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The New Microbiology: From Microbiomes to CRISPR

Author: Pascale Cossart1
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Affiliations: 1: Institut Pasteur, Paris, France
Content Type: Trade
Format: Paperback
Publication Year: 2018

Category: General Interest; History of Science

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Microbiology has undergone radical changes over the past few decades, ushering in an exciting new era in science. In , Pascale Cossart tells a splendid story about the revolution in microbiology, especially in bacteriology. This story has wide-ranging implications for human health and medicine, agriculture, environmental science, and our understanding of evolution. The revolution results from the powerful tools of molecular and cellular biology, genomics, and bioinformatics, which have yielded amazing discoveries, from entire genome sequences to video of bacteria invading host cells. This book is for both scientists and especially nonscientists who would like to learn more about the extraordinary world of bacteria.

Dr. Cossart's overview of the field of microbiology research, from infectious disease history to the ongoing scientific revolution resulting from CRISPR technologies, is presented in four parts.

  • introduces the world of bacteria and some recent discoveries about how they live, such as the role of regulatory RNAs including riboswitches, the CRISPR defense system, and resistance to antibiotics.
  • helps us see the new paradigm by which scientists view bacteria as highly social creatures that communicate in many ways, for example in the assemblies that reside in our intestine or in the environment.
  • reviews some of history’s worst epidemics and describes current and emerging infectious diseases, the organisms that cause them, and how they produce an infection.
  • introduces us to molecules derived from microbes that scientists have harnessed in the service of research and medicine, including the CRISPR/Cas9 genome-editing technology.

takes us on a journey through a remarkable revolution in science that is occurring here and now.

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