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Chapter 28 : Biotechnological Applications

Author: J. Grant Burgess1
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Affiliations: 1: School of Marine Science and Technology, University of Newcastle upon Tyne, Newcastle NE1 7R4, United Kingdom
Content Type: Monograph
Publication Year: 2006

Category: Environmental Microbiology

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Biotechnological Applications, Page 1 of 2

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Abstract:

This chapter provides a summary of the main applications which have been commercialized or which are being developed as biotechnological products or processes. Two oral vaccines are available. First is the WC/rBS vaccine, which consists of whole cells of O1 plus a recombinant subunit of the cholera toxin. This provides good protection. Second, a live attenuated vaccine is available which is a genetically manipulated strain, CVD103-HgR. As well as being useful for the development of cholera vaccines, there are also some interesting applications being looked at which use -derived toxins in other ways. The discovery of quorum sensing in species of in the 1980s is one of the most important developments in the history of microbiology. The evolution of quorum sensing was a major step which allowed bacteria to secure some of the adaptive advantages of more complex multicelled organisms. spp. have been found to produce a variety of extracellular proteases. , for example, produces six proteases, including an unusual detergent- resistant alkaline serine exoprotease. However, an enzyme-linked immunosorbent assay for the detection of in a variety of homogenized samples has been developed.

Citation: Burgess J. 2006. Biotechnological Applications, p 401-406. In Thompson F, Austin B, Swings J (ed), The Biology of Vibrios. ASM Press, Washington, DC. doi: 10.1128/9781555815714.ch28
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References

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1. Anonymous. 2004. Tetrodotoxin is safe and effective for severe, refractory cancer pain. J. Support. Oncol. 2: 18.
2. Applegate, B.,, C. Kelly,, L. Lackey,, J. McPherson,, S. Kehrmeyer,, F. M. Menn,, P. Bienkowski, and, G. Sayler. 1997. Pseudomonas putida B2: a todlux bioluminescent reporter for toluene and trichloroethylene co-metabolism. J. Ind. Microbiol. Biotechnol. 18: 4– 9.
3. Applegate, B. M.,, S. R. Kehrmeyer, and, G. S. Sayler. 1998. A chromosomally based tod-luxCDABE whole-cell reporter for benzene, toluene, ethybenzene, and xylene (BTEX) sensing. Appl. Environ. Microbiol. 64: 2730– 2735.
4. Austin, B.,, L. F. Stuckey,, P. A. W. Robertson,, I. Effendi, and, D. R. W. Griffith. 1995. A probiotic strain of Vibrio alginolyticus effective in reducing diseases caused by Aeromonas salmonicida, Vibrio anguillarum and Vibrio ordalii. J. Fish Dis. 18: 93– 96.
5. Bergerot, I.,, C. Ploix,, J. Petersen,, V. Moulin,, C. Rask,, N. Fabien,, M. Lindblad,, A. Mayer,, C. Czerkinsky,, J. Holmgren, and, C. Thivolet. 1997. A cholera toxoid-insulin conjugate as an oral vaccine against spontaneous autoimmune diabetes. Proc. Natl. Acad. Sci. USA 94: 4610– 4614.
6. Bonner, J. T. 2003. Evolution of development in the cellular slime molds. Evol. Dev. 5: 305– 313.
7. Bulich, A. A. 1979. Use of luminescent bacteria for determining relative toxicity in aquatic environments, p. 98– 106. In L. L. Marking and, R. A. Kimerle (ed.), Aquatic Toxicology. ASTM STP 667. American Society for Testing and Materials, Philadelphia, Pa.
8. Bulich, A. A., and, D. L. Isenberg. 1981. Use of the luminescent bacterial system for the rapid assessment of aquatic toxicity. ISA Trans. 20: 29– 33.
9. Burgess, J. G.,, K. G. Boyd,, E. Armstrong,, Z. Jiang,, L. Yan,, M. Berggren,, U. May,, T. Pisacane,, A. Granmo, and, D. R. Adams. 2003. The development of a marine natural product-based antifouling paint. Biofouling 19(Suppl.): 197– 205.
10. Burgess, J. G.,, E. M. Jordan,, M. Bregu,, A. Mearns-Spragg, and, K. G. Boyd. 1999. Microbial antagonism: a neglected avenue of natural products research. J. Biotechnol. 70: 27– 32.
