Chapter 6 : Bacterial Pathogens

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This chapter gives adequate information about bacterial pathogens and their host relationships and provides a general understanding of their biological traits and how they can cause work-related infections, especially laboratory-acquired infections (LAIs), when mishandled. It presents a synopsis of pathogenic bacteria that infect humans in their workplace, whether in the laboratory, industrial, or health care setting. The chapter discusses mechanisms that cause damage in bacterial infections. Some pathogenic bacteria, such as spp., which produce human dysentery, have evolved to trigger premature or unscheduled apoptosis in the host cells they infect. Knowledge of the mechanism of action of toxinogenic bacterial toxins helps in understanding certain disease processes of pathogenic bacteria. Compliance with recombinant-DNA guidelines is required when pathogenic bacteria or their genes or gene products are used. The chapter talks about classic human pathogens. Although spp. are members of normal gut and oral florae, work in the laboratory with these bacteria should be at biosafety level (BSL)-2 because they are known to cause human disease and can carry antibiotic resistance markers. Cutaneous anthrax is the most commonly acquired form in humans. The pathogenic bacteria , , and have animal reservoirs as their natural hosts and produce serious diseases in humans.

Citation: Coggin, Jr. J. 2006. Bacterial Pathogens, p 93-114. In Fleming D, Hunt D (ed), Biological Safety. ASM Press, Washington, DC. doi: 10.1128/9781555815899.ch6
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1. Abramova, E., A.,, L. M. Grinberg,, O. V. Yampolskaya, and, D. H. Walker. 1993. Pathology of inhalational anthrax in 42 cases from the Sverdlovsk outbreak of 1979. Proc. Natl. Acad. Sci. USA 90: 22912294.
2. Alexander, A. D. 1984. Leptospirosis in laboratory mice. Science 224: 1158.
3. Baillie, L. W.,, K. Fowler, and, P. C. Turnbull. 1999. Human immune responses to the UK human anthrax vaccine. J. Appl. Microbiol. 87: 306308.
4. Balfanz, J.,, P. Rautenberg, and, U. Ullmann. 1996. Molecular mechanisms of action of bacterial exotoxins. Zentbl. Bakteriol. 284: 170206.
5. Banwell, J. G. 1990. Pathophysiology of diarrheal disorders. Rev. Infect. Dis 12: 530.
6. Berrouane, Y. 1997. Laboratory-acquired infections, p. 607–618. In R. P. Wenzel (ed.), Prevention and Control of Nosocomial Infections. Williams & Wilkins, Baltimore, Md.
7. Black, R. E. 1990. Epidemiology of traveler’s diarrhea and relative importance of various pathogens. Rev. Infect. Dis. 12: S73.
8. Bohach, G. A.,, D. J. Fast,, R. D. Nelson, and, P. M. Schlievert. 1990. Staphylococcal and streptococcal pyrogenic toxins involved in toxic shock syndrome and related illness. Crit. Rev. Microbiol. 17: 251272.
9. Boucher, J. C.,, M. J. Schurr,, H. Yu, D. W. Rowen, and, V. Deretic. 1997. Pseudomonas aeruginosa in cystic fibrosis: role of mucC in the regulation of alginate production and stress sensitivity. Microbiology 143: 34733480.
10. Boyer, K. M., and, S. P. Gotoff. 1986. Prevention of early onset neonatal group B streptococcal disease with selective intrapartum chemoprophylaxis. N. Engl. J. Med 314: 1665.
11. Brachman, P. S. 1980. Inhalation anthrax. Ann. N. Y. Acad. Sci 353: 83.
12. Britigan, B. E., M. S. Cohen, and, P. E. Sparling. 1985. Gonococcal infection: a model of molecular pathogenesis. N. Engl. J. Med. 312: 16831694.
13. Brooks, G. E.,, J. S. Butel,, and S. A. Morse. 2004. Pathogenesis of bacterial infection, p. 147–160. In E. Jawetz,, J. L. Melnick, and, E. A. Adelberg (ed.), Medical Microbiology, 23rd ed. Lange Medical Books/McGraw Hill, New York, N.Y.
14. Brubaker, R. R. 1991. Factors promoting acute and chronic diseases caused by yersiniae. Clin. Microbiol. Rev. 4: 309324.
15. Burmeister, R. W.,, W. D. Tigertt, and, E. L. Overholt. 1962. Laboratory-acquired pneumonic plague. Ann. Intern. Med. 56: 789800.
