1887
No metrics data to plot.
The attempt to load metrics for this article has failed.
The attempt to plot a graph for these metrics has failed.

: Still Emerging and Elusive 20 Years On

MyBook is a cheap paperback edition of the original book and will be sold at uniform, low price.
Buy this Microbiology Spectrum Article
Price Non-Member $15.00
  • Authors: Laure F. Pittet1, Klara M. Posfay-Barbe2
  • Editors: W. Michael Scheld3, James M. Hughes4, Richard J. Whitley5
  • VIEW AFFILIATIONS HIDE AFFILIATIONS
    Affiliations: 1: Pediatric Infectious Diseases Unit, Children’s Hospital of Geneva, University Hospitals of Geneva, 1211 Geneva 14, Switzerland; 2: Pediatric Infectious Diseases Unit, Children’s Hospital of Geneva, University Hospitals of Geneva, 1211 Geneva 14, Switzerland; 3: Department of Infectious Diseases, University of Virginia Health System, Charlottesville, VA; 4: Division of Infectious Diseases, Department of Medicine, Emory University School of Medicine, Atlanta, GA; 5: Department of Pediatrics, University of Alabama at Birmingham, Birmingham, AL
  • Source: microbiolspec March 2016 vol. 4 no. 2 doi:10.1128/microbiolspec.EI10-0003-2015
  • Received 28 August 2015 Accepted 12 October 2015 Published 25 March 2016
  • Laure F. Pittet, Laure.Pittet@hcuge.ch
image of <span class="jp-italic">Bordetella holmesii</span>: Still Emerging and Elusive 20 Years On
    Preview this microbiology spectrum article:
    Zoom in
    Zoomout

    : Still Emerging and Elusive 20 Years On, Page 1 of 2

    | /docserver/preview/fulltext/microbiolspec/4/2/EI10-0003-2015-1.gif /docserver/preview/fulltext/microbiolspec/4/2/EI10-0003-2015-2.gif
  • Abstract:

    Since the first description of in 1995, almost 100 publications have contributed to the increasing knowledge of this emerging bacterium. Although first reported to induce bacteremia mainly in immunocompromised patients, it has also been isolated in healthy persons and has shown the capacity to induce pertussis-like symptoms and other clinical entities, such as meningitis, arthritis, or endocarditis. Respiratory diseases are generally less severe than those induced by . However, was found to have a higher capacity of invasiveness given the various infection sites in which it was isolated. The diagnosis is difficult, particularly as it is a slow-growing organism but also because respiratory infections are systematically misdiagnosed as . Treatment is delicate, as its susceptibility to macrolides (prescribed in respiratory infections) and ceftriaxone (used in invasive disease) is challenged. Regarding prevention, there is no consensus on prophylactic treatment following index cases and no vaccine is available. Epidemiological data are also sparse, with few prevalence studies available. In this chapter, we provide an overview of the current state of knowledge on .

  • Citation: Pittet L, Posfay-Barbe K. 2016. : Still Emerging and Elusive 20 Years On. Microbiol Spectrum 4(2):EI10-0003-2015. doi:10.1128/microbiolspec.EI10-0003-2015.

