1887

Ethical Considerations Regarding Classroom Use of Personal Genomic Information

    Authors: Lisa S. Parker1,*, Robin Grubs2
    VIEW AFFILIATIONS HIDE AFFILIATIONS
    Affiliations: 1: Department of Human Genetics and Center for Bioethics and Health Law, University of Pittsburgh, Pittsburgh, PA 15260; 2: Department of Human Genetics, University of Pittsburgh, Pittsburgh, PA 15260
    AUTHOR AND ARTICLE INFORMATION AUTHOR AND ARTICLE INFORMATION
    • Published 15 December 2014
    • *Corresponding author. Mailing address: Department of Human Genetics and Center for Bioethics and Health Law, University of Pittsburgh, 519 Barco Law Building, 3900 Forbes Ave., Pittsburgh, PA 15260. Phone: 412-648-7007. Fax: 412-648-2649. E-mail: lisap@pitt.edu.
    • ©2014 Author(s). Published by the American Society for Microbiology.
    Source: J. Microbiol. Biol. Educ. December 2014 vol. 15 no. 2 191-196. doi:10.1128/jmbe.v15i2.856
MyBook is a cheap paperback edition of the original book and will be sold at uniform, low price.
  • HTML
    60.05 Kb
  • PDF
    208.55 Kb
  • XML

    Abstract:

    Rapidly decreasing costs of genetic technologies—especially next-generation sequencing—and intensifying need for a clinical workforce trained in genomic medicine have increased interest in having students use personal genomic information to motivate and enhance genomics education. Numerous ethical issues attend classroom/pedagogical use of students’ personal genomic information, including their informed decision to participate, pressures to participate, privacy concerns, and psychosocial sequelae of learning genomic information. This paper addresses these issues, advocates explicit discussion of these issues to cultivate students’ ethical reasoning skills, suggests ways to mitigate potential harms, and recommends collection of ethically relevant data regarding pedagogical use of personal genomic information.

Key Concept Ranking

Single Nucleotide Polymorphism
0.46211627
DNA Fingerprinting
0.32456663
0.46211627

