1887

Chapter 39 : Nontuberculous Mycobacteria—Overview

MyBook is a cheap paperback edition of the original book and will be sold at uniform, low price.

Preview this chapter:
Zoom in
Zoomout

Nontuberculous Mycobacteria—Overview, Page 1 of 2

| /docserver/preview/fulltext/10.1128/9781555819866/9781555819859_Chap39-1.gif /docserver/preview/fulltext/10.1128/9781555819866/9781555819859_Chap39-2.gif

Abstract:

The term nontuberculous mycobacteria (NTM) generally refers to mycobacteria other than the complex and ( ). NTM are ubiquitous in the environment, including household water, natural water sources, and soil ( ). Human disease due to NTM is classified into four distinct clinical syndromes: chronic pulmonary disease, lymphadenitis, cutaneous disease, and disseminated disease. Of these, chronic pulmonary disease is the syndrome most commonly encountered clinically ( ).

Citation: Koh W. 2017. Nontuberculous Mycobacteria—Overview, p 655-661. In Schlossberg D (ed), Tuberculosis and Nontuberculous Mycobacterial Infections, Seventh Edition. ASM Press, Washington, DC. doi: 10.1128/microbiolspec.TNMI7-0024-2016
Highlighted Text: Show | Hide
Loading full text...

Full text loading...

Figures

Image of Figure 1
Figure 1

Fibrocavitary form of lung disease in a 62-year-old male patient. The patient underwent antituberculosis treatment and a right upper lobectomy at 30 years of age. Chest computed tomography shows a large cavity in the right upper lung field. Note the emphysema in both lungs.

Citation: Koh W. 2017. Nontuberculous Mycobacteria—Overview, p 655-661. In Schlossberg D (ed), Tuberculosis and Nontuberculous Mycobacterial Infections, Seventh Edition. ASM Press, Washington, DC. doi: 10.1128/microbiolspec.TNMI7-0024-2016
Permissions and Reprints Request Permissions
Download as Powerpoint
Image of Figure 2
Figure 2

Nodular bronchiectatic form of lung disease in a 63-year-old female patient. Chest computed tomography shows severe bronchiectasis in the right middle lobe and in the lingular segment of the left upper lobe. Note the multiple small nodules and tree-in-bud appearance suggesting bronchiolitis in both lungs.

Citation: Koh W. 2017. Nontuberculous Mycobacteria—Overview, p 655-661. In Schlossberg D (ed), Tuberculosis and Nontuberculous Mycobacterial Infections, Seventh Edition. ASM Press, Washington, DC. doi: 10.1128/microbiolspec.TNMI7-0024-2016
Permissions and Reprints Request Permissions
Download as Powerpoint

