Epidemiological Methods To Implicate Specific Microorganisms with Long-Term Complications

Kåre Mølbak

doi:10.1128/9781555815486.ch27

Chapter 27 : Epidemiological Methods To Implicate Specific Microorganisms with Long-Term Complications

Author: Kåre Mølbak¹

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Affiliations: 1: Statens Serum Institut, 5 Artillerivej, 2300 Copenhagen S, Denmark

Content Type: Monograph

Publication Year: 2009

Category: Clinical Microbiology

Book DOI: 10.1128/9781555815486

Chapter DOI: 10.1128/9781555815486.ch27

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Abstract:

This chapter presents the epidemiological methods to implicate microorganisms with long-term complications. It addresses the design of epidemiological studies, the validity of such studies, and the importance of population-and registry-based research. Three types of problems that affect the interpretation of epidemiological studies may be identified. These include selection bias, information bias, and confounding. Population-or community-based studies refer to large population studies in which cohorts are followed over several years. For chronic disease epidemiology, there are many examples of such studies. Examples from industrialized countries include human herpesvirus 8 and Kaposi’s sarcoma in HIV-positive individuals, human papilloma virus (HPV) and cervical cancer, Helicobacter pylori and gastric cancer, and population-based cohort studies of the epidemiology of gastrointestinal diseases. In the future, infections will be detected or described, and some of these may be linked to complications or sequelae that occur later in life. Epidemiological studies will, along with other lines of rigorous research, continue to be of importance to explore putative associations between infectious exposures and chronic conditions or illnesses.

Citation: Mølbak K. 2009. Epidemiological Methods To Implicate Specific Microorganisms with Long-Term Complications, p 477-486. In Fratamico P, Smith J, Brogden K (ed), Sequelae and Long-Term Consequences of Infectious Diseases. ASM Press, Washington, DC. doi: 10.1128/9781555815486.ch27

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References

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1. Aaby, P. 1995. Assumptions and contradictions in measles and measles immunization research: is measles good for something? Soc. Sci. Med. 41: 673– 686.

2. Aaby, P.,, C. S. Benn,, J. Nielsen,, I. M. Lisse,, A. Rodrigues, and, H. Jensen. 2007. DTP vaccination and child survival in observational studies with incomplete vaccination data. Trop. Med. Int. Health 12: 15– 24.

3. Aaby, P.,, A. Bhuiya,, L. Nahar,, K. Knudsen,, F. A. de, and, M. Strong. 2003. The survival benefit of measles immunization may not be explained entirely by the prevention of measles disease: a community study from rural Bangladesh. Int. J. Epidemiol. 32: 106– 116.

4. Aaby, P.,, J. Bukh,, I. M. Lisse, and, A. J. Smits. 1984. Overcrowding and intensive exposure as determinants of measles mortality. Am. J. Epidemiol. 120: 49– 63.

5. Aaby, P.,, M. L. Garly,, C. Bale,, C. Martins,, H. Jensen,, I. Lisse, and, H. Whittle. 2003. Survival of previously measles-vaccinated and measles-unvaccinated children in an emergency situation: an unplanned study. Pediatr. Infect. Dis. J. 22: 798– 805.

6. Aaby, P.,, M. L. Garly,, J. Nielsen,, H. Ravn,, C. Martins,, C. Bale,, A. Rodrigues,, C. S. Benn, and, I. M. Lisse. 2007. Increased female-male mortality ratio associated with inactivated polio and diphtheria-tetanus-pertussis vaccines: Observations from vaccination trials in Guinea-Bissau. Pediatr. Infect. Dis. J. 26: 247– 252.

7. Aaby, P.,, and H. Jensen. 2005. Do measles vaccines have nonspecific effects on mortality? Bull. W. H. O. 83: 238.

8. Aaby, P.,, A. Rodrigues,, S. Biai,, C. Martins,, J. E. Veirum,, C. S. Benn, and, H. Jensen. 2005. Vaccines and unexpected observations: flaws or cause for concern? Vaccine 23: 2407– 2408.

9. Alam, D. S.,, G. C. Marks,, A. H. Baqui,, M. Yunus, and, G. J. Fuchs. 2000. Association between clinical type of diarrhoea and growth of children under 5 years in rural Bangladesh. Int. J. Epidemiol. 29: 916– 921.