11. Burlage, R. S.,, G. S. Sayler, and, F. Larimer. 1990. Monitoring of naphthalene catabolism by bioluminescence with nahlux tran-scriptional fusions. J. Bacteriol. 172: 4749– 4757.
12. Calain, P.,, J. P. Chaine,, E. Johnson,, M. L. Hawley,, M. J. O’Leary,, H. Oshitani, and, C. L. Chaignat. 2004. Can oral cholera vaccination play a role in controlling a cholera outbreak? Vaccine 22: 2444– 2451.
13. Chiou, T. T.,, J. L. Wu,, T. T. Chen, and, J. K. Lu. 2005. Molecular cloning and characterization of cDNA of penaeidin-like antimicrobial peptide from tiger shrimp (Penaeus monodon). Mar. Biotechnol. (N.Y.) 7: 119– 127.
14. Christen, K. 2001. Bioterrorism and waterborne pathogens: how big is the threat? Environ. Sci. Technol. 35: 396A– 397A.
15. Elyakov, G. B.,, T. Kuznetsova,, V. V. Mikhailov,, I. I. Maltsev,, V. G. Voinov, and, S. A. Fedoryev. 1991. Brominated diphenyl ethers from a marine bacterium associated with the sponge Dysidea sp. Experientia 47: 632– 633.
16. Elyakov, G. B.,, T. A. Kuznetsova,, V. A. Sasunkevich, and, V. V. Mikhailov. 1994. New trends of marine biotechnology development. Pure Appl. Chem. 66: 811– 818.
17. Evans, M. H. 1972. Tetrodotoxin, saxitoxin, and related substances: their applications in neurobiology. Int. Rev. Neurobiol. 15: 83– 166.
18. Finch, R. G.,, D. I. Pritchard,, B. W. Bycroft,, P. Williams, and, G. S. Stewart. 1998. Quorum sensing: a novel target for anti-infective therapy. J. Antimicrob. Chemother. 42: 569– 571.
19. Fuqua, W. C.,, S. C. Winans, and, E. P. Greenberg. 1994. Quorum sensing in bacteria: the LuxR-LuxI family of cell density-responsive transcriptional regulators. J. Bacteriol. 176: 269– 275.
20. Fuqua, W. C.,, S. C. Winans, and, E. P. Greenberg. 1996. Census and consensus in bacterial ecosystems: the LuxR-LuxI family of quorum-sensing transcriptional regulators. Annu. Rev. Microbiol. 50: 727– 751.
21. Gray, K. M. 1997. Intercellular communication and group behavior in bacteria. Trends Microbiol. 5: 184– 188.
22. Green, U.,, J. H. Kremer,, M. Zillmer, and, C. Moldaenke. 2003. Detection of chemical threat agents in drinking water by an early warning real-time biomonitor. Environ. Toxicol. 18: 368– 374.
23. Hardman, A. M.,, G. S. Stewart, and, P. Williams. 1998. Quorum sensing and the cell-cell communication dependent regulation of gene expression in pathogenic and non-pathogenic bacteria. Antonie Leeuwenhoek 74: 199– 210.
24. Heitzer, A.,, K. Malachowsky,, J. E. Thonnard,, P. R. Bienkowski,, D. C. White, and, G. S. Sayler. 1994. Optical biosensor for environmental on-line monitoring of naphthalene and salicylate bioavailability with an immobilized bioluminescent catabolic reporter bacterium. Appl. Environ. Microbiol. 60: 1487– 1494.
25. Hentschel, U.,, M. Schmid,, M. Wagner,, L. Fieseler,, C. Gernert, and, J. Hacker. 2001. Isolation and phylogenetic analysis of bacteria with antimicrobial activities from the Mediterranean sponges Aplysina aerophoba and Aplysina cavernicola. FEMS Microbiol. Ecol. 35: 305– 312.
26. Holmgren, J.,, C. Czerkinsky,, K. Eriksson, and, A. Mharandi. 2003. Mucosal immunisation and adjuvants: a brief overview of recent advances and challenges. Vaccine 21(Suppl. 2): S89– S95.
27. Ikeuchi, H.,, S. Kunugi, and, K. Oda. 2000. Activity and stability of a neutral protease from Vibrio sp. (vimelysin) in a pressure-temperature gradient. Eur. J. Biochem. 267: 979– 983.
