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Epstein-Barr Virus

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  • Authors: Andrew Nowalk1, Michael Green2
  • Editors: Randall T. Hayden3, Donna M. Wolk4, Karen C. Carroll5, Yi-Wei Tang6
  • VIEW AFFILIATIONS HIDE AFFILIATIONS
    Affiliations: 1: University of Pittsburgh School of Medicine, Division of Infectious Diseases, Children’s Hospital of Pittsburgh of UPMC, Pittsburgh, PA 15224; 2: University of Pittsburgh School of Medicine, Division of Infectious Diseases, Children’s Hospital of Pittsburgh of UPMC, Pittsburgh, PA 15224; 3: St. Jude’s Children’s Research Hospital, Memphis, TN; 4: Geisinger Clinic, Danville, PA; 5: Johns Hopkins University Hospital, Baltimore, MD; 6: Memorial Sloan-Kettering Institute, New York, NY
  • Source: microbiolspec June 2016 vol. 4 no. 3 doi:10.1128/microbiolspec.DMIH2-0011-2015
  • Received 08 May 2015 Accepted 08 February 2016 Published 24 June 2016
  • Michael Green, Michael.green@chp.edu
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  • Abstract:

    This review covers relevant clinical and laboratory information relating to Epstein-Barr virus (EBV) infections in immunocompromised hosts. It describes the epidemiology and clinical manifestations with a primary focus on disease in solid organ and stem cell transplant recipients. The review pays particular attention to diagnostic approaches, including serologic testing and imaging, with an expanded discussion on the role of measuring the EBV load in peripheral blood, identifying both strengths and limitations of this assay. Additional attention is paid to potential additional strategies of immunologic monitoring that may enhance the performance of EBV load monitoring.

  • Citation: Nowalk A, Green M. 2016. Epstein-Barr Virus. Microbiol Spectrum 4(3):DMIH2-0011-2015. doi:10.1128/microbiolspec.DMIH2-0011-2015.

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References

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27. Wadowsky RM, Laus S, Green M, Webber SA, Rowe D. 2003. Measurement of Epstein-Barr virus DNA loads in whole blood and plasma by TaqMan PCR and in peripheral blood lymphocytes by competitive PCR. J Clin Microbiol 41:5245–5249. [PubMed][CrossRef]
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36. Gross TG. 2009. Treatment for Epstein-Barr virus-associated PTLD. Herpes 15:64–67. [PubMed]
37. San-Juan R, Manuel O, Hirsch HH, Fernández-Ruiz M, López-Medrano F, Comoli P, Caillard S, Grossi P, Aguado JM, ESGICH PTLD Survey Study Group, European Study Group of Infections in Compromised Hosts (ESGICH) from the European Society of Microbiology and Infectious Diseases (ESCMID). 2015. Current preventive strategies and management of Epstein-Barr virus-related post-transplant lymphoproliferative disease in solid organ transplantation in Europe. Results of the ESGICH Questionnaire-based Cross-sectional Survey. Clin Microbiol Infect 21:604.e1–604.e9. [PubMed][CrossRef]
38. Gross T, Orjuela MA, Perkins SL, Park JR, Lynch JC, Cairo MS, Smith LM, Hayashi RJ. 2012. Low-dose chemotherapy and rituximab for post-transplant disease (PTLD): A Children’s Oncology Group report. Am J Transplant 12:3069–3075. [PubMed][CrossRef]
39. Savoldo B, Goss JA, Hammer MM, Zhang L, Lopez T, Gee AP, Lin YF, Quiros-Tejeira RE, Reinke P, Schubert S, Gottschalk S, Finegold MJ, Brenner MK, Rooney CM, Heslop HE. 2006. Treatment of solid organ transplant recipients with autologous Epstein Barr virus-specific cytotoxic T lymphocytes (CTLs). Blood 108:2942–2949. [PubMed][CrossRef]
40. Ricciardelli I, Brewin J, Lugthart G, Albon SJ, Pule M, Amrolia PJ. 2013. Rapid generation of EBV-specific cytotoxic T lymphocytes resistant to calcineurin inhibitors for adoptive immunotherapy. Am J Transplant 13:3244–3252. [PubMed][CrossRef]
41. Ricciardelli I, Blundell MP, Brewin J, Thrasher A, Pule M, Amrolia PJ. 2014. Towards gene therapy for EBV-associated posttransplant lymphoma with genetically modified EBV-specific cytotoxic T cells. Blood 124:2514–2522. [PubMed][CrossRef]
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/content/journal/microbiolspec/10.1128/microbiolspec.DMIH2-0011-2015
2016-06-24
2017-11-21

Abstract:

This review covers relevant clinical and laboratory information relating to Epstein-Barr virus (EBV) infections in immunocompromised hosts. It describes the epidemiology and clinical manifestations with a primary focus on disease in solid organ and stem cell transplant recipients. The review pays particular attention to diagnostic approaches, including serologic testing and imaging, with an expanded discussion on the role of measuring the EBV load in peripheral blood, identifying both strengths and limitations of this assay. Additional attention is paid to potential additional strategies of immunologic monitoring that may enhance the performance of EBV load monitoring.

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Tables

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TABLE 1

Cumulative 1- and 5-year incidence of PTLD in pediatric and adult SOT recipients by transplanted organ as reported in the 2010 Organ Procurement and Transplantation Network/Scientific Registry of Transplant Recipients (OPTN/SRTR) Annual Report ( 9 )

Source: microbiolspec June 2016 vol. 4 no. 3 doi:10.1128/microbiolspec.DMIH2-0011-2015

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