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EcoSal Plus

image of EcoSal Plus
eISSN: 2324-6200

Cover image: Diagram of closed circular DNA. (Courtesy of N. Patrick Higgins and Alexander V. Vologodskii.)

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EcoSal Plus Contents

[+] [–] Domain 1

Historical Perspectives

Editor: James B. Kaper
Escherich and
and the French School of Molecular Biology
and the Emergence of Molecular Biology
The Legacy of 20th Century Phage Research
and 2000: the View From Here

[+] [–] Domain 2 Cell Architecture and Growth

Editor: James M. Slauch
Fimbriae: Classification and Biochemistry
Regulation of Fimbrial Expression
Structure and Assembly of Capsules
Outer Membrane Vesicles
The Nucleoid: an Overview
Modulation of Chemical Composition and Other Parameters of the Cell at Different Exponential Growth Rates

[+] [–] Domain 3


Editor: Valley Stewart

Introduction and Perspectives

Energy Generation/Redox Control

The Aerobic and Anaerobic Respiratory Chain of and : Enzymes and Energetics
ATP Synthesis by Oxidative Phosphorylation
NADH as Donor
Respiration of Nitrate and Nitrite
Succinate as Donor; Fumarate as Acceptor
Oxygen as Acceptor
- and -Oxide Reductases

Solute and Ion Transport

Solute and Ion Transport: Outer Membrane Pores and Receptors
Bacterial Ion Channels
Ammonia Transport
Binding Protein-Dependent Uptake of Maltose into Cells via an ATP-Binding Cassette Transporter
Copper Homeostasis in and Other
Magnesium Transport and Magnesium Homeostasis
Transition Metal Homeostasis

Pathways to Central Metabolism: Catabolism

Hexose/Pentose and Hexitol/Pentitol Metabolism
Catabolism of Hexuronides, Hexuronates, Aldonates, and Aldarates
Glycerol and Methylglyoxal Metabolism
Two-Carbon Compounds and Fatty Acids as Carbon Sources
C-Dicarboxylate Degradation in Aerobic and Anaerobic Growth
Molecular Basis for Bacterial Growth on Citrate or Malonate
Catabolism of Amino Acids and Related Compounds

Central Metabolism

Glycolysis and Flux Control
Tricarboxylic Acid Cycle and Glyoxylate Bypass
Fermentative Pyruvate and Acetyl-Coenzyme A Metabolism
Anaerobic Formate and Hydrogen Metabolism


Amino Acid Metabolism and Fluxes
Selenocysteine Lyase
Selenophosphate Synthetase
Regulation of Serine, Glycine, and One-Carbon Biosynthesis
Biosynthesis of Glutamate, Aspartate, Asparagine, -Alanine, and -Alanine
Biosynthesis of Proline
Biosynthesis and Regulation of the Branched-Chain Amino Acids†
Regulation of Glutamine Synthetase Activity
Biosynthesis of the Aromatic Amino Acids
Biosynthesis of Histidine
Biosynthesis of Arginine and Polyamines
Biosynthesis of Cysteine
Nucleotides, Nucleosides, and Nucleobases
Glycogen: Biosynthesis and Regulation
Biosynthesis of Membrane Lipids

Coenzymes, Cofactors and Prosthetic Groups

Biosynthesis of Riboflavin
Biosynthesis of Menaquinone (Vitamin K) and Ubiquinone (Coenzyme Q)
Biosynthesis of Pantothenic Acid and Coenzyme A
Biotin and Lipoic Acid: Synthesis, Attachment, and Regulation
Folate Biosynthesis, Reduction, and Polyglutamylation and the Interconversion of Folate Derivatives
Biosynthesis of Thiamin Pyrophosphate
Biosynthesis and Use of Cobalamin (B)
Biogenesis and Homeostasis of Nicotinamide Adenine Dinucleotide Cofactor
Biosynthesis of Hemes
Cytochrome Biogenesis
Biosynthesis and Insertion of the Molybdenum Cofactor
From Iron and Cysteine to Iron-Sulfur Clusters: the Biogenesis Protein Machineries

[+] [–] Domain 4

Synthesis and Processing of Macromolecules

Editor: Susan T. Lovett


How We Got to Where We Are: the Ribosome in the 21st Century
An Introduction to the Structure and Function of the Ribosome
Assembly of the 30S Ribosomal Subunit
Structural Basis for the Decoding Mechanism
Modification of the Ribosome and the Translational Machinery during Reduced Growth Due to Environmental Stress
Antibiotic Resistance Mechanisms, with an Emphasis on Those Related to the Ribosome
Aminoacyl-tRNA Synthetases in the Bacterial World
Modified Nucleosides of Ribosomal RNA
Transfer RNA Modification: Presence, Synthesis, and Function
Translation Initiation
The Tat Protein Export Pathway
Biogenesis and Membrane Targeting of Lipoproteins
Assembly of Outer Membrane β-Barrel Proteins: the Bam Complex
Type II Secretion in
Type V Secretion: the Autotransporter and Two-Partner Secretion Pathways


