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Chapter 13 : The Multiple Strategies of Pathogenic Bacteria

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Abstract:

Since the 1980s, pathogenic bacteria have been studied by a combination of novel approaches that show that they possess an incredible arsenal of infection strategies. After Louis Pasteur and Robert Koch, the study of bacterial pathogens consisted of isolating and classifying them, describing the infection by identifying which organs or tissues were infected, purifying and analyzing culture supernatants and their potential toxins, and then testing these in animals (mice or guinea pigs) or in cell cultures. Since those days, a wide array of new technologies has been developed, leading to a new era in infection biology.

Citation: Cossart P. 2018. The Multiple Strategies of Pathogenic Bacteria, p 103-110. In The New Microbiology: From Microbiomes to CRISPR. ASM Press, Washington, DC. doi: 10.1128/9781683670117.ch13
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Figures

Image of Figure 17.
Figure 17.

bacteria inside of a vacuole formed after entering human cells. Some bacteria are in the process of dividing.

Citation: Cossart P. 2018. The Multiple Strategies of Pathogenic Bacteria, p 103-110. In The New Microbiology: From Microbiomes to CRISPR. ASM Press, Washington, DC. doi: 10.1128/9781683670117.ch13
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Image of Figure 18.
Figure 18.

Cell infected with and actin comets. bacteria in mammalian cells recruit actin and polymerize it on its posterior pole. In this figure, the bacteria have been labeled with fluorescent anti- antibodies (red) and the actin (green) was detected with a specific marker (fluorescein isothiocyanate phalloidin). The nuclei of infected cells are labeled with DAPI (blue).

Citation: Cossart P. 2018. The Multiple Strategies of Pathogenic Bacteria, p 103-110. In The New Microbiology: From Microbiomes to CRISPR. ASM Press, Washington, DC. doi: 10.1128/9781683670117.ch13
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Download as Powerpoint

References

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