Chapter 14 : Long-Term Consequences of Infections in Immunocompetent and Immunodeficient Individuals

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Protozoans of the genus are small coccidian parasites that infect the mucosal epithelium of a variety of vertebrate hosts, including humans. The life cycle of most species is completed within the gastrointestinal tract (primarily the small intestine) of the host, with developmental stages being associated with the luminal surface of the mucosal epithelial cells. Cryptosporidiosis in the immunocompetent person is a self-limiting, acute gastroenteritis with a variety of presenting symptoms. Symptoms of cryptosporidiosis are generally similar but often develop insidiously in immunocompromised patients. The fact that both immunocompetent and immunocompromised persons develop a diarrheal illness suggests that symptoms are not totally dependent on an intact immune response. A recent paper analyzed the effect of the two major human pathogens, and , on oocyst shedding, symptoms, and long-term effects on growth. Primary immunodeficiencies (PIDs) are rare inherited disorders of the innate, cellular, and/or humoral immune system. In a study of the association between X-linked hyper-immunoglobulin M (IgM) syndrome (XHIM) and tumors of the pancreas, liver, and biliary tree, 14 of the 20 boys (70%) were found to be infected with species. The treatment of cryptosporidiosis in immunocompromised patients can, in principle, be based on (i) the use of antimicrobial agents, (ii) passive immunotherapy, and (iii) immune reconstitution.

Citation: Cacciò S, Pozio E, Guarino A, Albano F. 2009. Long-Term Consequences of Infections in Immunocompetent and Immunodeficient Individuals, p 245-257. In Fratamico P, Smith J, Brogden K (ed), Sequelae and Long-Term Consequences of Infectious Diseases. ASM Press, Washington, DC. doi: 10.1128/9781555815486.ch14
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1. Abdo, A.,, J. Klassen,, S. Urbanski,, E. Raber, and, M. G. Swain. 2003. Reversible sclerosing cholangitis secondary to cryptosporidiosis in a renal transplant patient. J. Hepatol. 38: 688691.
2. Abubakar, I.,, S. H. Aliyu,, C. Arumugam,, P. R. Hunter, and, N. K. Usman. 2007. Prevention and treatment of cryptosporidiosis in immunocompromised patients. Cochrane Database Syst. Rev. 1: CD004932.
3. Adams, E. J.,, L. S. Stephenson,, M. C. Latham, and, S. N. Kinoti. 1994. Physical activity and growth of Kenyan school children with hookworm, Trichuris trichiura and Ascaris lumbricoides infections are improved after treatment with albendazole. J. Nutr. 124: 11991206.
4. Arslan, H.,, E. K. Inci,, O. K. Azap,, H. Karakayali,, A. Torgay, and, M. Haberal. 2007. Etiologic agents of diarrhea in solid organ recipients. Transpl. Infect. Dis. 9: 270275.
5. Beaugerie, L.,, F. Carbonnel,, F. Carrat,, A. A. Rached,, C. Maslo,, J. P. Gendre,, W. Rozenbaum, and, J. Cosnes. 1998. Factors of weight loss in patients with HIV and chronic diarrhea. J. Acquir. Immune Defic. Syndr. Hum. Retrovirol. 19: 3439.
6. Berkman, D. S.,, A. G. Lescano,, R. H. Gilman,, S. L. Lopez, and, M. M. Black. 2002. Effects of stunting, diarrhoeal disease, and parasitic infection during infancy on cognition in late childhood: a follow-up study. Lancet 359: 564571.
7. Brown, J. L.,, and E. Pollitt. 1996. Malnutrition, poverty and intellectual development. Sci. Am. 274: 3843.
8. Bushen, O. Y.,, A. Kohli,, R. C. Pinkerton,, K. Dupnik,, R. D. Newman,, C. L. Sears,, R. Fayer,, A. A. Lima, and, R. L. Guerrant. 2007. Heavy cryptosporidial infections in children in northeast Brazil: comparison of Cryptosporidium hominis and Cryptosporidium parvum. Trans. R. Soc. Trop. Med. Hyg. 101: 378384.
9. Cacciò, S. M.,, and E. Pozio. 2006. Advances in the epidemiology, diagnosis and treatment of cryptosporidiosis. Expert Rev. Anti Infect. Ther. 4: 429443.
10. Cacciò, S. M.,, R. C. Thompson,, J. McLauchlin, and, H. V. Smith. 2005. Unravelling Cryptosporidium and Giardia epidemiology. Trends Parasitol. 21: 430437.
