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Ancient Resistome

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  • Authors: Abiola Olumuyiwa Olaitan1, Jean-Marc Rolain2
  • Editors: Michel Drancourt3, Didier Raoult4
  • VIEW AFFILIATIONS HIDE AFFILIATIONS
    Affiliations: 1: Aix Marseille Université, Unité de Recherche sur les Maladies Infectieuses et Tropicales Emergentes (URMITE), UMR CNRS 7278, IRD 198, INSERM 1095, Faculté de Médecine, Marseille, France; 2: Aix Marseille Université, Unité de Recherche sur les Maladies Infectieuses et Tropicales Emergentes (URMITE), UMR CNRS 7278, IRD 198, INSERM 1095, Faculté de Médecine, Marseille, France; 3: Aix Marseille Université Faculté de Médecine, Marseille, France; 4: Aix Marseille Université Faculté de Médecine, Marseille, France
  • Source: microbiolspec August 2016 vol. 4 no. 4 doi:10.1128/microbiolspec.PoH-0008-2015
  • Received 28 January 2015 Accepted 23 October 2015 Published 12 August 2016
  • Jean-Marc Rolain, jean-marc.rolain@univ-amu.fr
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  • Abstract:

    Antibiotic resistance is an ancient biological mechanism in bacteria, although its proliferation in our contemporary world has been amplified through antimicrobial therapy. Recent studies conducted on ancient environmental and human samples have uncovered numerous antibiotic-resistant bacteria and resistance genes. The resistance genes that have been reported from the analysis of ancient bacterial DNA include genes coding for several classes of antibiotics, such as glycopeptides, β-lactams, tetracyclines, and macrolides. The investigation of the resistome of ancient bacteria is a recent and emerging field of research, and technological advancements such as next-generation sequencing will further contribute to its growth. It is hoped that the knowledge gained from this research will help us to better understand the evolution of antibiotic resistance genes and will also be used in drug design as a proactive measure against antibiotic resistance.

  • Citation: Olaitan A, Rolain J. 2016. Ancient Resistome. Microbiol Spectrum 4(4):PoH-0008-2015. doi:10.1128/microbiolspec.PoH-0008-2015.