28. Jones, T. 2004. Peru-1 5 (AVANT). Curr. Opin. Investig. Drugs 5: 887– 891.
29. Jorquera, M. A.,, C. E. Riquelme,, L. A. Loyola, and, L. F. Munoz. 2000. Production of bactericidal substances by a marine vibrio isolated from cultures of the scallop Argopecten purpuratus. Aquacult. Int. 7: 433– 448.
30. Khan, A. S.,, D. L. Swerdlow, and, D. D. Juranek. 2001. Precautions against biological and chemical terrorism directed at food and water supplies. Public Health Rep. 116: 3– 14.
31. Kogure, K.,, M. L. Tamplin,, U. Simidu, and, R. R. Colwell. 1988. A tissue culture assay for tetrodotoxin, saxitoxin and related toxins. Toxicon 26: 191– 197.
32. Lebens, M., and, J. Holmgren. 1994. Mucosal vaccines based on the use of cholera toxin B subunit as immunogen and antigen carrier. Dev. Biol. Stand. 82: 215– 227.
33. Lee, M. J.,, D. Y. Jeong,, W. S. Kim,, H. D. Kim,, C. H. Kim,, W. W. Park,, Y. H. Park,, K. S. Kim,, H. M. Kim, and, D. S. Kim. 2000. A tetrodotoxin-producing Vibrio strain, LM-1, from the puffer fish Fugu vermicularis radiatus. Appl. Environ. Microbiol. 66: 1698– 1701.
34. Levine, M. M.,, J. B. Kaper,, D. Herrington,, J. Ketley,, G. Losonsky,, C. O. Tacket,, B. Tall, and, S. Cryz. 1988. Safety, immunogenicity, and efficacy of recombinant live oral cholera vaccines, CVD 103 and CVD 103-HgR. Lancet 2: 467– 470.
35. LoGrasso, P., and, J. McKelvy. 2003. Advances in pain therapeutics. Curr. Opin. Chem. Biol. 7: 452– 456.
36. Longeon, A.,, J. Peduzzi,, M. Barthelemy,, S. Corre,, J. L. Nicolas, and, M. Guyot. 2005. Purification and partial identification of novel antimicrobial protein from marine bacterium Pseudoalteromonas species strain X153. Mar. Biotechnol. (N.Y.) 6: 633– 641.
37. Lucas, M. E.,, J. L. Deen,, L. von Seidlein,, X. Y. Wang,, J. Ampuero,, M. Puri,, M. Ali,, M. Ansaruzzaman,, J. Amos,, A. Macuamule,, P. Cavailler,, P. J. Guerin,, C. Mahoudeau,, P. Kahozi-Sangwa,, C. L. Chaignat,, A. Barreto,, F. F. Songane, and, J. D. Clemens. 2005. Effectiveness of mass oral cholera vaccination in Beira, Mozambique. N. Engl. J. Med. 352: 757– 767.
38. Manefield, M.,, L. Harris,, S. A. Rice,, R. de Nys, and, S. Kjelleberg. 2000. Inhibition of luminescence and virulence in the black tiger prawn ( Penaeus monodon) pathogen Vibrio harveyi by intercellular signal antagonists. Appl. Environ. Microbiol. 66: 2079– 2084.
39. Manefield, M.,, M. Welch,, M. Givskov,, G. P. Salmond, and, S. Kjelleberg. 2001. Halogenated furanones from the red alga, Delisea pulchra, inhibit carbapenem antibiotic synthesis and exoenzyme virulence factor production in the phytopathogen Erwinia carotovora. FEMS Microbiol. Lett. 205: 131– 138.
40. Marwick, J. D.,, P. C. Wright, and, J. G. Burgess. 1999. Bioprocess intensification for production of novel marine bacterial antibiotics through bioreactor operation and design. Mar. Biotechnol. (N. Y.) 1: 495– 507.
41. Matsuo, K.,, T. Yoshikawa,, H. Asanuma,, T. Iwasaki,, Y. Hagi-wara,, Z. Chen,, S. E. Kadowaki,, H. Tsujimoto,, T. Kurata, and, S. I. Tamura. 2000. Induction of innate immunity by nasal influenza vaccine administered in combination with an adjuvant (cholera toxin). Vaccine 18: 2713– 2722.
42. Mearns-Spragg, A.,, M. Bregu,, K. G. Boyd, and, J. G. Burgess. 1998. Cross-species induction and enhancement of antimicrobial activity produced by epibiotic bacteria from marine algae and invertebrates, after exposure to terrestrial bacteria. Lett. Appl. Microbiol. 27: 142– 146.
