Chapter 26 : Interdomain Cross Talk

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This chapter defines four signaling categories that describe the different interdomain signaling mechanisms. These mechanisms are: (i) one-way sensing—one organism senses and responds to a diffusible signal produced by a second organism; (ii) co-opting of a signal—one organism uses the signal produced by another to regulate its own gene expression; (iii) modulation of a signal—one organism alters the production or stability of a signal from another organism; and (iv) two-way communication—multiple signals are exchanged between organisms. produces two acylhomoserine lactones (AHLs) signals, 3-oxo-C-homoserine lactone (3-O-C- HSL) and C-homoserine lactone (C-HSL). The increased virulence in the presence of dynorphin is due to induction of the biosynthetic operon, which leads to an increased production of hydroxy-alkylquinolones, including the quinolone signal (PQS) quorum-sensing molecule, which regulates a number of cytotoxic factors. Genetic and biochemical experiments indicated that 3-O-C-HSL, described for its role in quorum sensing, is sufficient to suppress hypha formation. Although the chapter has focused on signaling interactions that involve molecules whose primary role appears to be the transmission of information, there are likely many other signals, such as metabolites or pH and oxygen gradients, that may play equally important roles in the regulation of processes important during interdomain interactions. Physical interactions between organisms may also be important for communication within mixed species communities.

Citation: Cugini C, Kolter R, Hogan D. 2008. Interdomain Cross Talk, p 419-429. In Winans S, Bassler B (ed), Chemical Communication among Bacteria. ASM Press, Washington, DC. doi: 10.1128/9781555815578.ch26
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Different types of interdomain signaling interactions. (A) One-way communication describes instances in which one organism responds to a signal produced by another organism. (B) Co-opting of a signal occurs when one organism specifically uses the signaling molecule of another to regulate gene expression. (C) Modulation of a signal by another organism can either stimulate or dampen the elicited response. (D) Two-way communication describes a chemical conversation between two organisms. The signal producer is depicted as the shaded form.

Citation: Cugini C, Kolter R, Hogan D. 2008. Interdomain Cross Talk, p 419-429. In Winans S, Bassler B (ed), Chemical Communication among Bacteria. ASM Press, Washington, DC. doi: 10.1128/9781555815578.ch26
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Image of FIGURE 2

Diffusible molecules that participate in interdomain signaling interactions. The compounds on the left are bacterially derived; eukaryotic organisms produce the molecules on the right. The R group on the AHL and 3-O-AHL represents acyl chains from C=4 to C=16.

Citation: Cugini C, Kolter R, Hogan D. 2008. Interdomain Cross Talk, p 419-429. In Winans S, Bassler B (ed), Chemical Communication among Bacteria. ASM Press, Washington, DC. doi: 10.1128/9781555815578.ch26
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Image of FIGURE 3

and responses to secreted chemical signals.

Citation: Cugini C, Kolter R, Hogan D. 2008. Interdomain Cross Talk, p 419-429. In Winans S, Bassler B (ed), Chemical Communication among Bacteria. ASM Press, Washington, DC. doi: 10.1128/9781555815578.ch26
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1. Azghani, A. O.,, S. Idell,, M. Bains,, and R. E. Hancock. 2002. Pseudomonas aeruginosa outer membrane protein F is an adhesin in bacterial binding to lung epithelial cells in culture. Microb. Pathog. 33: 109114.
2. Bakare, N.,, V. Rickerts,, J. Bargon,, and G. Just-Nubling. 2003. Prevalence of Aspergillus fumigatus and other fungal species in the sputum of adult patients with cystic fibrosis. Mycoses 46: 1923.
3. Bauernfeind, A.,, R. M. Bertele,, K. Harms,, G. Horl,, R. Jungwirth,, C. Petermuller,, B. Przyklenk,, and C. Weisslein-Pfister. 1987. Qualitative and quantitative microbiological analysis of sputa of 102 patients with cystic fibrosis. Infection 15: 270277.
4. Beale, E.,, G. Li,, M. W. Tan,, and K. P. Rumbaugh. 2006. Caenorhabditis elegans senses bacterial autoinducers. Appl. Environ. Microbiol. 72: 51355137.