10. Anonymous. 2001. Gastric cancer and Helicobacter pylori: a combined analysis of 12 case control studies nested within prospective cohorts. Gut 49: 347– 353.

11. Bennish, M. L.,, and B. J. Wojtyniak. 1991. Mortality due to shigellosis: community and hospital data. Rev. Infect. Dis. 13( Suppl. 4) : S245– S251.

12. Beral, V.,, T. A. Peterman,, R. L. Berkelman, and, H. W. Jaffe. 1990. Kaposi’s sarcoma among persons with AIDS: a sexually transmitted infection? Lancet 335: 123– 128.

13. Bernard, S. M.,, R. A. Cartwright,, C. M. Darwin,, I. D. Richards,, B. Roberts,, C. O’Brien, and, C. C. Bird. 1987. Hodgkin’s disease: case control epidemiological study in Yorkshire. Br. J. Cancer 55: 85– 90.

14. Chowdhury, M. E.,, R. Botlero,, M. Koblinsky,, S. K. Saha,, G. Dieltiens, and, C. Ronsmans. 2007. Determinants of reduction in maternal mortality in Matlab, Bangladesh: a 30-year cohort study. Lancet 370: 1320– 1328.

15. Classen, J. B. 1996. The timing of immunization affects the development of diabetes in rodents. Autoimmunity 24: 137– 145.

16. Cutts, F. T.,, S. Franceschi,, S. Goldie,, X. Castellsague,, S. S. de,, G. Garnett,, W. J. Edmunds,, P. Claeys,, K. L. Goldenthal,, D. M. Harper, and, L. Markowitz. 2007. Human papillomavirus and HPV vaccines: a review. Bull. W. H. O. 85: 719– 726.

17. de Wit, M. A.,, M. P. Koopmans,, L. M. Kortbeek,, W. J. Wannet,, J. Vinje,, L. F. van,, A. I. Bartelds, and, Y. T. van Duynhoven. 2001. Sensor, a population-based cohort study on gastroenteritis in the Netherlands: incidence and etiology. Am. J. Epidemiol. 154: 666– 674.

18. Franceschi, S. 2005. The IARC commitment to cancer prevention: the example of papillomavirus and cervical cancer. Recent Results Cancer Res. 166: 277– 297.

19. Franco, E. L.,, N. F. Schlecht, and, D. Saslow. 2003. The epidemiology of cervical cancer. Cancer J. 9: 348– 359.

20. Frank, L. 2003. Epidemiology. The epidemiologist’s dream: Denmark. Science 301: 163.

21. Geier, D. A.,, and M. R. Geier. 2003. An assessment of the impact of thimerosal on childhood neurodevelopmental disorders. Pediatr. Rehabil. 6: 97– 102.

22. Geser, A.,, T. G. de,, G. Lenoir,, N. E. Day, and, E. H. Williams. 1982. Final case reporting from the Ugandan prospective study of the relationship between EBV and Burkitt’s lymphoma. Int. J. Cancer 29: 397– 400.

23. Giesecke, J. 2002. Modern Infectious Disease Epidemiology. Arnold, London, United Kingdom.

24. Greenland, S.,, and H. Morgenstern. 2001. Confounding in health research. Annu. Rev. Public Health 22: 189– 212.

25. Gustafson, P.,, V. F. Gomes,, C. S. Vieira,, B. Samb,, A. Naucler,, P. Aaby, and, I. Lisse. 2007. Clinical predictors for death in HIV-positive and HIV-negative tuberculosis patients in Guinea-Bissau. Infection 35: 69– 80.

26. Havelaar, A. H.,, M. A. de Wit,, K. R. van, and, K. E. van. 2000. Health burden in the Netherlands due to infection with thermophilic Campylobacter spp. Epidemiol. Infect. 125: 505– 522.

27. Hawkes, S.,, L. Morison,, S. Foster,, K. Gausia,, J. Chakraborty,, R. W. Peeling, and, D. Mabey. 1999. Reproductive-tract infections in women in low-income, low-prevalence situations: assessment of syndromic management in Matlab, Bangladesh. Lancet 354: 1776– 1781.

28. Helms, M.,, J. Simonsen, and, K. Molbak. 2004. Quinolone resistance is associated with increased risk of invasive illness or death during infection with Salmonella serotype Typhimurium. J. Infect. Dis. 190: 1652– 1654.

