Chapter 19 : Fungal-Bacterial Interactions

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This chapter describes a number of in vitro systems that have been used to model different aspects of fungal biology in naturally occurring complex, host-associated communities. The authors have divided fungal-bacterial model systems into categories based on the in vivo community that they seek to model. First, fungal-bacterial interactions associated with opportunistic infections are addressed. Subsequently, models designed to elucidate interactions in the oral microflora, intestinal environment, and the female reproductive tract are discussed. The chapter talks about the challenges and potential benefits of translating what has been learned with in vitro model systems to the analyses of in vivo fungal-bacterial communities. In general, when and or are found together in the lungs of cystic fibrosis (CF) patients, the numbers of fungal cells remain relatively small until patients are treated with antibacterial compounds that attenuate the infection. The study of - interactions in an in vitro model system might provide tools to better understand how these mycobacteria cause disease in the human lungs and how mixed bacterial-fungal infections could negatively impact the patient. Antibiotic-based studies may also be useful for creating model systems for the in vivo analysis of fungal-bacterial interactions on skin or on the mucosal surfaces of the mouth or female reproductive tract. Ultimately, the authors not only aim at predicting how microbes interact with one another but also determining the part that the host plays in governing and responding to different microbial communities.

Citation: Hogan D, Kolter R. 2006. Fungal-Bacterial Interactions, p 261-269. In Heitman J, Filler S, Edwards, Jr. J, Mitchell A (ed), Molecular Principles of Fungal Pathogenesis. ASM Press, Washington, DC. doi: 10.1128/9781555815776.ch19
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Image of Figure 1.
Figure 1.

Interactions between and . (A) biofilm surrounding a filament after 24 h of coincubation in conditioned M63 medium (35). (B) survival in (●) cell-free culture supernatant and (■) in conditioned medium containing 10 cells/ml.

Citation: Hogan D, Kolter R. 2006. Fungal-Bacterial Interactions, p 261-269. In Heitman J, Filler S, Edwards, Jr. J, Mitchell A (ed), Molecular Principles of Fungal Pathogenesis. ASM Press, Washington, DC. doi: 10.1128/9781555815776.ch19
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Image of Figure 2.
Figure 2.

Complex interactions affecting host-associated microbial communities.

Citation: Hogan D, Kolter R. 2006. Fungal-Bacterial Interactions, p 261-269. In Heitman J, Filler S, Edwards, Jr. J, Mitchell A (ed), Molecular Principles of Fungal Pathogenesis. ASM Press, Washington, DC. doi: 10.1128/9781555815776.ch19
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