococcus pyogenes. Antimicrob Agents Chemother 56 : 6425 6429.[CrossRef][PubMed]
187. Giovanetti E,, Brenciani A,, Tiberi E,, Bacciaglia A,, Varaldo PE . 2012. ICE Sp2905, the erm(TR)- tet(O) element of Streptococcus pyogenes, is formed by two independent integrative and conjugative elements. Antimicrob Agents Chemother 56 : 591 594.[CrossRef][PubMed]
188. Mingoia M,, Morici E,, Marini E,, Brenciani A,, Giovanetti E,, Varaldo PE . 2016. Macrolide resistance gene erm(TR) and erm(TR)-carrying genetic elements in Streptococcus agalactiae: characterization of ICE SagTR7, a new composite element containing IME Sp2907. J Antimicrob Chemother 71 : 593 600.[CrossRef][PubMed]
189. Huang K,, Song Y,, Zhang Q,, Zhang A,, Jin M . 2016. Characterisation of a novel integrative and conjugative element ICESsD9 carrying erm(B) and tet(O) resistance determinants in Streptococcus suis, and the distribution of ICESsD9-like elements in clinical isolates. J Glob Antimicrob Resist 7 : 13 18.[CrossRef][PubMed]
190. Palmieri C,, Magi G,, Creti R,, Baldassarri L,, Imperi M,, Gherardi G,, Facinelli B . 2013. Interspecies mobilization of an ermT-carrying plasmid of Streptococcus dysgalactiae subsp. equisimilis by a coresident ICE of the ICE Sa2603 family. J Antimicrob Chemother 68 : 23 26.[CrossRef][PubMed]
191. Croucher NJ,, Walker D,, Romero P,, Lennard N,, Paterson GK,, Bason NC,, Mitchell AM,, Quail MA,, Andrew PW,, Parkhill J,, Bentley SD,, Mitchell TJ . 2009. Role of conjugative elements in the evolution of the multidrug-resistant pandemic clone Streptococcus pneumoniae Spain23F ST81. J Bacteriol 191 : 1480 1489.[CrossRef][PubMed]
192. Douarre PE,, Sauvage E,, Poyart C,, Glaser P . 2015. Host specificity in the diversity and transfer of lsa resistance genes in group B Streptococcus. J Antimicrob Chemother 70 : 3205 3213.[PubMed]
193. Huang K,, Zhang Q,, Song Y,, Zhang Z,, Zhang A,, Xiao J,, Jin M . 2016. Characterization of spectinomycin resistance in Streptococcus suis leads to two novel insights into drug resistance formation and dissemination mechanism. Antimicrob Agents Chemother 60 : 6390 6392.[CrossRef][PubMed]
194. Marini E,, Palmieri C,, Magi G,, Facinelli B . 2015. Recombination between Streptococcus suis ICESsu32457 and Streptococcus agalactiae ICESa2603 yields a hybrid ICE transferable to Streptococcus pyogenes. Vet Microbiol 178 : 99 104.[CrossRef][PubMed]
195. Srinivasan V,, Metcalf BJ,, Knipe KM,, Ouattara M,, McGee L,, Shewmaker PL,, Glennen A,, Nichols M,, Harris C,, Brimmage M,, Ostrowsky B,, Park CJ,, Schrag SJ,, Frace MA,, Sammons SA,, Beall B . 2014. vanG element insertions within a conserved chromosomal site conferring vancomycin resistance to Streptococcus agalactiae and Streptococcus anginosus. MBio 5 : e01386-14.[CrossRef][PubMed]
196. Meng F,, Kanai K,, Yoshikoshi K . 2009. Structural characterization of Tn 916-like element in Streptococcus parauberis serotype II strains isolated from diseased Japanese flounder. Lett Appl Microbiol 48 : 770 776.[PubMed]