5. Berger, M. 2002. Inflammatory mediators in cystic fibrosis lung disease. Allergy Asthma Proc. 23: 1925.
6. Bredenbruch, F.,, R. Geffers,, M. Nimtz,, J. Buer,, and S. Haussler. 2006. The Pseudomonas aeruginosa quinolone signal (PQS) has an iron-chelating activity. Environ. Microbiol. 8: 13181329.
7. Broughton, W. J.,, S. Jabbouri,, and X. Perret. 2000. Keys to symbiotic harmony. J. Bacteriol. 182: 56415652.
8. Charlton, T. S.,, R. de Nys,, A. Netting,, N. Kumar,, M. Hentzer,, M. Givskov,, and S. Kjelleberg. 2000. A novel and sensitive method for the quantification of N-3-oxoacyl homoserine lactones using gas chromatography-mass spec-trometry: application to a model bacterial biofilm. Environ. Microbiol. 2: 530541.
9. Clarke, M. B.,, D. T. Hughes,, C. Zhu,, E. C. Boedeker,, and V. Sperandio. 2006. The QseC sensor kinase: a bacterial adrenergic receptor. Proc. Natl. Acad. Sci. USA 103: 1042010425.
10. Cook, D. R. 1999. Medicago truncatula—a model in the making! Curr. Opin. Plant Biol. 2: 301304.
11. Daniels, R.,, S. Reynaert,, H. Hoekstra,, C. Verreth,, J. Janssens,, K. Braeken,, M. Fauvart,, S. Beullens,, C. Heusdens,, I. Lambrichts,, D. E. De Vos,, J. Vanderleyden,, J. Vermant,, and J. Michiels. 2006. Quorum signal molecules as biosurfactants affecting swarming in Rhizobium etli. Proc. Natl. Acad. Sci. USA 103: 1496514970.
12. Davidson, S. K.,, T. A. Koropatnick,, R. Kossmehl,, L. Sycuro,, and M. J. McFall-Ngai. 2004. NO means ‘yes’ in the squid-vibrio symbiosis: nitric oxide (NO) during the initial stages of a beneficial association. Cell Microbiol. 6: 11391151.
13. De Kievit, T. R.,, R. Gillis,, S. Marx,, C. Brown,, and B. H. Iglewski. 2001. Quorum-sensing genes in Pseudomonas aeruginosa biofilms: their role and expression patterns. Appl. Environ. Microbiol. 67: 18651873.
14. de Nys, R.,, M. Givskov,, N. Kumar,, S. Kjelleberg,, and P. D. Steinberg. 2006. Furanones. Prog. Mol. Subcell. Biol. 42: 5586.
15. Diggle, S. P.,, S. Matthijs,, V. J. Wright,, M. P. Fletcher,, S. R. Chhabra,, I. L. Lamont,, X. Kong,, R. C. Hider,, P. Cornelis,, M. Camara,, and P. Williams. 2007. The Pseudomonas aeruginosa 4-quinolone signal molecules HHQ and PQS play multifunctional roles in quorum sensing and iron entrapment. Chem. Biol. 14: 8796.
16. Diggle, S. P.,, R. E. Stacey,, C. Dodd,, M. Camara,, P. Williams,, and K. Winzer. 2006. The galactophilic lectin, LecA, contributes to biofilm development in Pseudomonas aeruginosa. Environ. Microbiol. 8: 10951104.
17. DiMango, E.,, H. J. Zar,, R. Bryan,, and A. Prince. 1995. Diverse Pseudomonas aeruginosa gene products stimulate respiratory epithelial cells to produce interleukin-8. J. Clin. Invest. 96: 22042210.
18. Dong, Y. H.,, J. L. Xu,, X. Z. Li,, and L. H. Zhang. 2000. AiiA, an enzyme that inactivates the acylhomoserine lactone quorum-sensing signal and attenuates the virulence of Erwinia carotovora. Proc. Natl. Acad. Sci. USA 97: 35263531.
19. El-Azizi, M. A.,, S. E. Starks,, and N. Khardori. 2004. Interactions of Candida albicans with other Candida spp. and bacteria in the biofilms. J. Appl. Microbiol. 96: 10671073.
