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Mechanisms of Bacterial Resistance to Antimicrobial Agents

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  • Authors: Engeline van Duijkeren1, Anne-Kathrin Schink2, Marilyn C. Roberts3, Yang Wang4, Stefan Schwarz5
  • Editors: Frank Møller Aarestrup6, Stefan Schwarz7, Jianzhong Shen8, Lina Cavaco9
  • VIEW AFFILIATIONS HIDE AFFILIATIONS
    Affiliations: 1: Center for Infectious Disease Control, National Institute for Public Health and the Environment (RIVM), 3720 BA Bilthoven, The Netherlands; 2: Institute of Microbiology and Epizootics, Centre of Infection Medicine, Department of Veterinary Medicine, Freie Universität Berlin, 14163 Berlin, Germany; 3: Department of Environmental and Occupational Health Sciences, University of Washington, Seattle, WA 98195-7234; 4: Beijing Advanced Innovation Center for Food Nutrition and Human Health, College of Veterinary Medicine, China Agricultural University, Beijing, 100193, China; 5: Institute of Microbiology and Epizootics, Centre of Infection Medicine, Department of Veterinary Medicine, Freie Universität Berlin, 14163 Berlin, Germany; 6: Technical University of Denmark, Lyngby, Denmark; 7: Freie Universität Berlin, Berlin, Germany; 8: China Agricultural University, Beijing, China; 9: Statens Serum Institute, Copenhagen, Denmark
  • Source: microbiolspec April 2018 vol. 6 no. 2 doi:10.1128/microbiolspec.ARBA-0019-2017
  • Received 24 February 2017 Accepted 06 November 2017 Published 13 April 2018
  • Stefan Schwarz, stefan.schwarz@fu-berlin.de
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  • Abstract:

    During the past decades resistance to virtually all antimicrobial agents has been observed in bacteria of animal origin. This chapter describes in detail the mechanisms so far encountered for the various classes of antimicrobial agents. The main mechanisms include enzymatic inactivation by either disintegration or chemical modification of antimicrobial agents, reduced intracellular accumulation by either decreased influx or increased efflux of antimicrobial agents, and modifications at the cellular target sites (i.e., mutational changes, chemical modification, protection, or even replacement of the target sites). Often several mechanisms interact to enhance bacterial resistance to antimicrobial agents. This is a completely revised version of the corresponding chapter in the book published in 2006. New sections have been added for oxazolidinones, polypeptides, mupirocin, ansamycins, fosfomycin, fusidic acid, and streptomycins, and the chapters for the remaining classes of antimicrobial agents have been completely updated to cover the advances in knowledge gained since 2006.

  • Citation: van Duijkeren E, Schink A, Roberts M, Wang Y, Schwarz S. 2018. Mechanisms of Bacterial Resistance to Antimicrobial Agents. Microbiol Spectrum 6(2):ARBA-0019-2017. doi:10.1128/microbiolspec.ARBA-0019-2017.

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/content/journal/microbiolspec/10.1128/microbiolspec.ARBA-0019-2017
2018-04-13
2018-07-22

Abstract:

During the past decades resistance to virtually all antimicrobial agents has been observed in bacteria of animal origin. This chapter describes in detail the mechanisms so far encountered for the various classes of antimicrobial agents. The main mechanisms include enzymatic inactivation by either disintegration or chemical modification of antimicrobial agents, reduced intracellular accumulation by either decreased influx or increased efflux of antimicrobial agents, and modifications at the cellular target sites (i.e., mutational changes, chemical modification, protection, or even replacement of the target sites). Often several mechanisms interact to enhance bacterial resistance to antimicrobial agents. This is a completely revised version of the corresponding chapter in the book published in 2006. New sections have been added for oxazolidinones, polypeptides, mupirocin, ansamycins, fosfomycin, fusidic acid, and streptomycins, and the chapters for the remaining classes of antimicrobial agents have been completely updated to cover the advances in knowledge gained since 2006.

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Tables

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TABLE 1

Origins of antimicrobial agents

Source: microbiolspec April 2018 vol. 6 no. 2 doi:10.1128/microbiolspec.ARBA-0019-2017
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TABLE 2

Examples of resistance to antimicrobials by (modified from ref. 8 )

Source: microbiolspec April 2018 vol. 6 no. 2 doi:10.1128/microbiolspec.ARBA-0019-2017
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TABLE 3

Examples of resistance to antimicrobials by enzymatic inactivation

Source: microbiolspec April 2018 vol. 6 no. 2 doi:10.1128/microbiolspec.ARBA-0019-2017
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TABLE 4

Examples of resistance to antimicrobials by (modified from ref. 8 )

Source: microbiolspec April 2018 vol. 6 no. 2 doi:10.1128/microbiolspec.ARBA-0019-2017

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