Chapter 111 : Introduction

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Introduction, Page 1 of 2

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This is the introductory chapter to the section . Systemic autoimmune diseases are often associated with the production of autoantibodies that recognize a diverse array of cytoplasmic and nuclear antigens. The detection of disease-specific autoantibodies in asymptomatic individuals may permit early diagnosis and preventative treatment. Good examples are antimitochondrial antibodies in primary biliary cirrhosis, anti-Sm, RNP, Ro(SSA), and double-stranded DNA autoantibodies in systemic lupus erythematosus (SLE), and specific autoantibodies associated with rheumatoid arthritis, polymyositis, and scleroderma, all of which may appear prior to the onset of clinical manifestations. The chapters in this section reflect both the evolving technology and the need for reliable confirmatory tests, which frequently are older or more labor-intensive assays that are not readily available. Chapters also deal with the mainstream autoantibody assays employing solid-phase antigens, both natural and recombinant. They discuss the clinical use of antineutrophil cytoplasmic antibody testing in the diagnosis of vasculitis syndromes and the newer tests that detect autoantibodies against specific neutrophil proteins.

Citation: Reeves W. 2006. Introduction, p 993-994. In Detrick B, Hamilton R, Folds J (ed), Manual of Molecular and Clinical Laboratory Immunology, 7th Edition. ASM Press, Washington, DC. doi: 10.1128/9781555815905.ch111
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