20. Elliott, S. J.,, L. A. Wainwright,, T. K. McDaniel,, K. G. Jarvis,, Y. K. Deng,, L. C. Lai,, B. P. McNamara,, M. S. Donnenberg,, and J. B. Kaper. 1998. The complete sequence of the locus of enterocyte effacement (LEE) from enteropathogenic Escherichia coli E2348/69. Mol. Microbiol. 28: 14.
21. Erickson, D. L.,, R. Endersby,, A. Kirkham,, K. Stuber,, D. D. Vollman,, H. R. Rabin,, I. Mitchell,, and D. G. Storey. 2002. Pseudomonas aeruginosa quorum-sensing systems may control virulence factor expression in the lungs of patients with cystic fibrosis. Infect. Immun. 70: 17831790.
22. Gao, M.,, M. Teplitski,, J. B. Robinson,, and W. D. Bauer. 2003. Production of substances by Medicago truncatula that affect bacterial quorum sensing. Mol. Plant-Microbe Interact. 16: 827834.
23. Givskov, M.,, R. de Nys,, M. Manefield,, L. Gram,, R. Maximilien,, L. Eberl,, S. Molin,, P. D. Steinberg,, and S. Kjelleberg. 1996. Eukaryotic interference with homoserine lactone-mediated prokaryotic signalling. J. Bacteriol. 178: 66186622.
24. Gonzalez, J. E.,, and M. M. Marketon. 2003. Quorum sensing in nitrogen-fixing rhizobia. Microbiol. Mol. Biol. Rev. 67: 574592.
25. Goodson, M. S.,, W. J. Crookes-Goodson,, J. R. Kimbell,, and M. J. McFall-Ngai. 2006. Characterization and role of p53 family members in the symbiont-induced morphogenesis of the Euprymna scolopes light organ. Biol. Bull. 211: 717.
26. Goodson, M. S.,, M. Kojadinovic,, J. V. Troll,, T. E. Scheetz,, T. L. Casavant,, M. B. Soares,, and M. J. McFall-Ngai. 2005. Identifying components of the NF-kappaB pathway in the beneficial Euprymna scolopes- Vibrio fischeri light organ symbiosis. Appl. Environ. Microbiol. 71: 69346946.
27. Gupte, M.,, P. Kulkarni,, and B. N. Ganguli. 2002. Antifungal antibiotics. Appl. Microbiol. Biotechnol. 58: 4657.
28. Hogan, D. A.,, and R. Kolter. 2002. Pseudomonas-Candida interactions: an ecological role for virulence factors. Science 296: 22292232.
29. Hogan, D. A.,, A. Vik,, and R. Kolter. 2004. A Pseudomonas aeruginosa quorum-sensing molecule influences Candida albicans morphology. Mol. Microbiol. 54: 12121223.
30. Hornby, J. M.,, E. C. Jensen,, A. D. Lisec,, J. J. Tasto,, B. Jahnke,, R. Shoemaker,, P. Dussault,, and K. W. Nickerson. 2001. Quorum sensing in the dimorphic fungus Candida albicans is mediated by farnesol. Appl. Environ. Microbiol. 67: 29822992.
31. Hughes, W. T.,, and H. K. Kim. 1973. Mycoflora in cystic fibrosis: some ecologic aspects of Pseudomonas aeruginosa and Candida albicans. Mycopathol. Mycol. Appl. 50: 261269.
32. Joint, I. 2006. Bacterial conversations: talking, listening and eavesdropping. A NERC discussion meeting held at the Royal Society on 7 December 2005. J. R. Soc. Interface 3: 459463.
33. Joint, I.,, K. Tait,, M. E. Callow,, J. A. Callow,, D. Milton,, P. Williams,, and M. Camara. 2002. Cell-to-cell communication across the prokaryote-eukaryote boundary. Science 298: 1207.
34. Kanamaru, K.,, K. Kanamaru,, I. Tatsuno,, T. Tobe,, and C. Sasakawa. 2000. SdiA, an Escherichia coli homologue of quorum-sensing regulators, controls the expression of virulence factors in enterohaemorrhagic Escherichia coli O157:H7. Mol. Microbiol. 38: 805816.
35. Kaper, J. B.,, and V. Sperandio. 2005. Bacterial cell-to-cell signaling in the gastrointestinal tract. Infect. Immun. 73: 31973209.
36. Kaplan, H. B. 2003. Multicellular development and gliding motility in Myxococcus xanthus. Curr. Opin. Microbiol. 6: 572577.
