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Adaptive Characteristics of Innate Immune Responses in Macrophages

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  • Authors: Rob J. W. Arts1, Mihai G. Netea2
  • Editor: Siamon Gordon3
  • VIEW AFFILIATIONS HIDE AFFILIATIONS
    Affiliations: 1: Department of Internal Medicine, Radboud University Medical Center, Nijmegen, The Netherlands; 2: Department of Internal Medicine, Radboud University Medical Center, Nijmegen, The Netherlands; 3: Oxford University, Oxford, United Kingdom
  • Source: microbiolspec August 2016 vol. 4 no. 4 doi:10.1128/microbiolspec.MCHD-0023-2015
  • Received 16 September 2015 Accepted 05 April 2016 Published 12 August 2016
  • Mihai G. Netea, mihai.netea@radboudumc.nl
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  • Abstract:

    The innate immune system is considered to have no immune memory. However, lately there has been as shift in paradigm. Cells of the innate immune system, and especially monocytes and macrophages, are capable of building a nonspecific memory, resulting in either better or worse responses to secondary stimulations/infections, as a result of epigenetic changes. This review gives a general overview of the at-the-moment available data.

  • Citation: Arts R, Netea M. 2016. Adaptive Characteristics of Innate Immune Responses in Macrophages. Microbiol Spectrum 4(4):MCHD-0023-2015. doi:10.1128/microbiolspec.MCHD-0023-2015.

Key Concept Ranking

Mitogen-Activated Protein Kinase Pathway
0.47379228
Innate Immune System
0.4531754
Tumor Necrosis Factor alpha
0.44418094
Adaptive Immune System
0.4207668
Immune Systems
0.41681078
0.47379228

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2016-08-12
2017-11-22

Abstract:

The innate immune system is considered to have no immune memory. However, lately there has been as shift in paradigm. Cells of the innate immune system, and especially monocytes and macrophages, are capable of building a nonspecific memory, resulting in either better or worse responses to secondary stimulations/infections, as a result of epigenetic changes. This review gives a general overview of the at-the-moment available data.

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Figures

Image of FIGURE 1
FIGURE 1

Priming, activation, and tolerance as adaptive macrophage responses. A schematic representation of the possible responses of macrophages to a novel stimulus (e.g., LPS). While LPS causes macrophage activation followed by tolerance, low doses of LPS prime macrophages for enhanced innate immune responses: trained innate immunity. Both tolerance and trained innate immunity are results of long-term epigenetic changes in macrophage function (“memory”).

Source: microbiolspec August 2016 vol. 4 no. 4 doi:10.1128/microbiolspec.MCHD-0023-2015
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Image of FIGURE 2
FIGURE 2

Macrophages play a double role in inducing immunological memory following an infectious insult: on the one hand, they initiate adaptive immune responses; and on the other hand, they undergo epigenetic reprogramming to respond with an increased array of PRR expression and inflammatory cytokine production to a secondary infection (“trained innate immunity”). MHC, major histocompatibility complex.

Source: microbiolspec August 2016 vol. 4 no. 4 doi:10.1128/microbiolspec.MCHD-0023-2015
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Tables

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TABLE 1

Examples of memory of innate immunity in plants, invertebrates, and mammals

Source: microbiolspec August 2016 vol. 4 no. 4 doi:10.1128/microbiolspec.MCHD-0023-2015

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