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Chapter 16 : Inhibition of Antiviral Signaling Pathways by Paramyxovirus Proteins

Authors: Antonella Casola1, Xiaoyong Bao2, Allan R. Brasier3, Roberto P. Garofalo4
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Affiliations: 1: University of Texas Medical Branch, Galveston, TX 77555; 2: University of Texas Medical Branch, Galveston, TX 77555; 3: University of Texas Medical Branch, Galveston, TX 77555; 4: University of Texas Medical Branch, Galveston, TX 77555
Content Type: Monograph
Publication Year: 2009

Category: Viruses and Viral Pathogenesis; Microbial Genetics and Molecular Biology

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Inhibition of Antiviral Signaling Pathways by Paramyxovirus Proteins, Page 1 of 2

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Abstract:

The family includes enveloped, negative-sense, single-stranded (ss) RNA viruses, that are major and ubiquitous disease-causing pathogens of humans and animals. Among them are important viruses that cause acute respiratory morbidity, particularly in infants, the elderly, and immunocompromised subjects of any age. The family is taxonomically divided into two subfamilies: the , with five genera; and the , which includes two genera. The classification of the viruses is based on their genome organization, morphological and biological characteristics, and sequence relationship of the encoded proteins. To date, the paramyxovirus P gene-encoded proteins, the nonstructural (NS) (NS1 and NS2) proteins of pneumoviruses, and the envelope glycoproteins G and small hydrophobic (SH) protein have been shown to play a major role in antagonizing type I interferon (IFN) signaling and other host innate immune responses. A discussion of the inhibitory function for each of these proteins is presented in this chapter. A small hydrophobic (SH) protein (64 amino acids) is an integral membrane protein of respiratory syncytial virus (RSV). Human metapneumovirus (hMPV) expresses an SH protein that is nearly three times longer than the respiratory syncytial virus (RSV) SH and does not affect viral replication. During the early phase of RSV infection (12 to 24 h), the retinoic acid-inducible gene I (RIG-I)/mitochondrial antiviral signaling (MAVS) complex is important in canonical pathway activation.

Citation: Casola A, Bao X, Brasier A, Garofalo R. 2009. Inhibition of Antiviral Signaling Pathways by Paramyxovirus Proteins, p 247-265. In Brasier A, García-Sastre A, Lemon S (ed), Cellular Signaling and Innate Immune Responses to RNA Virus Infections. ASM Press, Washington, DC. doi: 10.1128/9781555815561.ch16
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Inhibition of Antiviral Signaling Pathways by Paramyxovirus Proteins
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Citation: Casola A, Bao X, Brasier A, Garofalo R. 2009. Inhibition of Antiviral Signaling Pathways by Paramyxovirus Proteins, p 247-265. In Brasier A, García-Sastre A, Lemon S (ed), Cellular Signaling and Innate Immune Responses to RNA Virus Infections. ASM Press, Washington, DC. doi: 10.1128/9781555815561.ch16
/content/10.1128/9781555815561.ch16.ch16fig01
Figure 1
Genetic map of the different genes of the family. Schematic representation of the genetic map of typical members of each genus of the (Adapted from reference , page 1453.)
10.1128/9781555815561/f0248-01_thmb.gif
10.1128/9781555815561/f0248-01.gif
Image of Figure 1
Figure 1

Genetic map of the different genes of the family. Schematic representation of the genetic map of typical members of each genus of the (Adapted from reference , page 1453.)

Citation: Casola A, Bao X, Brasier A, Garofalo R. 2009. Inhibition of Antiviral Signaling Pathways by Paramyxovirus Proteins, p 247-265. In Brasier A, García-Sastre A, Lemon S (ed), Cellular Signaling and Innate Immune Responses to RNA Virus Infections. ASM Press, Washington, DC. doi: 10.1128/9781555815561.ch16
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Figure 2
Schematic diagram of sites of antagonism of IFN production and signaling by paramyxovirus proteins.
10.1128/9781555815561/f0256-01_thmb.gif
10.1128/9781555815561/f0256-01.gif
Image of Figure 2
Figure 2

Schematic diagram of sites of antagonism of IFN production and signaling by paramyxovirus proteins.

Citation: Casola A, Bao X, Brasier A, Garofalo R. 2009. Inhibition of Antiviral Signaling Pathways by Paramyxovirus Proteins, p 247-265. In Brasier A, García-Sastre A, Lemon S (ed), Cellular Signaling and Innate Immune Responses to RNA Virus Infections. ASM Press, Washington, DC. doi: 10.1128/9781555815561.ch16
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References

