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The Mycobiome: Impact on Health and Disease States

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  • Authors: Najla El-Jurdi1, Mahmoud A. Ghannoum2
  • Editor: Joseph Heitman3
  • VIEW AFFILIATIONS HIDE AFFILIATIONS
    Affiliations: 1: Department of Medicine, Division of Hematology-Oncology, University Hospitals Cleveland Medical Center, Case Western Reserve University, Cleveland, OH 44106; 2: Center For Medical Mycology, Department of Dermatology, Case Western Reserve University, and University Hospitals Cleveland Medical Center, Cleveland, OH 44106; 3: Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, NC 27710
  • Source: microbiolspec June 2017 vol. 5 no. 3 doi:10.1128/microbiolspec.FUNK-0045-2016
  • Received 14 February 2016 Accepted 02 March 2017 Published 09 June 2017
  • Mahmoud Ghannoum, mahmoud.ghannoum@case.edu
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  • Abstract:

    The term “microbiome” refers to microorganisms (microbiota) and their genomes (metagenome) coexisting with their hosts. Some researchers coined the term “second genome” to underscore the importance of the microbiota and its collective metagenome on their host’s health and/or disease. It is now undeniable that the commensal fungal microorganisms, alongside the other components of the microbiota, play a central role in association with the human host. In recognition, projects were launched nationally and internationally to unify efforts to characterize the microbiome and elucidate the functional role of the microbiota and the mechanism(s) by which these organisms and their metabolites (metabolome) may affect health and disease states. In this article, we will highlight the role of the fungal community as an indispensable component of the microbiome.

  • Citation: El-Jurdi N, Ghannoum M. 2017. The Mycobiome: Impact on Health and Disease States. Microbiol Spectrum 5(3):FUNK-0045-2016. doi:10.1128/microbiolspec.FUNK-0045-2016.

Key Concept Ranking

Upper Gastrointestinal Tract
0.47606826
Lower Gastrointestinal Tract
0.47291675
Candida tropicalis
0.45833334
Candida albicans
0.45047325
0.47606826

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/content/journal/microbiolspec/10.1128/microbiolspec.FUNK-0045-2016
2017-06-09
2017-09-23

Abstract:

The term “microbiome” refers to microorganisms (microbiota) and their genomes (metagenome) coexisting with their hosts. Some researchers coined the term “second genome” to underscore the importance of the microbiota and its collective metagenome on their host’s health and/or disease. It is now undeniable that the commensal fungal microorganisms, alongside the other components of the microbiota, play a central role in association with the human host. In recognition, projects were launched nationally and internationally to unify efforts to characterize the microbiome and elucidate the functional role of the microbiota and the mechanism(s) by which these organisms and their metabolites (metabolome) may affect health and disease states. In this article, we will highlight the role of the fungal community as an indispensable component of the microbiome.

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FIGURE 1

Schema showing potential interactions between bacteria, fungi, and the host in the gut in Crohn’s disease (CD). Inter- and intrakingdom interactions impact the host immune system in the setting of CD, resulting in increased levels of proinflammatory cytokines (e.g., Th17 cytokines) under the influence of enteric pathogens and immunomodulatory components of biofilms (e.g., fungal β-glucans, bacterial lipopolysaccharides), causing increased oxidative damage and apoptotic cell death. Additionally, microbial-induced production of mucolytic enzymes may lead to barrier dysfunction, resulting in tissue damage and lesion formation. Interactions between fungi, bacteria, and the host in the gut of CD patients, showing an increase in the levels of , , and . Biofilm formation by gut microbiota can influence host response to microbial dysbiosis ( 71 ).

Source: microbiolspec June 2017 vol. 5 no. 3 doi:10.1128/microbiolspec.FUNK-0045-2016
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