References

1. Weyant RS, Hollis DG, Weaver RE, Amin MFM, Steigerwalt AG, O’Connor SP, Whitney AM, Daneshvar MI, Moss CW, Brenner DJ. 1995. Bordetella holmesii sp. nov., a new gram-negative species associated with septicemia. J Clin Microbiol 33:1–7. [PubMed]
2. Tang YW, Hopkins MK, Kolbert CP, Hartley PA, Severance PJ, Persing DH. 1998. Bordetella holmesii-like organisms associated with septicemia, endocarditis, and respiratory failure. Clin Infect Dis 26:389–392. [PubMed][CrossRef]
3. Loeffelholz MJ, Thompson CJ, Long KS, Gilchrist MJR. 2000. Detection of Bordetella holmesii using Bordetella pertussis IS481 PCR assay. J Clin Microbiol 38:467. [PubMed]
4. Reischl U, Lehn N, Sanden GN, Loeffelholz MJ. 2001. Real-time PCR assay targeting IS481 of Bordetella pertussis and molecular basis for detecting Bordetella holmesii. J Clin Microbiol 39:1963–1966. [PubMed][CrossRef]
5. Poddar SK. 2003. Detection and discrimination of B. pertussis and B. holmesii by real-time PCR targeting IS481 using a beacon probe and probe-target melting analysis. Mol Cell Probes 17:91–98. [PubMed][CrossRef]
6. Templeton KE, Scheltinga SA, Van der Zee A, Diederen BMW, Kruijssen AM, Goossens H, Kuijper E, Claas ECJ. 2003. Evaluation of real-time PCR for detection of and discrimination between Bordetella pertussis, Bordetella parapertussis, and Bordetella holmesii for clinical diagnosis. J Clin Microbiol 41:4121–4126. [PubMed][CrossRef]
7. Tatti KM, Wu KH, Tondella ML, Cassiday PK, Cortese MM, Wilkins PP, Sanden GN. 2008. Development and evaluation of dual-target real-time polymerase chain reaction assays to detect Bordetella spp. Diagn Microbiol Infect Dis 61:264–272. [PubMed][CrossRef]
8. Knorr L, Fox JD, Tilley PAG, Ahmed-Bentley J. 2006. Evaluation of real-time PCR for diagnosis of Bordetella pertussis infection. BMC Infect Dis 6:62. [PubMed][CrossRef]
9. Yih WK, Silva EA, Ida J, Harrington N, Lett SM, George H. 1999. Bordetella holmesii-like organisms isolated from Massachusetts patients with pertussis-like symptoms. Emerg Infect Dis 5:441–443. [PubMed][CrossRef]
10. Antila M, He Q, De Jong C, Aarts I, Verbakel H, Bruisten S, Keller S, Haanpera M, Makinen J, Eerola E, Viljanen MK, Mertsola J, Van Der Zee A. 2006. Bordetella holmesii DNA is not detected in nasopharyngeal swabs from Finnish and Dutch patients with suspected pertussis. J Med Microbiol 55:1043–1051. [PubMed][CrossRef]
11. Probert WS, Ely J, Schrader K, Atwell J, Nossoff A, Kwan S. 2008. Identification and evaluation of new target sequences for specific detection of Bordetella pertussis by real-time PCR. J Clin Microbiol 46:3228–3231. [PubMed][CrossRef]
12. Guthrie JL, Robertson AV, Tang P, Jamieson F, Drews SJ. 2010. Novel duplex real-time PCR assay detects Bordetella holmesii in specimens from patients with pertussis-like symptoms in Ontario, Canada. J Clin Microbiol 48:1435–1437. [PubMed][CrossRef]
13. Wei Q, Robinson CC, Lovell MA, Hengartner RJ, Kelly KA, Murry KD. 2010. A cautionary tale from Colorado: Bordetella holmesii circulates and can lead to false positive results in commonly-used Bordetella pertussis PCR. J Mol Diagn 12:883.
14. Njamkepo E, Bonacorsi S, Debruyne M, Gibaud SA, Guillot S, Guiso N. 2011. Significant finding of Bordetella holmesii DNA in nasopharyngeal samples from French patients with suspected pertussis. J Clin Microbiol 49:4347–4348. [PubMed][CrossRef]
15. Kamiya H, Otsuka N, Ando Y, Odaira F, Yoshino S, Kawano K, Takahashi H, Nishida T, Hidaka Y, Toyoizumi-Ajisaka H, Shibayama K, Kamachi K, Sunagawa T, Taniguchi K, Okabe N. 2012. Transmission of Bordetella holmesii during pertussis outbreak, Japan. Emerg Infect Dis 18:1166–1169. [PubMed][CrossRef]