/content/book/10.1128/9781555815561.ch16
1. Akira, S., and, K. Takeda. 2004. Toll-like receptor signalling. Nat. Rev. Immunol. 4: 499– 511.
2. Alff, P. J.,, I. N. Gavrilovskaya,, E. Gorbunova,, K. Endriss,, Y. Chong,, E. Geimonen,, N. Sen,, N. C. Reich, and, E. R. Mackow. 2006. The pathogenic NY-1 hantavirus G1 cytoplasmic tail inhibits RIG-I- and TBK-1-directed interferon responses. J. Virol. 80: 9676– 9686.
3. Anderson, K.,, A. M. King,, R. A. Lerch, and, G. W. Wertz. 1992. Polylactosaminoglycan modification of the respiratory syncytial virus small hydrophobic (SH) protein: a conserved feature among human and bovine respiratory syncytial viruses. Virology 191: 417– 430.
4. Anderson, L. J.,, J. C. Hierholzer,, C. Tsou,, R. M. Hendry,, B. F. Fernie,, Y. Stone, and, K. McIntosh. 1985. Antigenic characterization of respiratory syncytial virus strains with monoclonal antibodies. J. Infect. Dis. 151: 626– 633.
5. Andrejeva, J.,, K. S. Childs,, D. F. Young,, T. S. Carlos,, N. Stock,, S. Goodbourn, and, R. E. Randall. 2004. The V proteins of paramyxoviruses bind the IFN-inducible RNA helicase, mda-5, and inhibit its activation of the IFN-beta promoter. Proc. Natl. Acad. Sci. USA 101: 17264– 17269.
6. Andrejeva, J.,, E. Poole,, D. F. Young,, S. Goodbourn, and, R. E. Randall. 2002. The p127 subunit (DDB1) of the UV-DNA damage repair binding protein is essential for the targeted degradation of Stat1 by the V protein of the paramyxovirus simian virus 5. J. Virol. 76: 11379– 11386.
7. Arnold, R.,, B. Konig,, H. Werchau, and, W. Konig. 2004. Respiratory syncytial virus deficient in soluble G protein induced an increased proinflammatory response in human lung epithelial cells. Virology 330: 384– 397.
8. Awomoyi, A. A.,, P. Rallabhandi,, T. I. Pollin,, E. Lorenz,, M. B. Sztein,, M. S. Boukhvalova,, V. G. Hemming,, J. C. Blanco, and, S. N. Vogel. 2007. Association of TLR4 polymorphisms with symptomatic respiratory syncytial virus infection in high-risk infants and young children. J. Immunol. 179: 3171– 3177.
9. Bao, X.,, D. Kolli,, T. Liu,, Y. shan,, R. P. Garofalo, and, A. Casola. 2008. Human metapneumovirus small hydrophobic protein inhibits NF-κB transcriptional activity. J. Virol. Jun 11. [Epub ahead of print.]
10. Bao, X.,, T. Liu,, Y. Shan,, R. P. Garofalo, and, A. Casola. 2008. Human metapneumovirus glycoprotein G inhibits innate immune responses. PLoS Pathog. 4: e1000077.
11. Bao, X.,, T. Liu,, L. Spetch,, D. Kolli,, R. P. Garofalo, and, A. Casola. 2007. Airway epithelial cell response to human metapneumovirus infection. Virology 368: 91– 101.
12. Berghall, H.,, J. Siren,, D. Sarkar,, I. Julkunen,, P. B. Fisher,, R. Vainionpaa, and, S. Matikainen. 2006. The interferon-inducible RNA helicase, mda-5, is involved in measles virus-induced expression of antiviral cytokines. Microbes Infect. 8: 2138– 2144.
13. Biacchesi, S.,, Q. N. Pham,, M. H. Skiadopoulos,, B. R. Murphy,, P. L. Collins, and, U. J. Buchholz. 2005. Infection of nonhuman primates with recombinant human metapneumovirus lacking the SH, G, or M2–2 protein categorizes each as a nonessential accessory protein and identifies vaccine candidates. J. Virol. 79: 12608– 12613.
14. Biacchesi, S.,, M. H. Skiadopoulos,, G. Boivin,, C. T. Hanson,, B. R. Murphy,, P. L. Collins, and, U. J. Buchholz. 2003. Genetic diversity between human metapneumovirus subgroups. Virology 315: 1– 9.
15. Biacchesi, S.,, M. H. Skiadopoulos,, L. Yang,, E. W. Lamirande,, K. C. Tran,, B. R. Murphy,, P. L. Collins, and, U. J. Buchholz. 2004. Recombinant human metapneumovirus lacking the small hydrophobic SH and/or attachment G glycoprotein: deletion of G yields a promising vaccine candidate. J. Virol. 78: 12877– 12887.
16. Bieback, K.,, E. Lien,, I. M. Klagge,, E. Avota,, J. Schneider-Schaulies,, W. P. Duprex,, H. Wagner,, C. J. Kirschning,, V. ter Meulen, and, S. Schneider-Schaulies. 2002. Hemagglutinin protein of wild-type measles virus activates Toll-like receptor 2 signaling. J. Virol. 76: 8729– 8736.
17. Bonizzi, G.,, M. Bebien,, D. C. Otero,, K. E. Johnson-Vroom,, Y. Cao,, D. Vu,, A. G. Jegga,, B. J. Aronow,, G. Ghosh,, R. C. Rickert, and, M. Karin. 2004. Activation of IKKalpha target genes depends on recognition of specific kappaB binding sites by RelB:p52 dimers. EMBO J. 23: 4202– 4210.
18. Bonizzi, G., and, M. Karin. 2004. The two NF-kappa B activation pathways and their role in innate and adaptive immunity. Trends Immunol. 25: 280– 288.
19. Bose, S.,, N. Kar,, R. Maitra,, J. A. DiDonato, and, A. K. Banerjee. 2003. Temporal activation of NF-kappaB regulates an interferon-independent innate antiviral response against cytoplasmic RNA viruses. Proc. Natl. Acad. Sci. USA 100: 10890– 10895.
20. Bossert, B., and, K. K. Conzelmann. 2002. Respiratory syncytial virus (RSV) nonstructural (NS) proteins as host range determinants: a chimeric bovine RSV with NS genes from human RSV is attenuated in interferon-competent bovine cells. J. Virol. 76: 4287– 4293.
21. Bossert, B.,, S. Marozin, and, K. K. Conzelmann. 2003. Nonstructural proteins NS1 and NS2 of bovine respiratory syncytial virus block activation of interferon regulatory factor 3. J. Virol. 77: 8661– 8668.
22. Bukreyev, A.,, M. E. Serra,, F. R. Laham,, G. A. Melendi,, S. R. Kleeberger,, P. L. Collins, and, F. P. Polack. 2006. The cysteine-rich region and secreted form of the attachment G glycoprotein of respiratory syncytial virus enhance the cytotoxic T-lymphocyte response despite lacking major histocompatibility complex class I-restricted epitopes. J. Virol. 80: 5854– 5861.
23. Bukreyev, A.,, S. S. Whitehead,, B. R. Murphy, and, P. L. Collins. 1997. Recombinant respiratory syncytial virus from which the entire SH gene has been deleted grows efficiently in cell culture and exhibits site-specific attenuation in the respiratory tract of the mouse. J. Virol. 71: 8973– 8982.
24. Casola, A.,, N. Burger,, T. Liu,, M. Jamaluddin,, A. R. Brasier, and, R. P. Garofalo. 2001. Oxidant tone regulates RANTES gene transcription in airway epithelial cells infected with respiratory syncytial virus: role in viral-induced interferon regulatory factor activation. J. Biol. Chem. 276: 19715– 19722.
25. Childs, K.,, N. Stock,, C. Ross,, J. Andrejeva,, L. Hilton,, M. Skinner,, R. Randall, and, S. Goodbourn. 2007. mda-5, but not RIG-I, is a common target for paramyxovirus V proteins. Virology 359: 190– 200.
26. Choudhary, S.,, S. Boldogh,, R. Garofalo,, M. Jamaluddin, and, A. R. Brasier. 2005. Respiratory syncytial virus influences NF-kappaB-dependent gene expression through a novel pathway involving MAP3K14/NIK expression and nuclear complex formation with NF-kappaB2. J. Virol. 79: 8948– 8959.
