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Urinary Tract Infections in Infants and Children

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  • Author: Theresa A. Schlager1
  • Editors: Matthew A. Mulvey2, Ann E. Stapleton3, David J. Klumpp4
  • VIEW AFFILIATIONS HIDE AFFILIATIONS
    Affiliations: 1: Department of Emergency Medicine, University of Virginia, Charlottesville, VA 22908; 2: University of Utah, Salt Lake City, UT; 3: University of Washington, Seattle, WA; 4: Northwestern University, Chicago, IL
  • Source: microbiolspec September 2016 vol. 4 no. 5 doi:10.1128/microbiolspec.UTI-0022-2016
  • Received 20 March 2016 Accepted 24 March 2016 Published 23 September 2016
  • Theresa A. Schlager, tas8n@virginia.edu
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  • Abstract:

    Urinary tract infections (UTI) are one of the most common infections in children and symptoms may be nonspecific. The risk of renal scarring is highest in children under 1 year of age with febrile UTI and high-grade vesicoureteral reflux (VUR). Although treatment of UTI is usually straightforward, given increased rates of antimicrobial resistance worldwide, the choice of treatment for pediatric UTI should be guided by community resistance patterns whenever feasible. The benefit of antimicrobial prophylaxis after first UTI and/or in the presence of VUR remains controversial, but a recent meta-analysis supports continuous antimicrobial prophylaxis in children with VUR, indicating a need for more research in this area.

  • Citation: Schlager T. 2016. Urinary Tract Infections in Infants and Children. Microbiol Spectrum 4(5):UTI-0022-2016. doi:10.1128/microbiolspec.UTI-0022-2016.

Key Concept Ranking

Urinary Tract Infections
0.63812685
Asymptomatic Bacteriuria
0.42045793
White Blood Cells
0.4075755
0.63812685