37. Koropatnick, T. A.,, J. T. Engle,, M. A. Apicella,, E. V. Stabb,, W. E. Goldman,, and M. J. McFall-Ngai. 2004. Microbial factor-mediated development in a host-bacterial mutualism. Science 306: 11861188.
38. Lupp, C.,, M. Urbanowski,, E. P. Greenberg,, and E. G. Ruby. 2003. The Vibrio fischeri quorum-sensing systems ain and lux sequentially induce luminescence gene expression and are important for persistence in the squid host. Mol. Microbiol. 50: 319331.
39. Mahajan-Miklos, S.,, M. W. Tan,, L. G. Rahme,, and F. M. Ausubel. 1999. Molecular mechanisms of bacterial virulence elucidated using a Pseudomonas aeruginosa-Caenorhabditis elegans pathogenesis model. Cell 96: 4756.
40. Manefield, M.,, R. de Nys,, N. Kumar,, R. Read,, M. Givskov,, P. Steinberg,, and S. Kjelleberg. 1999. Evidence that halogenated furanones from Delisea pulchra inhibit acylated homoserine lactone (AHL)-mediated gene expression by displacing the AHL signal from its receptor protein. Microbiology 145: 283291.
41. Manefield, M.,, T. B. Rasmussen,, M. Henzter,, J. B. Andersen,, P. Steinberg,, S. Kjelleberg,, and M. Givskov. 2002. Halogenated furanones inhibit quorum sensing through accelerated LuxR turnover. Microbiology 148: 11191127.
42. Mathesius, U.,, S. Mulders,, M. Gao,, M. Teplitski,, G. Caetano-Anolles,, B. G. Rolfe,, and W. D. Bauer. 2003. Extensive and specific responses of a eukaryote to bacterial quorum-sensing signals. Proc. Natl. Acad. Sci. USA 100: 14441449.
43. McDaniel, T. K.,, K. G. Jarvis,, M. S. Donnenberg,, and J. B. Kaper. 1995. A genetic locus of enterocyte effacement conserved among diverse enterobacterial pathogens. Proc. Natl. Acad. Sci. USA 92: 16641668.
44. McFall-Ngai, M. J.,, and E. G. Ruby. 2000. Developmental biology in marine invertebrate symbioses. Curr. Opin. Microbiol. 3: 603607.
45. Milton, D. L.,, V. J. Chalker,, D. Kirke,, A. Hard-man,, M. Camara,, and P. Williams. 2001. The LuxM homologue VanM from Vibrio anguillarum directs the synthesis of N-(3-hydroxyhexanoyl) homoserine lactone and N-hexanoylhomoserine lactone. J. Bacteriol. 183: 35373547.
46. Milton, D. L.,, A. Hardman,, M. Camara,, S. R. Chhabra,, B. W. Bycroft,, G. S. Stewart,, and P. Williams. 1997. Quorum sensing in Vibrio anguillarum: characterization of the vanI/vanR locus and identification of the autoinducer N-(3-oxodecanoyl)-L-homoserine lactone. J. Bacteriol. 179: 30043012.
47. Paggi, R. A.,, C. B. Martone,, C. Fuqua,, and R. E. De Castro. 2003. Detection of quorum sensing signals in the haloalkaliphilic archaeon Natronococcus occultus. FEMS Microbiol. Lett. 221: 4952.
48. Parsek, M. R.,, and E. P. Greenberg. 2005. Sociomicrobiology: the connections between quorum sensing and biofilms. Trends Microbiol. 13: 2733.
49. Pauly, N.,, C. Pucciariello,, K. Mandon,, G. Innocenti,, A. Jamet,, E. Baudouin,, D. Herouart,, P. Frendo,, and A. Puppo. 2006. Reactive oxygen and nitrogen species and glutathione: key players in the legume- Rhizobium symbiosis. J. Exp. Bot. 57: 17691776.
50. Pearson, J. P.,, E. C. Pesci,, and B. H. Iglewski. 1997. Roles of Pseudomonas aeruginosa las and rhl quorum-sensing systems in control of elastase and rhamnolipid biosynthesis genes. J. Bacteriol. 179: 57565767.