16. Rodgers LE, Cohn A, Martin S, Clark T, Budd J, A. Terranella, S. Mandal, L. McGlone, A. Emanuel, L. Tondella, L. Pawloski, K. Tatti, M. Marcon, K. Spicer, A. Leber, R. Iyer, D. Salamon, N. Tucker, C. Hicks, M. DiOrio, E. Koch, LeMaile-Williams M. 2012. Bordetella holmesii epidemiology during an outbreak of pertussis-like illness—Ohio, 2010-2011, p 86. In 61st Annu Epidemic Intelligence Service (EIS) Conf, 18 April 2012. Centers for Disease Control and Prevention, Atlanta, GA.
17. Zhang X, Weyrich LS, Lavine JS, Karanikas AT, Harvill ET. 2012. Lack of cross-protection against Bordetella holmesii after pertussis vaccination. Emerg Infect Dis 18:1771–1779. [PubMed][CrossRef]
18. Cox HC, Jacob K, Whiley DM, Bletchly C, Nimmo GR, Nissen MD, Sloots TP. 2013. Further evidence that the IS481 target is suitable for real-time PCR detection of Bordetella pertussis. Pathology 45:202–203. [PubMed][CrossRef]
19. Bottero D, Griffith MM, Lara C, Flores D, Pianciola L, Gaillard ME, Mazzeo M, Zamboni MI, Spoleti MJ, Anchart E, Ruggeri D, Sorhouet C, Fiori S, Galas M, Tondella ML, Hozbor DF. 2013. Bordetella holmesii in children suspected of pertussis in Argentina. Epidemiol Infect 141:714–717. [PubMed][CrossRef]
20. Pittet LF, Emonet S, Francois P, Bonetti EJ, Schrenzel J, Hug M, Altwegg M, Siegrist CA, Posfay-Barbe KM. 2014. Diagnosis of whooping cough in Switzerland: differentiating Bordetella pertussis from Bordetella holmesii by polymerase chain reaction. PLoS One 9:e88936. [PubMed][CrossRef]
21. Spicer KB, Salamon D, Cummins C, Leber A, Marcon MJ. 2014. Occurrence of three Bordetella species during an outbreak of cough Illness in Ohio: epidemiology, clinical features, laboratory findings, and antimicrobial susceptibility. Pediatr Infect Dis J 33:e162–e167. [PubMed][CrossRef]
22. Miranda C, Wozniak A, Castillo C, Geoffroy E, Zumaran C, Porte L, Roman JC, Potin M, Garcia P. 2013. Presence of Bordetella holmesii in an outbreak of pertussis in Chile. Rev Chilena Infectol 30:237–243. (In Spanish.) [PubMed][CrossRef]
23. Zouari A, Smaoui H, Brun D, Njamkepo E, Sghaier S, Zouari E, Felix R, Menif K, Ben Jaballah N, Guiso N, Kechrid A. 2012. Prevalence of Bordetella pertussis and Bordetella parapertussis infections in Tunisian hospitalized infants: results of a 4-year prospective study. Diagn Microbiol Infect Dis 72:303–317. [PubMed][CrossRef]
24. Dinu S, Guillot S, Dragomirescu CC, Brun D, Lazar S, Vancea G, Ionescu BM, Gherman MF, Bjerkestrand AF, Ungureanu V, Guiso N, Damian M. 2014. Whooping cough in South-East Romania: a 1-year study. Diagn Microbiol Infect Dis 78:302–306. [PubMed][CrossRef]
25. van den Akker WM. 1998. Lipopolysaccharide expression within the genus Bordetella: influence of temperature and phase variation. Microbiology 144(Part 6):1527–1535. [PubMed][CrossRef]
26. Gerlach G, Janzen S, Beier D, Gross R. 2004. Functional characterization of the BvgAS two-component system of Bordetella holmesii. Microbiology 150:3715–3729. [PubMed][CrossRef]
27. Diavatopoulos DA, Cummings CA, Van Der Heide HGJ, Van Gent M, Liew S, Relman DA, Mooi FR. 2006. Characterization of a highly conserved island in the otherwise divergent Bordetella holmesii and Bordetella pertussis genomes. J Bacteriol 188:8385–8394. [PubMed][CrossRef]
28. Link S, Schmitt K, Beier D, Gross R. 2007. Identification and regulation of expression of a gene encoding a filamentous hemagglutinin-related protein in Bordetella holmesii. BMC Microbiol 7:100. [PubMed][CrossRef]
29. Horvat A, Gross R. 2009. Molecular characterization of the BvgA response regulator of Bordetella holmesii. Microbiol Res 164:243–252. [PubMed][CrossRef]
30. Gross R, Keidel K, Schmitt K. 2010. Resemblance and divergence: the “new” members of the genus Bordetella. Med Microbiol Immunol 199:155–163. [PubMed][CrossRef]