References

1. Lohr J, Downs S, Schlager T. 2008. Genitourinary tract infections, urinary tract infections, p 343–347. In Long SS, Pickering LK, Prober CG (ed), Principles and Practice of Pediatric Infectious Diseases, 3rd ed. Churchill Livingston/Elsevier, Inc, Philadelphia, PA. [CrossRef]
2. Crain EF, Gershel JC. 1990. Urinary tract infections in febrile infants younger than 8 weeks of age. Pediatrics 86:363–367. [PubMed]
3. Hoberman A, Chao HP, Keller DM, Hickey R, Davis HW, Ellis D. 1993. Prevalence of urinary tract infection in febrile infants. J Pediatr 123:17–23. [PubMed][CrossRef]
4. Roberts KB, Charney E, Sweren RJ, Ahonkhai VI, Bergman DA, Coulter MP, Fendrick GM, Lachman BS, Lawless MR, Pantell RH, et al. 1983. Urinary tract infection in infants with unexplained fever: A collaborative study. J Pediatr 103:864–867. [PubMed][CrossRef]
5. Bauchner H, Philipp B, Dashefsky B, Klein JO. 1987. Prevalence of bacteriuria in febrile children. Pediatr Infect Dis J 6:239–242. [PubMed][CrossRef]
6. Winberg J, Andersen HJ, Bergström T, Jacobsson B, Larson H, Lincoln K. 1974. Epidemiology of symptomatic urinary tract infection in childhood. Acta Paediatr Scand Suppl 252:1–20. [PubMed][CrossRef]
7. Keren R, Shaikh N, Pohl H, Gravens-Mueller L, Ivanova A, Zaoutis L, Patel M, deBerardinis R, Parker A, Bhatnagar S, Haralam MA, Pope M, Kearney D, Sprague B, Barrera R, Viteri B, Egigueron M, Shah N, Hoberman A. 2015. Risk factors for recurrent urinary tract infection and renal scarring. Pediatrics 136:e13–e21. [PubMed][CrossRef]
8. Feld LG, Mattoo TK. 2010. Urinary tract infections and vesicoureteral reflux in infants and children. Pediatr Rev 31:451–463. [PubMed][CrossRef]
9. Nambiar S, Herwaldt LA, Singh N. 2003. Outbreak of invasive disease caused by methicillin-resistant Staphylococcus aureus in neonates and prevalence in the neonatal intensive care unit. Pediatr Crit Care Med 4:220–226. [PubMed][CrossRef]
10. Bollgren I, Winberg J. 1976. The periurethral aerobic bacterial flora in healthy boys and girls. Acta Paediatr Scand 65:74–80. [PubMed][CrossRef]
11. Schlager TA, Hendley JO, Lohr JA, Whittam TS. 1993. Effect of periurethral colonization on the risk of urinary tract infection in healthy girls after their first urinary tract infection. Pediatr Infect Dis J 12:988–993. [PubMed][CrossRef]
12. Weichhart T, Haidinger M, Hörl WH, Säemann MD. 2008. Current concepts of molecular defence mechanisms operative during urinary tract infection. Eur J Clin Invest 38(Suppl 2):29–38. [PubMed][CrossRef]
13. Edén CS, Eriksson B, Hanson LA, Jodal U, Kaijser B, Janson GL, Lindberg U, Olling S. 1978. Adhesion to normal human uroepithelial cells of Escherichia coli from children with various forms of urinary tract infection. J Pediatr 93:398–403. [CrossRef]
14. Yun KW, Kim HY, Park HK, Kim W, Lim IS. 2014. Virulence factors of uropathogenic Escherichia coli of urinary tract infections and asymptomatic bacteriuria in children. J Microbiol Immunol Infect 47:455–461. [PubMed][CrossRef]
15. Ballek NK, McKenna PH. 2010. Lower urinary tract dysfunction in childhood. Urol Clin North Am 37:215–228. [PubMed][CrossRef]
16. Shapiro E. 1999. American Academy of Pediatrics policy statements on circumcision and urinary tract infection. Rev Urol 1:154–156. [PubMed]
17. Coleman R. 2011. Early management and long-term outcomes in primary vesico-ureteric reflux. BJU Int 108(Suppl 2):3–8. [PubMed][CrossRef]
18. Gloor JM, Ramsey PS, Ogburn PL Jr, Danilenko-Dixon DR, DiMarco CS, Ramin KD. 2002. The association of isolated mild fetal hydronephrosis with postnatal vesicoureteral reflux. J Matern Fetal Neonatal Med 12:196–200. [PubMed][CrossRef]
19. Shaikh N, Ewing AL, Bhatnagar S, Hoberman A. 2010. Risk of renal scarring in children with a first urinary tract infection: a systematic review. Pediatrics 126:1084–1091. [PubMed][CrossRef]
20. Hussein A, Askar E, Elsaeid M, Schaefer F. 2010. Functional polymorphisms in transforming growth factor-beta-1 (TGFbeta-1) and vascular endothelial growth factor (VEGF) genes modify risk of renal parenchymal scarring following childhood urinary tract infection. Nephrol Dial Transplant 25:779–785. [PubMed][CrossRef]
21. Zaffanello M, Tardivo S, Cataldi L, Fanos V, Biban P, Malerba G. 2011. Genetic susceptibility to renal scar formation after urinary tract infection: a systematic review and meta-analysis of candidate gene polymorphisms. Pediatr Nephrol 26:1017–1029. [PubMed][CrossRef]
22. Chandra M, Maddix H. 2000. Urodynamic dysfunction in infants with vesicoureteral reflux. J Pediatr 136:754–759. [PubMed][CrossRef]
23. Anonymous. 1999. Practice parameter: the diagnosis, treatment, and evaluation of the initial urinary tract infection in febrile infants and young children. American Academy of Pediatrics. Committee on Quality Improvement. Subcommittee on Urinary Tract Infection. Pediatrics 103:843–852. [PubMed]
24. Kass EH. 1957. Bacteriuria and the diagnosis of infections of the urinary tract, with observations on the use of methionine as a urinary antiseptic. AMA Arch Intern Med 100:709–714. [PubMed][CrossRef]
25. Hellerstein S. 1982. Recurrent urinary tract infections in children. Pediatr Infect Dis 1:271–281. [PubMed][CrossRef]
26. Ransley PG, Risdon RA. 1981. Reflux nephropathy: effects of antimicrobial therapy on the evolution of the early pyelonephritic scar. Kidney Int 20:733–742. [PubMed][CrossRef]