27. Civas, A.,, P. Genin,, P. Morin,, R. Lin, and, J. Hiscott. 2006. Promoter organization of the interferon-A genes differentially affects virus-induced expression and responsiveness to TBK1 and IKKepsilon. J. Biol. Chem. 281: 4856– 4866.
28. Collins, P. L., and, J. E. Crowe, Jr. 2007. Respiratory syncytial virus and metapneumovirus, p. 1601–1646. In D. M. Knipe and P. M. Howley (ed.)., Fields Virology, 3rd ed. Lippincott, Williams & Wilkins, Philadelphia, PA.
29. Collins, P. L.,, K. McIntosh, and, R. M. Chanock. 1996. Respiratory syncytial virus, p. 1313–1351. In B. N. Fields,, D. M. Knipe, and, P. M. Howley (ed.), Fields Virology, 5th ed. Lippincott, Williams & Wilkins, Philadelphia, PA.
30. Crowe, J. E., Jr. 2004. Human metapneumovirus as a major cause of human respiratory tract disease. Pediatr. Infect. Dis. J. 23: S215- S221.
31. Darnell, J. E., Jr. 1997. Stats and gene regulation. Science 277: 1630– 1635.
32. Der, S. D.,, A. Zhou,, B. R. Williams, and, R. H. Silverman. 1998. Identification of genes differentially regulated by interferon alpha, beta, or gamma using oligonucleotide arrays. Proc. Natl. Acad. Sci. USA 95: 15623– 15628.
33. Diebold, S. S.,, T. Kaisho,, H. Hemmi,, S. Akira, and, C. Reis e Sousa. 2004. Innate antiviral responses by means of TLR7-mediated recognition of single-stranded RNA. Science 303: 1529– 1531.
34. Dinwiddie, D. L., and, K. S. Harrod. 2008. Human metapneumovirus inhibits IFN-α signaling through inhibition of Stat1 phosphorylation. Am. J. Respir. Cell Mol. Biol. 38: 661– 670.
35. Ehl, S.,, R. Bischoff,, T. Ostler,, S. Vallbracht,, J. Schulte-Monting,, A. Poltorak, and, M. Freudenberg. 2004. The role of Toll-like receptor 4 versus interleukin-12 in immunity to respiratory syncytial virus. Eur. J. Immunol. 34: 1146– 1153.
36. Elango, N.,, J. Kovamees,, T. M. Varsanyi, and, E. Norrby. 1989. mRNA sequence and deduced amino acid sequence of the mumps virus small hydrophobic protein gene. J. Virol. 63: 1413– 1415.
37. Elliott, J.,, O. T. Lynch,, Y. Suessmuth,, P. Qian,, C. R. Boyd,, J. F. Burrows,, R. Buick,, N. J. Stevenson,, O. Touzelet,, M. Gadina,, U. F. Power, and, J. A. Johnston. 2007. Respiratory syncytial virus NS1 protein degrades Stat2 by using the Elongin-Cullin E3 ligase. J. Virol. 81: 3428– 3436.
38. Faisca, P.,, D. B. Tran Anh,, A. Thomas, and, D. Desmecht. 2006. Suppression of pattern-recognition receptor TLR4 sensing does not alter lung responses to pneumovirus infection. Microbes Infect. 8: 621– 627.
39. Falsey, A. R.,, D. Erdman,, L. J. Anderson, and, E. E. Walsh. 2003. Human metapneumovirus infections in young and elderly adults. J. Infect. Dis. 187: 785– 790.
40. Falsey, A. R.,, P. A. Hennessey,, M. A. Formica,, C. Cox, and, E. E. Walsh. 2005. Respiratory syncytial virus infection in elderly and high-risk adults. N. Engl. J. Med. 352: 1749– 1759.
41. Fitzgerald, K. A.,, S. M. McWhirter,, K. L. Faia,, D. C. Rowe,, E. Latz,, D. T. Golenbock,, A. J. Coyle,, S. M. Liao, and, T. Maniatis. 2003. IKKepsilon and TBK1 are essential components of the IRF3 signaling pathway. Nat. Immunol. 4: 491– 496.
42. Fuentes, S.,, K. C. Tran,, P. Luthra,, M. N. Teng, and, B. He. 2007. Function of the respiratory syncytial virus small hydrophobic protein. J. Virol. 81: 8361– 8366.
43. Gagro, A.,, M. Tominac,, V. Krsulovic-Hresic,, A. Bace,, M. Matic,, V. Drazenovic,, G. Mlinaric-Galinovic,, E. Kosor,, K. Gotovac,, I. Bolanca,, S. Batinica, and, S. Rabatic. 2004. Increased Toll-like receptor 4 expression in infants with respiratory syncytial virus bronchiolitis. Clin. Exp. Immunol. 135: 267– 272.
44. Garofalo, R. P.,, F. Mei,, R. Espejo,, G. Ye,, H. Haeberle,, S. Baron,, P. L. Ogra, and, V. E. Reyes. 1997. Respiratory syncytial virus infection of human respiratory epithelial cells up-regulates class I MHC expression through the induction of IFN-β and IL-1α. J. Immunol. 157: 2506– 2513.
45. Garofalo, R. P.,, M. Sabry,, M. Jamaluddin,, R. K. Yu,, A. Casola,, P. L. Ogra, and, A. R. Brasier. 1996. Transcriptional activation of the interleukin-8 gene by respiratory syncytial virus infection in alveolar epithelial cells: nuclear translocation of the RelA transcription factor as a mechanism producing airway mucosal inflammation. J. Virol. 70: 8773– 8781.
46. Garoufalis, E.,, I. Kwan,, R. Lin,, A. Mustafa,, N. Pepin,, A. Roulston,, J. Lacoste, and, J. Hiscott. 1994. Viral induction of the human beta interferon promoter: modulation of transcription by NF-κB/rel proteins and interferon regulatory factors. J. Virol. 68: 4707– 4715.
47. Geimonen, E.,, R. LaMonica,, K. Springer,, Y. Farooqui,, I. N. Gavrilovskaya, and, E. R. Mackow. 2003. Hantavirus pulmonary syndrome-associated hantaviruses contain conserved and functional ITAM signaling elements. J. Virol. 77: 1638– 1643.
48. Groskreutz, D. J.,, M. M. Monick,, L. S. Powers,, T. O. Yarovinsky,, D. C. Look, and, G. W. Hunninghake. 2006. Respiratory syncytial virus induces TLR3 protein and protein kinase R, leading to increased double-stranded RNA responsiveness in airway epithelial cells. J. Immunol. 176: 1733– 1740.
49. Guerrero-Plata, A.,, S. Baron,, J. S. Poast,, P. A. Adegboyega,, A. Casola, and, R. P. Garofalo. 2005. Activity and regulation of alpha interferon in respiratory syncytial virus and human metapneumovirus experimental infections. J. Virol. 79: 10190– 10199.
50. Guerrero-Plata, A.,, A. Casola,, G. Suarez,, X. Yu,, L. Spetch,, M. E. Peeples, and, R. P. Garofalo. 2006. Differential response of dendritic cells to human metapneumovirus and respiratory syncytial virus. Am. J. Respir. Cell Mol. Biol. 34: 320– 329.
51. Guo, B., and, G. Cheng. 2007. Modulation of the interferon antiviral response by the TBK1/IKKi adaptor protein TANK. J. Biol. Chem. 282: 11817– 11826.
52. Haeberle, H.,, R. Takizawa,, A. Casola,, A. R. Brasier,, H. J. Dieterich,, N. van Rooijen,, Z. Gatalica, and, R. P. Garofalo. 2002. Respiratory syncytial virus-induced activation of NF-κB in the lung involves alveolar macrophages and Toll-like receptor 4-dependent pathways. J. Infect. Dis. 186: 1199– 1206.
53. Haeberle, H. A.,, A. Casola,, Z. Gatalica,, S. Petronella,, H. J. Dieterich,, P. B. Ernst,, A. R. Brasier, and, R. P. Garofalo. 2004. IkappaB kinase is a critical regulator of chemokine expression and lung inflammation in respiratory syncytial virus infection. J. Virol. 78: 2232– 2241.
54. Hahm, B.,, J. H. Cho, and, M. B. Oldstone. 2007. Measles virus-dendritic cell interaction via SLAM inhibits innate immunity: selective signaling through TLR4 but not other TLRs mediates suppression of IL-12 synthesis. Virology 358: 251– 257.