43. Miller, M. B., and, B. L. Bassler. 2001. Quorum sensing in bacteria. Annu. Rev. Microbiol. 55: 165– 199.
44. Miller, M. B.,, K. Skorupski,, D. H. Lenz,, R. K. Taylor, and, B. L. Bassler. 2002. Parallel quorum sensing systems converge to regulate virulence in Vibrio cholerae. Cell 110: 303– 314.
45. O’Toole, G.,, H. B. Kaplan, and, R. Kolter. 2000. Biofilm formation as microbial development. Annu. Rev. Microbiol. 54: 49– 79.
46. Pearson, J. P.,, M. Feldman,, B. H. Iglewski, and, A. Prince. 2000. Pseudomonas aeruginosa cell-to-cell signaling is required for virulence in a model of acute pulmonary infection. Infect. Immun. 68: 4331– 4334.
47. Ploix, C.,, I. Bergerot,, A. Durand,, C. Czerkinsky,, J. Holmgren, and, C. Thivolet. 1999. Oral administration of cholera toxin B-insulin conjugates protects NOD mice from autoimmune diabetes by inducing CD4 + regulatory T-cells. Diabetes 48: 2150– 2156.
48. Porreca, F.,, J. Lai,, D. Bian,, S. Wegert,, M. H. Ossipov,, R. M. Eglen,, L. Kassotakis,, S. Novakovic,, D. K. Rabert,, L. Sangames-waran, and, J. C. Hunter. 1999. A comparison of the potential role of the tetrodotoxin-insensitive sodium channels, PN3/SNS and NaN/SNS2, in rat models of chronic pain. Proc. Natl. Acad. Sci. USA 96: 7640– 7644.
49. Powell, L. 1995. Biotechnology for the 21st Century: New Horizons. National Science and Technology Council, Biotechnology Research Subcommittee, London, England.
50. Raffa, R. B.,, J. R. Iannuzzo,, D. R. Levine,, K. K. Saeid,, R. C. Schwartz,, N. T. Sucic,, O. D. Terleckyj, and, J. M. Young. 2005. Bacterial communication (“quorum sensing”) via ligands and receptors: a novel pharmacologic target for the design of antibiotic drugs. J. Pharmacol. Exp. Ther. 312: 417– 423.
51. Rasch, M.,, C. Buch,, B. Austin,, W. J. Slierendrecht,, K. S. Ekmann,, J. L. Larsen,, C. Johansen,, K. Riedel,, L. Eberl,, M. Givskov, and, L. Gram. 2004. An inhibitor of bacterial quorum sensing reduces mortalities caused by vibriosis in rainbow trout (Oncorhynchus mykiss, Walbaum). Syst. Appl. Microbiol. 27: 350– 359.
52. Rasmussen, T. B.,, M. Manefield,, J. B. Andersen,, L. Eberl,, U. Anthoni,, C. Christophersen,, P. Steinberg,, S. Kjelleberg, and, M. Givskov. 2000. How Delisea pulchra furanones affect quorum sensing and swarming motility in Serratia liquefaciens MG1. Microbiology 146: 3237– 3244.
53. Roda, A.,, P. Pasini,, M. Mirasoli,, E. Michelini, and, M. Guardigli. 2004. Biotechnological applications of bioluminescence and chemiluminescence. Trends Biotechnol. 22: 295– 303.
54. Roosenberg, J. M., 2nd,, Y. M. Lin,, Y. Lu, and, M. J. Miller. 2000. Studies and syntheses of siderophores, microbial iron chelators, and analogs as potential drug delivery agents. Curr. Med. Chem. 7: 159– 197.
55. Rotz, L. D., and, J. M. Hughes. 2004. Advances in detecting and responding to threats from bioterrorism and emerging infectious disease. Nat. Med. 10(12 Suppl.): S130- S136.
56. Ruiz-Ponte, C.,, V. Cilia,, C. Lambert, and, J. L. Nicolas. 1998. Roseobacter gallaeciensis sp. nov., a new marine bacterium isolated from rearings and collectors of the scallop Pecten maximus. Int. J. Syst. Bacterial. 48: 537– 542.
57. Ruiz-Ponte, C.,, J. F. Samain,, J. L. Sanchez, and, J. L. Nicolas. 1999. The benefit of a Roseobacter species on the survival of scallop larvae. Mar. Biotechnol. (N.Y.) 1: 52– 59.
