Nucleotides, Nucleosides, and Nucleobases
- Authors: Kaj Frank Jensen1, Gert Dandanell2, Bjarne Hove-Jensen3, and Martin WillemoËs4
- Editor: Valley Stewart5
VIEW AFFILIATIONS HIDE AFFILIATIONSAffiliations: 1: Department of Biology, University of Copenhagen, Copenhagen, Denmark; 2: Department of Biology, University of Copenhagen, Copenhagen, Denmark; 3: Department of Biology, University of Copenhagen, Copenhagen, Denmark; 4: Department of Biology, University of Copenhagen, Copenhagen, Denmark; 5: University of California, Davis, Davis, CA
Received 07 February 2008 Accepted 27 May 2008 Published 18 August 2008
- Address correspondence to Kaj Frank Jensen firstname.lastname@example.org
We review literature on the metabolism of ribo- and deoxyribonucleotides, nucleosides, and nucleobases in Escherichia coli and Salmonella,including biosynthesis, degradation, interconversion, and transport. Emphasis is placed on enzymology and regulation of the pathways, at both the level of gene expression and the control of enzyme activity. The paper begins with an overview of the reactions that form and break the N-glycosyl bond, which binds the nucleobase to the ribosyl moiety in nucleotides and nucleosides, and the enzymes involved in the interconversion of the different phosphorylated states of the nucleotides. Next, the de novo pathways for purine and pyrimidine nucleotide biosynthesis are discussed in detail.Finally, the conversion of nucleosides and nucleobases to nucleotides, i.e.,the salvage reactions, are described. The formation of deoxyribonucleotides is discussed, with emphasis on ribonucleotidereductase and pathways involved in fomation of dUMP. At the end, we discuss transport systems for nucleosides and nucleobases and also pathways for breakdown of the nucleobases.
Citation: Jensen K, Dandanell G, Hove-Jensen B, WillemoËs M. 2008. Nucleotides, Nucleosides, and Nucleobases, EcoSal Plus 2008; doi:10.1128/ecosalplus.3.6.2