References

/content/book/10.1128/9781555819866.chap39
1. Griffith DE,, Aksamit T,, Brown-Elliott BA,, Catanzaro A,, Daley C,, Gordin F,, Holland SM,, Horsburgh R,, Huitt G,, Iademarco MF,, Iseman M,, Olivier K,, Ruoss S,, von Reyn CF,, Wallace RJ Jr,, Winthrop K , ATS Mycobacterial Diseases Subcommittee, American Thoracic Society, Infectious Disease Society of America . 2007. An official ATS/IDSA statement: diagnosis, treatment, and prevention of nontuberculous mycobacterial diseases. Am J Respir Crit Care Med 175 : 367416.[PubMed]
2. Falkinham JO III . 2015. Environmental sources of nontuberculous mycobacteria. Clin Chest Med 36 : 3541.[PubMed]
3. Bryant JM,, Grogono DM,, Greaves D,, Foweraker J,, Roddick I,, Inns T,, Reacher M,, Haworth CS,, Curran MD,, Harris SR,, Peacock SJ,, Parkhill J,, Floto RA . 2013. Whole-genome sequencing to identify transmission of Mycobacterium abscessus between patients with cystic fibrosis: a retrospective cohort study. Lancet 381 : 15511560.
4. Bryant JM , , et al . 2016. Emergence and spread of a human-transmissible multidrug-resistant nontuberculous mycobacterium. Science 354 : 751757.[PubMed]
5. Prevots DR,, Marras TK . 2015. Epidemiology of human pulmonary infection with nontuberculous mycobacteria: a review. Clin Chest Med 36 : 1334.[PubMed]
6. Stout JE,, Koh WJ,, Yew WW . 2016. Update on pulmonary disease due to non-tuberculous mycobacteria. Int J Infect Dis 45 : 123134.[PubMed]
7. Hoefsloot W , , et al, Nontuberculous Mycobacteria Network European Trials Group . 2013. The geographic diversity of nontuberculous mycobacteria isolated from pulmonary samples: an NTM-NET collaborative study. Eur Respir J 42 : 16041613.[PubMed]
8. van Ingen J . 2015. Microbiological diagnosis of nontuberculous mycobacterial pulmonary disease. Clin Chest Med 36 : 4354.[PubMed]
9. Wallace RJ Jr,, Iakhiaeva E,, Williams MD,, Brown-Elliott BA,, Vasireddy S,, Vasireddy R,, Lande L,, Peterson DD,, Sawicki J,, Kwait R,, Tichenor WS,, Turenne C,, Falkinham JO III . 2013. Absence of Mycobacterium intracellulare and presence of Mycobacterium chimaera in household water and biofilm samples of patients in the United States with Mycobacterium avium complex respiratory disease. J Clin Microbiol 51 : 17471752.[PubMed]
10. Koh WJ,, Jeong BH,, Jeon K,, Lee NY,, Lee KS,, Woo SY,, Shin SJ,, Kwon OJ . 2012. Clinical significance of the differentiation between Mycobacterium avium and Mycobacterium intracellulare in M avium complex lung disease. Chest 142 : 14821488.[PubMed]
11. Schweickert B,, Goldenberg O,, Richter E,, Göbel UB,, Petrich A,, Buchholz P,, Moter A . 2008. Occurrence and clinical relevance of Mycobacterium chimaera sp. nov., Germany. Emerg Infect Dis 14 : 14431446.[PubMed]
12. Boyle DP,, Zembower TR,, Reddy S,, Qi C . 2015. Comparison of clinical features, virulence, and relapse among Mycobacterium avium complex species. Am J Respir Crit Care Med 191 : 13101317.[PubMed]
13. Moon SM,, Park HY,, Jeon K,, Kim SY,, Chung MJ,, Huh HJ,, Ki CS,, Lee NY,, Shin SJ,, Koh WJ . 2015. Clinical significance of Mycobacterium kansasii isolates from respiratory specimens. PLoS One 10 : e0139621. [PubMed]
14. Floto RA,, Olivier KN,, Saiman L,, Daley CL,, Herrmann JL,, Nick JA,, Noone PG,, Bilton D,, Corris P,, Gibson RL,, Hempstead SE,, Koetz K,, Sabadosa KA,, Sermet-Gaudelus I,, Smyth AR,, van Ingen J,, Wallace RJ,, Winthrop KL,, Marshall BC,, Haworth CS , US Cystic Fibrosis Foundation and European Cystic Fibrosis Society . 2016. US Cystic Fibrosis Foundation and European Cystic Fibrosis Society consensus recommendations for the management of non-tuberculous mycobacteria in individuals with cystic fibrosis. Thorax 71(Suppl 1): i1i22.[PubMed]
