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Macrophages in Endocrine Glands, with Emphasis on Pancreatic Islets

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  • Author: Emil R. Unanue1
  • Editor: Siamon Gordon2
  • VIEW AFFILIATIONS HIDE AFFILIATIONS
    Affiliations: 1: Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63103; 2: Oxford University, Oxford, United Kingdom
  • Source: microbiolspec December 2016 vol. 4 no. 6 doi:10.1128/microbiolspec.MCHD-0048-2016
  • Received 23 August 2016 Accepted 25 October 2016 Published 23 December 2016
  • Emil R. Unanue, unanue@wustl.edu
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  • Abstract:

    We review here the macrophages found in endocrine tissues, placing emphasis on those residing in the islets of Langerhans of the pancreas. The islets represent the endocrine organ where macrophages have been examined in great detail and where our own studies and experience have been directed.

  • Citation: Unanue E. 2016. Macrophages in Endocrine Glands, with Emphasis on Pancreatic Islets. Microbiol Spectrum 4(6):MCHD-0048-2016. doi:10.1128/microbiolspec.MCHD-0048-2016.

Key Concept Ranking

Tumor Necrosis Factor
0.4609522
MHC Class II
0.4586004
Major Histocompatibility Complex
0.4211587
0.4609522

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2016-12-23
2017-09-20

Abstract:

We review here the macrophages found in endocrine tissues, placing emphasis on those residing in the islets of Langerhans of the pancreas. The islets represent the endocrine organ where macrophages have been examined in great detail and where our own studies and experience have been directed.

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Figures

Image of FIGURE 1
FIGURE 1

Pancreatic macrophages (MΦ). The pancreas contains three sets of macrophages. One set reside in the islets, labeled endocrine tissue, and have an M1-like transcriptional signature. Two sets are in the stroma in between the acinar gland, labeled as exocrine tissue. Both have an M2-like transcriptional signature. One set derives from blood monocytes; the second derives from yolk sac (YS) hematopoiesis. Reprinted from reference 10 , with permission.

Source: microbiolspec December 2016 vol. 4 no. 6 doi:10.1128/microbiolspec.MCHD-0048-2016
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Image of FIGURE 2
FIGURE 2

Testicular macrophages. The macrophages in the testes are found in two locations. One set are in the interstitium, forming a cluster with Leydig cells. The second set surround the seminiferous tubules—the peritubular macrophages. Reproduced from reference 27 , with permission.

Source: microbiolspec December 2016 vol. 4 no. 6 doi:10.1128/microbiolspec.MCHD-0048-2016
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Tables

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TABLE 1

Features of pancreatic macrophages

Source: microbiolspec December 2016 vol. 4 no. 6 doi:10.1128/microbiolspec.MCHD-0048-2016

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