11. Cacciò, S. M. 2005. Molecular epidemiology of human cryptosporidiosis. Parassitologia 47: 185192.
12. Call, S. A.,, G. Heudebert,, M. Saag, and, C. M. Wilcox. 2000. The changing etiology of chronic diarrhea in HIV-infected patients with CD4 cell counts less than 200 cells/mm 3. Am. J. Gastroenterol. 95: 31423146.
13. Calzetti, C.,, G. Magnani,, D. Confalonieri,, A. Capelli,, S. Moneta,, P. Scognamiglio, and, F. Fiaccadori. 1997. Pancreatite da Cryptosporidium parvum in pazienti con grave deficit immunitario correlato ad infezione da HIV. Ann. Ital. Med. Int. 12: 6366.
14. Cama, V. A.,, J. M. Ross,, S. Crawford,, V. Kawai,, R. Chavez-Valdez,, D. Vargas,, A. Vivar,, E. Ticona,, M. Navincopa,, J. Williamson,, Y. Ortega,, R. H. Gilman,, C. Bern, and, L. Xiao. 2007. Differences in clinical manifestations among Cryptosporidium species and subtypes in HIV-infected persons. J. Infect. Dis. 195: 684691.
15. Campos, M.,, E. Jouzdani,, C. Sempoux,, J. P. Buts,, R. Reding,, J. B. Otte, and, E. M. Sokal. 2000. Sclerosing cholangitis associated to cryptosporidiosis in liver-transplanted children. Eur. J. Pediatr. 159: 113115.
16. Carr, A.,, D. Marriott,, A. Field,, E. Vasak, and, D. A. Cooper. 1998. Treatment of HIV-1-associated microsporidiosis and cryptosporidiosis with combination antiretroviral therapy. Lancet 351: 256261.
17. Cegielski, J. P.,, Y. R. Ortega,, S. McKee,, J. F. Madden,, L. Gaido,, D. A. Schwartz,, K. Manji,, A. F. Jorgensen,, S. E. Miller,, U. P. Pulipaka,, A. E. Msengi,, D. H. Mwakyusa,, C. R. Sterling, and, L. B. Reller. 1999. Cryptosporidium, Enterocytozoon, and Cyclospora infections in pediatric and adult patients with diarrhea in Tanzania. Clin. Infect. Dis. 28: 314321.
18. Chappel, C. L.,, P. C. Okhuysen, and, A. C. White, Jr. 2003. Cryptosporidium parvum: infectivity, pathogenesis and the host-parasite relationship, p. 19–49. In R. C. A Thompson,, A. Arnason, and, U. M. Ryan (ed.), Cryptosporidium: from Molecules to Disease. Elsevier Press, Amsterdam, The Netherlands.
19. Checkley, W.,, L. D. Epstein,, R. H. Gilman,, R. E. Black,, L. Cabrera, and, C. R. Sterling. 1998. Effects of Cryptosporidium parvum infection in Peruvian children: growth faltering and subsequent catch-up growth. Am. J. Epidemiol. 148: 497506.
20. Checkley, W.,, R. H. Gilman,, L. D. Epstein,, M. Suarez,, J. F. Diaz,, L. Cabrera,, R. E. Black, and, C. R. Sterling. 1997. Asymptomatic and symptomatic cryptosporidiosis: their acute effect on weight gain in Peruvian children. Am. J. Epidemiol. 145: 156163.
21. Cicirello, H. G.,, K. S. Kehl,, D. G. Addiss,, M. J. Chusid,, R. I. Glass,, J. P. Davis, and, P. L. Havens. 1997. Cryptosporidiosis in children during a massive waterborne outbreak in Milwaukee, Wisconsin: clinical, laboratory and epidemiologic findings. Epidemiol. Infect. 19: 5360.
22. Clavel, A.,, A. C. Arnal,, E. C. Sanchez,, J. Cuesta,, S. Letona,, J. A. Amiguet,, F. J. Castillo,, M. Varea, and, R. Gomez-Lus. 1996. Respiratory cryptosporidiosis: case series and review of the literature. Infection 24: 341346.
23. Colford, J. M., Jr.,, I. B. Tager,, A. M. Hirozawa,, G. F. Lemp,, T. Aragon T, and, C. Petersen. 1996. Cryptosporidiosis among patients infected with human immunodeficiency virus. Factors related to symptomatic infection and survival. Am. J. Epidemiol. 144: 807816.
