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Fungal Recognition and Host Defense Mechanisms

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  • Authors: I. M. Dambuza1, S. M. Levitz2, M. G. Netea3, G. D. Brown4
  • Editor: Joseph Heitman5
  • VIEW AFFILIATIONS HIDE AFFILIATIONS
    Affiliations: 1: MRC Centre for Medical Mycology, Aberdeen Fungal Group, Institute of Medical Sciences, University of Aberdeen, Aberdeen AB252ZD, United Kingdom; 2: Department of Medicine, University of Massachusetts Medical School, Worcester, MA 01605; 3: Department of Internal Medicine and Radboud Center for Infectious Diseases (RCI), Radboud University Medical Center, Nijmegen, The Netherlands; 4: MRC Centre for Medical Mycology, Aberdeen Fungal Group, Institute of Medical Sciences, University of Aberdeen, Aberdeen AB252ZD, United Kingdom; 5: Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, NC 27710
  • Source: microbiolspec July 2017 vol. 5 no. 4 doi:10.1128/microbiolspec.FUNK-0050-2016
  • Received 06 March 2016 Accepted 15 May 2017 Published 28 July 2017
  • G. D. Brown, gordon.brown@abdn.ac.uk
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  • Abstract:

    Fungi have emerged as premier opportunistic microbes of the 21st century, having a considerable impact on human morbidity and mortality. The huge increase in incidence of these diseases is largely due to the HIV pandemic and use of immunosuppressive therapies, underscoring the importance of the immune system in defense against fungi. This article will address how the mammalian immune system recognizes and mounts a defense against medically relevant fungal species.

  • Citation: Dambuza I, Levitz S, Netea M, Brown G. 2017. Fungal Recognition and Host Defense Mechanisms. Microbiol Spectrum 5(4):FUNK-0050-2016. doi:10.1128/microbiolspec.FUNK-0050-2016.

Key Concept Ranking

Immune Systems
0.6879974
Innate Immune System
0.6070807
Adaptive Immune System
0.5976686
Fungal Infections
0.49570414
T Helper Cells
0.44664598
Transforming Growth Factor beta
0.43778583
0.6879974

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/content/journal/microbiolspec/10.1128/microbiolspec.FUNK-0050-2016
2017-07-28
2017-09-19

Abstract:

Fungi have emerged as premier opportunistic microbes of the 21st century, having a considerable impact on human morbidity and mortality. The huge increase in incidence of these diseases is largely due to the HIV pandemic and use of immunosuppressive therapies, underscoring the importance of the immune system in defense against fungi. This article will address how the mammalian immune system recognizes and mounts a defense against medically relevant fungal species.

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FIGURE 1

More than half a century of immunogical theories.

Source: microbiolspec July 2017 vol. 5 no. 4 doi:10.1128/microbiolspec.FUNK-0050-2016
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FIGURE 2

Signaling pathways involved in antifungal immunity.

Source: microbiolspec July 2017 vol. 5 no. 4 doi:10.1128/microbiolspec.FUNK-0050-2016
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FIGURE 3

PRRs and the fungal components they recognize. (Adapted with modifications from reference 12 ).

Source: microbiolspec July 2017 vol. 5 no. 4 doi:10.1128/microbiolspec.FUNK-0050-2016
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FIGURE 4

Schematic representation of the sequential inflammatory immune reaction involved in antifungal immune responses.

Source: microbiolspec July 2017 vol. 5 no. 4 doi:10.1128/microbiolspec.FUNK-0050-2016
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TABLE 1

Selected human genetic associations with fungal susceptibility discussed in this article

Source: microbiolspec July 2017 vol. 5 no. 4 doi:10.1128/microbiolspec.FUNK-0050-2016

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