Initiation of DNA Replication
Replisome Dynamics during Chromosome Duplication
DNA Methylation
The DNA Exonucleases of
DNA Helicases
DNA Topoisomerases
Translesion DNA Synthesis
Stress-Induced Mutagenesis
Direct DNA Lesion Reversal and Excision Repair in
DNA Mismatch Repair
Homologous Recombination—Experimental Systems, Analysis, and Significance
Homologous Recombination—Enzymes and Pathways


Promoter Escape by RNA Polymerase
Nus Factors of
Exoribonucleases and Endoribonucleases
Messenger RNA Decay

Complex Lipids and Carbohydrates

Peptidoglycan Recycling
Undecaprenyl Phosphate Synthesis

[+] [–] Domain 5

Responding to the Environment

Editor: James M. Slauch

The Cold Shock Response
The SOS Regulatory Network
Oxidative Stress
Osmotic Stress
Envelope Stress Responses
Stationary-Phase Gene Regulation in  §

[+] [–] Domain 6

Evolution and Genomics

Editor: David A. Rasko

The Influence of Ecological Factors on the Distribution and the Genetic Structure of
Evolution and Ecology of
The Ecology and Evolution of Microbial Defense Systems in
The Origin of Mutants under Selection: Interactions of Mutation, Growth, and Selection

[+] [–] Domain 7

Genetics and Genetic Tools

Editor: James M. Slauch


The Cytology of Bacterial Conjugation

[+] [–] Domain 8


Editor: Michael S. Donnenberg

Adherence and Colonization

Adhesins of Enterotoxigenic Strains That Infect Animals
Adhesins of Diffusely Adherent and Enteroaggregative
Adhesins of Enterohemorrhagic
Adhesins of Enteropathogenic
Type 1 Fimbriae, Curli, and Antigen 43: Adhesion, Colonization, and Biofilm Formation

Toxins and Secretion Systems

The Hemolysin
Autotransporter Proteins
Cytotoxic Necrotizing Factors: Rho-Activating Toxins from
Heat-Labile Enterotoxins
Shiga Toxins: Potent Poisons, Pathogenicity Determinants, and Pharmacological Agents

Regulation of Virulence

Virulence Gene Regulation in
Virulence Gene Regulation in

Interactions with the Host

NLRs: Nucleotide-Binding Domain and Leucine-Rich-Repeat-Containing Proteins
and Enteropathogenic Interactions with Host Cells: Signaling Pathways
Cytokines in Salmonellosis
Nitric Oxide in and Infections
Modulation of Iron Availability at the Host-Pathogen Interface in Phagocytic Cells
Adaptive Immune Responses during Infection
Mucosal Immune Responses to and Infections
as an Inducer of Autoimmunity
Vaccines against Infections Caused by , , and Pathogenic
Cytokines and Sepsis
Imaging Techniques for the Study of and Infections

Extraintestinal Infections

Molecular Epidemiology of Extraintestinal Pathogenic
Epidemiology and Pathogenesis in Food-Producing Animals
Invasive Salmonellosis in Humans

[+] [–] Domain 9 Life in Communities and the Environment

Editor: David Gordon

The Life of Commensal in the Mammalian Intestine
Colonization of Abiotic Surfaces
Cell-to-Cell Signaling in and

[+] [–] Domain 10 Bioinformatics and Systems Biology

Editor: Peter D. Karp

Reconstruction and Use of Microbial Metabolic Networks: the Core Metabolic Model as an Educational Guide
The EcoCyc Database

Volumes & Issues

About EcoSal Plus

EcoSal Plus is an authoritative online reference that publishes an ever-growing body of expert reviews covering virtually all aspects of E. coli, Salmonella, and other members of the family Enterobacteriaceae and their use as model microbes for biological explorations. This serial is intended primarily to serve the needs of the research community as a comprehensive and continuously updated archive of the entire corpus of knowledge about the enteric bacterial cell.  All aspects of these organisms are covered, including physiology, metabolism, genetics, pathogenesis, ecology, genomics, systems biology, and history. These thoughtful reviews provide the integrated background needed for most microbiology investigations and are essential reading for research scientists. Features include: Articles contain links to K12 genes on the EcoCyc database site. Articles are available as downloadable PDF files. Images and tables are downloadable to PowerPoint files. For subscription information, see the Home page.

Editor in Chief: James B. Kaper, PhD

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