24. Collins, C. D.,, C. Blanshard,, M. Cramp,, B. Gazzard, and, J. A. Gleeson. 1992. Case report: pneumatosis intestinalis occurring in association with cryptosporidiosis and HIV infection. Clin. Radiol. 46: 410411.
25. Connolly, K. J.,, and J. D. Kvalsvig. 1993. Infection, nutrition and cognitive performance in children. Parasitology 107: 187200.
26. Conti, S.,, M. Masocco,, P. Pezzotti,, V. Toccaceli,, M. Vichi,, S. Boros,, R. Urciuoli,, C. Valdarchi, and, G. Rezza. 2000. Differential impact of combined antiretroviral therapy on the survival of Italian patients with specific AIDS-defining illnesses. J. Acquir. Immune Defic. Syndr. 25: 451458.
27. Datta, D,, B. Gazzard, and, J. Stebbing. 2003. The diagnostic yield of stool analysis in 525 HIV-1-infected individuals. AIDS 17: 17111713.
28. Dillingham, R. A.,, A. A. Lima, and, R. L. Guerrant. 2002. Cryptosporidiosis: epidemiology and impact. Microbes Infect. 4: 10591066.
29. Fayer, R. 2003. Cryptosporidium: from molecules to disease, p. 11–18. In R. C. A. Thompson,, A. Arnason, and, U. M. Ryan (ed.), Cryptosporidium: from Molecules to Disease, Elsevier Press, Amsterdam, The Netherlands.
30. Forbes, A.,, C. Blanshard, and, B. Gazzard. 1993. Natural history of AIDS related sclerosing cholangitis: a study of 20 cases. Gut 34: 116121.
31. Garone, M. A.,, B. J. Winston, and, J. H. Lewis. 1986. Cryptosporidiosis of the stomach. Am. J. Gastroenterol. 81: 465470.
32. Gerber, D. A.,, M. Green,, R. Jaffe,, D. Greenberg,, G. Mazariegos, and, J. Reyes. 2000. Cryptosporidial infections after solid organ transplantation in children. Pediatr. Transplant. 4: 5055.
33. Godwin, T. A. 1991. Cryptosporidiosis in the acquired immunodeficiency syndrome: a study of 15 autopsy cases. Hum. Pathol. 22: 12151224.
34. Gomez Morales, M. A.,, C. M. Ausiello,, A. Guarino,, F. Urbani,, M. I. Spagnuolo,, C. Pignata, and, E. Pozio. Severe, protracted intestinal cryptosporidiosis associated with interferon gamma deficiency: pediatric case report. Clin. Infect. Dis., 22: 848850.
35. Gomez Morales, M. A.,, C. M. Ausiello,, F. Urbani, and, E. Pozio. 1995. Crude extract and recombinant protein of Cryptosporidium parvum oocysts induce proliferation of human peripheral blood mononuclear cells in vitro. J. Infect. Dis. 172: 211216.
36. Grube, H.,, B. Ramratnam,, C. Ley, and, T, P. Flanigan. 1997. Resolution of AIDS associated cryptosporidiosis after treatment with indinavir. Am. J. Gastroenterol. 92: 726.
37. Guarino, A.,, A. Castaldo,, S. Russo,, M. I. Spagnolo,, R. B. Canani,, L. Tarallo,, L. Di Benedetto, and, A. Rubino. 1997. Enteric cryptosporidiosis in pediatric HIV-infection. J. Pediatr. Gastroenterol. Nutr. 25: 182187.
38. Guerrant, D. I.,, S. R. Moore,, A. A. Lima,, P. D. Patrick,, J. B. Schorling, and, R. L. Guerrant. 1999. Association of early childhood diarrhea and cryptosporidiosis with impaired physical fitness and cognitive function four-seven years later in a poor urban community in northeast Brazil. Am. J. Trop. Med. Hyg. 61: 707713.
39. Hayward, A. R.,, J. Levy,, F. Facchetti,, L. Notarangelo,, H. D. Ochs,, A. Etzioni,, J. Y. Bonnefoy,, M. Cosyns, and, A. Weinberg. 1997. Cholangiopathy and tumors of the pancreas, liver and biliary tree in boys with hyper IgM. J. Immunol. 158: 977983.
