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Zika Virus Disease

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  • Author: Werner Slenczka1
  • Editors: W. Michael Scheld2, James M. Hughes3, Richard J. Whitley4
  • VIEW AFFILIATIONS HIDE AFFILIATIONS
    Affiliations: 1: Philipps-University Marburg, Institute of Virology, 35037 Marburg, Germany; 2: Department of Infectious Diseases, University of Virginia Health System, Charlottesville, VA; 3: Division of Infectious Diseases, Department of Medicine, Emory University School of Medicine, Atlanta, GA; 4: Department of Pediatrics, University of Alabama at Birmingham, Birmingham, AL
  • Source: microbiolspec May 2016 vol. 4 no. 3 doi:10.1128/microbiolspec.EI10-0019-2016
  • Received 29 February 2016 Accepted 02 March 2016 Published 27 May 2016
  • Werner Slenczka, slenczka-marburg@t-online.de
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  • Abstract:

    The history of Zika virus disease serves as a paradigm of a typical emerging viral infection. Zika virus disease, a mosquito-borne flavivirus, was first isolated in 1947 in the Zika forest of Uganda. The same virus was also isolated from jungle-dwelling mosquitoes ( [] ). In many areas of Africa and South Asia human infections with Zika virus were detected by both serology and virus isolation. About 80% of infections are asymptomatic, and in 20% a mostly mild disease with fever, rash, arthralgia, and conjunctivitis may occur. Fetal infections with malformations were not recorded in Africa or Asia. Zika virus was imported to northern Brazil possibly during the world soccer championship that was hosted by Brazil in June through July 2014. A cluster of severe fetal malformations with microcephaly and ocular defects was noted in 2015 in the northeast of Brazil, and intrauterine infections with Zika virus were confirmed. The dramatic change in Zika virus pathogenicity upon its introduction to Brazil has remained an enigma.

  • Citation: Slenczka W. 2016. Zika Virus Disease. Microbiol Spectrum 4(3):EI10-0019-2016. doi:10.1128/microbiolspec.EI10-0019-2016.

Key Concept Ranking

Yellow fever virus
0.51157606
West Nile Fever
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Human Pathogenic Viruses
0.4078603
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References

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2016-05-27
2017-09-21

Abstract:

The history of Zika virus disease serves as a paradigm of a typical emerging viral infection. Zika virus disease, a mosquito-borne flavivirus, was first isolated in 1947 in the Zika forest of Uganda. The same virus was also isolated from jungle-dwelling mosquitoes ( [] ). In many areas of Africa and South Asia human infections with Zika virus were detected by both serology and virus isolation. About 80% of infections are asymptomatic, and in 20% a mostly mild disease with fever, rash, arthralgia, and conjunctivitis may occur. Fetal infections with malformations were not recorded in Africa or Asia. Zika virus was imported to northern Brazil possibly during the world soccer championship that was hosted by Brazil in June through July 2014. A cluster of severe fetal malformations with microcephaly and ocular defects was noted in 2015 in the northeast of Brazil, and intrauterine infections with Zika virus were confirmed. The dramatic change in Zika virus pathogenicity upon its introduction to Brazil has remained an enigma.

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