15. Tortoli E,, Kohl TA,, Brown-Elliott BA,, Trovato A,, Cardoso Leao S,, Garcia MJ,, Vasireddy S,, Turenne CY,, Griffith DE,, Philley JV,, Baldan R,, Campana S,, Cariani L,, Colombo C,, Taccetti G,, Teri A,, Niemann S,, Wallace RJ Jr,, Cirillo DM . 2016. Emended description of Mycobacterium abscessus, Mycobacterium abscessus subs. abscessus, Mycobacterium abscessus subsp. bolletii and designation of Mycobacterium abscessus subsp. massiliense comb. nov. Int J Syst Evol Microbiol 66 : 44714479.[PubMed]
16. Koh WJ,, Stout JE,, Yew WW . 2014. Advances in the management of pulmonary disease due to Mycobacterium abscessus complex. Int J Tuberc Lung Dis 18 : 11411148.[PubMed]
17. Koh WJ,, Jeon K,, Lee NY,, Kim BJ,, Kook YH,, Lee SH,, Park YK,, Kim CK,, Shin SJ,, Huitt GA,, Daley CL,, Kwon OJ . 2011. Clinical significance of differentiation of Mycobacterium massiliense from Mycobacterium abscessus . Am J Respir Crit Care Med 183 : 405410.[PubMed]
18. Piersimoni C,, Scarparo C . 2009. Extrapulmonary infections associated with nontuberculous mycobacteria in immunocompetent persons. Emerg Infect Dis 15 : 13511358; quiz, 1544.[PubMed]
19. Kasperbauer S,, Huitt G . 2013. Management of extrapulmonary nontuberculous mycobacterial infections. Semin Respir Crit Care Med 34 : 143150.[PubMed]
20. Chan ED,, Iseman MD . 2013. Underlying host risk factors for nontuberculous mycobacterial lung disease. Semin Respir Crit Care Med 34 : 110123.[PubMed]
21. Honda JR,, Knight V,, Chan ED . 2015. Pathogenesis and risk factors for nontuberculous mycobacterial lung disease. Clin Chest Med 36 : 111.[PubMed]
22. Wu UI,, Holland SM . 2015. Host susceptibility to non-tuberculous mycobacterial infections. Lancet Infect Dis 15 : 968980.[PubMed]
23. Lake MA,, Ambrose LR,, Lipman MC,, Lowe DM . 2016. “Why me, why now?” Using clinical immunology and epidemiology to explain who gets nontuberculous mycobacterial infection. BMC Med 14 : 54. [PubMed]
24. Kim RD,, Greenberg DE,, Ehrmantraut ME,, Guide SV,, Ding L,, Shea Y,, Brown MR,, Chernick M,, Steagall WK,, Glasgow CG,, Lin J,, Jolley C,, Sorbara L,, Raffeld M,, Hill S,, Avila N,, Sachdev V,, Barnhart LA,, Anderson VL,, Claypool R,, Hilligoss DM,, Garofalo M,, Fitzgerald A,, Anaya-O’Brien S,, Darnell D,, DeCastro R,, Menning HM,, Ricklefs SM,, Porcella SF,, Olivier KN,, Moss J,, Holland SM . 2008. Pulmonary nontuberculous mycobacterial disease: prospective study of a distinct preexisting syndrome. Am J Respir Crit Care Med 178 : 10661074.[PubMed]
25. Kartalija M,, Ovrutsky AR,, Bryan CL,, Pott GB,, Fantuzzi G,, Thomas J,, Strand MJ,, Bai X,, Ramamoorthy P,, Rothman MS,, Nagabhushanam V,, McDermott M,, Levin AR,, Frazer-Abel A,, Giclas PC,, Korner J,, Iseman MD,, Shapiro L,, Chan ED . 2013. Patients with nontuberculous mycobacterial lung disease exhibit unique body and immune phenotypes. Am J Respir Crit Care Med 187 : 197205.[PubMed]
26. Fowler CJ,, Olivier KN,, Leung JM,, Smith CC,, Huth AG,, Root H,, Kuhns DB,, Logun C,, Zelazny A,, Frein CA,, Daub J,, Haney C,, Shelhamer JH,, Bryant CE,, Holland SM . 2013. Abnormal nasal nitric oxide production, ciliary beat frequency, and Toll-like receptor response in pulmonary nontuberculous mycobacterial disease epithelium. Am J Respir Crit Care Med 187 : 13741381.[PubMed]