40. Hong, D. K.,, C. J. Wong, and, K. Gutierrez. 2007. Severe cryptosporidiosis in a seven-year-old renal transplant recipient. Case report and review of the literature. Pediatr. Transplant. 11: 94100.
41. Hunter, P. R.,, S. Hughes,, S. Woodhouse,, N. Raj,, Q. Syed,, R. M. Chalmers,, N. Q. Verlander, and, J. Goodacre. 2004. Health sequelae of human cryptosporidiosis in immunocompetent patients. Clin. Infect. Dis. 39: 504510.
42. Hunter P. R.,, and G. Nichols. 2002. Epidemiology and clinical features of Cryptosporidium infection in immunocompromised patients. Clin. Microbiol. Rev. 15: 145154.
43. Iribarren, J. A.,, A. Castiella,, C. Lobo,, P. Lopez,, M. A. von Wichmann,, J. Arrizabalaga,, F. J. Rodriguez-Arrondo, and, L. F. Alzate. 1997. AIDS associated cryptosporidiosis with antral narrowing. A new case. J. Clin. Gastroenterol. 25: 693694.
44. Javier Enriquez, F.,, C. R. Avila,, J. Ignacio Santos,, J. Tanaka-Kido,, O. Vallejo, and, C. R. Sterling. 1997. Cryptosporidium infections in Mexican children: clinical, nutritional, enteropathogenic, and diagnostic evaluations. Am. J. Trop. Med. Hyg. 56: 254257.
45. Kazlow, P. G.,, K. Shah,, K. J. Benkov,, R. Dische, and, N. S. LeLeiko. 1986. Esophageal cryptosporidiosis in a child with acquired immune deficiency syndrome. Gastroenterology 91: 13011303.
46. Keusch, G. T. 2003. The history of nutrition: malnutrition, infection and immunity. J. Nutr. 133: 336S340S.
47. Kirkpatrick, B. D.,, C. D. Huston,, D. Wagner,, F. Noel,, P. Rouzier,, J. W. Pape,, G. Bois,, C. J. Larsson,, W. K. Alston,, K. Tenney,, C. Powden,, J. P. O’Neill, and, C. L. Sears. 2006. Serum mannose-binding lectin deficiency is associated with cryptosporidiosis in young Haitian children. Clin. Infect. Dis. 43: 289294.
48. Lopez-Velez, R.,, R. Tarazona,, A. Garcia Camacho,, E. Gomez-Mampaso,, A. Guerrero,, V. Moreira, and, R. Villanueva. 1995. Intestinal and extraintestinal cryptosporidiosis in AIDS patients. Eur. J. Clin. Microbiol. Infect. Dis. 14: 677681.
49. MacKenzie, W. R.,, W. L. Schell,, K. A. Blair,, D. G. Addiss,, D. E. Peterson,, N. J. Hoxie,, J. J. Kazmierczak, and, J. P. Davis. 1995 Massive outbreak of waterborne Cryptosporidium infection in Milwaukee, Wisconsin: recurrence of illness and risk of secondary transmission. Clin. Infect. Dis. 21: 5762.
50. Maggi, P.,, A. M. Larocca,, N. Ladisa,, S. Carbonara,, O. Brandonisio,, G. Angarano, and, G. Pastore. 2001. Opportunistic parasitic infections of the intestinal tract in the era of highly active antiretroviral therapy: is the CD4 + count so important? Clin. Infect. Dis. 33: 16091611.
51. Manz, M.,, and M. Steuerwald. 2007. Cryptosporidiosis in a patient on PEG interferon and ribavirin for recurrent hepatitis C after living donor liver transplantation. Transpl. Infect. Dis. 9: 6061.
52. Marion, R.,, A. Baishanbo,, G. Gargala,, A. François,, P. Ducrotté,, C. Duclos,, J. Fioramonti,, J. J. Ballet, and, L. Favennec. 2006. Transient neonatal Cryptosporidium parvum infection triggers long-term jejunal hypersensitivity to distension in immunocompetent rats. Infect. Immun. 74: 43874389.
53. McLauchlin J.,, C. F. Amar,, S. Pedraza-Díaz,, G. Mieli-Vergani,, N. Hadzic, and, E. G. Davies. 2003. Polymerase chain reaction-based diagnosis of infection with Cryptosporidium in children with primary immunodeficiencies. Pediatr. Infect. Dis. J. 22: 329335.