55. Hall, C. B. 2001. Respiratory syncytial virus and parainfluenza virus. N. Engl. J. Med. 344: 1917– 1928.
56. He, B.,, G. P. Leser,, R. G. Paterson, and, R. A. Lamb. 1998. The paramyxovirus SV5 small hydrophobic (SH) protein is not essential for virus growth in tissue culture cells. Virology 250: 30– 40.
57. He, B.,, G. Y. Lin,, J. E. Durbin,, R. K. Durbin, and, R. A. Lamb. 2001. The SH integral membrane protein of the paramyxovirus simian virus 5 is required to block apoptosis in MDBK cells. J. Virol. 75: 4068– 4079.
58. Helin, E.,, R. Vainionpaa,, T. Hyypia,, I. Julkunen, and, S. Matikainen. 2001. Measles virus activates NF-kappa B and Stat transcription factors and production of IFNalpha/beta and IL-6 in the human lung epithelial cell line A549. Virology 290: 1– 10.
59. Hendricks, D. A.,, K. McIntosh, and, J. L. Patterson. 1988. Further characterization of the soluble form of the G glycoprotein of respiratory syncytial virus. J. Virol. 62: 2228– 2233.
60. Hiebert, S. W.,, R. G. Paterson, and, R. A. Lamb. 1985. Hemagglutinin-neuraminidase protein of the paramyxovirus simian virus 5: nucleotide sequence of the mRNA predicts an N-terminal membrane anchor. J. Virol. 54: 1– 6.
61. Hiebert, S. W.,, R. G. Paterson, and, R. A. Lamb. 1985. Identification and predicted sequence of a previously unrecognized small hydrophobic protein, SH, of the paramyxovirus simian virus 5. J. Virol. 55: 744– 751.
62. Hippenstiel, S.,, B. Opitz,, B. Schmeck, and, N. Suttorp. 2006. Lung epithelium as a sentinel and effector system in pneumonia—molecular mechanisms of pathogen recognition and signal transduction. Respir. Res. 7: 97.
63. Hornung, V.,, J. Schlender,, M. Guenthner-Biller,, S. Rothenfusser,, S. Endres,, K. K. Conzelmann, and, G. Hartmann. 2004. Replication-dependent potent IFN-alpha induction in human plasmacytoid dendritic cells by a single-stranded RNA virus. J. Immunol. 173: 5935– 5943.
64. Horvai, A. E.,, L. Xu,, E. Korzus,, G. Brard,, D. Kalafus,, T. M. Mullen,, D. W. Rose,, M. G. Rosenfeld, and, C. K. Glass. 1997. Nuclear integration of JAK/Stat and Ras/ AP-1 signaling by CBP and p300. Proc. Natl. Acad. Sci. USA 94: 1074– 1079.
65. Horvath, C. M. 2004. Silencing Stats: lessons from paramyxovirus interferon evasion. Cytokine Growth Factor Rev. 15: 117– 127.
66. Horvath, C. M. 2004. Weapons of Stat destruction. Interferon evasion by paramyxovirus V protein. Eur. J. Biochem. 271: 4621– 4628.
67. Huang, Y. T.,, P. L. Collins, and, G. W. Wertz. 1985. Characterization of the 10 proteins of human respiratory syncytial virus: identification of a fourth envelope-associated protein. Virus Res. 2: 157– 173.
68. Jamaluddin, M.,, A. Casola,, R. P. Garofalo,, Y. Han,, T. Elliott,, P. L. Ogra, and, A. R. Brasier. 1998. The major component of IκBα proteolysis occurs independently of the proteasome pathway in respiratory syncytial virus-infected pulmonary epithelial cells. J. Virol. 72: 4849– 4857.
69. Jamaluddin, M.,, S. Wang,, I. Boldogh,, B. Tian, and, A. R. Brasier. 2007. TNF-α-induced NF-κB/RelA Ser (276) phosphorylation and enhanceosome formation is mediated by an ROS-dependent PKAc pathway. Cell. Signal. 19: 1419– 1433.
70. Jamaluddin, M.,, S. Wang,, R. P. Garofalo,, T. Elliott,, A. Casola,, S. Baron, and, A. R. Brasier. 2001. IFN-beta mediates coordinate expression of antigen-processing genes in RSV-infected pulmonary epithelial cells. Am. J. Physiol. 280: L248- L257.
71. Jewell, N. A.,, N. Vaghefi,, S. E. Mertz,, P. Akter,, R. S. Peebles, Jr.,, L. O. Bakaletz,, R. K. Durbin,, E. Flano, and, J. E. Durbin. 2007. Differential type I interferon induction by respiratory syncytial virus and influenza A virus in vivo. J. Virol. 81: 9790– 9800.
72. Jin, H.,, H. Zhou,, X. Cheng,, R. Tang,, M. Munoz, and, N. Nguyen. 2000. Recombinant respiratory syncytial viruses with deletions in the NS1, NS2, SH, and M2–2 genes are attenuated in vitro and in vivo. Virology 273: 210– 218.
73. Kahn, J. S. 2006. Epidemiology of human metapneumovirus. Clin. Microbiol. Rev. 19: 546– 557.
74. Kang, D. C.,, R. V. Gopalkrishnan,, Q. Wu,, E. Jankowsky,, A. M. Pyle, and, P. B. Fisher. 2002. mda-5: an interferoninducible putative RNA helicase with double-stranded RNA-dependent ATPase activity and melanoma growth-suppressive properties. Proc. Natl. Acad. Sci. USA 99: 637– 642.
75. Karron, R. A.,, D. A. Buonagurio,, A. F. Georgiu,, S. S. Whitehead,, J. E. Adamus,, M. L. Clements-Mann,, D. O. Harris,, V. B. Randolph,, S. A. Udem,, B. R. Murphy, and, M. S. Sidhu. 1997. Respiratory syncytial virus (RSV)SH and G proteins are not essential for viral replication in vitro: clinical evaluation and molecular characterization of a cold-passaged, attenuated RSV subgroup B mutant. Proc. Natl. Acad. Sci. USA 94: 13961– 13966.
76. Kato, H.,, S. Sato,, M. Yoneyama,, M. Yamamoto,, S. Uematsu,, K. Matsui,, T. Tsujimura,, K. Takeda,, T. Fujita,, O. Takeuchi, and, S. Akira. 2005. Cell type-specific involvement of RIG-I in antiviral response. Immunity 23: 19– 28.
77. Kato, H.,, O. Takeuchi,, S. Sato,, M. Yoneyama,, M. Yamamoto,, K. Matsui,, S. Uematsu,, A. Jung,, T. Kawai,, K. J. Ishii,, O. Yamaguchi,, K. Otsu,, T. Tsujimura,, C. S. Koh,, C. Reis e Sousa,, Y. Matsuura,, T. Fujita, and, S. Akira. 2006. Differential roles of MDA5 and RIG-I helicases in the recognition of RNA viruses. Nature 441: 101– 105.
78. Kawai, T.,, K. Takahashi,, S. Sato,, C. Coban,, H. Kumar,, H. Kato,, K. J. Ishii,, O. Takeuchi, and, S. Akira. 2005. IPS-1, an adaptor triggering RIG-I- and Mda5-mediated type I interferon induction. Nat. Immunol. 6: 981– 988.
79. Kim, T. K., and, T. Maniatis. 1997. The mechanism of transcriptional synergy of an in vitro assembled interferon-beta enhanceosome. Mol. Cell 1: 119– 129.
80. Komatsu, T.,, K. Takeuchi,, J. Yokoo, and, B. Gotoh. 2004. C and V proteins of Sendai virus target signaling pathways leading to IRF-3 activation for the negative regulation of interferon-beta production. Virology 325: 137– 148.
81. Kovacsovics, M.,, F. Martinon,, O. Micheau,, J. L. Bodmer,, K. Hofmann, and, J. Tschopp. 2002. Overexpression of Helicard, a CARD-containing helicase cleaved during apoptosis, accelerates DNA degradation. Curr. Biol. 12: 838– 843.
82. Krempl, C. D.,, A. Wnekowicz,, E. W. Lamirande,, G. Nayebagha,, P. L. Collins, and, U. J. Buchholz. 2007. Identification of a novel virulence factor in recombinant pneumonia virus of mice. J. Virol. 81: 9490– 9501.
83. Kumar, H.,, T. Kawai,, H. Kato,, S. Sato,, K. Takahashi,, C. Coban,, M. Yamamoto,, S. Uematsu,, K. J. Ishii,, O. Takeuchi, and, S. Akira. 2006. Essential role of IPS-1 in innate immune responses against RNA viruses. J. Exp. Med. 203: 1795– 1803.