16. Centers for Disease Control and Prevention and National Institutes of Health. 2006. Biosafety in Microbiological and Biomedical Laboratories, 5th ed. L. C. Chosewood and, D. E. Wilson (ed.). U.S. Department of Health and Human Services, Washington, D.C.
17. Centor, R. M.,, F A. Meier, and, H. P. Dalton. 1986. Throat cultures and rapid tests for diagnosis of group A streptococcal pharyngitis. Ann. Intern. Med 105: 892.
18. Dillon, H. C. 1979. Poststreptococcal glomerulonephritis following pyoderma. Rev. Infect. Dis 1: 935.
19. Dillon, J. A., and, K. H. Yeung. 1989. Beta-lactamase plasmids and chromosomally mediated antibiotic resistance in pathogenic Neisseria species. Clin. Microbiol. Rev. 2 (Suppl.) : S125S133.
20. Dooley, C.,, P. H. Cohen,, P. L. Fitzgibbons,, M. Bauer, M. D. Appleman, G. I. Perez-Perez, and, M. J. Blaser. 1989. Prevalence of Helicobacter pylori infection and histologic gastritis in asymptomatic persons. N. Engl. J. Med. 321: 15621566.
21. Drage, L. A. 1999. Life-threatening rashes: dermatologic signs of four infectious diseases. Mayo Clin. Proc. 74: 6872.
22. Dworkin, M. S.,, D. E. Anderson,, Jr., T. G. Schwan,, P. C. Shoemaker,, S. N. Banerjee,, B. O. Kassen, and, W. Burgdorfer. 1998. Tick-borne relapsing fever in the northwestern United States and southwestern Canada. Clin. Infect. Dis. 26: 122131.
23. Eslick, G. D.,, L. L. Lim,, J. E. Byles,, H. H. Xia, and, N. J. Tally. 1999. Association of Helicobacter pylori infection with gastric carcinoma: a meta-analysis. Am. J. Gastroenterol. 94: 23732379.
24. Hamadeh, G. N.,, B. W. Turner,, W. Trible, Jr., B. J. Hoffmann, and, R. M. Anderson. 1992. Laboratory outbreak of Q fever. J. Fam. Pract. 35: 683685.
25. Hook, E. W., III, and, K. K. Holmes. 1985. Gonococcal infections. Ann. Intern. Med 102: 229.
26. Jackson, L. A.,, B. A. Perkins, and, J. D. Wenger. 1993. Cat scratch disease in the United States: an analysis of three national databases. Am. J. Public Health 83: 17071711.
27. Kirby, B. D.,, K. M. Snyder,, R. D. Meyer, and, S. M. Finegold. 1980. Legionnaires’ disease: report of 65 nosocomially acquired cases and review of the literature. Medicine 59: 188205.
28. Koornhof, H. J.,, R. A. Smego, Jr., and, M. Nicol. 1999. Yersiniosis. II. The pathogenesis of Yersinia infections. Eur. J. Clin. Microbiol. Infect. Dis. 18: 87112.
29. Levine, M. M. 1987. Escherichia coli that cause diarrhea: enterotoxigenic, enteropathogenic, enteroinvasive, enterohemorrhagic, and enteroadherent. J. Infect. Dis 155: 377.
30. Lietman, T., and, S. Blower. 1999. Tuberculosis vaccines. Science 286: 13001301.
31. Lowry, P. W., and, L. S. Tompkins. 1993. Nosocomial legionellosis: a review of pulmonary and extrapulmonary syndromes. Am. J. Infect. Control 21: 21.
32. Mazzaccaro, R. J.,, S. Stenger,, K. L. Rock,, S. A. Porcelli,, M. B. Brenner,, R. L. Modlin, and, B. R. Bloom. 1998. Cytotoxic T lymphocytes in resistance to tuberculosis. Adv. Exp. Med. Biol. 452: 85101.
33. Michaux-Charachon, S.,, G. Bourg,, E. Jumas-Black, P. Guigue-Talet,, A. Allardet-Servent, D. O’Callaghan, and, M. Ramuz. 1997. Genome structure and phylogeny in the genus Brucella. J. Bacteriol. 179: 32443249.
34. Miller, C. D.,, J. R. Songer, and, J. E. Sullivan. 1987. A twenty-five year review of laboratory-acquired human infections at the National Animal Disease Center. Am. Ind. Hyg. Assoc. J. 48: 271275.
35. Morrison, D. C.,, R. Silverstein,, M. Luchi, and, A. Shnyra. 1999. Structure-function relationships of bacterial endotoxins. Contribution to microbial sepsis. Infect. Dis. Clin. N. Am. 13: 313340.
36. National Institutes of Health. 2002. NIH Guidelines for Research Involving Recombinant DNA Molecules (NIH Guidelines), 59 FR 34496 (July 5, 1994), as amended. [On line. The current amended version can be accessed at http://www4.od.nih.gov/oba/rac/guidelines/guidelines.html..]
37. Nonaka, T.,, A. Kuwae,, C. Sasakawa, and, S. ImajohOhmi. 1999. Shigella flexneri YSH6000 induces two types of cell death, apoptosis and oncosis, in the differentiated human monoblastic cell line U937. FEMS Microbiol. Lett. 174: 8995.
38. Olle-Goig, J. E., and, J. Canela-Soler. 1987. An outbreak of Brucella melitensis infection by airborne transmission among laboratory workers. Am. J. Public Health 77: 335338.