29. Helms, M.,, J. Simonsen, and, K. Molbak. 2006. Foodborne bacterial infection and hospitalization: a registry-based study. Clin. Infect. Dis. 42: 498– 506.

30. Helms, M.,, J. Simonsen,, K. E. Olsen, and, K. Molbak. 2005. Adverse health events associated with antimicrobial drug resistance in Campylobacter species: a registry-based cohort study. J. Infect. Dis. 191: 1050– 1055.

31. Helms, M.,, P. Vastrup,, P. Gerner-Smidt, and, K. Molbak. 2002. Excess mortality associated with antimicrobial drug-resistant Salmonella typhimurium. Emerg. Infect. Dis. 8: 490– 495.

32. Helms, M.,, P. Vastrup,, P. Gerner-Smidt, and, K. Molbak. 2003. Short and long term mortality associated with foodborne bacterial gastrointestinal infections: registry based study. BMJ 326: 357.

33. Hill, A. B. 1965. The environment and disease: association or causation? Proc. R. Soc Med. 58: 295– 300.

34. Hjalgrim, H.,, K. E. Smedby,, K. Rostgaard,, D. Molin,, S. Hamilton-Dutoit,, E. T. Chang,, E. Ralfkiaer,, C. Sundstrom,, H. O. Adami,, B. Glimelius, and, M. Melbye. 2007. Infectious mononucleosis, childhood social environment, and risk of Hodgkin lymphoma. Cancer Res. 67: 2382– 2388.

35. Holmgren, B.,, S. Z. da,, P. Vastrup,, O. Larsen,, S. Andersson,, H. Ravn, and, P. Aaby. 2007. Mortality associated with HIV-1, HIV-2, and HTLV-I single and dual infections in a middle-aged and older population in Guinea-Bissau. Retrovirology 4: 85.

36. Howitz, M.,, T. G. Krause,, J. B. Simonsen,, S. Hoffmann,, M. Frisch,, N. M. Nielsen,, J. Robbins,, R. Schneerson,, K. Molbak, and, M. A. Miller. 2007. Lack of association between group B meningococcal disease and autoimmune disease. Clin. Infect. Dis. 45: 1327– 1334.

37. Howitz, M.,, J. Simonsen,, T. G. Krause,, J. Robbins,, R. Schneerson,, K. Mølbak, and, M. A. Miller. 2009. Risk of adverse birth outcome after group B meningococcal disease: results from Danish National Cohort. Pediatr. Infect. Dis. 28: 199– 203.

38. Hviid, A. 2006. Postlicensure epidemiology of childhood vaccination: the Danish experience. Expert Rev. Vaccines 5: 641– 649.

39. Hviid, A.,, M. Stellfeld,, J. Wohlfahrt, and, M. Melbye. 2003. Association between thimerosal-containing vaccine and autism. JAMA 290: 1763– 1766.

40. Hviid, A.,, M. Stellfeld,, J. Wohlfahrt, and, M. Melbye. 2004. Childhood vaccination and type 1 diabetes. N. Engl. J. Med. 350: 1398– 1404.

41. Irving, P. M.,, and P. R. Gibson. 2008. Infections and IBD. Nat. Clin. Pract. Gastroenterol. Hepatol. 5: 18– 27.

42. Jensen, H.,, C. S. Benn,, I. M. Lisse,, A. Rodrigues,, P. K. Andersen, and, P. Aaby. 2007. Survival bias in observational studies of the impact of routine immunizations on childhood survival. Trop. Med. Int. Health 12: 5– 14.

43. Kannel, W. B.,, and R. D. Abbott. 1984. Incidence and prognosis of unrecognized myocardial infarction. An update on the Framingham study. N. Engl. J. Med. 311: 1144– 1147.

44. Kjaer, S. K. 1998. Risk factors for cervical neoplasia in Denmark. APMIS Suppl. 80: 1– 41.

45. Kjaer, S. K.,, A. J. van den Brule,, G. Paull,, E. I. Svare,, M. E. Sherman,, B. L. Thomsen,, M. Suntum,, J. E. Bock,, P. A. Poll, and, C. J. Meijer. 2002. Type specific persistence of high risk human papillomavirus (HPV) as indicator of high grade cervical squamous intraepithelial lesions in young women: population based prospective follow up study. BMJ 325: 572.