84. Kurt-Jones, E. A.,, L. Popova,, L. Kwinn,, L. M. Haynes,, L. P. Jones,, R. A. Tripp,, E. E. Walsh,, M. W. Freeman,, D. T. Golenbock,, L. J. Anderson, and, R. W. Finberg. 2000. Pattern recognition receptors TLR4 and CD14 mediate response to respiratory syncytial virus. Nat. Immunol. 1: 398– 401.
85. Lamb, R. A., and, G. D. Parks. 2007. Paramyxoviridae: the viruses and their replication. In D. M. Knipe and, P. M. Howley (ed.), Fields Virology, 5th ed. Lippincott, Williams & Wilkins, Philadephia, PA.
86. Lamb, R. A., and, D. Kolakofsky. 2001. Paramyxoviridae: the viruses and their replication, p. 689–724. In D. M. Knipe and, P. M. Howley (ed.), Fundamental Virology, 4th ed. Lippincott, Williams and Wilkins, Philadelphia, PA.
87. Leader, S., and, K. Kohlhase. 2002. Respiratory syncytial virus-coded pediatric hospitalizations, 1997 to 1999. Pediatr. Infect. Dis. J. 21: 629– 632.
88. Levine, S.,, R. Klaiber-Franco, and, P. R. Paradiso. 1987. Demonstration that glycoprotein G is the attachment protein of respiratory syncytial virus. J. Gen. Virol. 68(Pt. 9): 2521– 2524.
89. Liao, S.-L.,, X. Bao,, T. Liu,, C. Hong,, R. P. Garofalo, and, A. Casola. Role of RNA helicases in human metapneumovirus-induced cellular signaling. J. Gen. Virol., in press.
90. Lin, G. Y.,, R. G. Paterson,, C. D. Richardson, and, R. A. Lamb. 1998. The V protein of the paramyxovirus SV5 interacts with damage-specific DNA binding protein. Virology 249: 189– 200.
91. Lin, R.,, C. Heylbroeck,, P. M. Pitha, and, J. Hiscott. 1998. Virus-dependent phosphorylation of the IRF-3 transcription factor regulates nuclear translocation, transactivation potential, and proteasome-mediated degradation. Mol. Cell. Biol. 18: 2986– 2996.
92. Lin, Y.,, A. C. Bright,, T. A. Rothermel, and, B. He. 2003. Induction of apoptosis by paramyxovirus simian virus 5 lacking a small hydrophobic gene. J. Virol. 77: 3371– 3383.
93. Liu, P.,, M. Jamaluddin,, K. Li,, R. P. Garofalo,, A. Casola, and, A. R. Brasier. 2007. Retinoic acid-inducible gene I mediates early antiviral response and Toll-like receptor 3 expression in respiratory syncytial virus-infected airway epithelial cells. J. Virol. 81: 1401– 1411.
94. Liu, T.,, S. Castro,, A. R. Brasier,, M. Jamaluddin,, R. P. Garofalo, and, A. Casola. 2004. Reactive oxygen species mediate virus-induced Stat activation: role of tyrosine phosphatases. J. Biol. Chem. 279: 2461– 2469.
95. Lo, M. S.,, R. M. Brazas, and, M. J. Holtzman. 2005. Respiratory syncytial virus nonstructural proteins NS1 and NS2 mediate inhibition of Stat2 expression and alpha/beta interferon responsiveness. J. Virol. 79: 9315– 9319.
96. Loo, Y. M.,, J. Fornek,, N. Crochet,, G. Bajwa,, O. Perwitasari,, L. Martinez-Sobrido,, S. Akira,, M. A. Gill,, A. Garcia-Sastre,, M. G. Katze, and, M. Gale, Jr. 2008. Distinct RIG-I and MDA5 signaling by RNA viruses in innate immunity. J. Virol. 82: 335– 345.
97. Melchjorsen, J.,, S. B. Jensen,, L. Malmgaard,, S. B. Rasmussen,, F. Weber,, A. G. Bowie,, S. Matikainen, and, S. R. Paludan. 2005. Activation of innate defense against a paramyxovirus is mediated by RIG-I and TLR7 and TLR8 in a cell-type-specific manner. J. Virol. 79: 12944– 12951.
98. Meylan, E.,, K. Burns,, K. Hofmann,, V. Blancheteau,, F. Martinon,, M. Kelliher, and, J. Tschopp. 2004. RIP1 is an essential mediator of Toll-like receptor 3-induced NF-kappa B activation. Nat. Immunol. 5: 503– 507.
99. Meylan, E.,, J. Curran,, K. Hofmann,, D. Moradpour,, M. Binder,, R. Bartenschlager, and, J. Tschopp. 2005. Cardif is an adaptor protein in the RIG-I antiviral pathway and is targeted by hepatitis C virus. Nature 437: 1167– 1172.
100. Meylan, E.,, J. Tschopp, and, M. Karin. 2006. Intracellular pattern recognition receptors in the host response. Nature 442: 39– 44.
101. Mogensen, T. H., and, S. R. Paludan. 2005. Reading the viral signature by Toll-like receptors and other pattern recognition receptors. J. Mol. Med. 83: 180– 192.
102. Monick, M. M.,, T. O. Yarovinsky,, L. S. Powers,, N. S. Butler,, A. B. Carter,, G. Gudmundsson, and, G. W. Hunninghake. 2003. Respiratory syncytial virus up-regulates TLR4 and sensitizes airway epithelial cells to endotoxin. J. Biol. Chem. 278: 53035– 53044.
103. Mordmuller, B.,, D. Krappmann,, M. Esen,, E. Wegener, and, C. Scheidereit. 2003. Lymphotoxin and lipopolysaccharide induce NF-kappaB-p52 generation by a co-translational mechanism. EMBO Rep. 4: 82– 87.
104. Morrison, M. D.,, W. Reiley,, M. Zhang, and, S. C. Sun. 2005. An atypical tumor necrosis factor (TNF) receptor-associated factor-binding motif of B cell-activating factor belonging to the TNF family (BAFF) receptor mediates induction of the noncanonical NF-kappaB signaling pathway. J. Biol. Chem. 280: 10018– 10024.
105. O’Neill, L. A., and, A. G. Bowie. 2007. The family of five: TIR-domain-containing adaptors in Toll-like receptor signalling. Nat. Rev. Immunol. 7: 353– 364.
106. Opitz, B.,, M. Vinzing,, V. van Laak,, B. Schmeck,, G. Heine,, S. Gunther,, R. Preissner,, H. Slevogt,, P. D. N’Guessan,, J. Eitel,, T. Goldmann,, A. Flieger,, N. Suttorp, and, S. Hippenstiel. 2006. Legionella pneumophila induces IFNbeta in lung epithelial cells via IPS-1 and IRF3, which also control bacterial replication. J. Biol. Chem. 281: 36173– 36179.
107. Palosaari, H.,, J. P. Parisien,, J. J. Rodriguez,, C. M. Ulane, and, C. M. Horvath. 2003. Stat protein interference and suppression of cytokine signal transduction by measles virus V protein. J. Virol. 77: 7635– 7644.
108. Park, M. S.,, M. L. Shaw,, J. Munoz-Jordan,, J. F. Cros,, T. Nakaya,, N. Bouvier,, P. Palese,, A. Garcia-Sastre, and, C. F. Basler. 2003. Newcastle disease virus (NDV)-based assay demonstrates interferon-antagonist activity for the NDV V protein and the Nipah virus V, W, and C proteins. J. Virol. 77: 1501– 1511.
109. Pestka, S.,, C. D. Krause, and, M. R. Walter. 2004. Interferons, interferon-like cytokines, and their receptors. Immunol. Rev. 202: 8– 32.
110. [Reference deleted.]
111. Peters, R. T., and, T. Maniatis. 2001. A new family of IKK-related kinases may function as I kappa B kinase kinases. Biochim. Biophys. Acta 1471: M57- M62.
112. Polack, F. P.,, P. M. Irusta,, S. J. Hoffman,, M. P. Schiatti,, G. A. Melendi,, M. F. Delgado,, F. R. Laham,, B. Thumar,, R. M. Hendry,, J. A. Melero,, R. A. Karron,, P. L. Collins, and, S. R. Kleeberger. 2005. The cysteine-rich region of respiratory syncytial virus attachment protein inhibits innate immunity elicited by the virus and endotoxin. Proc. Natl. Acad. Sci. USA 102: 8996– 9001.