27. Montini G, Tullus K, Hewitt I. 2011. Febrile urinary tract infections in children. N Engl J Med 365:239–250. [PubMed][CrossRef]
28. Fan NC, Chen HH, Chen CL, Ou LS, Lin TY, Tsai MH, Chiu CH. 2014. Rise of community-onset urinary tract infection caused by extended-spectrum β-lactamase-producing Escherichia coli in children. J Microbiol Immunol Infect 47:399–405. [PubMed][CrossRef]
29. Saadeh SA, Mattoo TK. 2011. Managing urinary tract infections. Pediatr Nephrol 26:1967–1976. [PubMed][CrossRef]
30. Peters CA, Skoog SJ, Arant BS, Jr., Copp HL, Elder JS, Hudson RG, Khoury AE, Lorenzo AJ, Pohl HG, Shapiro E, Snodgrass WT, Diaz M. 2010. Summary of the AUA Guideline on management of primary vesicoureteral reflux in children. J Urol 184:1134–1144. [PubMed][CrossRef]
31. Montini G, Zucchetta P, Tomasi L, Talenti E, Rigamonti W, Picco G, Ballan A, Zucchini A, Serra L, Canella V, Gheno M, Venturoli A, Ranieri M, Caddia V, Carasi C, Dall’amico R, Hewitt I. 2009. Value of imaging studies after a first febrile urinary tract infection in young children: data from Italian renal infection study 1. Pediatrics 123:e239–246. [PubMed][CrossRef]
32. Kawauchi A, Yamao Y, Ukimura O, Kamoi K, Soh J, Miki T. 2001. Evaluation of reflux kidney using renal resistive index. J Urol 165:2010–2012. [CrossRef]
33. Jodal U, Smellie JM, Lax H, Hoyer PF. 2006. Ten-year results of randomized treatment of children with severe vesicoureteral reflux. Final report of the International Reflux Study in Children. Pediatr Nephrol 21:785–792. [PubMed][CrossRef]
34. Craig JC, Simpson JM, Williams GJ, Lowe A, Reynolds GJ, McTaggart SJ, Hodson EM, Carapetis JR, Cranswick NE, Smith G, Irwig LM, Caldwell PH, Hamilton S, Roy LP; Prevention of Recurrent Urinary Tract Infection in Children with Vesicoureteric Reflux and Normal Renal Tracts (PRIVENT). 2009. Antibiotic prophylaxis and recurrent urinary tract infection in children. N Engl J Med 361:1748–1759. [PubMed][CrossRef]
35. DeMuri GP, Wald ER. 2008. Imaging and antimicrobial prophylaxis following the diagnosis of urinary tract infection in children. Pediatr Infect Dis J 27:553–554. [PubMed][CrossRef]
36. Pennesi M, Travan L, Peratoner L, Bordugo A, Cattaneo A, Ronfani L, Minisini S, Ventura A, North East Italy Prophylaxis in VUR Study Group. 2008. Is antibiotic prophylaxis in children with vesicoureteral reflux effective in preventing pyelonephritis and renal scars? A randomized, controlled trial. Pediatrics 121:e1489–e1494. [PubMed][CrossRef]
37. Roussey-Kesler G, Gadjos V, Idres N, Horen B, Ichay L, Leclair MD, Raymond F, Grellier A, Hazart I, de Parscau L, Salomon R, Champion G, Leroy V, Guigonis V, Siret D, Palcoux JB, Taque S, Lemoigne A, Nguyen JM, Guyot C. 2008. Antibiotic prophylaxis for the prevention of recurrent urinary tract infection in children with low grade vesicoureteral reflux: results from a prospective randomized study. J Urol 179:674–679; discussion 679. [PubMed][CrossRef]
38. Hari P, Hari S, Sinha A, Kumar R, Kapil A, Pandey RM, Bagga A. 2015. Antibiotic prophylaxis in the management of vesicoureteric reflux: a randomized double-blind placebo-controlled trial. Pediatr Nephrol 30:479–486. [PubMed][CrossRef]
39. Hoberman A, Chesney RW; RIVUR Trial Investigators. 2014. Antimicrobial prophylaxis for children with vesicoureteral reflux. N Engl J Med 371:1072–1073. [PubMed]
40. RIVUR Trial Investigators, Hoberman A, Greenfield SP, Mattoo TK, Keren R, Mathews R, Pohl HG, Kropp BP, Skoog SJ, Nelson CP, Moxey-Mims M, Chesney RW, Carpenter MA. 2014. Antimicrobial prophylaxis for children with vesicoureteral reflux. N Engl J Med 370:2367–2376. [PubMed][CrossRef]
41. de Bessa J Jr, de Carvalho Mrad FC, Mendes EF, Bessa MC, Paschoalin VP, Tiraboschi RB, Sammour ZM, Gomes CM, Braga LH, Bastos Netto JM. 2015. Antibiotic prophylaxis for prevention of febrile urinary tract infections in children with vesicoureteral reflux: a meta-analysis of randomized, controlled trials comparing dilated to nondilated vesicoureteral reflux. J Urol 193(Suppl 5):1772–1777. [PubMed][CrossRef]
42. Lee SJ, Shim YH, Cho SJ, Lee JW. 2007. Probiotics prophylaxis in children with persistent primary vesicoureteral reflux. Pediatr Nephrol 22:1315–1320. [PubMed][CrossRef]
43. Shamseer L, Vohra S, American Academy of Pediatrics Provisional Section on Complementary Holistic and Integrative Medicine. 2007. Complementary, holistic, and integrative medicine: cranberry. Pediatr Rev 28:e43–e45. [PubMed][CrossRef]
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2016-09-23
2017-12-12

Abstract:

Urinary tract infections (UTI) are one of the most common infections in children and symptoms may be nonspecific. The risk of renal scarring is highest in children under 1 year of age with febrile UTI and high-grade vesicoureteral reflux (VUR). Although treatment of UTI is usually straightforward, given increased rates of antimicrobial resistance worldwide, the choice of treatment for pediatric UTI should be guided by community resistance patterns whenever feasible. The benefit of antimicrobial prophylaxis after first UTI and/or in the presence of VUR remains controversial, but a recent meta-analysis supports continuous antimicrobial prophylaxis in children with VUR, indicating a need for more research in this area.

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