46. Kristensen, I.,, P. Aaby, and, H. Jensen. 2000. Routine vaccinations and child survival: follow up study in Guinea-Bissau, West Africa. BMJ 321: 1435– 1438.

47. Larouze, B.,, G. Saimot,, E. D. Lustbader,, W. T. London,, B. G. Werner, and, M. Payet. 1976. Host responses to hepatitis-B infection in patients with primary hepatic carcinoma and their families. A case/control study in Senegal, West Africa. Lancet ii: 534– 538.

48. Löffler, E. 1988. Mitteilungen aus den Kaiserliche Gesundheitsamt. Vol 11, 1884., p. 180. In D. T. Brock (ed.), Robert Koch. A Life in Medicine and Bacteriology. Science Technical Publishers, Madison, WI.

49. Madsen, K. M.,, A. Hviid,, M. Vestergaard,, D. Schendel,, J. Wohlfahrt,, P. Thorsen,, J. Olsen, and, M. Melbye. 2002. A population-based study of measles, mumps, and rubella vaccination and autism. N. Engl. J. Med. 347: 1477– 1482.

50. Mangione-Smith, R.,, M. N. Elliott,, L. McDonald, and, E. A. McGlynn. 2002. An observational study of antibiotic prescribing behavior and the Hawthorne effect. Health Serv. Res. 37: 1603– 1623.

51. Marshall, B. J.,, J. A. Armstrong,, D. B. McGechie, and, R. J. Glancy. 1985. Attempt to fulfill Koch’s postulates for pyloric Campylobacter. Med. J. Aust. 142: 436– 439.

52. McDonald, K. L.,, S. I. Huq,, L. M. Lix,, A. B. Becker, and, A. L. Kozyrskyj. 2008. Delay in diphtheria, pertussis, tetanus vaccination is associated with a reduced risk of childhood asthma. J. Allergy Clin. Immunol. 121: 626– 631.

53. Melbye, M.,, P. M. Cook,, H. Hjalgrim,, K. Begtrup,, G. R. Simpson,, R. J. Biggar,, P. Ebbesen, and, T. F. Schulz. 1998. Risk factors for Kaposi’s-sarcoma-associated herpesvirus (KSHV/HHV-8) seropositivity in a cohort of homosexual men, 1981-1996. Int. J. Cancer 77: 543– 548.

54. Mishu, B.,, A. A. Ilyas,, C. L. Koski,, F. Vriesendorp,, S. D. Cook,, F. A. Mithen, and, M. J. Blaser. 1993. Serologic evidence of previous Campylobacter jejuni infection in patients with the Guillain-Barre syndrome. Ann. Intern. Med. 118: 947– 953.

55. Mølbak, K. 2000. The epidemiology of diarrhoeal diseases in early childhood. A review of community studies in Guinea-Bissau. Dan. Med. Bull. 47: 340– 358.

56. Mølbak, K.,, M. Andersen,, P. Aaby,, N. Hojlyng,, M. Jakobsen,, M. Sodemann, and, A. P. da Silva. 1997. Cryptosporidium infection in infancy as a cause of malnutrition: a community study from Guinea-Bissau, west Africa. Am. J. Clin. Nutr. 65: 149– 152.

57. Mølbak, K.,, and A. H. Havelaar. 2008. Burden of illness of campylobacteriosis and sequelae, p. 151–161. In I. Nachamkin,, C. M. Szymanski, and, M. J. Blaser (ed.), Campylobacter, 3rd ed. ASM Press, Washington, DC.

58. Mølbak, K.,, N. Hojlyng,, A. Gottschau,, J. C. Sa,, L. Ingholt,, A. P. da Silva, and, P. Aaby. 1993. Cryptosporidiosis in infancy and childhood mortality in Guinea Bissau, West Africa. BMJ 307: 417– 420.

59. Nomura, A.,, G. N. Stemmermann,, P. H. Chyou,, G. I. Perez-Perez, and, M. J. Blaser. 1994. Helicobacter pylori infection and the risk for duodenal and gastric ulceration. Ann. Intern. Med. 120: 977– 981.

60. O’Brien, S. J.,, and R. A. Feldman. 2003. Mortality associated with foodborne bacterial gastrointestinal infections: case selection and clinical data are important. BMJ 326: 1265.

