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ASM presents the latest molecular studies of virulence, colonization, gene regulation, and the O1 antigen. Gives an in-depth and analytical approach to the epidemiology of cholera that includes outbreak investigations, case-control studies, and surveillance functions. Describes the molecular approach to epidemiologic problems and questions. Tracks the global spread of cholera by genetically defining individual strains. Addresses possible intervention and prevention strategies, including the latest vaccines, and their public health relevance.

Electronic only, 478 pages, illustrations, index.

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Based on the author’s experiences teaching virology for more than 35 years, Virology: Molecular Biology and Pathogenesis enables readers to develop a deep understanding of fundamental virology by emphasizing principles and discussing viruses in the context of virus families. Moreover, individual virus families are examined within the context of the Baltimore classification system, a key unifying theme that allows readers to assume basic facts about the replication strategy of a virus based on the nature of its genome.

The first chapter provides an historical overview, followed by a chapter introducing the principles of animal virus classification and the Baltimore classification system. The next chapter explores the various modes of virus infection and disease. Chapter 4 then considers host defenses against microorganisms and viral countermeasures to subvert those host defenses.

Armed with a solid foundation in basic principles, readers move on to eighteen subsequent chapters, each one dedicated to a particular virus family. These chapters detail the organization of the viral genome and its pattern of expression, with additional discussions covering viral structure, entry, assembly, release, and associated medical issues.

The flow of chapters in Virology constitutes a continuous narrative in which key principles are regularly reintroduced to show how they apply in different contexts. This emphasis on principles coupled with the text’s clear, straightforward writing style enables upper-level undergraduate and graduate students as well as professionals to grasp core principles of virology with ease.

Key Features

• Organization by virus family within the context of the Baltimore classification system provides a strategic framework for mastering the principles of virology
• Provides a uniform organization and logical flow of chapters as well as a consistent, accessible writing style
• Highlight boxes review fundamental molecular and cellular biology, introduce pioneers in the field of virology, and address serious public policy issues
• Key unanswered and thought-provoking scientific questions encourage critical thinking
• Examples show how virology has played a role in crucial public policy decisions

For more on the book and information on requesting an examination copy please visit http://www.asmscience.org/instructors

Hardcover, 750 pages, full-color illustrations, index.

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Interested in all things virology? Engage with Leonard C. Norkin on Facebook and read his virology anecdotes.

Bacterial diseases remain a critical issue in public health despite the advent of antibiotics, and the problem presents a rich field for genetic and molecular biology applications. The fourth edition of Virulence Mechanisms of Bacterial Pathogens presents entirely new material on this issue in a ground-breaking overview of the latest knowledge. Internationally recognized authorities explain the wide variety of mechanisms used by bacterial pathogens to cause disease, and then summarize proven strategies for overcoming bacterial virulence mechanisms.

Organized into six accessible sections, this unique volume broadly reviews the pathogenesis of bacterial diseases and mechanisms of host-pathogen interactions for non-specialists and advanced students in the fields of bacteriology and immunology. Beginning with a section on virulence genes, the book continues with sections on pathogenic microbial communities; bacterial attachment, invasion, and colonization; bacterial effects on host cells; and resistance to pathogens. The last section contains a concluding perspective on the state and future of studies on bacterial pathogenicity.

The study of bacterial pathogenicity is now one of the most popular subjects in microbiology. This volume provides an essential source of the latest information on the mechanisms of bacterial pathogens and also serves as a textbook for graduate courses on bacterial pathogenesis. The contents will be vital to specialists in bacterial pathogenicity, such as molecular biologists, physician scientists, dental scientists, veterinarians, molecular biologists, industry researchers, and technicians.

Out of Print, hardcover, 349 pages, full-color insert, illustrations, index.

Viral Studies conducted in the 1950s contributed tremendously to the scientific understanding of molecular mechanisms present in living organisms. Viruses and the Evolution of Life is an intriguing presentation of the virus-host relationship, as revealed through an examination of host evolution. This new volume avails the informed reader of a new perspective on the evolution of life while targeting the expert reader with discussion of specific scientific literature.

While it is generally accepted among evolutionary biologists that viruses are not self-sustaining and therefore cannot be alive, their impact on life is dramatic. Starting with prebiotic precursors of life, the book features an engaging discussion of various life forms and how each group has been affected by viruses. The author develops the concept of and distinction between acute and persisting viruses, an area of study that has heretofore largely been ignored. The relationship between the familiar disease-causing viruses and those viruses from which they emerge is also clarified.

Electronic Only, 395 pages, illustrations, index.