39. Olyhoek, T.,, B. A. Crowe, and, M. Achtman. 1987. Clonal population structure of Neisseria meningitidis serogroup A isolated from epidemics and pandemics between 1915 and 1983. Rev. Infect. Dis. 9: 665.
40. Onderdonk, A. B.,, M. E. Shapiro,, R. W. Finberg,, D. F. Zaleznik, and, D. L. Kasper. 1984. Use of a model of intraabdominal sepsis for studies of the pathogenicity of Bacteroides fragilis. Rev. Infect. Dis. 6 (Suppl. 1) : S91S95.
41. Oster, C. N.,, D. S. Burke,, R. H. Kenyon,, M. S. Ascher,, P. Harber, and, C. E. Pedersen. 1977. Laboratory-acquired Rocky Mountain spotted fever. The hazard of aerosol transmission. N. Engl. J. Med. 297: 859863.
42. Pike, R. M. 1976. Laboratory-associated infections. Summary and analysis of 3921 cases. Health Lab. Sci. 13: 105114.
43. Quinn, R. W. 1989. Comprehensive review of morbidity and mortality trends for rheumatic fever, streptococcal disease, and scarlet fever: the decline of rheumatic fever. Rev. Infect. Dis 11: 928.
44. Rahn, D. W., and, S. E. Malawista. 1991. Lyme disease: recommendations for diagnosis and treatment. Ann. Intern. Med 114: 472.
45. Schaechter, M. 1998. Damage by microbial agents, p. 115–125. In M. Schaechter,, N. C. Engleberg,, B. I. Eisenstein, and, G. Medoff (ed.), Mechanisms of Microbial Disease, 3rd ed. Williams & Wilkins, Baltimore, Md.
46. Seydel, U.,, A. B. Schromm,, R. Blunck, and, K. Brandenburg. 2000. Chemical structure, molecular conformation, and bioactivity of endotoxins. Chem. Immunol. 74: 524.
47. Sharp, S. E. 1999. Commensal and pathogenic microorganisms of humans, p. 23–32. In P. R. Murray,, E. J. Baron,, M. A. Pfaller,, F. C. Tenover, and, R. H. Yolken (ed.), Manual of Clinical Microbiology, 7th ed. ASM Press, Washington, D.C.
48. Sheagren, J. N. 1984. Staphylococcus aureus : the persistent pathogen (two parts). N. Engl. J. Med. 310: 13681437.
49. Steere, A. C. 1989. Lyme disease. N. Engl. J. Med. 321: 586.
50. Steinthorsdottir, V. H. Halldorsson, and, O. S. Andresson. 2000. Clostridium perfringens beta-toxin forms multimeric transmembrane pores in human endothelial cells. Microb. Pathog. 28: 4550.
51. Stevens, D. L. 1999. The flesh-eating bacterium: what’s next? J. Infect. Dis. 179 (Suppl. 2) : S366S374.
52. Talan, D. A.,, D. M. Citron,, F. M. Abrahamian,, G. J. Moran, and, E. J. Goldstein for the Emergency Medicine Animal Bite Infection Study Group. 1999. Bacteriologic analysis of infected dog and cat bites. N. Engl. J. Med. 340: 8592.
53. Tuomanen, E. I.,, R. Austrian, and, H. R. Masure. 1995. Pathogenesis of pneumococcal infection. N. Engl. J. Med. 332: 12801284.
54. Venezio, F. R.,, R. M. Gullberg,, G. O. Westenfelder,, J. P. Phair, and, F. V. Cook. 1986. Group G streptococcal endocarditis and bacteremia. Am. J. Med. 81: 2934.
55. Voss, A. 1999. Prevention and control of laboratory-acquired infections, p. 165–173. In P. R. Murray,, E. J. Baron,, M. A. Pfaller,, F. C. Tenover, and, R. H. Yolken (ed.), Manual of Clinical Microbiology, 7th ed. ASM Press, Washington, D.C.
56. Waitkins, S. A. 1985. From the PHLS. Update on leptospirosis. Br. Med. J. 290: 15021503.
57. Weinrauch, Y., and, A. Zychlinsky. 1999. The induction of apoptosis by bacterial pathogens. Annu. Rev. Microbiol. 53: 155187.


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Major toxinogenic bacteria

Citation: Coggin, Jr. J. 2006. Bacterial Pathogens, p 93-114. In Fleming D, Hunt D (ed), Biological Safety. ASM Press, Washington, DC. doi: 10.1128/9781555815899.ch6
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Pathogenic bacteria

Citation: Coggin, Jr. J. 2006. Bacterial Pathogens, p 93-114. In Fleming D, Hunt D (ed), Biological Safety. ASM Press, Washington, DC. doi: 10.1128/9781555815899.ch6
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Rickettsial diseases

Citation: Coggin, Jr. J. 2006. Bacterial Pathogens, p 93-114. In Fleming D, Hunt D (ed), Biological Safety. ASM Press, Washington, DC. doi: 10.1128/9781555815899.ch6

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