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Metabolic Perspectives on Persistence

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  • Authors: Travis E. Hartman1, Zhe Wang2, Robert S. Jansen3, Susana Gardete4, Kyu Y. Rhee5
  • Editors: William R. Jacobs Jr.7, Helen McShane8, Valerie Mizrahi9, Ian M. Orme10
  • VIEW AFFILIATIONS HIDE AFFILIATIONS
    Affiliations: 1: Departments of Medicine; 2: Departments of Medicine; 3: Departments of Medicine; 4: Departments of Medicine; 5: Departments of Medicine; 6: Microbiology & Immunology, Division of Infectious Diseases, Weill Cornell Medical College, New York, NY 10065; 7: Howard Hughes Medical Institute, Albert Einstein School of Medicine, Bronx, NY 10461; 8: University of Oxford, Oxford OX3 7DQ, United Kingdom; 9: University of Cape Town, Rondebosch 7701, South Africa; 10: Colorado State University, Fort Collins, CO 80523
  • Source: microbiolspec February 2017 vol. 5 no. 1 doi:10.1128/microbiolspec.TBTB2-0026-2016
  • Received 30 July 2016 Accepted 06 August 2016 Published 01 February 2017
  • Kyu Y. Rhee, kyr9001@med.cornell.edu
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  • Abstract:

    Accumulating evidence has left little doubt about the importance of persistence or metabolism in the biology and chemotherapy of tuberculosis. However, knowledge of the intersection between these two factors has only recently begun to emerge. Here, we provide a focused review of metabolic characteristics associated with persistence. We focus on metabolism because it is the biochemical foundation of all physiologic processes and a distinguishing hallmark of physiology and pathogenicity. In addition, it serves as the chemical interface between host and pathogen. Existing knowledge, however, derives largely from physiologic contexts in which replication is the primary biochemical objective. The goal of this review is to reframe current knowledge of metabolism in the context of persistence, where quiescence is often a key distinguishing characteristic. Such a perspective may help ongoing efforts to develop more efficient cures and inform on novel strategies to break the cycle of transmission sustaining the pandemic.

  • Citation: Hartman T, Wang Z, Jansen R, Gardete S, Rhee K. 2017. Metabolic Perspectives on Persistence. Microbiol Spectrum 5(1):TBTB2-0026-2016. doi:10.1128/microbiolspec.TBTB2-0026-2016.

Key Concept Ranking

Fatty Acid Biosynthesis
0.46207282
Ferrous Iron Oxidation
0.4043137
0.46207282

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/content/journal/microbiolspec/10.1128/microbiolspec.TBTB2-0026-2016
2017-02-01
2017-05-28

Abstract:

Accumulating evidence has left little doubt about the importance of persistence or metabolism in the biology and chemotherapy of tuberculosis. However, knowledge of the intersection between these two factors has only recently begun to emerge. Here, we provide a focused review of metabolic characteristics associated with persistence. We focus on metabolism because it is the biochemical foundation of all physiologic processes and a distinguishing hallmark of physiology and pathogenicity. In addition, it serves as the chemical interface between host and pathogen. Existing knowledge, however, derives largely from physiologic contexts in which replication is the primary biochemical objective. The goal of this review is to reframe current knowledge of metabolism in the context of persistence, where quiescence is often a key distinguishing characteristic. Such a perspective may help ongoing efforts to develop more efficient cures and inform on novel strategies to break the cycle of transmission sustaining the pandemic.

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TABLE 1

Predicted essential genes for survival of at 8 weeks that are not significantly inhibited at 4 weeks

Source: microbiolspec February 2017 vol. 5 no. 1 doi:10.1128/microbiolspec.TBTB2-0026-2016

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