Chapter 74 : in Macrophage Function and Susceptibility to Infection with

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Genetic analysis in the mouse has been used to identify host genes and proteins that play important roles in natural defences against a broad range of infectious diseases. In mouse, susceptibility to infection with is genetically controlled. Intracellular pathogens have evolved different strategies to inhibit or escape the bacteriostatic or bactericidal defense mechanisms of host macrophages. Electron microscopy studies indicated that -containing phagosome (LCP) morphology diverges from classic phagosomes: within the first 5 min of infection, LCPs become surrounded by host vesicles; 15 min postinfection, the thickness of the phagosomal membrane resembles that of the endoplasmic reticulum (ER), and 6 h after infection, ribosomes are found attached to the cytoplasmic face of LCPs. Nontransgenic permissive A/J peritoneal and bone marrow-derived macrophages allowed massive replication over a 72-h infection period (2.8 ± 0.3 and 1.6 ± 0.4 log CFU respectively) compared to macrophages from -resistant transgenic animals (0.74 ± 0.18 and -0.52 ± 0.26 log CFU respectively). It has been proposed that, like other members of the NLR family, Birc1e/Naip5 may function as an intracellular sensor of products and may trigger immune responses through inflammatory caspases.

Citation: Fortier A, Gros P. 2006. in Macrophage Function and Susceptibility to Infection with , p 307-309. In Cianciotto N, Kwaik Y, Edelstein P, Fields B, Geary D, Harrison T, Joseph C, Ratcliff R, Stout J, Swanson M (ed), . ASM Press, Washington, DC. doi: 10.1128/9781555815660.ch74
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