31. Planet PJ, Narechania A, Hymes SR, Gagliardo C, Huard RC, Whittier S, Della-Latta P, Ratner AJ. 2013. Bordetella holmesii: initial genomic analysis of an emerging opportunist. Pathog Dis 67:132–135. [PubMed][CrossRef]
32. Tatti KM, Loparev VN, Ranganathanganakammal S, Changayil S, Frace M, Weil MR, Sammons S, Maccannell D, Mayer LW, Tondella ML. 2013. Draft genome sequences of Bordetella holmesii strains from blood (F627) and nasopharynx (H558). Genome Announc 1:e0005613. [PubMed][CrossRef]
33. Harvill ET, Goodfield LL, Ivanov Y, Smallridge WE, Meyer JA, Cassiday PK, Tondella ML, Brinkac L, Sanka R, Kim M, Losada L. 2014. Genome sequences of nine Bordetella holmesii strains isolated in the United States. Genome Announc 2:e00438-14. doi:10.1128/genomeA.00438-14. [PubMed][CrossRef]
34. Njamkepo E, Delisle F, Hagege I, Gerbaud G, Guiso N. 2000. Bordetella holmesii isolated from a patient with sickle cell anemia: analysis and comparison with other Bordetella holmesii isolates. Clin Microbiol Infect 6:131–136. [PubMed][CrossRef]
35. Greig JR, Gunda SS, Kwan JTC. 2001. Bordetella holmesii bacteraemia in an individual on haemodialysis. Scand J Infect Dis 33:716–717. [PubMed][CrossRef]
36. Russell FM, Davis JM, Whipp MJ, Janssen PH, Ward PB, Vyas JR, Starr M, Sawyer SM, Curtis N. 2001. Severe Bordetella holmesii infection in a previously healthy adolescent confirmed by gene sequence analysis. Clin Infect Dis 33:129–130. [PubMed][CrossRef]
37. Shepard CW, Daneshvar MI, Kaiser RM, Ashford DA, Lonsway D, Patel JB, Morey RE, Jordan JG, Weyant RS, Fischer M. 2004. Bordetella holmesii bacteremia: a newly recognized clinical entity among asplenic patients. Clin Infect Dis 38:799–804. [PubMed][CrossRef]
38. Dorbecker C, Licht C, Korber F, Plum G, Haefs C, Hoppe B, Seifert H. 2007. Community-acquired pneumonia due to Bordetella holmesii in a patient with frequently relapsing nephrotic syndrome. J Infect 54:e203–e205. [PubMed][CrossRef]
39. Lam MC, Verity R, Tyrrell GJ, Arent R, Nigrin J, Forgie SE. 2008. Gram-negative bacteremia and asplenia in a well 15-year-old girl. Can J Infect Dis Med Microbiol 19:391–392. [PubMed][CrossRef]
40. McCavit TL, Grube S, Revell P, Quinn CT. 2008. Bordetella holmesii bacteremia in sickle cell disease. Pediatr Blood Cancer 51:814–816. [PubMed][CrossRef]
41. Clare S, Ahmed T, Singh R, Gough S. 2010. Bordetella holmesii: a rare cause of bacterial endocarditis in a post-splenectomy patient. BMJ Case Rep. doi:10.1136/bcr.11.2009.2459. [PubMed][CrossRef]
42. Monnier S, Therby A, Couzon B, Doucet-Populaire F, Greder-Belan A. 2010. Bordetella holmesii bacteremia in a 26-year-old patient with sickle cell disease. Med Mal Infect 40:299–301. [PubMed][CrossRef]
43. Abouanaser S, Srigley J, Wilcox L, Johnstone J. 2011. Prosthetic joint infection caused by Bordetella holmesii. Can J Infect Dis Med Microbiol 22:22A.
44. Barrado L, Barrios M, Sanz F, Chaves F. 2011. Bordetella holmesii bacteremia in a child with sickle cell disease. Enfermed Infecc Microbiol Clin 29:779–780. [PubMed][CrossRef]
45. Kanji J, Gee S, Ahmed-Bentley J, Lee MC, Nigrin J, Verity R, Solomon N. 2011. Bordatella holmesii bacteremia in Northern Alberta: a 5-year case review. Can J Infect Dis Med Microbiol 22:22A.
46. Moissenet D, Leverger G, Merens A, Bonacorsi S, Guiso N, Vu-Thien H. 2011. Septic arthritis caused by Bordetella holmesii in an adolescent with chronic haemolytic anaemia. J Med Microbiol 60:1705–1707. [PubMed][CrossRef]
47. Bassetti M, Nicco E, Roberto Giacobbe D, Marchese A, Coppo E, Barbieri R, Viscoli C. 2012. Bordetella holmesii endocarditis in a patient with systemic lupus erythematous treated with immunosuppressive agents. J Chemother 24:240–242. [PubMed][CrossRef]
48. Bush LM, Davidson E, Daugherty J. 2012. Bordetella holmesii prosthetic valve endocarditis: a case report and review. Infect Dis Clin Pract 20:248–253. [CrossRef]
