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Chapter 5 : A 21st Century Plague

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A 21st Century Plague, Page 1 of 2

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Abstract:

Flesh and muscle melt from the bones of the sick in packed hospital wards and lonely bush kraals. Corpses stack up in morgues until those on top crush the identity from the faces underneath. Raw earth mounds scar the landscape, grave after grave, without name or number. Bereft children grieve for parents lost in their prime, for siblings scattered to the winds. The victims don’t cry out. Doctors and obituaries do not give the killer a name. Families recoil in shame. Leaders shirk responsibility. The stubborn silence heralds victory for the disease: denial cannot keep (it) at bay.

Citation: Sherman I. 2017. A 21st Century Plague, p 90-111. In The Power of Plagues, Second Edition. ASM Press, Washington, DC. doi: 10.1128/9781683670018.ch5
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Figures

Image of Figure 5.1
Figure 5.1

A sketch by the author of Lorraine aged 11, who has AIDS, comforted by her grandmother. (Based on a photograph by James Nachtwey—VIII Photo Agency and used with permission.)

Citation: Sherman I. 2017. A 21st Century Plague, p 90-111. In The Power of Plagues, Second Edition. ASM Press, Washington, DC. doi: 10.1128/9781683670018.ch5
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Image of Figure 5.2A
Figure 5.2A

A scanning electron microscope image of HIV budding from the surface of a lymphocyte. (Courtesy of CDC/C. Goldsmith/P. Feorino/ E.L. Palmer/W.R. McManus, 1989).

Citation: Sherman I. 2017. A 21st Century Plague, p 90-111. In The Power of Plagues, Second Edition. ASM Press, Washington, DC. doi: 10.1128/9781683670018.ch5
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Image of Figure 5.2B
Figure 5.2B

Appearance of HIV as seen with the transmission microscope. (Courtesy of CDC/Maureen Metcalf/Tom Hodge, 2011)

Citation: Sherman I. 2017. A 21st Century Plague, p 90-111. In The Power of Plagues, Second Edition. ASM Press, Washington, DC. doi: 10.1128/9781683670018.ch5
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Image of Figure 5.3
Figure 5.3

A diagrammatic view of the human immunodeficiency virus (HIV) when sliced in half

Citation: Sherman I. 2017. A 21st Century Plague, p 90-111. In The Power of Plagues, Second Edition. ASM Press, Washington, DC. doi: 10.1128/9781683670018.ch5
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Image of Figure 5.4
Figure 5.4

The life cycle of the retrovirus. The virus attaches to the cell, and the viral RNA is reverse-transcribed into DNA by the viral transcriptase and integrates itself (as a provirus) into the host DNA (using the integrase). There it gets transcribed into mRNAs coding for viral proteins (integrase, transcriptase, protease) and viral RNA genes. The viral proteins and the virus genomic RNA are assembled into virus progeny.

Citation: Sherman I. 2017. A 21st Century Plague, p 90-111. In The Power of Plagues, Second Edition. ASM Press, Washington, DC. doi: 10.1128/9781683670018.ch5
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Image of Figure 5.5
Figure 5.5

Clinical characteristics of an HIV infection. At 1, virus production occurs and this results in fever, fatigue, diarrhea and body aches. At 2, antibody is produced, and the number of virus particles in the blood begins to decline. At 3, the T4 lymphocytes decline. At 4, antibody levels decline dramatically, and T cell function is lost. At 5, virus particle production is re-established (Source CDC)

Citation: Sherman I. 2017. A 21st Century Plague, p 90-111. In The Power of Plagues, Second Edition. ASM Press, Washington, DC. doi: 10.1128/9781683670018.ch5
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References

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