54. Mead, J. R. 2002. Cryptosporidiosis and the challenges of chemotherapy. Drug Resist. Updat. 5: 4757.
55. Mendez, M. A.,, and L. S. Adair. 1999. Severity and timing of stunting in the first two years of life affect performance on cognitive tests in late childhood. J. Nutr. 129: 15551562.
56. Miao, Y. M.,, F. M. Awad-El-Kariem,, C. Franzen,, D. S. Ellis,, A. Müller,, H. M. Counihan,, P. J. Hayes, and, B. G. Gazzard. 2000. Eradication of cryptosporidia and microsporidia following successful antiretroviral therapy. J. Acquir. Immune Defic. Syndr. 25: 124129.
57. Molbak, K.,, M. Andersen,, P. Aaby,, N. Hojlyng,, M. Jakobsen,, M. Sodemann, and, A. P. da Silva. 1997. Cryptosporidium infection in infancy as a cause of malnutrition: a community study from Guinea-Bissau, West Africa. Am. J. Clin. Nutr. 65: 149152.
58. Mönkemüller, K. E.,, S. A. Call,, A. J. Lazenby, and, C. M. Wilcox. 2000. Declining prevalence of opportunistic gastrointestinal disease in the era of combination antiretroviral therapy. Am. J. Gastroenterol. 95: 457462.
59. Moon, A.,, W. Spivak, and, L. J. Brandt. 1999. Cryptosporidium-induced gastric obstruction in a child with congenital HIV infection: case report and review of the literature. J. Pediatr. Gastroenterol. Nutr. 28: 108111.
60. Neira, P.,, M. T. Tardío,, M. Carabelli, and, L. Villalón. 1989. Cryptosporidiosis in the V Region Chile: III. Study of malnourished patients, 1985-87. Bol. Chil. Parasitol. 44: 3436.
61. Niehaus, M. D.,, S. R. Moore,, P. D. Patrick,, L. L. Derr,, B. Lorntz,, A. A. Lima, and, R. L. Guerrant. 2002. Early childhood diarrhea is associated with diminished cognitive function 4 to 7 years later in children in a northeast Brazilian shantytown. Am. J. Trop. Med. Hyg. 66: 590593.
62. Nokes, C.,, S. M. Grantham-McGregor,, A. W. Sawyer,, E. S. Cooper,, B. A. Robinson, and, D. A. Bundy. 1994. Parasitic helminth infection and cognitive function in school children. Parasitology 104: 539547.
63. Oberhuber, G.,, E. Lauer,, M. Stolte, and, F. Borchard. 1991. Cryptosporidiosis of the appendix vermiformis: a case report. Z. Gastroenterol. 29: 606608.
64. Okhuysen, P. C.,, C. L. Chappell,, J. Crabb,, L. M. Valdez,, E. T. Douglass, and, H. L. DuPont. 1998. Prophylactic effect of bovine anti- Cryptosporidium hyperimmune colostrum immunoglobulin in healthy volunteers challenged with Cryptosporidium parvum. Clin. Infect. Dis. 26: 13241329.
65. Powell, C. A.,, S. P. Walker,, J. H. Himes,, P. D. Fletcher, and, S. M. Grantham-McGregor. 1995. Relationships between physical growth, mental development and nutritional supplementation in stunted children: the Jamaican study. Acta Paediatr. 84: 2229.
66. Pozio E.,, and M. A. Gomez Morales. 2005. The impact of HIV-protease inhibitors on opportunistic parasites. Trends Parasitol. 21: 5863.
67. Pozio, E.,, F. Rivasi, and, S. M. Cacciò. 2004. Infection with Cryptosporidium hominis and reinfection with Cryptosporidium parvum in a transplanted ileum. APMIS 112: 309313.
68. Pozio, E.,, G. Rezza,, A. Boschini,, P. Pezzotti,, A. Tamburrini,, P. Rossi,, M. Di Fine,, C. Smacchia,, A. Schiesari,, E. Gattei,, R. Zucconi, and, P. Ballerini. 1997. Clinical cryptosporidiosis and HIV-induced immunosuppression: findings from a longitudinal study of HIV-positive and negative former drug users. J. Infect. Dis. 176: 969975.
69. Riggs, M. W. 2002. Recent advances in cryptosporidiosis: the immune response. Microbes Infect. 4: 10671080.
70. Rodrigues, F.,, E. G. Davies,, P. Harrison,, J. McLauchlin,, J. Karani,, B. Portmann,, A. Jones,, P. Veys,, G. Mieli-Vergani, and, N. Hadzić. 2004. Liver disease in children with primary immunodeficiencies. J. Pediatr. 145: 333339.