49. Chambaraud T, Dickson Z, Ensergueix G, Barraud O, Essig M, Lacour C, Allard J, Bocquentin F, Aldigier JC, Rerolle JP. 2012. Bordetella holmesii bacteremia in a renal transplant recipient: emergence of a new pathogen. Transpl Infect Dis 14:E134–E136. [PubMed][CrossRef]
50. de Nobrega R, Kotecha K. 2012. Bordetella holmesii in asplenic patients: a new pathogen? Arch Dis Child 97:A89–A90. [CrossRef]
51. Jonckheere S, De Baere T, Schroeyers P, Soetens O, De Bel A, Surmont I. 2012. Prosthetic valve endocarditis caused by Bordetella holmesii, an Acinetobacter look-alike. J Med Microbiol 61:874–877. [PubMed][CrossRef]
52. Livovsky DM, Leibowitz D, Hidalgo-Grass C, Temper V, Salameh S, Korem M. 2012. Bordetella holmesii meningitis in an asplenic patient with systemic lupus erythematosus. J Med Microbiol 61:1165–1167. [PubMed][CrossRef]
53. Nei T, Hyodo H, Sonobe K, Dan K, Saito R. 2012. First report of infectious pericarditis due to Bordetella holmesii in an adult patient with malignant lymphoma. J Clin Microbiol 50:1815–1817. [PubMed][CrossRef]
54. van Balen T, Nieman AE, Hermans MH, Schneeberger PM, de Vries E. 2012. Bordetella holmesii meningitis in a 12-year-old anorectic girl. Pediatr Infect Dis J 31:421–422. [PubMed][CrossRef]
55. Katsukawa C, Kushibiki C, Nishito A, Nishida R, Kuwabara N, Kawahara R, Otsuka N, Miyaji Y, Toyoizumi-Ajisaka H, Kamachi K. 2013. Bronchitis caused by Bordetella holmesii in a child with asthma misdiagnosed as mycoplasmal infection. J Infect Chemother 19:534–537. [PubMed][CrossRef]
56. Nguyen LB, Epelboin L, Gabarre J, Lecso M, Guillot S, Bricaire F, Caumes E, Guiso N. 2013. Recurrent Bordetella holmesii bacteremia and nasal carriage in a patient receiving rituximab. Emerg Infect Dis 19:1703–1705. [PubMed][CrossRef]
57. Pittet LF, Emonet S, Ansari M, Girardin E, Schrenzel J, Siegrist C-A, Posfay-Barbe KM. 2013. Bordetella holmesii bacteremia in a child with nephroblastoma. Swiss Med Wkly 143:50S.
58. Soloaga R, Carrion N, Almuzara M, Barberis C, Pidone J, Guelfand L, Vay C. 2013. Bordetella holmesii endocarditis in an asplenic patient. Rev Argent Microbiol 45:86–88. [PubMed][CrossRef]
59. Stoddard JM. 2013. A case of Bordetella holmesii endocarditis in an asplenic pediatric patient. Clin Lab Sci 26:171–174. [PubMed]
60. Abouanaser SF, Srigley JA, Nguyen T, Dale SE, Johnstone J, Wilcox L, Jamieson F, Rawte P, Pernica JM. 2013. Bordetella holmesii: n emerging cause of septic arthritis. J Clin Microbiol 51:1313–1315. [PubMed][CrossRef]
61. Fishbain JT, Riederer K, Sawaf H, Mody R. 2015. Invasive Bordetella holmesii infections. Infect Dis 47:65–68. [PubMed][CrossRef]
62. Pittet LF, Emonet S, Schrenzel J, Siegrist CA, Posfay-Barbe KM. 2014. Bordetella holmesii: an under-recognised Bordetella species. Lancet Infect Dis 14:510–519. [PubMed][CrossRef]
63. Vandamme PA, Peeters C, Cnockaert M, Inganas E, Falsen E, Moore ER, Nunes OC, Manaia CM, Spilker T, LiPuma JJ. 24 July 2015. Bordetella bronchialis sp. nov., Bordetella flabilis sp. nov. and Bordetella sputigena sp. nov., isolated from human respiratory specimens, and reclassification of Achromobacter sediminum (Zhang et al. 2014) as Verticia sediminum gen. nov., comb. nov. Int J Syst Evol Microbiol. doi:10.1099/ijsem.0.000473. [CrossRef]
64. Tizolova A, Guiso N, Guillot S. 2013. Insertion sequences shared by Bordetella species and implications for the biological diagnosis of pertussis syndrome. Eur J Clin Microbiol Infect Dis 32:89–96. [PubMed][CrossRef]
65. Bouchez V, Guiso N. 2013. Bordetella holmesii: comparison of two isolates from blood and a respiratory sample. Adv Infect Dis 3:123–133. [CrossRef]
66. Gerlach G, von Wintzingerode F, Middendorf B, Gross R. 2001. Evolutionary trends in the genus Bordetella. Microbes Infect 3:61–72. [PubMed][CrossRef]