61. Osterholm, M. T.,, J. P. Davis,, R. W. Gibson,, J. S. Mandel,, L. A. Wintermeyer,, C. M. Helms,, J. C. Forfang,, J. Rondeau, and, J. M. Vergeront. 1982. Tri-state toxic-state syndrome study. I. Epidemiologic findings. J. Infect. Dis. 145: 431– 440.

62. Parravicini, C.,, S. J. Olsen,, M. Capra,, F. Poli,, G. Sirchia,, S. J. Gao,, E. Berti,, A. Nocera,, E. Rossi,, G. Bestetti,, M. Pizzuto,, M. Galli,, M. Moroni,, P. S. Moore, and, M. Corbellino. 1997. Risk of Kaposi’s sarcoma-associated herpes virus transmission from donor allografts among Italian posttransplant Kaposi’s sarcoma patients. Blood 90: 2826– 2829.

63. Parsonnet, J.,, G. D. Friedman,, D. P. Vandersteen,, Y. Chang,, J. H. Vogelman,, N. Orentreich, and, R. K. Sibley. 1991. Helicobacter pylori infection and the risk of gastric carcinoma. N. Engl. J. Med. 325: 1127– 1131.

64. Reeves, W. C.,, L. A. Brinton,, M. Garcia,, M. M. Brenes,, R. Herrero,, E. Gaitan,, F. Tenorio,, R. C. de Britton, and, W. E. Rawls. 1989. Human papillomavirus infection and cervical cancer in Latin America. N. Engl. J. Med. 320: 1437– 1441.

65. Rook, G. A.,, and L. R. Brunet. 2002. Give us this day our daily germs. Biologist (London) 49: 145– 149.

66. Roth, A.,, M. Sodemann,, H. Jensen,, A. Poulsen,, P. Gustafson,, C. Weise,, J. Gomes,, Q. Djana,, M. Jakobsen,, M. L. Garly,, A. Rodrigues, and, P. Aaby. 2006. Tuberculin reaction, BCG scar, and lower female mortality. Epidemiology 17: 562– 568.

67. Rothman, K. J.,, and S. Greenland. 1998. Causation and causal inference, p. 7–28. In K. J. Rothman and, S. Greenland (ed.), Modern Epidemiology. Lippincott-Raven, Philadelphia, PA.

68. Rothman, K. J.,, and S. Greenland. 1998. Modern Epidemiology. Lippincott-Raven, Philadelphia, PA.

69. Sasazuki, S.,, M. Inoue,, M. Iwasaki,, T. Otani,, S. Yamamoto,, S. Ikeda,, T. Hanaoka, and, S. Tsugane. 2006. Effect of Helicobacter pylori infection combined with CagA and pepsinogen status on gastric cancer development among Japanese men and women: a nested case-control study. Cancer Epidemiol. Biomarkers Prev. 15: 1341– 1347.

70. Schmidt, W. P.,, M. S. Van Der Loeff,, P. Aaby,, H. Whittle,, R. Bakker,, M. Buckner,, F. Dias, and, R. G. White. 2008. Behaviour change and competitive exclusion can explain the diverging HIV-1 and HIV-2 prevalence trends in Guinea-Bissau. Epidemiol. Infect. 136: 551– 561.

71. Shands, K. N.,, G. P. Schmid,, B. B. Dan,, D. Blum,, R. J. Guidotti,, N. T. Hargrett,, R. L. Anderson,, D. L. Hill,, C. V. Broome,, J. D. Band, and, D. W. Fraser. 1980. Toxic-shock syndrome in menstruating women: association with tampon use and Staphylococcus aureus and clinical features in 52 cases. N. Engl. J. Med. 303: 1436– 1442.

72. Shepard, C. W.,, E. P. Simard,, L. Finelli,, A. E. Fiore, and, B. P. Bell. 2006. Hepatitis B virus infection: epidemiology and vaccination. Epidemiol. Rev. 28: 112– 125.

73. Smith, J. L.,, and D. Bayles. 2007. Postinfectious irritable bowel syndrome: a long-term consequence of bacterial gastroenteritis. J. Food Prot. 70: 1762– 1769.

74. Spiller, R. C. 2007. Role of infection in irritable bowel syndrome. J. Gastroenterol. 42( Suppl. 17) : 41– 47.

75. Sytkowski, P. A.,, W. B. Kannel, and, R. B. D’Agostino. 1990. Changes in risk factors and the decline in mortality from cardiovascular disease. The Framingham Heart Study. N. Engl. J. Med. 322: 1635– 1641.