71. Rossi. P.,, F. Rivasi,, M. Codeluppi,, A. Catania,, A. Tamburrini,, E. Righi, and, E. Pozio. 1998. Gastric involvement in AIDS-associated cryptosporidiosis. Gut 43: 476477.
72. Samson, V. E.,, and W. R. Brown. 1996. Pneumatosis cystoides intestinalis in AIDS-associated cryptosporidiosis. More than an incidental finding? J. Clin. Gastroenterol. 22: 311312.
73. Schmidt, W.,, U. Wahnschaffe,, M. Schäfer,, T. Zippel,, M. Arvand,, A. Meyerhans,, E. O. Riecken, and, R. Ullrich. 2001. Rapid increase of mucosal CD4 T cells followed by clearance of intestinal cryptosporidiosis in an AIDS patient receiving highly active antiretroviral therapy. Gastroenterology 120: 984987.
74. Sidhu, S.,, S. Flamm, and, S. Chopra. 1994. Pneumatosis cystoides intestinalis: an incidental finding in a patient with AIDS and cryptosporidial diarrhea. Am. J. Gastroenterol. 89: 15781579.
75. Stephenson, L. S.,, M. C. Latham,, E. J. Adams,, S. N. Kinoti, and, A. Pertet. 1993. Physical fitness, growth and appetite of Kenyan school children with hookworm, Trichuris trichiura and Ascaris lumbricoides infections are improved four months after a single dose of albendazole. J. Nutr. 123: 10361046.
76. Thompson, R. C.,, M. E. Olson,, G. Zhu,, S. Enomoto,, M. S. Abrahamsen, and, N. S. Hijjawi. 2005. Cryptosporidium and cryptosporidiosis. Adv. Parasitol. 59: 77158.
77. Toniati P.,, S. Giliani,, A. Jones,, G. de Saint Basile,, P. Airo,, G. Savoldi,, M. Vihinen, and, L. D. Notarangelo. 2002. Report of the ESID collaborative study on clinical features and molecular analysis of X-linked hyper-IgM syndrome. Eur. Soc. Immunodeficiencies Newsl. F9 (Suppl) : 40.
78. Vakil, N. B.,, S. M. Schwartz,, B. P. Buggy,, C. F. Brummitt,, M. Kherellah,, D. M. Letzer,, I. H. Gilson, and, P. G. Jones. 1996. Biliary cryptosporidiosis in HIV-infected people after the waterborne outbreak of cryptosporidiosis in Milwaukee. N. Engl. J. Med. 334: 1923.
79. White, C. A., Jr. 2004. Nitazoxanide: a new broad spectrum antiparasitic agent. Expert Rev. Anti Infect. Ther. 2: 4349.
80. Wolska-Kusnierz, B.,, A. Bajer,, S. M. Cacciò,, E. Heropolitanska-Pliszka,, E. Bernatowska,, P. Socha,, J. van Dongen,, M. Bednarska,, A. Paziewska, and, E. Sinski. 2007. Cryptosporidium infection in patients with primary immunodeficiencies. J. Pediatr. Gastroenterol. Nutr. 45: 458464.
81. Xiao, L.,, R. Fayer,, U. Ryan, and, S. J. Upton. 2004. Cryptosporidium taxonomy: recent advances and implications for public health. Crit. Rev. Microbiol. 17: 7297.


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Table 1.

List of the currently recognized human pathogens in the genus

Citation: Cacciò S, Pozio E, Guarino A, Albano F. 2009. Long-Term Consequences of Infections in Immunocompetent and Immunodeficient Individuals, p 245-257. In Fratamico P, Smith J, Brogden K (ed), Sequelae and Long-Term Consequences of Infectious Diseases. ASM Press, Washington, DC. doi: 10.1128/9781555815486.ch14
Generic image for table
Table 2.

Summary of long-term functional and growth impairment in children with cryptosporidiosis

Citation: Cacciò S, Pozio E, Guarino A, Albano F. 2009. Long-Term Consequences of Infections in Immunocompetent and Immunodeficient Individuals, p 245-257. In Fratamico P, Smith J, Brogden K (ed), Sequelae and Long-Term Consequences of Infectious Diseases. ASM Press, Washington, DC. doi: 10.1128/9781555815486.ch14

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