67. Di Sabatino A, Carsetti R, Corazza GR. 2011. Post-splenectomy and hyposplenic states. Lancet 378:86–97. [PubMed][CrossRef]
68. Rodgers L, Martin SW, Cohn A, Budd J, Marcon M, Terranella A, Mandal S, Salamon D, Leber A, Tondella ML, Tatti K, Spicer K, Emanuel A, Koch E, McGlone L, Pawloski L, Lemaile-Williams M, Tucker N, Iyer R, Clark TA, Diorio M. 2013. Epidemiologic and laboratory features of a large outbreak of pertussis-like illnesses associated with co-circulating Bordetella holmesii and Bordetella pertussis—Ohio, 2010-2011. Clin Infect Dis 56:322–331. [PubMed][CrossRef]
69. Bottero D, Griffith MM, Lara C, Flores D, Pianciola L, Gaillard ME, Mazzeo M, Zamboni MI, Spoleti MJ, Anchart E, Ruggeri D, Sorhouet C, Fiori S, Galas M, Tondella ML, Hozbor DF. 2013. Bordetella holmesii in children suspected of pertussis in Argentina. Epidemiol Infect 141:714–717. [PubMed][CrossRef]
70. Tartof SY, Gounder P, Weiss D, Lee L, Cassiday PK, Clark TA, Briere EC. 2014. Bordetella holmesii bacteremia cases in the United States, April 2010–January 2011. Clin Infect Dis 58:e39–e43. [PubMed][CrossRef]
71. van Balen T, Nieman AE, Hermans MHA, Schneeberger PM, de Vries E. 2012. Bordetella holmesii meningitis in a 12-year old anorectic girl. Pediatr Infect Dis J 31:421–422. [PubMed][CrossRef]
72. Livovsky DMM, Leibowitz D, Hidalgo-Grass C, Temper V, Salameh S, Korem M. 2012. Bordetella holmesii meningitis in an asplenic patient with systemic lupus erythematosus. J Med Microbiol 61:1165–1167. [PubMed][CrossRef]
73. Centers for Disease Control and Prevention. 2007. Outbreaks of respiratory illness mistakenly attributed to pertussis—New Hampshire, Massachusetts, and Tennessee, 2004–2006. MMWR Morb Mortal Wkly Rep 56:837–842. [PubMed]
74. Mazengia E, Silva EA, Peppe JA, Timperi R, George H. 2000. Recovery of Bordetella holmesii from patients with pertussis-like symptoms: use of pulsed-field gel electrophoresis to characterize circulating strains. J Clin Microbiol 38:2330–2333. [PubMed]
75. Mattoo S, Cherry JD. 2005. Molecular pathogenesis, epidemiology, and clinical manifestations of respiratory infections due to Bordetella pertussis and other Bordetella subspecies. Clin Microbiol Rev 18:326–382. [PubMed][CrossRef]
76. Muyldermans G, Soetens O, Antoine M, Bruisten S, Vincart B, Doucet-Populaire F, Fry NK, Olcen P, Scheftel JM, Senterre JM, Van Der Zee A, Riffelmann M, Pierard D, Lauwers S. 2005. External quality assessment for molecular detection of Bordetella pertussis in European laboratories. J Clin Microbiol 43:30–35. [PubMed][CrossRef]
77. Dalby T, Fry NK, Krogfelt KA, Jensen JS, He Q. 2013. Evaluation of PCR methods for the diagnosis of pertussis by the European surveillance network for vaccine-preventable diseases (EUVAC.NET). Eur J Clin Microbiol Infect Dis 32:1285–1289. [PubMed][CrossRef]
78. McIntyre PB, Sintchenko V. 2013. The “how” of PCR testing for Bordetella pertussis depends on the “why.” Clin Infect Dis 56:332–334. [PubMed][CrossRef]
79. Loeffelholz MJ, Thompson CJ, Long KS, Gilchrist MJ. 1999. Comparison of PCR, culture, and direct fluorescent-antibody testing for detection of Bordetella pertussis. J Clin Microbiol 37:2872–2876. [PubMed]
80. Faulkner A, Skoff T, Martin S, Cassiday P, Tondella ML, Liang J, Ejigiri OG. 2011. Manual for the Surveillance of Vaccine-Preventable Diseases. Centers for Disease Control and Prevention, Atlanta, GA.
81. Tatti KM, Martin SW, Boney KO, Brown K, Clark TA, Tondella ML. 2013. Qualitative assessment of pertussis diagnostics in United States laboratories. Pediatr Infect Dis J 32:942–945. [PubMed][CrossRef]
82. Register KB, Sanden GN. 2006. Prevalence and sequence variants of IS481 in Bordetella bronchiseptica: implications for IS481-based detection of Bordetella pertussis. J Clin Microbiol 44:4577–4583. [PubMed][CrossRef]
