Chapter 14 : Mechanisms of Antibiotic Resistance in

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This chapter discusses the mechanisms involved in resistance to various antibiotics, with particular emphasis on new information obtained during the last few years. One's understanding of the resistance mechanisms is limited to and , and little information is available on antimicrobial resistance in other spp. Fluoroquinolone (FQ) antimicrobials are important in the treatment of enteric infections including campylobacteriosis. Macrolide antibiotics, such as erythromycin, clarithromycin, azithromycin, and telithromycin, are important drugs for the treatment of respiratory tract infections and gastric diseases caused by and in humans. To date, two mechanisms have been described for resistance to tetracyclines. The first mechanism involves a ribosomal protection protein termed Tet(O). The second mechanism of tetracycline resistance in involves the efflux system. Several studies reported that the majority of and isolates produce β-lactamases. The multidrug efflux pump CmeABC has been shown to contribute to both intrinsic and acquired resistance to tetracycline. The contribution of efflux pumps to antimicrobial resistance in is increasingly recognized. Inhibition of the efflux systems may not only control antibiotic resistance but also prevent colonization in vivo. Future efforts should be directed for understanding the interplay of various mechanisms in conferring antimicrobial resistance and the molecular basis underlying the emergence and transmission of antibiotic-resistant .

Citation: Zhang Q, Plummer P. 2008. Mechanisms of Antibiotic Resistance in , p 263-276. In Nachamkin I, Szymanski C, Blaser M (ed), , Third Edition. ASM Press, Washington, DC. doi: 10.1128/9781555815554.ch14
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