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EcoSal Plus

Domain 5:

Responding to the Environment

The SOS Regulatory Network

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  • Authors: Lyle A. Simmons1, James J. Foti2, Susan E. Cohen3, and Graham C. Walker4
  • Editor: James M. Slauch5
  • VIEW AFFILIATIONS HIDE AFFILIATIONS
    Affiliations: 1: Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139; 2: Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139; 3: Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139; 4: Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139; 5: The Schoold of Molecular and Cellular Biology, University of Illinois at Urbana-Champaign, Urbana, IL
  • Received 05 February 2008 Accepted 17 April 2008 Published 25 July 2008
  • Address correspondence to Graham C. Walker gwalker@mit.edu
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  • Abstract:

    All organisms possess a diverse set of genetic programs that are used to alter cellular physiology in response to environmental cues. The gram-negative bacterium induces a gene regulatory network known as the “SOS response” following exposure to DNA damage, replication fork arrest, and a myriad of other environmental stresses. For over 50 years, E. coli has served as the paradigm for our understanding of the transcriptional and physiological changes that occur after DNA damage. In this chapter, we summarize the current view of the SOS response and discuss how this genetic circuit is regulated. In addition to examining the SOS response, we include a discussion of the SOS regulatory networks found in other bacteria to provide a broad perspective on the mechanism and diverse physiological responses that ensueto protect cells and maintain genome integrity.

  • Citation: Simmons L, Foti J, Cohen S, Walker G. 2008. The SOS Regulatory Network, EcoSal Plus 2008; doi:10.1128/ecosalplus.5.4.3

Key Concept Ranking

Mobile Genetic Elements
0.8024083
DNA Synthesis
0.5358201
DNA Damage and Repair
0.42512447
Two-Component Signal Transduction Systems
0.4215282
Type III Secretion System
0.41446638
Bacterial Proteins
0.3931652
0.8024083

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