76. Tarimo, E. 1991. Community-based studies in sub-Saharan Africa: an overview, p. 243–247. In R. G. Feachem and, D. T. Jamison (ed.), Disease and Mortality in Sub-Saharan Africa. Oxford University Press, Oxford, United Kingdom.

77. Trottier, H.,, and E. L. Franco. 2006. The epidemiology of genital human papillomavirus infection. Vaccine 24( Suppl. 1) : S1– S15.

78. Valentiner-Branth, P.,, H. Steinsland,, T. K. Fischer,, M. Perch,, F. Scheutz,, F. Dias,, P. Aaby,, K. Molbak, and, H. Sommerfelt. 2003. Cohort study of Guinean children: incidence, pathogenicity, conferred protection, and attributable risk for enteropathogens during the first 2 years of life. J. Clin. Microbiol. 41: 4238– 4245.

79. Vasto, S.,, G. Colonna-Romano,, A. Larbi,, A. Wikby,, C. Caruso, and, G. Pawelec. 2007. Role of persistent CMV infection in configuring T cell immunity in the elderly. Immun. Ageing 4: 2.

80. Veirum, J. E.,, M. Sodemann,, S. Biai,, M. Jakobsen,, M. L. Garly,, K. Hedegaard,, H. Jensen, and, P. Aaby. 2005. Routine vaccinations associated with divergent effects on female and male mortality at the paediatric ward in Bissau, Guinea-Bissau. Vaccine 23: 1197– 1204.

81. Vestergaard, M.,, A. Hviid,, K. M. Madsen,, J. Wohlfahrt,, P. Thorsen,, D. Schendel,, M. Melbye, and, J. Olsen. 2004. MMR vaccination and febrile seizures: evaluation of susceptible subgroups and long-term prognosis. JAMA 292: 351– 357.

82. Wakefield, A. J.,, S. H. Murch,, A. Anthony,, J. Linnell,, D. M. Casson,, M. Malik,, M. Berelowitz,, A. P. Dhillon,, M. A. Thomson,, P. Harvey,, A. Valentine,, S. E. Davies, and, J. A. Walker-Smith. 1998. Ileal-lymphoid-nodular hyperplasia, non-specific colitis, and pervasive developmental disorder in children. Lancet 351: 637– 641.

83. Walboomers, J. M.,, M. V. Jacobs,, M. M. Manos,, F. X. Bosch,, J. A. Kummer,, K. V. Shah,, P. J. Snijders,, J. Peto,, C. J. Meijer, and, N. Munoz. 1999. Human papillomavirus is a necessary cause of invasive cervical cancer worldwide. J. Pathol. 189: 12– 19.

84. Wheeler, J. G.,, D. Sethi,, J. M. Cowden,, P. G. Wall,, L. C. Rodrigues,, D. S. Tompkins,, M. J. Hudson, and, P. J. Roderick. 1999. Study of infectious intestinal disease in England: rates in the community, presenting to general practice, and reported to national surveillance. The Infectious Intestinal Disease Study Executive. BMJ 318: 1046– 1050.

85. Winer, J. B.,, R. A. Hughes,, M. J. Anderson,, D. M. Jones,, H. Kangro, and, R. P. Watkins. 1988. A prospective study of acute idiopathic neuropathy. II. Antecedent events. J. Neurol. Neurosurg. Psychiatry 51: 613– 618.

86. Ylitalo, N.,, P. Sorensen,, A. M. Josefsson,, P. K. Magnusson,, P. K. Andersen,, J. Ponten,, H. O. Adami,, U. B. Gyllensten, and, M. Melbye. 2000. Consistent high viral load of human papillomavirus 16 and risk of cervical carcinoma in situ: a nested case-control study. Lancet 355: 2194– 2198.

Tables

Epidemiological Methods To Implicate Specific Microorganisms with Long-Term Complications

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/content/10.1128/9781555815486.ch27.ch27tab01

Table 1.

Infectious disease associations with long-term complications

Table 1.

Infectious disease associations with long-term complications

/content/10.1128/9781555815486.ch27.ch27tab02

Table 2.

Advantages and disadvantages of the cohort and the case-control studies to implicate specific microorganisms with long-term complications

Table 2.

Advantages and disadvantages of the cohort and the case-control studies to implicate specific microorganisms with long-term complications