Pathogenesis of Human Pulmonary Tuberculosis: Insights from the Rabbit Model

Author: Arthur M. Dannenberg, Jr.1
Affiliations: 1: Center for Tuberculosis Research Departments of Environmental Health Sciences, Molecular Microbiology and Immunology, and Epidemiology, Bloomberg School of Public Health Department of Pathology, School of Medicine Johns Hopkins University, Baltimore, Maryland 21205
Content Type: Monograph
Publication Year: 2006

Category: Clinical Microbiology; Bacterial Pathogenesis

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This work examines the pathogenesis of human pulmonary tuberculosis in all of its stages, with a primary focus on the rabbit model. Tuberculosis in the rabbit most closely resembles that found in humans, including caseous necrosis, liquefaction, and cavity formation with bronchial spread of the disease. Other animal models-mouse, guinea pig, and monkey-are compared with the rabbit and human models.

Authored by a noted and experienced expert in the field, reviews the interplay of the delayed-type hypersensitivity and cell-mediated immunity, clearly showing how both are needed to control the growth of the tubercle bacillus and how antibodies contribute to these cellular immune responses. The pathology and structure of tuberculous lesions are thoroughly investigated. Other significant topics discussed include the histochemistry of macrophage activation; the roles of various cytokines; the effects of glucocorticoids, estrogens, thyroid hormones, and irradiation on the disease; and principles of immunization against tuberculosis, including vaccine development. The final chapter describes many areas in which future research could contribute to our knowledge, treatment, and control of this disease. The text is complemented by high-quality illustrations of both human and rabbit disease.

updates and revises the ground-breaking work of Max B. Lurie, summarizing the combined 80 years of research by Drs. Lurie and Dannenberg. The book offers a comprehensive resource for clinicians, public health investigators, and laboratory researchers in tuberculosis and immunology.

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