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Nucleotide Manipulatives to Illustrate the Central Dogma

    Authors: Sonja B. Yung1,*, Todd P. Primm1
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    Affiliations: 1: Department of Biological Sciences, Sam Houston State University, Huntsville, TX 77341
    AUTHOR AND ARTICLE INFORMATION AUTHOR AND ARTICLE INFORMATION
    • Supplemental materials available at http://jmbe.asm.org
    • *Corresponding author. Mailing address: Department of Biological Sciences, Sam Houston State University, 1900 Avenue I, LDB 148, Huntsville, TX 77341. Phone: 936-294-3271. E-mail: sby003@shsu.edu.
    • ©2015 Author(s). Published by the American Society for Microbiology.
    Source: J. Microbiol. Biol. Educ. December 2015 vol. 16 no. 2 274-277. doi:10.1128/jmbe.v16i2.901
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    Abstract:

    The central dogma is a core concept that is critical for introductory biology and microbiology students to master. However, students often struggle to conceptualize the processes involved, and fail to move beyond simply memorizing the basic facts. To encourage critical thinking, we have designed a set of magnetic nucleotide manipulatives that allow students to model DNA structure, along with the processes of replication, transcription, and translation.

References & Citations

1. Boomer S, Latham K2011Manipulatives-based laboratory for majors biology – a hands-on approach to understanding respiration and photosynthesisJ Microbiol Biol Educ12212713410.1128/jmbe.v12i2.245236537563577247 http://dx.doi.org/10.1128/jmbe.v12i2.245
2. Hentzen A2000Manipulatives help to teach molecular diagnostic conceptsMol Diag Educ319513517
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/content/journal/jmbe/10.1128/jmbe.v16i2.901
2015-12-01
2017-08-17

Abstract:

The central dogma is a core concept that is critical for introductory biology and microbiology students to master. However, students often struggle to conceptualize the processes involved, and fail to move beyond simply memorizing the basic facts. To encourage critical thinking, we have designed a set of magnetic nucleotide manipulatives that allow students to model DNA structure, along with the processes of replication, transcription, and translation.

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Figures

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FIGURE 1

Example of nucleotide triphosphate (dTTP) and pyrophosphate.

Source: J. Microbiol. Biol. Educ. December 2015 vol. 16 no. 2 274-277. doi:10.1128/jmbe.v16i2.901
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FIGURE 2

dsDNA structure.

Source: J. Microbiol. Biol. Educ. December 2015 vol. 16 no. 2 274-277. doi:10.1128/jmbe.v16i2.901
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FIGURE 3

DNA replication.

Source: J. Microbiol. Biol. Educ. December 2015 vol. 16 no. 2 274-277. doi:10.1128/jmbe.v16i2.901
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FIGURE 4

Transcription.

Source: J. Microbiol. Biol. Educ. December 2015 vol. 16 no. 2 274-277. doi:10.1128/jmbe.v16i2.901
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FIGURE 5

Translation, showing mRNA:tRNA codon/anticodon matches, and then peptide bond formation as it occurs on the ribosome.

Source: J. Microbiol. Biol. Educ. December 2015 vol. 16 no. 2 274-277. doi:10.1128/jmbe.v16i2.901
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