51. Perret, X.,, C. Staehelin,, and W. J. Broughton. 2000. Molecular basis of symbiotic promiscuity. Microbiol. Mol. Biol. Rev. 64: 180201.
52. Pestka, S.,, C. D. Krause,, and M. R. Walter. 2004. Interferons, interferon-like cytokines, and their receptors. Immunol. Rev. 202: 832.
53. Rankin, C. H. 2004. Invertebrate learning: what can’t a worm learn? Curr. Biol. 14: R617- R618.
54. Rasmussen, T. B.,, M. Manefield,, J. B. Andersen,, L. Eberl,, U. Anthoni,, C. Christophersen,, P. Steinberg,, S. Kjelleberg,, and M. Givskov. 2000. How Delisea pulchra furanones affect quorum sensing and swarming motility in Serratia liquefaciens MG1. Microbiology 146: 32373244.
55. Rice, S. A.,, M. Givskov,, P. Steinberg,, and S. Kjelleberg. 1999. Bacterial signals and antagonists: the interaction between bacteria and higher organisms. J. Mol. Microbiol. Biotechnol. 1: 2331.
56. Riedlinger, J.,, S. D. Schrey,, M. T. Tarkka,, R. Hampp,, M. Kapur,, and H. P. Fiedler. 2006. Auxofuran, a novel metabolite that stimulates the growth of fly agaric, is produced by the mycorrhiza helper bacterium Streptomyces strain AcH 505. Appl. Environ. Microbiol. 72: 35503557.
57. Schrey, S. D.,, M. Schellhammer,, M. Ecke,, R. Hampp,, and M. T. Tarkka. 2005. Mycorrhiza helper bacterium Streptomyces AcH 505 induces differential gene expression in the ectomycorrhizal fungus Amanita muscaria. New Phytol. 168: 205216.
58. Schuster, M.,, and E. P. Greenberg. 2006. A network of networks: quorum-sensing gene regulation in Pseudomonas aeruginosa. Int. J. Med. Microbiol. 296: 7381.
59. Shiner, E. K.,, D. Terentyev,, A. Bryan,, S. Sennoune,, R. Martinez-Zaguilan,, G. Li,, S. Gyorke,, S. C. Williams,, and K. P. Rumbaugh. 2006. Pseudomonas aeruginosa autoinducer modulates host cell responses through calcium signalling. Cell. Microbiol. 8: 16011610.
60. Smith, R. S.,, E. R. Fedyk,, T. A. Springer,, N. Mukaida,, B. H. Iglewski,, and R. P. Phipps. 2001. IL-8 production in human lung fibroblasts and epithelial cells activated by the Pseudomonas autoinducer N-3-oxododecanoyl homoserine lactone is transcriptionally regulated by NF-kappa B and activator protein-2. J. Immunol. 167: 366374.
61. Smith, R. S.,, S. G. Harris,, R. Phipps,, and B. Iglewski. 2002. The Pseudomonas aeruginosa quorum-sensing molecule N-(3-oxododecanoyl)homoserine lactone contributes to virulence and induces inflammation in vivo. J. Bacteriol. 184: 11321139.
62. Smith, R. S.,, and B. H. Iglewski. 2003. P. aeruginosa quorum-sensing systems and virulence. Curr. Opin. Microbiol. 6: 5660.
63. Smith, R. S.,, R. Kelly,, B. H. Iglewski,, and R. P. Phipps. 2002. The Pseudomonas autoinducer N-(3-oxododecanoyl) homoserine lactone induces cyclooxygenase-2 and prostaglandin E2 production in human lung fibroblasts: implications for inflammation. J. Immunol. 169: 26362642.
64. Sperandio, V.,, J. L. Mellies,, R. M. Delahay,, G. Frankel,, J. A. Crawford,, W. Nguyen,, and J. B. Kaper. 2000. Activation of enteropathogenic Escherichia coli (EPEC) LEE2 and LEE3 operons by Ler. Mol. Microbiol. 38: 781793.
65. Sperandio, V.,, A. G. Torres,, B. Jarvis,, J. P. Nataro,, and J. B. Kaper. 2003. Bacteria-host communication: the language of hormones. Proc. Natl. Acad. Sci. USA 100: 89518956.
