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G Protein-Coupled Receptors in Macrophages

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  • Authors: Hsi-Hsien Lin1, Martin Stacey3
  • Editor: Siamon Gordon4
  • VIEW AFFILIATIONS HIDE AFFILIATIONS
    Affiliations: 1: Department of Microbiology and Immunology, College of Medicine, Chang Gung University, Tao-Yuan, Taiwan; 2: Chang Gung Immunology Consortium and Department of Anatomic Pathology, Chang Gung Memorial Hospital-Linkou, 333 Tao-Yuan, Taiwan; 3: School of Molecular and Cellular Biology, University of Leeds, Leeds, LS2 9JT, United Kingdom; 4: Oxford University, Oxford, United Kingdom
  • Source: microbiolspec July 2016 vol. 4 no. 4 doi:10.1128/microbiolspec.MCHD-0028-2016
  • Received 01 February 2016 Accepted 08 February 2016 Published 29 July 2016
  • Hsi-Hsien Lin, hhlin@mail.cgu.edu.tw and Martin Stacey, m.stacey@leeds.ac.uk
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  • Abstract:

    As the largest receptor gene family in the human genome, with >800 members, the signal-transducing G protein-coupled receptors (GPCRs) play critical roles in nearly all conceivable physiological processes, ranging from the sensing of photons and odorants to metabolic homeostasis and migration of leukocytes. Unfortunately, an exhaustive review of the several hundred GPCRs expressed by myeloid cells/macrophages (P.J. Groot-Kormelink, L .Fawcett, P.D. Wright, M. Gosling, and T.C. Kent, 12:57, 2012, doi:10.1186/1471-2172-13-57) is beyond the scope of this chapter; however, we will endeavor to cover the GPCRs that contribute to the major facets of macrophage biology, i.e., those whose expression is restricted to macrophages and the GPCRs involved in macrophage differentiation/polarization, microbial elimination, inflammation and resolution, and macrophage-mediated pathology. The chemokine receptors, a major group of myeloid GPCRs, will not be extensively covered as they are comprehensively reviewed elsewhere.

  • Citation: Lin H, Stacey M. 2016. G Protein-Coupled Receptors in Macrophages. Microbiol Spectrum 4(4):MCHD-0028-2016. doi:10.1128/microbiolspec.MCHD-0028-2016.

Key Concept Ranking

Cyclic AMP-Protein Kinase A Pathway
0.45328075
Acute Respiratory Distress Syndrome
0.44426534
Complement System
0.43938395
Tumor Necrosis Factor alpha
0.43287393
0.45328075

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/content/journal/microbiolspec/10.1128/microbiolspec.MCHD-0028-2016
2016-07-29
2017-09-26

Abstract:

As the largest receptor gene family in the human genome, with >800 members, the signal-transducing G protein-coupled receptors (GPCRs) play critical roles in nearly all conceivable physiological processes, ranging from the sensing of photons and odorants to metabolic homeostasis and migration of leukocytes. Unfortunately, an exhaustive review of the several hundred GPCRs expressed by myeloid cells/macrophages (P.J. Groot-Kormelink, L .Fawcett, P.D. Wright, M. Gosling, and T.C. Kent, 12:57, 2012, doi:10.1186/1471-2172-13-57) is beyond the scope of this chapter; however, we will endeavor to cover the GPCRs that contribute to the major facets of macrophage biology, i.e., those whose expression is restricted to macrophages and the GPCRs involved in macrophage differentiation/polarization, microbial elimination, inflammation and resolution, and macrophage-mediated pathology. The chemokine receptors, a major group of myeloid GPCRs, will not be extensively covered as they are comprehensively reviewed elsewhere.

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FIGURE 1

GPCR signaling and the activation/deactivation of heterotrimeric G proteins. Green circle, ligand; GAP, GTPase-activating protein; PI3K, phosphatidylinositol 3-kinase; PKC, protein kinase C; PLC, phospholipase C.

Source: microbiolspec July 2016 vol. 4 no. 4 doi:10.1128/microbiolspec.MCHD-0028-2016
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TABLE 1

Physiological and pathological roles of macrophage GPCRs

Source: microbiolspec July 2016 vol. 4 no. 4 doi:10.1128/microbiolspec.MCHD-0028-2016

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