58. Sangali, S., and, A. Brandelli. 2000. Feather keratin hydrolysis by a Vibrio sp. strain kr2. J. Appl. Microbiol. 89: 735– 743.
59. Schantz, E. J., and, E. A. Johnson. 1992. Properties and use of botulinum toxin and other microbial neurotoxins in medicine. Microbiol Rev. 56: 80– 99.
60. Simidu, U.,, K. Kita-Tsukamoto,, T. Yasumoto, and, M. Yotsu. 1990. Taxonomy of four marine bacterial strains that produce tetrodotoxin. Int. J. Syst. Bacteriol. 40: 331– 336.
61. Simidu, U.,, T. Noguchi,, D. F. Hwang,, Y. Shida, and, K. Hashimoto. 1987. Marine bacteria which produce tetrodotoxin. Appl. Environ. Microbiol. 53: 1714– 1715.
62. Skyler, J. S. 2002. Effects of insulin in relatives of patients with type 1 diabetes mellitus. N. Engl. J. Med. 346: 1685– 1691.
63. Tamura, S. I., and, T. Kurata. 2000. A proposal for safety standards for human use of cholera toxin (or Escherichia coli heat-labile enterotoxin) derivatives as an adjuvant of nasal inactivated influenza vaccine. Jpn. J. Infect. Dis. 53: 98– 106.
64. Thomashow, L. S. 1996. Biological control of plant root pathogens. Curr. Opin. Biotechnol. 7: 343– 347.
65. Vergne, A. F.,, A. J. Walz, and, M. J. Miller. 2000. Iron chelators from mycobacteria (1954–1999) and potential therapeutic applications. Nat. Prod. Rep. 17: 99– 116.
66. Voinov, V. G.,, Y. N. El’kin,, T. A. Kuznetsova,, I. I. Mal’tsev,, V. V. Mikhailov, and, V. A. Sasunkevich. 1991. Use of mass spectrometry for the detection and identification of bromine-containing diphenyl ethers. J. Chromatogr. 586: 360– 362.
67. Von Bodman, S. B.,, W. D. Bauer, and, D. L. Coplin. 2003. Quorum sensing in plant-pathogenic bacteria. Annu. Rev. Phytopathol. 41: 455– 482.
68. Williams, P.,, M. Camara,, A. Hardman,, S. Swift,, D. Milton,, V. J. Hope,, K. Winzer,, B. Middleton,, D. I. Pritchard, and, B. W. Bycroft. 2000. Quorum sensing and the population-dependent control of virulence. Philos. Trans. R. Soc. Lond. B Biol. Sci. 355: 667– 680.
69. Winzer, K., and, P. Williams. 2001. Quorum sensing and the regulation of virulence gene expression in pathogenic bacteria. Int. J. Med. Microbiol. 291: 131– 143.
70. Yan, L.,, K. G. Boyd,, D. R. Adams, and, J. G. Burgess. 2003. Biofilm-specific cross-species induction of antimicrobial compounds in bacilli. Appl. Environ. Microbiol. 69: 3719– 3727.
71. Yoshikawa, K.,, K. Adachi,, M. Nishijima,, T. Takadera,, S. Tamaki,, K. Harada,, K. Mochida, and, H. Sano. 2000. Beta-cyanoalanine production by marine bacteria on cyanide-free medium and its specific inhibitory activity toward cyanobacteria. Appl. Environ. Microbiol. 66: 718– 722.
72. Yoshino, N.,, F. X. Lu,, K. Fujihashi,, Y. Hagiwara,, K. Kataoka,, D. Lu,, L. Hirst,, M. Honda,, F. W. van Ginkel,, Y. Takeda,, C. J. Miller,, H. Kiyono, and, J. R. McGhee. 2004. A novel adjuvant for mucosal immunity to HIV-1 gp120 in nonhuman primates. J. Immunol. 173: 6850– 6857.
73. Yu, C. F.,, P. H. Yu,, P. L. Chan,, Q. Yan, and, P. K. Wong. 2004. Two novel species of tetrodotoxin-producing bacteria isolated from toxic marine puffer fishes. Toxicon 4: 641– 647.
74. Zhu, J.,, M. B. Miller,, R. E. Vance,, M. Dziejman,, B. L. Bassler, and, J. J. Mekalanos. 2002. Quorum-sensing regulators control virulence gene expression in Vibrio cholerae. Proc. Natl. Acad. Sci. USA 99: 3129– 3134.

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