83. Sloan LM, Hopkins MK, Mitchell PS, Vetter EA, Rosenblatt JE, Harmsen WS, Cockerill FR, Patel R. 2002. Multiplex lightcycler PCR assay for detection and differentiation of Bordetella pertussis and Bordetella parapertussis in nasopharyngeal specimens. J Clin Microbiol 40:96–100. [PubMed][CrossRef]
84. Tatti KM, Sparks KN, Boney KO, Tondella ML. 2011. Novel multitarget real-time PCR assay for rapid detection of Bordetella species in clinical specimens. J Clin Microbiol 49:4059–4066. [PubMed][CrossRef]
85. Mooi FR, Bruisten S, Linde I, Reubsaet F, Heuvelman K, van der Lee S, J. King A. 2012. Characterization of Bordetella holmesii isolates from patients with pertussis-like illness in the Netherlands. FEMS Immunol Med Microbiol 64:289–291. [PubMed][CrossRef]
86. Otsuka N, Yoshino S, Kawano K, Toyoizumi-Ajisaka H, Shibayama K, Kamachi K. 2012. Simple and specific detection of Bordetella holmesii by using a loop-mediated isothermal amplification assay. Microbiol Immunol 56:486–489. [PubMed][CrossRef]
87. Seng P, Drancourt M, Gouriet F, La Scola B, Fournier PE, Rolain JM, Raoult D. 2009. Ongoing revolution in bacteriology: routine identification of bacteria by matrix-assisted laser desorption ionization time-of-flight mass spectrometry. Clin Infect Dis 49:543–551. [PubMed][CrossRef]
88. Panagopoulos MI, Jean MS, Brun D, Guiso N, Bekal S, Ovetchkine P, Tapiero B. 2010. Bordetella holmesii bacteremia in asplenic children: report of four cases initially misidentified as Acinetobacter lwoffii. J Clin Microbiol 48:3762–3764. [PubMed][CrossRef]
89. Lindquist SW, Weber DJ, Mangum ME, Hollis DG, Jordan J. 1995. Bordetella holmesii sepsis in an asplenic adolescent. Pediatr Infect Dis J 14:813–815. [PubMed][CrossRef]
90. Wang K, Bettiol S, Thompson MJ, Roberts NW, Perera R, Heneghan CJ, Harnden A. 2014. Symptomatic treatment of the cough in whooping cough. Cochrane Database Syst Rev 9:CD003257. [PubMed][CrossRef]
91. Tan T, Dalby T, Forsyth K, Halperin SA, Heininger U, Hozbor D, Plotkin S, Ulloa-Gutierrez R, von Konig CH. 2015. Pertussis across the globe: recent epidemiologic trends from 2000–2013. Pediatr Infect Dis J 34:e222-32. doi:10.1097/INF.0000000000000795. [CrossRef]
92. Weber DJ, Miller MB, Brooks RH, Brown VM, Rutala WA. 2010. Healthcare worker with “pertussis”: consequences of a false-positive polymerase chain reaction test result. Infect Control Hosp Epidemiol 31:306–307. [PubMed][CrossRef]
93. Siegel JD, Rhinehart E, Jackson M, Chiarello L, Health Care Infection Control Practices Advisory Committee. 2007. 2007 guideline for isolation precautions: preventing transmission of infectious agents in health care settings. Am J Infect Control 35:S65–S164. [PubMed][CrossRef]
94. Thibault L, Nolin M, Jacques A, Daoud H, De Grandmont M, Delage G. 2012. Bacterial contamination of platelet concentrates: implication of negative culture when retesting the blood product after a positive result with the BacT/ALERT 3D. Transfusion 52:201A.
95. Pittet LF, Posfay-Barbe KM. 2015. Bordetella holmesii infection: current knowledge and a vision for future research. Expert Rev Anti Infect Ther 13:965–971. [PubMed][CrossRef]
96. Williams MM, Taylor TH, Jr., Warshauer DM, Martin MD, Valley AM, Tondella ML. 2015. Harmonization of Bordetella pertussis real-time PCR diagnostics in the United States in 2012. J Clin Microbiol 53:118–123. [PubMed][CrossRef]
97. Miranda C, Porte L, Garcia P. 2012. Bordetella holmesii in nasopharyngeal samples from Chilean patients with suspected Bordetella pertussis infection. J Clin Microbiol 50:1505. [PubMed][CrossRef]
microbiolspec.EI10-0003-2015.citations
cm/4/2
content/journal/microbiolspec/10.1128/microbiolspec.EI10-0003-2015
Loading