27. Szymanski EP,, Leung JM,, Fowler CJ,, Haney C,, Hsu AP,, Chen F,, Duggal P,, Oler AJ,, McCormack R,, Podack E,, Drummond RA,, Lionakis MS,, Browne SK,, Prevots DR,, Knowles M,, Cutting G,, Liu X,, Devine SE,, Fraser CM,, Tettelin H,, Olivier KN,, Holland SM . 2015. Pulmonary nontuberculous mycobacterial Infection. a multisystem, multigenic disease. Am J Respir Crit Care Med 192 : 618628.[PubMed]
28. Somoskovi A,, Salfinger M . 2014. Nontuberculous mycobacteria in respiratory infections: advances in diagnosis and identification. Clin Lab Med 34 : 271295.[PubMed]
29. van Ingen J,, Kuijper EJ . 2014. Drug susceptibility testing of nontuberculous mycobacteria. Future Microbiol 9 : 10951110.[PubMed]
30. CLSI . 2011. Susceptibility Testing of Mycobacteria, Nocardiae, and Other Aerobic Actinomycetes. Approved standard, 2nd ed. CLSI document M24-A2. Clinical and Laboratory Standards Institute, Wayne, PA.
31. van Ingen J,, Boeree MJ,, van Soolingen D,, Mouton JW . 2012. Resistance mechanisms and drug susceptibility testing of nontuberculous mycobacteria. Drug Resist Updat 15 : 149161.[PubMed]
32. Brown-Elliott BA,, Nash KA,, Wallace RJ Jr . 2012. Antimicrobial susceptibility testing, drug resistance mechanisms, and therapy of infections with nontuberculous mycobacteria. Clin Microbiol Rev 25 : 545582.[PubMed]
33. Choi GE,, Shin SJ,, Won CJ,, Min KN,, Oh T,, Hahn MY,, Lee K,, Lee SH,, Daley CL,, Kim S,, Jeong BH,, Jeon K,, Koh WJ . 2012. Macrolide treatment for Mycobacterium abscessus and Mycobacterium massiliense infection and inducible resistance. Am J Respir Crit Care Med 186 : 917925.[PubMed]
34. Philley JV,, Griffith DE . 2013. Management of nontuberculous mycobacterial (NTM) lung disease. Semin Respir Crit Care Med 34 : 135142.[PubMed]
35. van Ingen J,, Ferro BE,, Hoefsloot W,, Boeree MJ,, van Soolingen D . 2013. Drug treatment of pulmonary nontuberculous mycobacterial disease in HIV-negative patients: the evidence. Expert Rev Anti Infect Ther 11 : 10651077.[PubMed]
36. Kang YA,, Koh WJ . 2016. Antibiotic treatment for nontuberculous mycobacterial lung disease. Expert Rev Respir Med 10 : 557568.[PubMed]
37. Adjemian J,, Prevots DR,, Gallagher J,, Heap K,, Gupta R,, Griffith D . 2014. Lack of adherence to evidence-based treatment guidelines for nontuberculous mycobacterial lung disease. Ann Am Thorac Soc 11 : 916.[PubMed]

Tables

Generic image for table
Table 1

Classification of NTM commonly causing human disease

Citation: Koh W. 2017. Nontuberculous Mycobacteria—Overview, p 655-661. In Schlossberg D (ed), Tuberculosis and Nontuberculous Mycobacterial Infections, Seventh Edition. ASM Press, Washington, DC. doi: 10.1128/microbiolspec.TNMI7-0024-2016
Generic image for table
Table 2

Pulmonary and extrapulmonary disease caused by NTM

Citation: Koh W. 2017. Nontuberculous Mycobacteria—Overview, p 655-661. In Schlossberg D (ed), Tuberculosis and Nontuberculous Mycobacterial Infections, Seventh Edition. ASM Press, Washington, DC. doi: 10.1128/microbiolspec.TNMI7-0024-2016
Generic image for table
Table 3

Diagnostic criteria of NTM lung disease

Citation: Koh W. 2017. Nontuberculous Mycobacteria—Overview, p 655-661. In Schlossberg D (ed), Tuberculosis and Nontuberculous Mycobacterial Infections, Seventh Edition. ASM Press, Washington, DC. doi: 10.1128/microbiolspec.TNMI7-0024-2016

This is a required field
Please enter a valid email address
Please check the format of the address you have entered.
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error