The Mycobacterial Cell Envelope

Editors: Mamadou Daffé1, Jean-Marc Reyrat2, Groupe Avenir3
Affiliations: 1: Department of Molecular Mechanisms of Mycobacterial Infections Institut de Pharmacologie et de Biologie Structurale du Centre National de la Recherche Scientifique (CNRS) and Université Paul Sabatier Toulouse, France; 2: Faculté de Médecine René Descartes Université Paris Descartes; 3: Unité de Pathogénie des Infections Systémiques—U570 INSERM Paris, France
Content Type: Monograph
Publication Year: 2008
MyBook is a cheap paperback edition of the original book and will be sold at uniform, low price.

The first comprehensive volume on the unique attributes of the mycobacterial cell envelope Mycobacteria are responsible for many high-profile diseases in both humans and animals including leprosy, Buruli ulcer, Johne’s disease, and most notably, tuberculosis. explains the unique characteristics that cause this large group of bacteria to function differently. The envelope, a complex arrangement of lipids, proteins and carbohydrates, is the interface between the pathogen and its human host. The cell envelope’s low permeability, along with a chemical structure capable of resisting lysis by host cell enzymes, seems to be responsible for the resistance of the mycobacterial cell to destruction by the host. Additionally, envelope components are involved in the uptake of the mycobacterium by the cell and also in modifying the responses of the cell and of the host’s immune system.

Organized into two large sections, first describes the shared features of all mycobacterial cell envelopes. Topics addressed in the first section include the chemical nature of the cell envelope, general and specialized transport functions, vulnerabilities of the cell envelope, and its process of biosynthesis. The second section describes features more specific to individual mycobacterial cell envelopes. These unique features, including protein adhesion, sulfolipidsof , and a mycobacterial toxin, hold the keys to better understanding the cell envelope’s importance.

This comprehensive volume summarizes the complex architecture of the mycobacterial cell envelope and presents the major breakthroughs in this field. In each chapter, world-renowned experts present in-depth coverage of the major components of this complex structure. This volume will be essential for gaining an integrated view of this important field, and it will serve as a valuable reference for those working in the areas of biochemistry, genetics, genomics, and immunology.

Book Summary

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 The Quarterly Review of Biology

03 February 2015

As this title suggests this is truly a publication about the cell envelope of mycobacteria. The first section (16 chapters) describes the general properties of the mycobacterial cell envelope, including separate chapters on subjects such as ABC Transporter systems, ponns, biosynthesis of lipids, and constituents of the cell envelope. The second part (six chapters) is concerned with specific features of one or a few species of mycobacteria, particularly  M. tuberculosis. the book is well produced with references at the end of each chapter, but with all of the color plates collected together in the middle of the volume.

The Quarterly Review of Biology

volume 83, Page 317

Reviewer: Dr. Daniel E. Dykhuizen

Review Date: September 2008

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