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Antimicrobial Resistance in spp. and spp.

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  • Authors: Agnese Lupo1, Marisa Haenni2, Jean-Yves Madec3
  • Editors: Frank Møller Aarestrup4, Stefan Schwarz5, Jianzhong Shen6, Lina Cavaco7
  • VIEW AFFILIATIONS HIDE AFFILIATIONS
    Affiliations: 1: Université de Lyon–ANSES, Unité Antibiorésistance et Virulence Bactériennes, Lyon, France; 2: Université de Lyon–ANSES, Unité Antibiorésistance et Virulence Bactériennes, Lyon, France; 3: Université de Lyon–ANSES, Unité Antibiorésistance et Virulence Bactériennes, Lyon, France; 4: Technical University of Denmark, Lyngby, Denmark; 5: Freie Universität Berlin, Berlin, Germany; 6: China Agricultural University, Beijing, China; 7: Statens Serum Institute, Copenhagen, Denmark
  • Source: microbiolspec May 2018 vol. 6 no. 3 doi:10.1128/microbiolspec.ARBA-0007-2017
  • Received 17 October 2017 Accepted 07 February 2018 Published 03 May 2018
  • Agnese Lupo, agnese.lupo@anses.fr
image of Antimicrobial Resistance in <span class="jp-italic">Acinetobacter</span> spp. and <span class="jp-italic">Pseudomonas</span> spp.
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  • Abstract:

    The nonfermenting bacteria belonging to spp. and spp. are capable of colonizing both humans and animals and can also be opportunistic pathogens. More specifically, the species and have been recurrently reported as multidrug-resistant and even pandrug-resistant in clinical isolates. Both species were categorized among the ESKAPE pathogens, ESKAPE standing for , , , , , and species. These six pathogens are the major cause of nosocomial infections in the United States and are a threat all over the world because of their capacity to become increasingly resistant to all available antibiotics. and are both intrinsically resistant to many antibiotics due to complementary mechanisms, the main ones being the low permeability of their outer membrane, the production of the AmpC beta-lactamase, and the production of several efflux systems belonging to the resistance-nodulation-cell division family. In addition, they are both capable of acquiring multiple resistance determinants, such as beta-lactamases or carbapenemases. Even if such enzymes have rarely been identified in bacteria of animal origin, they may sooner or later spread to this reservoir. The goal of this article is to give an overview of the resistance phenotypes described in these pathogens and to provide a comprehensive analysis of all data that have been reported on spp. and spp. from animal hosts.

  • Citation: Lupo A, Haenni M, Madec J. 2018. Antimicrobial Resistance in spp. and spp.. Microbiol Spectrum 6(3):ARBA-0007-2017. doi:10.1128/microbiolspec.ARBA-0007-2017.

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/content/journal/microbiolspec/10.1128/microbiolspec.ARBA-0007-2017
2018-05-03
2018-05-23

Abstract:

The nonfermenting bacteria belonging to spp. and spp. are capable of colonizing both humans and animals and can also be opportunistic pathogens. More specifically, the species and have been recurrently reported as multidrug-resistant and even pandrug-resistant in clinical isolates. Both species were categorized among the ESKAPE pathogens, ESKAPE standing for , , , , , and species. These six pathogens are the major cause of nosocomial infections in the United States and are a threat all over the world because of their capacity to become increasingly resistant to all available antibiotics. and are both intrinsically resistant to many antibiotics due to complementary mechanisms, the main ones being the low permeability of their outer membrane, the production of the AmpC beta-lactamase, and the production of several efflux systems belonging to the resistance-nodulation-cell division family. In addition, they are both capable of acquiring multiple resistance determinants, such as beta-lactamases or carbapenemases. Even if such enzymes have rarely been identified in bacteria of animal origin, they may sooner or later spread to this reservoir. The goal of this article is to give an overview of the resistance phenotypes described in these pathogens and to provide a comprehensive analysis of all data that have been reported on spp. and spp. from animal hosts.

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FIGURE 1

Overview of spp., sequence types, and acquired carbapenem resistance mechanisms.

Source: microbiolspec May 2018 vol. 6 no. 3 doi:10.1128/microbiolspec.ARBA-0007-2017
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TABLE 1

Antimicrobial susceptibility to fluoroquinolones and aminoglycosides in isolates of animal origin

Source: microbiolspec May 2018 vol. 6 no. 3 doi:10.1128/microbiolspec.ARBA-0007-2017

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