Citations loading...

Loading

Article metrics loading...

/content/journal/microbiolspec/10.1128/microbiolspec.EI10-0003-2015
2016-03-25
2017-03-30

Abstract:

Since the first description of in 1995, almost 100 publications have contributed to the increasing knowledge of this emerging bacterium. Although first reported to induce bacteremia mainly in immunocompromised patients, it has also been isolated in healthy persons and has shown the capacity to induce pertussis-like symptoms and other clinical entities, such as meningitis, arthritis, or endocarditis. Respiratory diseases are generally less severe than those induced by . However, was found to have a higher capacity of invasiveness given the various infection sites in which it was isolated. The diagnosis is difficult, particularly as it is a slow-growing organism but also because respiratory infections are systematically misdiagnosed as . Treatment is delicate, as its susceptibility to macrolides (prescribed in respiratory infections) and ceftriaxone (used in invasive disease) is challenged. Regarding prevention, there is no consensus on prophylactic treatment following index cases and no vaccine is available. Epidemiological data are also sparse, with few prevalence studies available. In this chapter, we provide an overview of the current state of knowledge on .

Highlighted Text: Show | Hide
Loading full text...

Full text loading...

Figures

Image of FIGURE 1
FIGURE 1

Shown is an optic microscopic study showing colonies of Gram-negative coccobacilli identified as . The strain was isolated from a Swiss patient with bacteremia ( 57 ). (Courtesy of Stéphane Emonet, University of Geneva, Geneva, Switzerland.)

Source: microbiolspec March 2016 vol. 4 no. 2 doi:10.1128/microbiolspec.EI10-0003-2015
Permissions and Reprints Request Permissions
Download as Powerpoint
Image of FIGURE 2
FIGURE 2

Shown is a scanning electron microscopy view of a strain after 24 h of culture on tryptic soy broth liquid medium (×20,000). The patient is the same as for Fig. 1 . (Courtesy of François Barja, University of Geneva, Geneva, Switzerland.)

Source: microbiolspec March 2016 vol. 4 no. 2 doi:10.1128/microbiolspec.EI10-0003-2015
Permissions and Reprints Request Permissions
Download as Powerpoint
Image of FIGURE 3a
FIGURE 3a

Colonies of growing on a sheep blood agar plate and producing brown pigments after 48 h of culture on Mueller-Hinton medium . The patient is the same as for Fig. 1 . (Courtesy of Stéphane Emonet, University of Geneva, Geneva, Switzerland.)

Source: microbiolspec March 2016 vol. 4 no. 2 doi:10.1128/microbiolspec.EI10-0003-2015
Permissions and Reprints Request Permissions
Download as Powerpoint
Image of FIGURE 3b
FIGURE 3b

Colonies of growing on a sheep blood agar plate and producing brown pigments after 48 h of culture on Mueller-Hinton medium . The patient is the same as for Fig. 1 . (Courtesy of Stéphane Emonet, University of Geneva, Geneva, Switzerland.)

Source: microbiolspec March 2016 vol. 4 no. 2 doi:10.1128/microbiolspec.EI10-0003-2015
Permissions and Reprints Request Permissions
Download as Powerpoint
Image of FIGURE 4
FIGURE 4

Comparison of genome maps of and . strain CS (GenBank accession number CP002695.1) is shown on the right side, and strain F627 (GenBank accession number AOEW00000000.1) is shown on the left side. The genome is in the form of two individual contigs, as illustrated by the two different shades of green. The grey links indicate sequence similarities at the protein level between the two genomes. Only local gene synteny is observed between the two bacteria. Red dots show the positions of IS, which has 19 occurrences in strain F627 and 227 occurrences in strain CS. (Figure courtesy of David Hernandez, University of Geneva, Geneva, Switzerland; reproduced from reference 62 with permission.)

Source: microbiolspec March 2016 vol. 4 no. 2 doi:10.1128/microbiolspec.EI10-0003-2015
Permissions and Reprints Request Permissions
Download as Powerpoint

Tables

Generic image for table
TABLE 1

Biochemical characteristics of and comparison with other spp.

Source: microbiolspec March 2016 vol. 4 no. 2 doi:10.1128/microbiolspec.EI10-0003-2015

Supplemental Material

No supplementary material available for this content.

This is a required field
Please enter a valid email address
Please check the format of the address you have entered.
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error