66. Tait, K.,, I. Joint,, M. Daykin,, D. L. Milton,, P. Williams,, and M. Camara. 2005. Disruption of quorum sensing in seawater abolishes attraction of zoospores of the green alga Ulva to bacterial biofilms. Environ. Microbiol. 7: 229240.
67. Takaoka, A.,, and H. Yanai. 2006. Interferon signalling network in innate defence. Cell. Microbiol. 8: 907922.
68. Teplitski, M.,, H. Chen,, S. Rajamani,, M. Gao,, M. Merighi,, R. T. Sayre,, J. B. Robinson,, B. G. Rolfe,, and W. D. Bauer. 2004. Chlamydomonas reinhardtii secretes compounds that mimic bacterial signals and interfere with quorum sensing regulation in bacteria. Plant Physiol. 134: 137146.
69. Teplitski, M.,, J. B. Robinson,, and W. D. Bauer. 2000. Plants secrete substances that mimic bacterial N-acyl homoserine lactone signal activities and affect population density-dependent behaviors in associated bacteria. Mol. Plant-Microbe Interact. 13: 637648.
70. Visick, K. L.,, J. Foster,, J. Doino,, M. McFall-Ngai,, and E. G. Ruby. 2000. Vibrio fischeri lux genes play an important role in colonization and development of the host light organ. J. Bacteriol. 182: 45784586.
71. Visick, K. L.,, and C. Fuqua. 2005. Decoding microbial chatter: cell-cell communication in bacteria. J. Bacteriol. 187: 55075519.
72. Walters, M.,, and V. Sperandio. 2006. Quorum sensing in Escherichia coli and Salmonella. Int. J. Med. Microbiol. 296: 125131.
73. Weijer, C. J. 2004. Dictyostelium morphogenesis. Curr. Opin. Genet. Dev. 14: 392398.
74. Wheeler, G. L.,, K. Tait,, A. Taylor,, C. Brownlee,, and I. Joint. 2006. Acyl-homoserine lactones modulate the settlement rate of zoospores of the marine alga Ulva intestinalis via a novel chemokinetic mechanism. Plant Cell. Environ. 29: 608618.
75. Williams, S. C.,, E. K. Patterson,, N. L. Carty,, J. A. Griswold,, A. N. Hamood,, and K. P. Rumbaugh. 2004. Pseudomonas aeruginosa autoinducer enters and functions in mammalian cells. J. Bacteriol. 186: 22812287.
76. Winzer, K.,, C. Falconer,, N. C. Garber,, S. P. Diggle,, M. Camara,, and P. Williams. 2000. The Pseudomonas aeruginosa lectins PA-IL and PA-IIL are controlled by quorum sensing and by RpoS. J. Bacteriol. 182: 64016411.
77. Wu, L.,, O. Estrada,, O. Zaborina,, M. Bains,, L. Shen,, J. E. Kohler,, N. Patel,, M. W. Musch,, E. B. Chang,, Y. X. Fu,, M. A. Jacobs,, M. I. Nishimura,, R. E. Hancock,, J. R. Turner,, and J. C. Alverdy. 2005. Recognition of host immune activation by Pseudomonas aeruginosa. Science 309: 774777.
78. Xiao, G.,, E. Deziel,, J. He,, F. Lepine,, B. Lesic,, M. H. Castonguay,, S. Milot,, A. P. Tampakaki,, S. E. Stachel,, and L. G. Rahme. 2006. MvfR, a key Pseudomonas aeruginosa pathogenicity LTTR-class regulatory protein, has dual ligands. Mol. Microbiol. 62: 16891699.
79. Zaborina, O.,, F. Lepine,, G. Xiao,, V. Valuckaite,, Y. Chen,, T. Li,, M. Ciancio,, A. Zaborin,, E. Petroff,, J. R. Turner,, L. G. Rahme,, E. Chang,, and J. C. Alverdy. 2007. Dynorphin activates quorum sensing quinolone signaling in Pseudomonas aeruginosa. PLoS Pathog. 3: e35.
80. Zhang, L. H.,, and Y. H. Dong. 2004. Quorum sensing and signal interference: diverse implications. Mol. Microbiol. 53: 15631571.
81. Zhang, Y.,, H. Lu,, and C. I. Bargmann. 2005. Pathogenic bacteria induce aversive olfactory learning in Caenorhabditis elegans. Nature 438: 179184.

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