197. Palmieri C,, Magi G,, Mingoia M,, Bagnarelli P,, Ripa S,, Varaldo PE,, Facinelli B . 2012. Characterization of a Streptococcus suis tet(O/W/32/O)-carrying element transferable to major streptococcal pathogens. Antimicrob Agents Chemother 56 : 4697 4702.[CrossRef][PubMed]
198. Richards VP,, Zadoks RN,, Pavinski Bitar PD,, Lefébure T,, Lang P,, Werner B,, Tikofsky L,, Moroni P,, Stanhope MJ . 2012. Genome characterization and population genetic structure of the zoonotic pathogen, Streptococcus canis. BMC Microbiol 12 : 293 309.[CrossRef][PubMed]
199. Bekele T,, Molla B . 2001. Mastitis in lactating camels ( Camelus dromedarius) in Afar Region, north-eastern Ethiopia. Berl Munch Tierarztl Wochenschr 114 : 169 172.[PubMed]
200. Evans JJ,, Pasnik DJ,, Klesius PH,, Al-Ablani S . 2006. First report of Streptococcus agalactiae and Lactococcus garvieae from a wild bottlenose dolphin ( Tursiops truncatus). J Wildl Dis 42 : 561 569.[CrossRef][PubMed]
201. Jordal S,, Glambek M,, Oppegaard O,, Kittang BR . 2015. New tricks from an old cow: infective endocarditis caused by Streptococcus dysgalactiae subsp. dysgalactiae. J Clin Microbiol 53 : 731 734.[CrossRef][PubMed]
202. Nomoto R,, Munasinghe LI,, Jin DH,, Shimahara Y,, Yasuda H,, Nakamura A,, Misawa N,, Itami T,, Yoshida T . 2004. Lancefield group C Streptococcus dysgalactiae infection responsible for fish mortalities in Japan. J Fish Dis 27 : 679 686.[CrossRef][PubMed]
203. Hilmarsdóttir I,, Valsdóttir F . 2007. Molecular typing of beta-hemolytic streptococci from two patients with lower-limb cellulitis: identical isolates from toe web and blood specimens. J Clin Microbiol 45 : 3131 3132.[CrossRef][PubMed]
204. Kawata K,, Minakami T,, Mori Y,, Katsumi M,, Kataoka Y,, Ezawa A,, Kikuchi N,, Takahashi T . 2003. rDNA sequence analyses of Streptococcus dysgalactiae subsp. equisimilis isolates from pigs. Int J Syst Evol Microbiol 53 : 1941 1946.[CrossRef][PubMed]
205. Lopardo HA,, Vidal P,, Sparo M,, Jeric P,, Centron D,, Facklam RR,, Paganini H,, Pagniez NG,, Lovgren M,, Beall B . 2005. Six-month multicenter study on invasive infections due to Streptococcus pyogenes and Streptococcus dysgalactiae subsp. equisimilis in Argentina. J Clin Microbiol 43 : 802 807.[CrossRef][PubMed]
206. Nei T,, Akutsu K,, Shima A,, Tsuboi I,, Suzuki H,, Yamamoto T,, Tanaka K,, Shinoyama A,, Kojima Y,, Washio Y,, Okawa S,, Sonobe K,, Norose Y,, Saito R . 2012. A case of streptococcal toxic shock syndrome due to group G streptococci identified as Streptococcus dysgalactiae subsp. equisimilis. J Infect Chemother 18 : 919 924.[CrossRef][PubMed]
207. Savini V,, Catavitello C,, Talia M,, Manna A,, Pompetti F,, Di Bonaventura G,, Di Giuseppe N,, Febbo F,, Balbinot A,, Di Zacomo S,, Esattore F,, D’Antonio D . 2008. Beta-lactam failure in treatment of two group G Streptococcus dysgalactiae subsp. equisimilis pharyngitis patients. J Clin Microbiol 46 : 814 816.[CrossRef][PubMed]
208. Siljander T,, Karppelin M,, Vähäkuopus S,, Syrjänen J,, Toropainen M,, Kere J,, Vuento R,, Jussila T,, Vuopio-Varkila J . 2008. Acute bacterial, nonnecrotizing cellulitis in Finland: microbiological findings. Clin Infect Dis 46 : 855 861.[CrossRef][PubMed]