It is hard to discover new antibiotics. The field of antiinfectives has a unique history which does not follow the expected path of knowledge leading to cures. We now know incomparably more than we did during the golden era of antibiotic discovery from the 1940s to 1960s, but seem no longer capab...More...
Recent studies of host-associated microbial communities highlight how little we know about the roles played by microbial residents during infections. Historically, research on pathogenesis neglected the roles of resident communities within which most pathogens function. Indeed, many researchers e...More...
Emergent multidrug-resistant (MDR) and extensively drug-resistant (XDR) strains of Mycobacterium tuberculosis are causing a crisis in efforts to treat patients with tuberculosis (TB). Such infections are highly lethal and on the rise, particularly in developing nati...More...