113. Poole, E.,, B. He,, R. A. Lamb,, R. E. Randall, and, S. Goodbourn. 2002. The V proteins of simian virus 5 and other paramyxoviruses inhibit induction of interferon-beta. Virology 303: 33– 46.
114. Principi, N.,, S. Bosis, and, S. Esposito. 2006. Human metapneumovirus in paediatric patients. Clin. Microbiol. Infect. 12: 301– 308.
115. Ramaswamy, M.,, L. Shi,, S. M. Varga,, S. Barik,, M. A. Behlke, and, D. C. Look. 2006. Respiratory syncytial virus nonstructural protein 2 specifically inhibits type I interferon signal transduction. Virology 344: 328– 339.
116. Reimers, K.,, K. Buchholz, and, H. Werchau. 2005. Respiratory syncytial virus M2–1 protein induces the activation of nuclear factor kappa B. Virology 331: 260– 268.
117. Rodriguez, J. J.,, C. D. Cruz, and, C. M. Horvath. 2004. Identification of the nuclear export signal and Stat-binding domains of the Nipah virus V protein reveals mechanisms underlying interferon evasion. J. Virol. 78: 5358– 5367.
118. Rodriguez, J. J.,, J. P. Parisien, and, C. M. Horvath. 2002. Nipah virus V protein evades alpha and gamma interferons by preventing Stat1 and Stat2 activation and nuclear accumulation. J. Virol. 76: 11476– 11483.
119. Rodriguez, J. J.,, L. F. Wang, and, C. M. Horvath. 2003. Hendra virus V protein inhibits interferon signaling by preventing Stat1 and Stat2 nuclear accumulation. J. Virol. 77: 11842– 11845.
120. Rothenfusser, S.,, N. Goutagny,, G. DiPerna,, M. Gong,, B. G. Monks,, A. Schoenemeyer,, M. Yamamoto,, S. Akira, and, K. A. Fitzgerald. 2005. The RNA helicase Lgp2 inhibits TLR-independent sensing of viral replication by retinoic acid-inducible gene-I. J. Immunol. 175: 5260– 5268.
121. Rudd, B. D.,, E. Burstein,, C. S. Duckett,, X. Li, and, N. W. Lukacs. 2005. Differential role for TLR3 in respiratory syncytial virus-induced chemokine expression. J. Virol. 79: 3350– 3357.
122. Rudd, B. D.,, J. J. Smit,, R. A. Flavell,, L. Alexopoulou,, M. A. Schaller,, A. Gruber,, A. A. Berlin, and, N. W. Lukacs. 2006. Deletion of TLR3 alters the pulmonary immune environment and mucus production during respiratory syncytial virus infection. J. Immunol. 176: 1937– 1942.
123. Saha, S. K.,, E. M. Pietras,, J. Q. He,, J. R. Kang,, S. Y. Liu,, G. Oganesyan,, A. Shahangian,, B. Zarnegar,, T. L. Shiba,, Y. Wang, and, G. Cheng. 2006. Regulation of antiviral responses by a direct and specific interaction between TRAF3 and Cardif. EMBO J. 25: 3257– 3263.
124. Sarkar, S. N.,, K. L. Peters,, C. P. Elco,, S. Sakamoto,, S. Pal, and, G. C. Sen. 2004. Novel roles of TLR3 tyrosine phosphorylation and PI3 kinase in double-stranded RNA signaling. Nat. Struct. Mol. Biol. 11: 1060– 1067.
125. Sasai, M.,, M. Shingai,, K. Funami,, M. Yoneyama,, T. Fujita,, M. Matsumoto, and, T. Seya. 2006. NAK-associated protein 1 participates in both the TLR3 and the cytoplasmic pathways in type I IFN induction. J. Immunol. 177: 8676– 8683.
126. Sato, M.,, N. Tanaka,, N. Hata,, E. Oda, and, T. Taniguchi. 1998. Involvement of the IRF family transcription factor IRF-3 in virus-induced activation of the IFN-beta gene. FEBS Lett. 425: 112– 116.
127. Sato, S.,, M. Sugiyama,, M. Yamamoto,, Y. Watanabe,, T. Kawai,, K. Takeda, and, S. Akira. 2003. Toll/IL-1 receptor domain-containing adaptor inducing IFN-beta (TRIF) associates with TNF receptor-associated factor 6 and TANK-binding kinase 1, and activates two distinct transcription factors, NF-kappa B and IFN-regulatory factor-3, in the Toll-like receptor signaling. J. Immunol. 171: 4304– 4310.
128. Schindler, C.,, D. E. Levy, and, T. Decker. 2007. JAK-Stat signaling: from interferons to cytokines. J. Biol. Chem. 282: 20059– 20063.
129. Schlender, J.,, V. Hornung,, S. Finke,, M. Gunthner-Biller,, S. Marozin,, K. Brzozka,, S. Moghim,, S. Endres,, G. Hartmann, and, K. K. Conzelmann. 2005. Inhibition of Toll-like receptor 7- and 9-mediated alpha/beta interferon production in human plasmacytoid dendritic cells by respiratory syncytial virus and measles virus. J. Virol. 79: 5507– 5515.
130. Schwarze, J., and, U. Schauer. 2004. Enhanced virulence, airway inflammation and impaired lung function induced by respiratory syncytial virus deficient in secreted G protein. Thorax 59: 517– 521.
131. Senftleben, U.,, Y. Cao,, G. Xiao,, F. R. Greten,, G. Krahn,, G. Bonizzi,, Y. Chen,, Y. Hu,, A. Fong,, S. C. Sun, and, M. Karin. 2001. Activation by IKKalpha of a second, evolutionary conserved, NF-kappa B signaling pathway. Science 293: 1495– 1499.
132. Servant, M. J.,, B. tenOever,, C. LePage,, L. Conti,, S. Gessani,, I. Julkunen,, R. Lin, and, J. Hiscott. 2001. Identification of distinct signaling pathways leading to the phosphorylation of interferon regulatory factor 3. J. Biol. Chem. 276: 355– 363.
133. Seth, R. B.,, L. Sun,, C. K. Ea, and, Z. J. Chen. 2005. Identification and characterization of MAVS, a mitochondrial antiviral signaling protein that activates NFkappaB and IRF 3. Cell 122: 669– 682.
134. Sharma, S.,, B. R. tenOever,, N. Grandvaux,, G. P. Zhou,, R. Lin, and, J. Hiscott. 2003. Triggering the interferon antiviral response through an IKK-related pathway. Science 300: 1148– 1151.
135. Shaw, M. L.,, W. B. Cardenas,, D. Zamarin,, P. Palese, and, C. F. Basler. 2005. Nuclear localization of the Nipah virus W protein allows for inhibition of both virus-and Toll-like receptor 3-triggered signaling pathways. J. Virol. 79: 6078– 6088.
136. Shaw, M. L.,, A. Garcia-Sastre,, P. Palese, and, C. F. Basler. 2004. Nipah virus V and W proteins have a common Stat1-binding domain yet inhibit Stat1 activation from the cytoplasmic and nuclear compartments, respectively. J. Virol. 78: 5633– 5641.
137. Skiadopoulos, M. H.,, S. Biacchesi,, U. J. Buchholz,, J. M. Riggs,, S. R. Surman,, E. Amaro-Carambot,, J. M. McAuliffe,, W. R. Elkins,, M. St. Claire,, P. L. Collins, and, B. R. Murphy. 2004. The two major human metapneumovirus genetic lineages are highly related antigenically, and the fusion (F) protein is a major contributor to this antigenic relatedness. J. Virol. 78: 6927– 6937.
138. Spann, K. M.,, K. C. Tran,, B. Chi,, R. L. Rabin, and, P. L. Collins. 2004. Suppression of the induction of alpha, beta, and lambda interferons by the NS1 and NS2 proteins of human respiratory syncytial virus in human epithelial cells and macrophages [corrected]. J. Virol. 78: 4363– 4369.
139. Spann, K. M.,, K. C. Tran, and, P. L. Collins. 2005. Effects of nonstructural proteins NS1 and NS2 of human respiratory syncytial virus on interferon regulatory factor 3, NF-kappaB, and proinflammatory cytokines. J. Virol. 79: 5353– 5362.
140. Takeuchi, K.,, K. Tanabayashi,, M. Hishiyama, and, A. Yamada. 1996. The mumps virus SH protein is a membrane protein and not essential for virus growth. Virology 225: 156– 162.
