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Chapter 1 : Clinical Manifestations of Food Allergic Disease
Authors:
Tamara T. Perry1,
Amy M. Scurlock2,
Stacie M. Jones3
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Affiliations:
1: University of Arkansas for Medical Sciences, Division of Allergy and Immunology, Department of Pediatrics, Arkansas Children’s Hospital, Little Rock, AR 72202;
2: University of Arkansas for Medical Sciences, Division of Allergy and Immunology, Department of Pediatrics, Arkansas Children’s Hospital, Little Rock, AR 72202;
3: University of Arkansas for Medical Sciences, Division of Allergy and Immunology, Department of Pediatrics, Arkansas Children’s Hospital, Little Rock, AR 72202
Content Type: Monograph
Publication Year:
2006
Category: Immunology; Applied and Industrial Microbiology
Book DOI:
10.1128/9781555815721
Chapter DOI:
10.1128/9781555815721.ch1
MyBook is a cheap paperback edition of the original book and will be sold at uniform, low price.
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Abstract:
Adverse reactions to foods are classified as either food hypersensitivity (allergy) or food intolerance. IgE-mediated hypersensitivity accounts for the majority of well-characterized food allergic reactions, although non-IgE-mediated immune mechanisms are believed to be responsible for a variety of hypersensitivity disorders. This chapter examines adverse food reactions that are IgE mediated and non-IgE mediated and those entities that have characteristics of both. The true prevalence of adverse food reactions is still unknown. The vast majority of food allergic reactions are secondary to a limited number of foods. Oral tolerance to food allergens occurs as the result of an appropriate suppression of the immune system when the gut mucosa comes in contact with dietary proteins. Gastrointestinal clinical manifestations are generally milder, and histologic examination of the gut mucosa shows less-extensive changes than with those patients presenting with primary gastrointestinal disease. Celiac disease is an extensive enteropathy leading to malabsorption. Once the diagnosis of food allergy is established, the only proven therapy is the strict elimination of the food from the patient’s diet. Certain factors place some individuals at increased risk for more severe anaphylactic reactions: (i) history of a previous anaphylactic reaction; (ii) history of asthma, especially if poorly controlled; (iii) allergy to peanuts, nuts, fish, and shellfish; (iv) use of ß-blockers or angiotensin-converting enzyme inhibitors; and (v) (possibly) being female. Primary prevention of food allergies relates to blocking immunologic sensitization to foods. Patient education and support are essential for food-allergic patients.
Citation:
Perry T, Scurlock A, Jones S.
2006.
Clinical Manifestations of Food Allergic Disease,
p 3-17.
In
Maleki S, Burks A, Helm R (ed),
Food Allergy.
ASM Press, Washington, DC.
doi: 10.1128/9781555815721.ch1
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Tables
Clinical Manifestations of Food Allergic Disease
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Citation:
Perry T, Scurlock A, Jones S.
2006.
Clinical Manifestations of Food Allergic Disease,
p 3-17.
In
Maleki S, Burks A, Helm R (ed),
Food Allergy.
ASM Press, Washington, DC.
doi: 10.1128/9781555815721.ch1
Table 1.
Food hypersensitivity disorders a
Citation:
Perry T, Scurlock A, Jones S.
2006.
Clinical Manifestations of Food Allergic Disease,
p 3-17.
In
Maleki S, Burks A, Helm R (ed),
Food Allergy.
ASM Press, Washington, DC.
doi: 10.1128/9781555815721.ch1
/content/10.1128/9781555815721.ch01.ch01tbl02
Table 2.
Food intolerance: nonimmunologic adverse reactions
Table 2.
Food intolerance: nonimmunologic adverse reactions
Citation:
Perry T, Scurlock A, Jones S.
2006.
Clinical Manifestations of Food Allergic Disease,
p 3-17.
In
Maleki S, Burks A, Helm R (ed),
Food Allergy.
ASM Press, Washington, DC.
doi: 10.1128/9781555815721.ch1
/content/10.1128/9781555815721.ch01.ch01tbl03
Table 3.
Pollen-food allergy syndrome (oral allergy syndrome)
Table 3.
Pollen-food allergy syndrome (oral allergy syndrome)
Citation:
Perry T, Scurlock A, Jones S.
2006.
Clinical Manifestations of Food Allergic Disease,
p 3-17.
In
Maleki S, Burks A, Helm R (ed),
Food Allergy.
ASM Press, Washington, DC.
doi: 10.1128/9781555815721.ch1
/content/10.1128/9781555815721.ch01.ch01tbl04
Table 4.
Gastrointestinal food allergic disorders
Table 4.
Gastrointestinal food allergic disorders
Citation:
Perry T, Scurlock A, Jones S.
2006.
Clinical Manifestations of Food Allergic Disease,
p 3-17.
In
Maleki S, Burks A, Helm R (ed),
Food Allergy.
ASM Press, Washington, DC.
doi: 10.1128/9781555815721.ch1