References & Citations

1. Boguski MS, Boguski RM, Berman MR2013Personal genotypes are teachable momentsGenome Med52210.1186/gm426235141253706876 http://dx.doi.org/10.1186/gm426
2. Burke A12January2012posting date.DNA sequencing is now improving faster than Moore’s Law! Forbes[Online.] http://www.forbes.com/sites/techonomy/2012/01/12/dna-sequencing-is-now-improving-faster-than-moores-law/
3. Callier SL2012Swabbing students: should universities be allowed to facilitate educational DNA testing?Am. J. Bioeth.124324010.1080/15265161.2012.656803224524753390747 http://dx.doi.org/10.1080/15265161.2012.656803
4. Daley LA, et al2013Personal DNA testing in college classrooms: perspectives of students and professorsGenet Test Mol Biomarkers644645210.1089/gtmb.2012.0404 http://dx.doi.org/10.1089/gtmb.2012.0404
5. Daly E13April2005posting dateDNA tells students they aren’t who they thoughtNew York Times[Online.] http://www.nytimes.com/2005/04/13/nyregion/13penn.html?_r=0
6. Estes R18December2012posting dateProving Native American ancestry using DNADNAeXplained[Online.] http://dna-explained.com/2012/12/18/proving-native-american-ancestry-using-dna/
7. Forrow L, Arnold R, Parker LS1993Preventive ethics: expanding the horizons of clinical ethicsJ Clin Ethics42872947803823
8. Grubs RE, Parker LS, Hamilton RJ2014Subtle psychosocial sequelae of genetic test resultsCurr. Genet. Med. Rep.[Online.] http://link.springer.com/article/10.1007%2Fs40142-014-0053-710.1007/s40142-014-0053-7 http://dx.doi.org/10.1007/s40142-014-0053-7
9. Hamilton R2012Being young, female, and BRCA positiveAm J Nurs112263110.1097/01.NAJ.0000421021.62295.3b22982855 http://dx.doi.org/10.1097/01.NAJ.0000421021.62295.3b
10. Hamilton RJ, Hurley KE2010Conditions and consequences of a BRCA mutation in young, single women of childbearing ageOncol Nurs Forum3762763410.1188/10.ONF.627-63420797954 http://dx.doi.org/10.1188/10.ONF.627-634
11. Hamilton RJ, Williams JK, Bowers BJ, Calzone K2008Life trajectories, genetic testing, and risk reduction decisions in 18–39-year-old women at risk for hereditary breast and ovarian cancerJ Genet Couns1814715410.1007/s10897-008-9200-1 http://dx.doi.org/10.1007/s10897-008-9200-1
12. Harmon A11November2007posting dateIn DNA era: new worries about prejudiceNew York Times[Online.] http://www.nytimes.com/2007/11/11/us/11dna.html?pagewanted=all
13. Haspel RL, et al2010A call to action: training pathology residents in genomics and personalized medicineAm J Clin Pathol13383283410.1309/AJCPN6Q1QKCLYKXM20472839 http://dx.doi.org/10.1309/AJCPN6Q1QKCLYKXM
14. Hayden EC15January2014posting dateIs the $1,000 genome for real?Nature[Online.] http://www.nature.com/news/is-the-1-000-genome-for-real-1.14530
15. Karczewski KJ, et al2012Interpretome: a freely available, modular, and secure personal genome interpretation enginePac Symp Biocomput2012339350
16. Kuehn BM2010Inconsistent results, inaccurate claims plague direct-to-consumer gene testsJAMA304121313131510.1001/jama.2010.132820858870 http://dx.doi.org/10.1001/jama.2010.1328
17. Ormond KE, Hudgins L, Ladd JM, Magnus DM, Greely HT, Cho MK2011Medical and graduate students’ attitudes toward personal genomicsGenet Med1340040810.1097/GIM.0b013e31820562f621270640 http://dx.doi.org/10.1097/GIM.0b013e31820562f6
18. Rogers JC, Taylor ATS2011Teaching about genetic testing issues in the undergraduate classroom: a case studyJ. Gen. Couns.20323124010.1007/s10897-011-9352-2 http://dx.doi.org/10.1007/s10897-011-9352-2
19. Salari K, Karczewski KJ, Hudgins L, Ormond KE23July2013posting dateEvidence that personal genome testing enhances student learning in a course on genomics and personalized medicinePLoS One87e68853[Online.]10.1371/journal.pone.0068853239358983720862 http://dx.doi.org/10.1371/journal.pone.0068853
20. Sanderson CS, et al2013Informed decision-making among students analyzing their personal genomes on a whole genome sequencing course: a longitudinal cohort studyGenome Med5113310.1186/gm518 http://dx.doi.org/10.1186/gm518
21. Soto-Cruz I, Legorreta-Herrera M2009Analysis of a p53 mutation associated with cancer susceptibility for biochemistry and genetic laboratory coursesBiochem Mol Biol Educ3723624210.1002/bmb.2030421567743 http://dx.doi.org/10.1002/bmb.20304
22. Taylor K13October2011posting dateBitter fight to determine who is an American Indian turns to DNA testing. Indian Country Today Medical Network[Online.] http://indiancountrytodaymedianetwork.com/2011/10/13/bitter-fight-determine-who-american-indian-turns-dna-testing-57165
23. U.S. Department of Health and Human ServicesCode of Federal Regulations. Title 45 – Public Welfare CFR 46
24. U.S. Food and Drug Administration1September2014posting date23andMe, Inc. Warning letter 2013[Online.] http://www.fda.gov/ICECI/EnforcementActions/WarningLetters/2013/ucm376296.htm
25. Walt DR, et al2011Lessons learned from the introduction of personalized genotyping into a medical school curriculumGenet Med13636610.1097/GIM.0b013e3181f872ac http://dx.doi.org/10.1097/GIM.0b013e3181f872ac
26. Weijer C, Emanuel EJ2000Protecting communities in biomedical researchScience28954821142114410.1126/science.289.5482.114210970227 http://dx.doi.org/10.1126/science.289.5482.1142
27. Werner-Lin A2008Beating the biological clock: the compressed family life cycle of young women with BRCA gene alterationsSoc Work Health Care4741643710.1080/0098138080217350919042494 http://dx.doi.org/10.1080/00981380802173509
28. Wolf SM, et al2008Managing incidental findings in human subjects research: analysis and recommendationsJ. Law Med. Ethics36221924810.1111/j.1748-720X.2008.00266.x185471912575242 http://dx.doi.org/10.1111/j.1748-720X.2008.00266.x
jmbe.v15i2.856.citations
jmbe/15/2
content/journal/jmbe/10.1128/jmbe.v15i2.856
Loading

Citations loading...

Supplemental Material

No supplementary material available for this content.

Loading

Article metrics loading...

/content/journal/jmbe/10.1128/jmbe.v15i2.856
2014-12-15
2017-09-25

Abstract:

Rapidly decreasing costs of genetic technologies—especially next-generation sequencing—and intensifying need for a clinical workforce trained in genomic medicine have increased interest in having students use personal genomic information to motivate and enhance genomics education. Numerous ethical issues attend classroom/pedagogical use of students’ personal genomic information, including their informed decision to participate, pressures to participate, privacy concerns, and psychosocial sequelae of learning genomic information. This paper addresses these issues, advocates explicit discussion of these issues to cultivate students’ ethical reasoning skills, suggests ways to mitigate potential harms, and recommends collection of ethically relevant data regarding pedagogical use of personal genomic information.

Highlighted Text: Show | Hide
Loading full text...

Full text loading...

/deliver/fulltext/jmbe/15/2/jmbe-15-191.xml.a.html?itemId=/content/journal/jmbe/10.1128/jmbe.v15i2.856&mimeType=html&fmt=ahah

This is a required field
Please enter a valid email address
Please check the format of the address you have entered.
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error