141. Tal, G.,, A. Mandelberg,, I. Dalal,, K. Cesar,, E. Somekh,, A. Tal,, A. Oron,, S. Itskovich,, A. Ballin,, S. Houri,, A. Beigelman,, O. Lider,, G. Rechavi, and, N. Amariglio. 2004. Association between common Toll-like receptor 4 mutations and severe respiratory syncytial virus disease. J. Infect. Dis. 189: 2057– 2063.
142. Taniguchi, T., and, A. Takaoka. 2002. The interferonalpha/beta system in antiviral responses: a multimodal machinery of gene regulation by the IRF family of transcription factors. Curr. Opin. Immunol. 14: 111– 116.
143. Teng, M. N., and, P. L. Collins. 1999. Altered growth characteristics of recombinant respiratory syncytial viruses which do not produce NS2 protein. J. Virol. 73: 466– 473.
144. Teng, M. N., and, P. L. Collins. 2002. The central conserved cystine noose of the attachment G protein of human respiratory syncytial virus is not required for efficient viral infection in vitro or in vivo. J. Virol. 76: 6164– 6171.
145. Teng, M. N.,, S. S. Whitehead,, A. Bermingham,, M. St. Claire,, W. R. Elkins,, B. R. Murphy, and, P. L. Collins. 2000. Recombinant respiratory syncytial virus that does not express the NS1 or M2–2 protein is highly attenuated and immunogenic in chimpanzees. J. Virol. 74: 9317– 9321.
146. Teng, M. N.,, S. S. Whitehead, and, P. L. Collins. 2001. Contribution of the respiratory syncytial virus G glyco-protein and its secreted and membrane-bound forms to virus replication in vitro and in vivo. Virology 289: 283– 296.
147. tenOever, B. R.,, M. J. Servant,, N. Grandvaux,, R. Lin, and, J. Hiscott. 2002. Recognition of the measles virus nucleocapsid as a mechanism of IRF-3 activation. J. Virol. 76: 3659– 3669.
148. Thompson, A. J., and, S. A. Locarnini. 2007. Toll-like receptors, RIG-I-like RNA helicases and the antiviral innate immune response. Immunol. Cell Biol. 85: 435– 445.
149. Tian, B., Y. Zhang,, B. Luxon,, R. P. Garofalo,, A. Casola,, M. Sinha, and, A. R. Brasier. 2002. Identification of NF-κB dependent gene networks in respiratory syncytial virus-infected cells. J. Virol. 76: 6800– 6814.
150. Tripp, R. A.,, L. P. Jones,, L. M. Haynes,, H. Zheng,, P. M. Murphy, and, L. J. Anderson. 2001. CX3C chemokine mimicry by respiratory syncytial virus G glycoprotein. Nat. Immunol.. 2: 732– 738.
151. Ulane, C. M., and, C. M. Horvath. 2002. Paramyxoviruses SV5 and HPIV2 assemble Stat protein ubiquitin ligase complexes from cellular components. Virology 304: 160– 166.
152. Ulane, C. M.,, J. J. Rodriguez,, J. P. Parisien, and, C. M. Horvath. 2003. Stat3 ubiquitylation and degradation by mumps virus suppress cytokine and oncogene signaling. J. Virol. 77: 6385– 6393.
153. van den Hoogen, B. G.,, T. M. Bestebroer,, A. D. Osterhaus, and, R. A. Fouchier. 2002. Analysis of the genomic sequence of a human metapneumovirus. Virology 295: 119– 132.
154. van den Hoogen, B. G.,, J. C. de Jong,, J. Groen,, T. Kuiken,, R. de Groot,, R. A. Fouchier, and, A. D. Osterhaus. 2001. A newly discovered human pneumovirus isolated from young children with respiratory tract disease. Nat. Med. 7: 719– 724.
155. van der Sluijs, K. F.,, L. van Elden,, M. Nijhuis,, R. Schuurman,, S. Florquin,, H. M. Jansen,, R. Lutter, and, T. van der Poll. 2003. Toll-like receptor 4 is not involved in host defense against respiratory tract infection with Sendai virus. Immunol. Lett. 89: 201– 206.
156. Wacharapluesadee, S.,, B. Lumlertdacha,, K. Boongird,, S. Wanghongsa,, L. Chanhome,, P. Rollin,, P. Stockton,, C. E. Rupprecht,, T. G. Ksiazek, and, T. Hemachudha. 2005. Bat Nipah virus, Thailand. Emerg. Infect. Dis. 11: 1949– 1951.
157. Whitehead, S. S.,, A. Bukreyev,, M. N. Teng,, C. Y. Firestone,, M. St. Claire,, W. R. Elkins,, P. L. Collins, and, B. R. Murphy. 1999. Recombinant respiratory syncytial virus bearing a deletion of either the NS2 or SH gene is attenuated in chimpanzees. J. Virol. 73: 3438– 3442.
158. Williams, J. V.,, P. A. Harris,, S. J. Tollefson,, L. L. Halburnt-Rush,, J. M. Pingsterhaus,, K. M. Edwards,, P. F. Wright, and, J. E. Crowe, Jr. 2004. Human metapneumovirus and lower respiratory tract disease in otherwise healthy infants and children. N. Engl. J. Med. 350: 443– 450.
159. Wilson, R. L.,, S. M. Fuentes,, P. Wang,, E. C. Taddeo,, A. Klatt,, A. J. Henderson, and, B. He. 2006. Function of small hydrophobic proteins of paramyxovirus. J. Virol. 80: 1700– 1709.
160. Xu, L. G.,, Y. Y. Wang,, K. J. Han,, L. Y. Li,, Z. Zhai, and, H. B. Shu. 2005. VISA is an adapter protein required for virus-triggered IFN-beta signaling. Mol. Cell 19: 727– 740.
161. Yokota, S.,, T. Okabayashi,, N. Yokosawa, and, N. Fujii. 2008. Measles virus P protein suppresses Toll-like receptor signal through up-regulation of ubiquitin-modifying enzyme A20. FASEB J. 22: 74– 83.
162. Yokota, S.,, H. Saito,, T. Kubota,, N. Yokosawa,, K. Amano, and, N. Fujii. 2003. Measles virus suppresses interferon-alpha signaling pathway: suppression of Jak1 phosphorylation and association of viral accessory proteins, C and V, with interferon-alpha receptor complex. Virology 306: 135– 146.
163. Yoneyama, M.,, M. Kikuchi,, T. Natsukawa,, N. Shinobu,, T. Imaizumi,, M. Miyagishi,, K. Taira,, S. Akira, and, T. Fujita. 2004. The RNA helicase RIG-I has an essential function in double-stranded RNA-induced innate antiviral responses. Nat. Immunol.. 5: 730– 737.
164. Yoneyama, M.,, W. Suhara,, Y. Fukuhara,, M. Fukuda,, E. Nishida, and, T. Fujita. 1998. Direct triggering of the type I interferon system by virus infection: activation of a transcription factor complex containing IRF-3 and CBP/p300. EMBO. J. 17: 1087– 1095.
165. Zhang, W.,, H. Yang,, X. Kong,, S. Mohapatra,, H. S. Juan-Vergara,, G. Hellermann,, S. Behera,, R. Singam,, R. F. Lockey, and, S. S. Mohapatra. 2005. Inhibition of respiratory syncytial virus infection with intranasal siRNA nanoparticles targeting the viral NS1 gene. Nat. Med. 11: 56– 62.
166. Zhao, T.,, L. Yang,, Q. Sun,, M. Arguello,, D. W. Ballard,, J. Hiscott, and, R. Lin. 2007. The NEMO adaptor bridges the nuclear factor-kappaB and interferon regulatory factor signaling pathways. Nat. Immunol. 8: 592– 600.
167. Zheng, S.,, B. P. De,, S. Choudhary,, S. A. Comhair,, T. Goggans,, R. Slee,, B. R. Williams,, J. Pilewski,, S. J. Haque, and, S. C. Erzurum. 2003. Impaired innate host defense causes susceptibility to respiratory virus infections in cystic fibrosis. Immunity 18: 619– 630.
168. Zhong, H.,, R. E. Voll, and, S. Ghosh. 1998. Phosphorylation of NF-kappa B p65 by PKA stimulates transcriptional activity by promoting a novel bivalent interaction with the coactivator CBP/p300. Mol. Cell 1: 661– 671.

