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Chapter 26 : Interdomain Cross Talk
Authors:
Carla Cugini1,
Roberto Kolter2,
Deborah A. Hogan3
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Affiliations:
1: Department of Microbiology and Immunology, Dartmouth Medical School, Hanover, New Hampshire 03755;
2: Department of Microbiology and Molecular Genetics, Harvard Medical School, Boston, Massachusctts 02115;
3: Department of Microbiology and Immunology, Dartmouth Medical School, Hanover, New Hampshire 03755
Content Type: Monograph
Publication Year:
2008
Category: Microbial Genetics and Molecular Biology; Bacterial Pathogenesis
Book DOI:
10.1128/9781555815578
Chapter DOI:
10.1128/9781555815578.ch26
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Abstract:
This chapter defines four signaling categories that describe the different interdomain signaling mechanisms. These mechanisms are: (i) one-way sensing—one organism senses and responds to a diffusible signal produced by a second organism; (ii) co-opting of a signal—one organism uses the signal produced by another to regulate its own gene expression; (iii) modulation of a signal—one organism alters the production or stability of a signal from another organism; and (iv) two-way communication—multiple signals are exchanged between organisms. Pseudomonas aeruginosa produces two acylhomoserine lactones (AHLs) signals, 3-oxo-C12-homoserine lactone (3-O-C12- HSL) and C4-homoserine lactone (C4-HSL). The increased virulence in the presence of dynorphin is due to induction of the pqs biosynthetic operon, which leads to an increased production of hydroxy-alkylquinolones, including the P. aeruginosa quinolone signal (PQS) quorum-sensing molecule, which regulates a number of cytotoxic factors. Genetic and biochemical experiments indicated that P. aeruginosa 3-O-C12-HSL, described for its role in quorum sensing, is sufficient to suppress C. albicans hypha formation. Although the chapter has focused on signaling interactions that involve molecules whose primary role appears to be the transmission of information, there are likely many other signals, such as metabolites or pH and oxygen gradients, that may play equally important roles in the regulation of processes important during interdomain interactions. Physical interactions between organisms may also be important for communication within mixed species communities.
Citation:
Cugini C, Kolter R, Hogan D.
2008.
Interdomain Cross Talk,
p 419-429.
In
Winans S, Bassler B (ed),
Chemical Communication among Bacteria.
ASM Press, Washington, DC.
doi: 10.1128/9781555815578.ch26
Figures
Interdomain Cross Talk
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Citation:
Cugini C, Kolter R, Hogan D.
2008.
Interdomain Cross Talk,
p 419-429.
In
Winans S, Bassler B (ed),
Chemical Communication among Bacteria.
ASM Press, Washington, DC.
doi: 10.1128/9781555815578.ch26
/content/10.1128/9781555815578.ch26.ch26fig01
FIGURE 1
Different types of interdomain signaling interactions. (A) One-way communication describes instances in which one organism responds to a signal produced by another organism. (B) Co-opting of a signal occurs when one organism specifically uses the signaling molecule of another to regulate gene expression. (C) Modulation of a signal by another organism can either stimulate or dampen the elicited response. (D) Two-way communication describes a chemical conversation between two organisms. The signal producer is depicted as the shaded form.
10.1128/9781555815578/f0420-01_thmb.gif
10.1128/9781555815578/f0420-01.gif
FIGURE 1
Different types of interdomain signaling interactions. (A) One-way communication describes instances in which one organism responds to a signal produced by another organism. (B) Co-opting of a signal occurs when one organism specifically uses the signaling molecule of another to regulate gene expression. (C) Modulation of a signal by another organism can either stimulate or dampen the elicited response. (D) Two-way communication describes a chemical conversation between two organisms. The signal producer is depicted as the shaded form.
Citation:
Cugini C, Kolter R, Hogan D.
2008.
Interdomain Cross Talk,
p 419-429.
In
Winans S, Bassler B (ed),
Chemical Communication among Bacteria.
ASM Press, Washington, DC.
doi: 10.1128/9781555815578.ch26
/content/10.1128/9781555815578.ch26.ch26fig02
FIGURE 2
Diffusible molecules that participate in interdomain signaling interactions. The compounds on the left are bacterially derived; eukaryotic organisms produce the molecules on the right. The R group on the AHL and 3-O-AHL represents acyl chains from C=4 to C=16.
10.1128/9781555815578/f0421-01_thmb.gif
10.1128/9781555815578/f0421-01.gif
FIGURE 2
Diffusible molecules that participate in interdomain signaling interactions. The compounds on the left are bacterially derived; eukaryotic organisms produce the molecules on the right. The R group on the AHL and 3-O-AHL represents acyl chains from C=4 to C=16.
Citation:
Cugini C, Kolter R, Hogan D.
2008.
Interdomain Cross Talk,
p 419-429.
In
Winans S, Bassler B (ed),
Chemical Communication among Bacteria.
ASM Press, Washington, DC.
doi: 10.1128/9781555815578.ch26
/content/10.1128/9781555815578.ch26.ch26fig03
FIGURE 3
P. aeruginosa and C. albicans responses to secreted chemical signals.
10.1128/9781555815578/f0425-01_thmb.gif
10.1128/9781555815578/f0425-01.gif
FIGURE 3
P. aeruginosa and C. albicans responses to secreted chemical signals.
Citation:
Cugini C, Kolter R, Hogan D.
2008.
Interdomain Cross Talk,
p 419-429.
In
Winans S, Bassler B (ed),
Chemical Communication among Bacteria.
ASM Press, Washington, DC.
doi: 10.1128/9781555815578.ch26
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