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References

1. Warinner C, Speller C, Collins MJ. 2015. A new era in palaeomicrobiology: prospects for ancient dental calculus as a long-term record of the human oral microbiome. Philos Trans R Soc Lond B Biol Sci 370:20130376. doi:10.1098/rstb.2013.0376. [PubMed][CrossRef]
2. Drancourt M, Roux V, Dang LV, Tran-Hung L, Castex D, Chenal-Francisque V, Ogata H, Fournier PE, Crubezy E, Raoult D. 2004. Genotyping, Orientalis-like Yersinia pestis, and plague pandemics. Emerg Infect Dis 10:1585–1592. [PubMed][CrossRef]
3. Drancourt M, Raoult D. 2005. Palaeomicrobiology: current issues and perspectives. Nat Rev Microbiol 3:23–35. [PubMed][CrossRef]
4. Jansson JK, Tas N. 2014. The microbial ecology of permafrost. Nat Rev Microbiol 12:414–425. [PubMed][CrossRef]
5. Gilichinsky D, Vishnivetskaya T, Petrova M, Spirina E, Mamykin V, Rivkina E. 2008. Bacteria in permafrost, p 83–102. In Margesin R, Schinner F, Marx JC, Gerday C (ed), Psychrophiles: from Biodiversity to Biotechnology. Springer, Berlin, Germany. [CrossRef]
6. Jin Y, Yip HK. 2002. Supragingival calculus: formation and control. Crit Rev Oral Biol Med 13:426–441. [PubMed][CrossRef]
7. Warinner C, Rodrigues JF, Vyas R, Trachsel C, Shved N, Grossmann J, Radini A, Hancock Y, Tito RY, Fiddyment S, Speller C, Hendy J, Charlton S, Luder HU, Salazar-Garcia DC, Eppler E, Seiler R, Hansen LH, Castruita JA, Barkow-Oesterreicher S, Teoh KY, Kelstrup CD, Olsen JV, Nanni P, Kawai T, Willerslev E, von MC, Lewis CM, Jr., Collins MJ, Gilbert MT, Ruhli F, Cappellini E. 2014. Pathogens and host immunity in the ancient human oral cavity. Nat Genet 46:336–344. [PubMed][CrossRef]
8. D’Costa VM, King CE, Kalan L, Morar M, Sung WW, Schwarz C, Froese D, Zazula G, Calmels F, Debruyne R, Golding GB, Poinar HN, Wright GD. 2011. Antibiotic resistance is ancient. Nature 477:457–461. [PubMed][CrossRef]
9. Marshall CG, Lessard IA, Park I, Wright GD. 1998. Glycopeptide antibiotic resistance genes in glycopeptide-producing organisms. Antimicrob Agents Chemother 42:2215–2220. [PubMed]
10. D’Costa VM, McGrann KM, Hughes DW, Wright GD. 2006. Sampling the antibiotic resistome. Science 311:374–377. [PubMed][CrossRef]
11. Mindlin SZ, Soina VS, Ptrova MA, Gorlenko Z. 2008. Isolation of antibiotic resistance bacterial strains from East Siberia permafrost sediments. Genetika 44:36–44. [PubMed]
12. Petrova M, Gorlenko Z, Mindlin S. 2009. Molecular structure and translocation of a multiple antibiotic resistance region of a Psychrobacter psychrophilus permafrost strain. FEMS Microbiol Lett 296:190–197. [PubMed][CrossRef]
13. Petrova MA, Gorlenko Z, Soina VS, Mindlin SZ. 2008. Association of the strA-strB genes with plasmids and transposons in the present-day bacteria and in bacterial strains from permafrost. Genetika 44:1281–1286. [PubMed][CrossRef]
14. Vishnivetskaya TA, Petrova MA, Urbance J, Ponder M, Moyer CL, Gilichinsky DA, Tiedje JM. 2006. Bacterial community in ancient Siberian permafrost as characterized by culture and culture-independent methods. Astrobiology 6:400–414. [PubMed][CrossRef]
15. Bhullar K, Waglechner N, Pawlowski A, Koteva K, Banks ED, Johnston MD, Barton HA, Wright GD. 2012. Antibiotic resistance is prevalent in an isolated cave microbiome. PLoS One 7:e34953. doi:10.1371/journal.pone.0034953. [PubMed]
16. Appelt S, Fancello L, Le BM, Raoult D, Drancourt M, Desnues C. 2014. Viruses in a 14th-century coprolite. Appl Environ Microbiol 80:2648–2655. [PubMed][CrossRef]
17. Rolain JM, Fancello L, Desnues C, Raoult D. 2011. Bacteriophages as vehicles of the resistome in cystic fibrosis. J Antimicrob Chemother 66:2444–2447. [PubMed][CrossRef]
18. Mazaheri Nezhad FR, Barton MD, Heuzenroeder MW. 2011. Bacteriophage-mediated transduction of antibiotic resistance in enterococci. Lett Appl Microbiol 52:559–564. [PubMed][CrossRef]
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2016-08-12
2017-08-17

Abstract:

Antibiotic resistance is an ancient biological mechanism in bacteria, although its proliferation in our contemporary world has been amplified through antimicrobial therapy. Recent studies conducted on ancient environmental and human samples have uncovered numerous antibiotic-resistant bacteria and resistance genes. The resistance genes that have been reported from the analysis of ancient bacterial DNA include genes coding for several classes of antibiotics, such as glycopeptides, β-lactams, tetracyclines, and macrolides. The investigation of the resistome of ancient bacteria is a recent and emerging field of research, and technological advancements such as next-generation sequencing will further contribute to its growth. It is hoped that the knowledge gained from this research will help us to better understand the evolution of antibiotic resistance genes and will also be used in drug design as a proactive measure against antibiotic resistance.

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TABLE 1

Antibiotic resistance genes uncovered from ancient samples

Source: microbiolspec August 2016 vol. 4 no. 4 doi:10.1128/microbiolspec.PoH-0008-2015

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