Tables

Inhibition of Antiviral Signaling Pathways by Paramyxovirus Proteins
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Citation: Casola A, Bao X, Brasier A, Garofalo R. 2009. Inhibition of Antiviral Signaling Pathways by Paramyxovirus Proteins, p 247-265. In Brasier A, García-Sastre A, Lemon S (ed), Cellular Signaling and Innate Immune Responses to RNA Virus Infections. ASM Press, Washington, DC. doi: 10.1128/9781555815561.ch16
/content/10.1128/9781555815561.ch16.ch16tab01
Table 1
Major members of the family
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Table 1

Major members of the family

Citation: Casola A, Bao X, Brasier A, Garofalo R. 2009. Inhibition of Antiviral Signaling Pathways by Paramyxovirus Proteins, p 247-265. In Brasier A, García-Sastre A, Lemon S (ed), Cellular Signaling and Innate Immune Responses to RNA Virus Infections. ASM Press, Washington, DC. doi: 10.1128/9781555815561.ch16
/content/10.1128/9781555815561.ch16.ch16tab02
Table 2
Viral proteins encoded by the P gene in members of the
Generic image for table
Table 2

Viral proteins encoded by the P gene in members of the

Citation: Casola A, Bao X, Brasier A, Garofalo R. 2009. Inhibition of Antiviral Signaling Pathways by Paramyxovirus Proteins, p 247-265. In Brasier A, García-Sastre A, Lemon S (ed), Cellular Signaling and Innate Immune Responses to RNA Virus Infections. ASM Press, Washington, DC. doi: 10.1128/9781555815561.ch16

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